离子选择电极电位法研究S2O8^2—与I^—反应动力学

用离子选择电极电位法对S_2O_8~(2-)-Ⅰ~-体系反应动力学问题进行了探讨,研究了离子强度对反应速度的影响。结果表明:离子选择电极电位法可用于此体系的动力学研究,并且得到满意的结果;提出了该电极适用的浓度条件;得出生成CuI~+步骤为催化反应决定步骤的新结论;随着离子强度的增加dE/dt值增大,即反应速度加快。     

An evaluation of numerical integration algorithms for the estimation of the area under the curve (AUC) in pharmacokinetic studies

Six numerical integration algorithms based on linear and log trapezoidal methods as well as four cubic-spline methods were proposed for estimation of area under the curve (AUC). These six different algorithms were implemented using IMSL/IDL^TM command language and evaluated using data simulated under five different dosing conditions and two different sampling conditions. Comparisons between AUC estimations using these six different algorithms and the theoretical results were made in terms of both overall AUC values and the superimposability of the concentration-time profiles. In well designed studies with ample data points, the algorithm based on IMSL/IDL^TM function CSSHAPE with concavity preservation gave the best performance. In contrast, when the frequency of blood collection was limited, the algorithm based on the log trapezoidal rule proved to be stable with reasonable accuracy, and is recommended as the practical method for numerical interpolation and integration in pharmacokinetic studies. Algorithms based on the combination of the log trapezoidal rule and cubic-spline methods using IMSL/IDL^TM function CSSHAPE can be developed to enhance overall performance.     

差商最速下降法及其收敛性

证明了精确线搜索下的差商最速下降法的整体收敛性,提出了非精确线搜索下的有关算法并证明了收敛性。     

蕨麻素冻干脂质体的制备及理化性质的研究

目的 制备蕨麻素冻干脂质体注射剂并研究其理化性质。方法 采用薄膜超声分散法并冷冻干燥来制备蕨麻素脂质体，用葡聚糖凝胶（Sephadex G-50）微型柱离心法测定包封率。结果 制得的蕨麻素脂质体包封率为56．62％，粒径范围为71．70—166．47nm，透射显微镜下观察脂质体为粒径均匀的球类或近球状小囊泡。结论 蕨麻素脂质体处方和制备工艺稳定可行，重现性好。     

PHA对单产和联产白细胞介素-2活性的影响

本文研究了用人外周血白细胞在细胞浓度为5×10~5个/ml、培养时间为24h,PHA加量对单独生产白细胞介素_2(单产)及联合生产a_干扰素、白细胞介素-2(联产)的影响.单产中,以25μg/mlPHA刺激量为宜;联产中以100μg/ml刺激量最好.联产比单产所得白细胞介素-2产量高10倍以上,且纯度高.     

临床医学院教学管理工作的思考

临床医学院教学管理工作直接影响到临床教学质量。非直属临床医学院没有专职教师,教研室管理比较松散。做好非直属临床医学院的教学管理工作,进一步增强教学意识,改进教学方法,规范教学要求,对于保证临床教学任务的落实、确保教学质量显得十分重要。     

中医药学研究方法的解构与特性分析

将中医药学研究方法从观念理论、核心方法和技术手段3个方面进行解构，并对其内在特性进行详细分析。明确提出中医药学研究方法的范式特性、观念理论的思辨性、核心方法的主观性以及整体刚性和局部柔性的特性，揭示了中医药研究方法的优势与不足，为中医药研究方法论的创新提供理论依据。     

Effect of the NK3 receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans

Visceral hypersensitivity is important in the pathophysiology of irritable bowel syndrome and thus a target for modulation in drug development. Neurokinin (NK) receptors, including NK(3) receptors, are expressed in the motor and sensory systems of the digestive tract. The aim of this study was to compare the effects of two different doses (25 and 100 mg) of the NK(3) receptor antagonist, talnetant (SB223412) with placebo on rectal sensory function and compliance in healthy volunteers studied at two centres. Rectal barostat tests were performed on 102 healthy volunteers, randomized to receive either oral talnetant 25 or 100 mg or placebo over 14-17 days. Studies were performed on three occasions: day 1 immediately prior to 1st dose, day 1 4 h postdose, and after 14- to17-day therapy. Compliance, and pressure thresholds for first sensation, urgency, discomfort and pain were measured using ascending method of limits, and sensory intensity ratings for gas, urgency, discomfort and pain determined during four random phasic distensions (12, 24, 36 and 48 mmHg). Talnetant had no effect on rectal compliance, sensory thresholds or intensity ratings compared with placebo. In general, the results obtained at the two centres differed minimally, with intensity scores at one centre consistently somewhat lower. At the doses tested, talnetant has no effect on rectal compliance or distension-induced rectal sensation in healthy participants.     

反坦克武器击中坦克时舱室内有害气体测试方法的探讨

为探讨在模拟实验条件下，坦克受到反我武器攻击后舱室内有害气体的取样方法和分析方法，用3种武器发射3种弹药攻击坦克，在远距离控制取样设备，取样后在实验室进行坦克舱室内有害气体浓度分析，结果取样成功，坦克被击中后，一氧化碳气体含量有明显的增高，氮氧化物、二氧化硫增高幅度不大，氧含量无明显变化，说明对坦克舱室进行远距离现场控制气体采样是可行的；坦克的受反坦克武器打击后，除弹片和冲击波等致伤因素外，还会造成坦克内乘员一氧化碳中毒。     

Fluctuations in Tumor Blood Flow under Normotension and the Effect of Angiotensin II-induced Hypertension

To elucidate the significance of angiotensin II (AID-induced hypertension chemotherapy, changes of tissue blood flow both in normal subcutis and in tumors (AH109A, LY80) were measured with the hydrogen gas clearance method. A newly-developed anesthetic machine was used to keep the animals' condition constant. Tissue blood flow in normal subcutis and tumors always fluctuated with time under normotension. The nature and the rate of fluctuation in tumor Wood flow were almost identical in two different types of tumors. However, the fluctuation of blood flow in tumor and that in normal subcutis were almost always inversely related when blood flows in these different tissues were measured simultaneously, i.e., when tissue blood flow in normal subcutis decreased, tumor blood flow increased, and vice versa. The findings supported the idea that the connection mode between the tumor vascular bed and normal vascular bed is a parallel circuit. Vascular resistance in the normal vascular bed under All-induced hypertension seemed to be greater than that under normotension, because the All-increased tumor blood flow always exceeded the maximum tumor blood flow under normotension. Due to the fluctuations of tumor blood flow, no-flow or low-flow areas, resistant to delivery of anti-cancer drugs, moved sporadically within the tumor under the normotensive condition. However, good conditions for drug delivery to tumor tissue were induced by All-induced hypertension.