Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia |
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引用本文: | 王茂生,李君,邸海侠,李振丽,杨淑莲,侯伟,阎金玉,赵晓民.Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia[J].Chinese Journal of Integrated Traditional and Western Medicine,2007,13(2):98-102. |
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作者姓名: | 王茂生 李君 邸海侠 李振丽 杨淑莲 侯伟 阎金玉 赵晓民 |
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作者单位: | TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,TCM Hospital of Langfang City Chinese Hemopathic Therapeutic Center of TCM,Hebei 065000,Hebei 065000,Hebei 065000,Hebei 065000,Hebei 065000,Hebei 065000,Hebei 065000,Hebei 065000 |
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摘 要: | Objective:To observe the clinical effect of Astragalus Injection(黄芪注射液,AI) and its immuno-regulatory action in treating chronic aplastic anemia(CAA).Methods:Sixty patients with CAA were randomly assigned to two groups equally,both were treated with Stanozolol three times a day,2 mg each time through oral intake,but AI was given additionally to the patients in the treated group once a day via intravenous dripping.All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,with follow-up adopted.The clinical effi cacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were observed.Results:The total effective rate in the treated group was 83.3%(25/30),which was higher than that in the control group 66.7%(20/30),showing significant difference between them(P<0.05).Levels of hemoglobin,WBC,reticular cell and platelet were elevated in both groups after treatment,but the improvement was signif icantly better in the treated group than that in the control group with respect to the former three indexes(P<0.05).The level of CD4 increased and that of CD8 decreased signifi cantly after treatment in the treated group(P<0.05),which showed significant difference as compared with those in the control group(P<0.05).Levels of serum TNF-α and IL-2 lowered after treatment in both groups,but signifi cance only showed in the treated group(P<0.05).The degree of proliferation in bone marrow got raised signifi cantly and the percentage of non-hemopoietic cells reduced signifi cantly in the treated group after treatment,also showing significant difference to those in the control group(P<0.05).Conclusion:AI could promote the recovery of hemopoietic function,which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.
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关 键 词: | tumor necrosis factor- α |
收稿时间: | 22 December 2006 |
修稿时间: | 2006-12-22 |
Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia |
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Authors: | Dr Mao-sheng Wang Jun Li Hai-xia Di Zhen-li Li Shu-Lian Yang Wei Hou Jin-yu Yan and Xiao-min Zhao |
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Institution: | (1) TCM Hospital of Langfang City, Chinese Hemopathic Therapeutic Center of TCM, Hebei, 065000, China |
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Abstract: | Objective To observe the clinical effect of Astragalus Injection (黄芪注射液, AI) and its immuno-regulatory action in treating chronic aplastic
anemia (CAA).
Methods Sixty patients with CAA were randomly assigned to two groups equally, both were treated with Stanozolol three times a day,
2 mg each time through oral intake, but AI was given additionally to the patients in the treated group once a day via intravenous
dripping. All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,
with follow-up adopted. The clinical efficacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as
well as the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) were observed.
Results The total effective rate in the treated group was 83.3% (25/30), which was higher than that in the control group 66.7% (20/30),
showing significant difference between them (P<0.05). Levels of hemoglobin, WBC, reticular cell and platelet were elevated in both groups after treatment, but the improvement
was significantly better in the treated group than that in the control group with respect to the former three indexes (P<0.05). The level of CD4+ increased and that of CD8+ decreased significantly after treatment in the treated group (P<0.05), which showed significant difference as compared with those in the control group (P<0.05). Levels of serum TNF-α and IL-2 lowered after treatment in both groups, but significance only showed in the treated
group (P<0.05). The degree of proliferation in bone marrow got raised significantly and the percentage of non-hemopoietic cells reduced
significantly in the treated group after treatment, also showing significant difference to those in the control group (P<0.05).
Conclusion AI could promote the recovery of hemopoietic function, which might be through improving T-lymphocyte subsets and reducing
the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.
Supported by the Funds of Langfang Municipal Department of Science and Technology (No. 2005050245) |
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Keywords: | Astragalus Injection chronic aplastic anemia T-lymphocyte subsets interleukin-2 |
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