颈椎前路Hybrid术治疗颈椎退行性疾病

目的:探讨颈椎前路Hybrid术治疗颈椎退行性疾病的临床疗效并观察其术后1年影像学上间盘置换节段异位骨化的发生率.方法:对2015年1月至2018年4月接受颈椎前路Hybrid术符合纳入和排除标准并获得完整临床随访资料的35例患者进行回顾性分析,其中24例获得完整影像学随访资料,男15例,女20例,年龄39～70(55...     

虎力散胶囊外用治疗膝关节骨关节炎疼痛的临床疗效分析

目的验证虎力散胶囊外用治疗骨性关节炎疼痛的临床疗效。方法回顾性分析81例膝关节骨关节炎患者,并分为A组（虎力散胶囊组）54例,B组（理疗组）27例进行临床对比观察。结果 A组和B组CR＋PR率分别为92.6%和33.3%,P〈0.05,两组比较差异有统计学意义。结论虎力散胶囊外用是缓解膝关节骨关节炎疼痛的一种有效的治疗方法。     

小针刀配合蠲痹汤加减治疗肝肾亏虚型膝关节骨性关节炎的临床效果研究〖JZ)〗〖HS)〗

目的:探讨小针刀配合蠲痹汤加减治疗肝肾亏虚型膝关节骨性关节炎的临床效果。方法:选取2017年5月至2019年1月在北京中医医院顺义医院收治的肝肾亏虚型膝关节骨性关节炎患者126例作为研究对象,按照随机数字表法将其分为对照组和观察组,每组63例。对照组单独应用小针刀治疗,观察组在对照组的基础上加用蠲痹汤加减治疗。观察2组患者临床疗效,以及治疗前后膝关节功能评分(HSS评分)、关节肿胀积分、骨摩擦音个数及中医证候积分。结果:观察组治疗总有效率为95. 2%(60/63),高于对照组的82. 5%(52/63),2组比较差异有统计学意义(P 0. 05);治疗前,2组患者HSS评分、关节肿胀积分、骨摩擦音关节及中医证候积分比较,差异均无统计学意义(均P 0. 05);治疗后,观察组患者HSS评分中疼痛评分、功能及总分均高于对照组(均P 0. 05),观察组患者关节肿胀积分、骨摩擦音关节个数及中医证候积分均显著低于对照组(均P 0. 05)。结论:小针刀配合蠲痹汤加减治疗肝肾亏虚型膝关节骨性关节炎疗效显著,可有效减轻患者疼痛,提高膝关节功能,减轻患者关节肿胀程度,值得临床应用。     

后路枕颈融合内固定联合椎体成形术治疗枢椎转移瘤病理性骨折的疗效观察

背景:椎体成形术与后路融合内固定术用于治疗脊柱椎体继发性转移瘤,然而鲜有涉及上颈椎区域转移瘤的研究报告.目的:观察后路枕颈部融合固定术联合椎体成形术治疗枢椎转移瘤病理性骨折的疗效和安全性.方法:回顾性分析2004年3月至2018年8月收治的12例枢椎转移瘤病理性骨折患者的临床资料.所有患者均出现枕颈部疼痛,其中8例出现...     

颈椎前路Hybrid术在治疗颈椎退行性疾病中对活动度和曲度的影响

目的:观察颈椎前路Hybrid术后6个月影像学上颈椎曲度和活动度的变化.方法:回顾性分析2017年1月至2018年7月接受颈椎前路Hybrid术的颈椎退行性疾病患者,符合纳入标准并获得术前和术后6个月影像学资料者29例.男11例,女18例,年龄34～76(55.86±10.69)岁,手术时间2～4(3.03±0.51)...     

体外静水压环境下细胞因子诱导骨髓间充质干细胞向髓核样细胞分化

BACKGROUND: Differentiation of bone marrow mesenchymal stem cells is induced by integrated factors. In vitro interaction of cytokine complex and certain cell mechanical stimulation is carried out to further improve the efficiency of bone marrow mesenchymal stem cells differentiating into nucleus pulposus-like cells.OBJECTIVE: To investigate the differentiation of bone marrow mesenchymal stem cells into nucleus pulposus-like cells induced by transforming growth factor-β1 and insulin-like growth factor-1 under hydrostatic pressure.METHODS:Bone marrow mesenchymal stem cells from adult rats were separated, cultured and purified in vitro. Passage 3 cells were induced in vitro with transforming growth factor-β1 and insulin-like growth factor-1 under hydrostatic pressure (hydrostatic pressure group), with transforming growth factor-β1 and insulin-like growth factor-1 under normal pressure (drug group), or with normal culture medium under normal pressure (blank control group).RESULTS AND CONCLUSION: At day 14 after culture, polygonal nucleus pulposus-like cells were observed in the hydrostatic pressure group, but irregular cells in the drug group. There was no obvious change in the blank control group. Levels of collagen type II and DNA were higher in the hydrostatic pressure group than the other two groups. These findings indicate that the combination of transforming growth factor-β1 and insulin-like growth factor-1 can successfully induce the differentiation of bone marrow mesenchymal stem cells into nucleus pulposus-like cells under hydrostatic pressure, and the differentiation efficiency is higher under hydrostatic pressure than under normal pressure.  中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

奇正青鹏膏剂治疗膝关节骨关节炎疼痛的临床疗效分析

目的验证奇正青鹏膏剂治疗骨性关节炎疼痛的临床疗效。方法回顾性分析156例膝关节骨关节炎病人,分为青鹏膏组88例(主要应用奇正青鹏膏剂),理疗组68例进行临床对比观察。理疗组采用超短波治疗。结果青鹏膏组和理疗组的完全缓解(CR)+部分缓解(PR)率分别为86.8%和35.6%,两组比较差异有统计学意义(P<0.05)。结论奇正青鹏膏剂是缓解膝关节骨关节炎疼痛的一种有效药物。