Effects of Anti-CD59 on Complement- induced Platelet Activation in Adult Males with Coronary Heart Disease

INTRoDUCTIoN The abnormal activation of platelet takes Dart in the process of coronary heart disease.Besides improv.ing artery arteriosclerosis,the activation of platelet plays an important role in acute coronary syndrome,ischemic and reperfusion injury and restenosis after coronary artery angioplasty.Many studies indicate that active complement components can induce platelet ac。tivation.And some pathophysiologic changes andtreatments in CHD,such as the injury of endothelial cell,myocar…     

浅谈肛瘘的手术治疗

肛瘘是临床较为常见的一种疾病,一般不能自愈,目前其根本的治疗方法仍是手术。近年来我国肛瘘手术都在原有的基础上做了创新和改进,但基本方法没变。可分为括约肌保存手术和括约肌切断手术两大类。每种手术都有利弊,根据临床检查确定肛瘘的类型,选择合适的手术治疗方法,达到减轻患者痛苦,降低术后复发率的目的。     

双钢板固定治疗成人肱骨髁间粉碎性骨折效果观察

目的分析双钢板同定治疗成人肱骨髁间骨折的疗效。方法对我院2002年8月-2009年3月期间27例成人肱骨髁粉碎性骨折行切开复位双钢板固定治疗的患者进行随访分析。结果全部27例患者均得到随访,随访时间6～48个月,平均21-2个月,骨折全部愈合,术后患肢功能按Cassebaum法评分：优18例,良5例,可4例,优良率85．2％。结论双钢板固定法能使成人髁间粉碎性骨折得到稳定的固定,利于患肢行早期功能锻炼,是治疗成人肱骨髁间粉碎忡骨折的掂好的方法．     

冠状动脉异常起源于肺动脉的超声诊断及误诊分析

目的:探讨超声心动图在冠状动脉异常起源于肺动脉的诊断价值,并对误诊原因作分析。方法:对超声诊断为冠状动脉异常起源于肺动脉并手术证实的5例病例进行分析。结果:5例冠状动脉异常起源于肺动脉首次正确诊断全部由超声实现,其主要超声特征是:主动脉发出单支扩张冠脉;肺动脉发出异常分支并且血流倒灌;丰富冠脉侧支循环;常伴有左室长期心肌缺血继发表现。3例患者曾经进行超声心动图检查曾误诊为冠状动脉肺动脉瘘。结论:超声心动图诊断冠状动脉起源于肺动脉有非常重要的诊断价值。     

Dual Effects of Bilirubin on the Proliferation of Rat Renal NRK52E Cells and ITS Association with Gap Junctions

Objective:

The effect of bilirubin on renal pathophysiology is controversial. This study aimed to observe the effects of bilirubin on the proliferation of normal rat renal tubular epithelial cell line (NRK52E) and its potential interplay with gap junction function.

Methods:

Cultured NRK52E cells, seeded respectively at high- or low- densities, were treated with varying concentrations of bilirubin for 24 hours. Cell injury was assessed by measuring cell viability and proliferation, and gap junction function was assessed by Parachute dye-coupling assay. Connexin 43 protein was assessed by Western blotting.

Results:

At doses from 17.1 to 513μmol/L, bilirubin dose-dependently enhanced cell viability and colony-formation rates when cells were seeded at either high- or low- densities (all p<0.05 vs. solvent group) accompanied with enhanced intercellular fluorescence transmission and increased Cx43 protein expression in high-density cells. However, the above effects of BR were gradually reversed when its concentration increased from 684 to 1026μmol/L. In high-density cells, gap junction inhibitor 12-O-tetradecanoylphorbol 13-acetate attenuated bilirubin-induced enhancement of colony-formation and fluorescence transmission. However, in the presence of high concentration bilirubin (1026μmol/L), activation of gap junction with retinoid acid decreased colony-formation rates.

Conclusion:

Bilirubin can confer biphasic effects on renal NRK52E cell proliferation potentially by differentially affecting gap junction functions.     

联合MSCT及低场磁共振在诊断卵巢性索间质性肿瘤的应用研究

目的探讨联合MSCT及低场磁共振（MRI）在诊断卵巢性索间质性肿瘤的诊断价值。方法回顾性分析2011年4月至2012年8月笔者所在医院经手术治疗病理检查明确诊断的28例卵巢性索间质性肿瘤患者病例资料,对所有患者的联合MSCT及低场MRI影像学特点进行分析。结果所有患者的影像学诊断均符合手术后病理检查结果 ,诊断符合率为100%。结论低场MRI可清晰观察到患者的实性肿块,MSCT可显示患者的骨化情况,弥补MRI不足,两者联合诊断符合率高,对诊断有积极意义。     

慢性精神分裂症患者认知功能及其影响因素

目的:了解慢性精神分裂症患者认知功能及其影响因素。方法:对67例慢性精神分裂症患者及63例非慢性精神分裂症患者进行威斯康辛测验(WCST),连线测验(TAT),简易精神状况检查表(MMSE)评定认知功能,使用阳性与阴性症状量表(PANSS)评定临床症状。结果:研究组较对照组WCST、TMT及MMSE的各项认知功能指标评分比较除连线测验A外,其余各项差异均无统计学意义(P>0.05)。结论:慢性精神分裂症患者注意功能损害及损害程度与病程有关。     

正常新生儿、婴幼儿部分颅脑结构的MRI测量

目的通过头颅MRI测量2岁以内正常小儿部分颅脑结构的数值,提高对小儿颅脑结构的认识。方法 545例0～2岁正常小儿的头颅MRI资料,按月龄分7组;分别测量头颅前后径、左右径,大脑半球长度、宽度、高度,胼胝体前后径和膝部、体部、压部厚度,小脑上下径、前后径及左右径,桥脑前后径、上下径、左右径,延髓上段前后径、左右径。结果测量值经统计学处理取平均值和标准差,具体数据见正文表格。结论测定2岁以内小儿颅脑结构正常数值,丰富和完善影像解剖学数据,为小儿脑发育的评估提供有意义的参考价值。     

外固定架治疗股骨粗隆间骨折临床观察

目的探讨临床上应用外固定架治疗股骨粗隆间骨折的治疗方法和临床疗效。方法回顾性分析我院收治的68例股骨粗隆间骨折患者的病例资料,所有患者均应用外固定架进行治疗。结果所有患者经治疗后,优37例（54.4%）,良25例（36.8%）,可6例（8.8%）,差0例（0%）,优良率为91.2%。所有患者均为一期愈合,无一例手术并发症发生,所有患者均进行随访复查,随访时间半年以上。结论外固定架治疗股骨粗隆间骨折疗效肯定,手术操作简单,对患者创伤小,术后短时间内可活动。其缺点有感染和螺纹针松动等。     

注射聚丙烯酰胺水凝胶行隆乳术后并发症及相关原因分析

目的分析聚丙烯酰胺水凝胶隆乳术后并发症及相关原因.方法收集2000~2005年接受注射聚丙烯酰胺水凝胶隆乳手术后出现并发症到重庆市中山医院就诊的患者共26例.全部患者术前经高频超声或 MRI检查,在全麻下沿乳晕边缘切口行开放手术,术中采用大量含抗菌药物的生理盐水冲洗,术后在手术区域行加压包扎,给予抗菌药物治疗.结果术后随访3~18个月,24例患者并发症消失,其中20例患者乳房切开愈合较好;4例再次行乳房矫形手术,乳房形态恢复.2例再次行手术,取出残留的凝胶,症状缓解.结论直视下开放式手术是治疗聚丙烯酰胺水凝胶行隆乳术后并发症的有效方法.