全文获取类型
收费全文 | 947篇 |
免费 | 58篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 23篇 |
妇产科学 | 21篇 |
基础医学 | 69篇 |
口腔科学 | 13篇 |
临床医学 | 95篇 |
内科学 | 192篇 |
皮肤病学 | 9篇 |
神经病学 | 43篇 |
特种医学 | 45篇 |
外科学 | 121篇 |
综合类 | 68篇 |
预防医学 | 56篇 |
眼科学 | 6篇 |
药学 | 124篇 |
2篇 | |
中国医学 | 29篇 |
肿瘤学 | 104篇 |
出版年
2024年 | 1篇 |
2023年 | 76篇 |
2022年 | 152篇 |
2021年 | 112篇 |
2020年 | 96篇 |
2019年 | 47篇 |
2018年 | 43篇 |
2017年 | 31篇 |
2016年 | 29篇 |
2015年 | 27篇 |
2014年 | 72篇 |
2013年 | 59篇 |
2012年 | 59篇 |
2011年 | 56篇 |
2010年 | 42篇 |
2009年 | 31篇 |
2008年 | 13篇 |
2007年 | 14篇 |
2006年 | 10篇 |
2005年 | 2篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有1021条查询结果,搜索用时 15 毫秒
51.
《Digestive and liver disease》2022,54(9):1202-1208
ObjectivesWe developed a computer-aided diagnosis system called ECRCCAD using standard white-light endoscopy (WLE) for predicting conventional adenomas with high-grade dysplasia (HGD) to optimise the patients' management decisions during colonoscopy.MethodsPretraining model was used to fine-tune the model parameters by transfer learning. 2,397 images of HGD and 2,487 low-grade dysplasia (LGD) images were randomly assigned (8:1:1) to the training, optimising, and internal validation dataset. The prospective validation dataset is the frames accessed from colonoscope videoes. One independent rural hospital provided an external validation dataset. Histopathological diagnosis was used as the standard criterion. The capability of the ECRCCAD to distinguish HGD was assessed and compared with two expert endoscopists.ResultsThe accuracy, sensitivity and specificity for diagnosis of HGD in the internal validation set were 90.5%, 93.2%, 87.9%, respectively. While 88.2%, 85.4%, 89.8%, respectively, for the external validation set. For the prospective validation set, ECRCCAD achieved an AUC of 93.5% in diagnosing HGD. The performance of ECRCCAD in diagnosing HGD was better than that of the expert endoscopist in the external validation set (88.2% vs. 71.5%, P < 0.0001).ConclusionECRCCAD had good diagnostic capability for HGD and enabled a more convenient and accurate diagnosis using WLE. 相似文献
52.
53.
目的:探讨轮转护士在临床护理工作中产生医疗纠纷的原因及采取的相应对策。方法:查阅文献,结合本院轮转护士在临床轮转过程中产生的医疗纠纷,分析各种影响因素并采取预防对策。结果:实施有效的科学管理及人性化管理、注重护理流程管理、带教老师实施有针对性带教。结论:通过对每年新入院的轮转护士进行规范化培训及科学管理,可有效地预防医疗纠纷的发生。 相似文献
54.
取消药品加成是公立医院改革的重要内容。取消药品加成政策对医院收入结构和结余等方面带来了影响和成本压力;对此,要加大政府对公立医院的投入、加强医院成本管理、优化医疗服务,使取消药品加成政策能够顺利进行。 相似文献
55.
目的 评价帕罗西汀与其他选择性5-HT再摄取抑制药的疗效及安全性。方法 计算机检索Cochrane图书馆、ISI数据库、中国知网(CNKI)、维普(VIP)、万方数字化期刊数据库,纳入帕罗西汀与其他选择性5-HT再摄取抑制药疗效及安全性随机对照试验(randomized controlled trial,RCT)、系统评价和meta分析文献,对纳入文献的RCTs进行方法学质量评价和meta分析,参考纳入文献的系统评价和meta分析结论。结果 帕罗西汀与其他选择性5-HT再摄取抑制药疗效及安全性对比分析共纳入15个RCTs。2组抗抑郁总有效率差异有统计学意义(OR=1.45,95%CI=1.01~2.09,P=0.04);治疗2周和6周后HAMD评分差异有统计学意义(MD=-2.04,95%CI=-2.59~-1.49,P<0.000 01;MD=-0.69,95%CI=-1.18~-0.21,P=0.005);治疗6周后药物不良反应发生率差异有统计学意义(OR=0.88,95%CI=0.78~0.99,P=0.04)。结论 与其他选择性5-HT再摄取抑制药相比较,帕罗西汀的总有效率及起效速度较低,不良反应发生率较高,其不再推荐为一线抗抑郁药。 相似文献
56.
