Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia

Objective:To observe the clinical effect of Astragalus Injection(黄芪注射液,AI) and its immuno-regulatory action in treating chronic aplastic anemia(CAA).Methods:Sixty patients with CAA were randomly assigned to two groups equally,both were treated with Stanozolol three times a day,2 mg each time through oral intake,but AI was given additionally to the patients in the treated group once a day via intravenous dripping.All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,with follow-up adopted.The clinical effi cacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were observed.Results:The total effective rate in the treated group was 83.3%(25/30),which was higher than that in the control group 66.7%(20/30),showing significant difference between them(P<0.05).Levels of hemoglobin,WBC,reticular cell and platelet were elevated in both groups after treatment,but the improvement was signif icantly better in the treated group than that in the control group with respect to the former three indexes(P<0.05).The level of CD4 increased and that of CD8 decreased signifi cantly after treatment in the treated group(P<0.05),which showed significant difference as compared with those in the control group(P<0.05).Levels of serum TNF-α and IL-2 lowered after treatment in both groups,but signifi cance only showed in the treated group(P<0.05).The degree of proliferation in bone marrow got raised signifi cantly and the percentage of non-hemopoietic cells reduced signifi cantly in the treated group after treatment,also showing significant difference to those in the control group(P<0.05).Conclusion:AI could promote the recovery of hemopoietic function,which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.     

高渗三黄液治疗难治性溃疡的疗效观察

目的 探讨高渗三黄液对临床难治性溃疡的有效性和安全性.方法 采用随机、对照的研究方法,将219例难治性溃疡患者随机分为治疗组（自拟高渗三黄液治疗）和对照组（传统外科换药治疗）.连续用药2周,分别于给药后1周和2周进行临床治愈率及有效率的比较.结果 两组患者临床综合疗效比较：给药后1周及给药后2周,两者总有效率比较,差异有统计学意义（P＜0.05）,治疗组疗效明显高于对照组.两组患者均未见严重不良反应.结论 高渗三黄液组治疗难治性溃疡明显优于传统换药治疗.     

护理干预预防大剂量甲氨蝶呤化疗后口腔溃疡的效果观察

甲氨蝶呤为二氢叶酸还原酶抑制剂,临床大剂量应用时主要用于治疗急性淋巴细胞白血病,但应用后常导致严重口腔溃疡,给病人带来极大痛苦。因此,预防病人化疗后口腔溃疡的发生在治疗护理过程中极为关键。我们通过在病人化疗过程中给予护理干预,预防化疗后口腔溃疡的发生,取得了满意的效果。     

中医药在造血干细胞移植中的应用进展

总结中医药介入造血干细胞移植中的相关文献：中医药介入造血干细胞移植可提高动员效果,加快移植后造血及免疫重建,减少并发症,延长患者生存期,中医药介入造血干细胞移植取得了初步成效。     

参芪清热颗粒联合复方丹参注射、生脉注射液治疗急性白血病临床研究

[目的]探究参芪清热颗粒联合复方丹参注射液、生脉注射液治疗急性白血病(Acute leukemia,AL)的疗效.[方法]将193例AL患者分为治疗组106例,对照组87例.对照组单纯给予国际标准化疗方案治疗;治疗组在此基础上采用复方丹参、生脉注射液逆转耐药并中药分阶段干预治疗,观察并比较两组疗效.[结果]治疗组初治患者有效率81.43％,与对照组初治有效率74.36％比较,差异无统计学意义(P＞0.05);难治患者有效率69.44％,与对照组难治有效率38.46％比较,差异有统计学意义(P＜0.05).治疗组白细胞最低值及感染率与对照组比较,变化无统计学意义(P＞0.05);白细胞＜2.0×109/L的持续时间及感染时间比对照组缩短(P＜0.05);血制品的输注亦比对照组减少(P＜0.05),心脏副作用减轻.[结论]采用益气养阴、活血化瘀中药制剂联合生脉、复方丹参注射液配合化疗治疗AL,能提高疗效,降低毒副作用,改善患者生存质量.     

中西医结合治疗重症中暑的临床研究

目的评价中西医结合治疗方案对重症中暑的治疗效果。方法重症中暑患者133例,其中热射病(暑厥证)62例,热衰竭(阳暑证)71例,随机分为中西医结合治疗组与对照组,对照组采用单纯西医治疗,中西医结合组在对照组基础上分别加用安宫牛黄丸、生脉饮治疗。对比分析各组高热持续时间、发热持续时间、症状体征持续时间及脏器功能损害发生情况。结果热射病(暑厥证)中西医结合组患者意识恢复较快、发热持续时间及高热持续时间明显短于对照组;MODS发生率亦低于对照组。热衰竭(阳暑证)中西医结合组发热持续时间与对照组无统计学差异,心动过速较对照组缓解较快,心肌酶异常发生率低于对照组。结论中西医结合治疗重症中暑疗效确切,优势明显,具有较好的应用前景。     

海藻湿敷治疗静脉输液外渗的疗效观察

[目的]观察海藻湿敷治疗静脉输液外渗的疗效。[方法]选取静脉输液外渗引起局部组织肿胀、疼痛的病人66例,随机分为治疗组34例和对照组32例,治疗组应用海藻湿敷治疗,对照组采用硫酸镁湿敷治疗。[结果]治疗组总有效率94.12%,对照组总有效率81.25%,二者比较差异有统计学意义(P<0.05)。[结论]海藻湿敷治疗静脉输液外渗效果优于硫酸镁湿敷法。     

白细胞减少症中医诊疗经验辑要

白细胞减少症是由于各种病因引起的一组临床综合征。可归属于中医学的“虚劳”、“温病”等病证范畴。其病机变化虽多,但不外气血亏虚、阴阳失调,心、肝、脾、肾机能受损,其中脾肾两虚为其发病关键,虚、热、瘀、湿为其主要病理表现。依据临床证候,四诊合参,结合八纲、脏腑辨证,分为气血两虚、脾肾阳虚、肝肾阴虚、毒瘀互结四型辨证论治,气血两虚、阴阳失调,脏腑功能失常为本,正虚不固,六淫外袭而反复发热、感染为标,其中脾肾两虚为其发病关键,故治疗当以扶正兼祛外邪为基本法则。治疗上以补气养血、健脾补肾为本,以虚、热、瘀、湿为标,辨证论治与辨病论治的有机结合,中西医优化选择。     

超声在输卵管间质部妊娠诊断和治疗中的应用价值

目的探讨腔内超声诊断及超声引导下甲氨蝶呤(MTX)局部注射治疗在输卵管间质部妊娠(TIP)中的价值。方法对中国人民解放军总医院就诊的618例异位妊娠患者进行研究。研究分为2部分:诊断部分:610例患者有手术病理结果,并在术前曾接受腔内超声检查,评价腔内超声诊断TIP的灵敏度、特异度及总符合率;治疗部分:8例患者临床和超声表现符合TIP,接受了超声引导下MTX局部注射治疗,分析该治疗方法的适用人群。结果诊断部分:经手术病理证实的610例异位妊娠患者中28例为TIP,3例被超声误诊为TIP。腔内超声诊断TIP总符合率为98.52%,灵敏度79.57%,特异度99.48%。治疗部分:8例患者中,1例治疗失败转为手术治疗,7例顺利康复。结论腔内超声诊断TIP的符合率高,对临床治疗方案的选择有很大指导意义。妊娠包块显示清晰、未破裂且无明显内出血的TIP患者,若其病灶较小或血清β-hCG较低,可选择超声引导下介入治疗。此法损伤小,疗效好。