Jingxiong Huang Jing Wu Liang Zhao Wen Liu Jihong Wei Zhenguo Hu Bing Hao Hua Wu Long Sun Haojun Chen 《Annals of nuclear medicine》2020,34(4):289-298
The value of salivary gland scintigraphy (SGS) in the evaluation of Sjögren’s syndrome (SS) remains controversial. The aim of this study was to evaluate the diagnostic efficacy of quantitative SGS in patients with xerostomia and to assess the correlation between scintigraphic parameters and pathological features of salivary glands. Medical records of 165 patients with xerostomia who underwent [99mTc] pertechnetate SGS and labial biopsy were retrospectively reviewed. The maximum accumulation ratio (MAR), maximum secretion ratio (MSR), and time interval from stimulation to minimum count (Tmin) of the parotid glands were calculated to quantify the glandular activity. Furthermore, pre-stimulatory oral activity index (PRI) and post-stimulatory oral activity index (POI) were calculated to quantify the oral activity. All parameters except for Tmin were significantly lower in patients with SS than in those without SS. Among the five SGS parameters, PRI showed the highest areas under the curve value (0.9005; p < 0.001), and PRI > 32.75 was associated with a sensitivity of 78.5% and specificity of 86.4% for the diagnosis of SS. A decrease in MAR, MSR, PRI, and POI and an increase in Tmin correlate significantly with the histopathologic grade of labial gland biopsy and disease severity of SS. No significant differences in glandular parameters (MAR, MSR, and Tmin) were found between the non-SS and early-stage SS groups. Conventional scintigraphic parameters could be used as simple, reliable, and sensitive indicators for the early diagnosis of SS and determination of disease severity. 相似文献
57.
Jianfeng Yao Axia Song Wenbin Cao Shulian Chen Lukun Zhou Shannan Cao Peng Liu Mei Wang Yuanfu Xu Aiming Pang Sizhou Feng Mingzhe Han 《International journal of hematology》2014,99(3):329-337
Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To investigate the clinical significance of AECA in allo-HSCT recipients with GVHD, we detected AECA by cyto-enzyme-linked immunosorbent assay (cyto-ELISA) in allo-HSCT recipients with acute and/or chronic GVHD (aGVHD and cGVHD). Incidences of anti-HMEC-1 AECA (anti-HMEC) and anti-EA.hy926 AECA (anti-EAHY) were significantly higher in patients with grade II–IV than grade 0–I aGVHD (P = 0.049, P = 0.011, respectively). There was no difference in the incidence of AECA between patients with and without cGVHD. Patients with anti-EAHY positive in the early stage post-transplant demonstrated a higher incidence of cGVHD (P = 0.044). In patients with grade 0–I aGVHD, AECA-positive patients had higher overall survival and disease-free survival (P < 0.05), and tended to have lower incidences of relapse and transplant-related mortality. Our data suggest that AECA plays an important role in the pathogenesis of GVHD. 相似文献
58.
Liu Yuan Jaquith Jane M. Mccarthy-Fruin Kathleen Zhu Xingxing Zhou Xian Li Yanfeng Crowson Cynthia Davis John M. Thanarajasingam Uma Zeng Hu 《Clinical rheumatology》2020,39(12):3631-3637
Clinical Rheumatology - To determine the clinical and serologic similarities and differences between inflammatory arthritis induced by immune checkpoint inhibitors (IA-irAE) and rheumatoid... 相似文献
59.
60.
Yueming Li Xuru Xu Shuping Weng Chuan Yan Jianwei Chen Rongping Ye 《Journal of digital imaging》2020,33(6):1365
The objective of this study was to determine the clinical value of computed tomography (CT) image-based texture analysis in predicting microvascular invasion of primary hepatocellular carcinoma (HCC). CT images of patients with HCC from May 2017 to May 2019 confirmed by surgery and histopathology were retrospectively analyzed. Image features including tumor margin, tumor capsule, peritumoral enhancement, hypoattenuating halo, intratumoral arteries, and tumor-liver differences were assessed. All patients were divided into microvascular invasion (MVI)–negative group (n = 34) and MVI-positive group (n = 68). Preoperative CT images were further imported into MaZda software, where the regions of interest of the lesions were manually delineated. Texture features of lesions based on pre-contrast, arterial, portal, and equilibrium phase CT images were extracted. Thirty optimal texture parameters were selected from each phase by Fisher’s coefficient (Fisher), classification error probability combined with average correlation coefficient (POE+ACC), and mutual information (MI). Finally, receiver operating characteristic curve analysis was performed. The results showed that the Edmonson-Steiner grades, tumor size, tumor margin, and intratumoral artery characteristics were significantly different between the two groups (P = 0.012, < 0.001, < 0.001, = 0.003, respectively). There were 58 parameters with significant differences between the MVI-negative and MVI-positive groups (P < 0.001 for all). Among them, 12, 14, 17, and 15 parameters were derived from the pre-contrast phase, arterial phase, portal phase, and equilibrium phase respectively. According to the ROC analysis, optimal texture parameters based on the pre-contrast, arterial, portal, and equilibrium phases were 135dr_GLevNonU (AUC, 0.766; the cutoff value, 1055.00), Vertl_RLNonUni (AUC, 0.764; the cutoff value, 5974.38), 45dgr_GLevNonU (AUC, 0.762; the cutoff value, 924.34), and Vertl_RLNonUni (AUC, 0.754; the cutoff value, 4868.80), respectively. Texture analysis of preoperative CT images may be used as a non-invasive method to predict microvascular invasion in patients with primary hepatocellular carcinomas, and further to guide the treatment and evaluate prognosis. The most valuable parameters were derived from the gray-level run-length matrix. 相似文献