Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor‐loaded porous calcium phosphate cement: a pilot study in a canine model

Objectives: To study the effects of the bone morphogenetic protein‐2 (BMP‐2)/fibroblast growth factor (bFGF)‐loaded porous calcium phosphate cement (CPC) on the repair of bone defects around dental implants. Material and methods: Thirty critical‐sized bone defects in beagle dogs were repaired with engineered bone composed of autologous bone‐marrow‐derived mesenchymal stem cells (BMSCs), BMP‐2, bFGF and CPC. Repairs were divided into six groups: BMSC/BMP‐2/bFGF/CPC, BMSC/BMP‐2/CPC, BMSC/bFGF/CPC, BMSC/CPC, CPC and no treatment. Polychrome sequential fluorescent labels were also performed post‐operatively. Fluorescence histological examinations of undecalcified sections at post‐operative week 12 were performed to clarify changes in the new bone around the dental implants. Results: The animals exhibited a perfect post‐operative course, with none experiencing any infection. Undecalcified sections showed that new bone was actively formed in the BMP‐2/bFGF group after 12 weeks. The bone mineralization apposition rate was better in the BMP‐2/bFGF group than in the other groups (P<0.05). Conclusion: BMP‐2 and bFGF together are more effective than either one alone in promoting the formation of new bone and may exert a synergistic activity at bone defects around dental implants. To cite this article:
Wang L, Zou D, Zhang S, Zhao J, K Pan, Huang Y. Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor‐loaded porous calcium phosphate cement: a pilot study in a canine model.
Clin. Oral Impl. Res. 22 , 2011; 173–181.
doi: 10.1111/j.1600‐0501.2010.01976.x     

医院制剂再注册后的发展方向

目的:为医院制剂的生存和发展寻求出路。方法:通过阐述医院制剂的现状,分析医院制剂与相关药学研究中存在的问题,探寻医院制剂发展的可行方向。结果:医院制剂要得到发展,各医院必须提高现有制剂技术;密切结合医院特色,为临床提供特需制剂;在现有制剂的基础上向新药转化;开展与临床密切相关的药剂学工作和药学相关基础研究。结论:实现从单纯保障供应型向技术供应型和开发研究型的转化将是医院制剂发展的可行之路。     

The improved oval forceps suture-guiding method for minimally invasive Achilles tendon repair

ObjectiveTo discuss the effect and advantage of the improved oval forceps suture-guiding method combined with anchor nail in the treatment of acute Achilles tendon rupture.MethodsA retrospective research was performed on 35 cases of acute Achilles tendon rupture treated with the improved oval forceps suture-guiding method from January 2013 to October 2016. Instead of the Achillon device, we perform the Achillon technique with the use of simple oval forceps, combined with absorbable anchor nail, percutaneously to repair the acute Achilles tendon rupture.ResultsAll patients were followed up for at least 12 months (range, 12–19 months), and all the patients underwent successful repair of their acute Achilles tendon rupture using the improved oval forceps suture-guiding method without any major intra- or postoperative complications. All the patients returned to work with pre-injury levels of activity at a mean of 12.51 ± 0.76 weeks. Mean AOFAS ankle-hindfoot scores improved from 63.95 (range, 51–78) preoperatively to 98.59 (range, 91–100) at last follow-up. This was statistically significant difference (P < 0.001). Mean Achilles Tendon Total Rupture Score (ATRS) at final follow-up was 94.87 (range, 90–100).ConclusionThe improved oval forceps suture-guiding method could make the advantage of minimally invasive repair with less complications, reduced surgical time and similar functional outcomes compared with the traditional open surgery. In addition, our new technique could save the cost of surgery with the compare of the Achillon device. At the same time for the cases which the remote broken tendon ends were within 2 cm from the calcaneal nodules, because of the less tendon tissue was left in the remote side, traditional percutaneous methods are incapable to ensure the reconstruction strength. By using the anchor nail, the improved technique has better repair capacity and expands the operation indication of oval forceps method.     

Application of pre-contoured anatomic locking plate for treatment of humerus split type greater tuberosity fractures: A prospective review of 68 cases with an average follow-up of 2.5 years

ObjectivesAlthough various implants exist for 3- and 4-part proximal humerus fractures, few implants are appropriate for humerus split type greater tuberosity fractures. The goal of this study was to assess the efficacy of pre-contoured anatomic locking plate for humerus split type greater tuberosity fractures.MethodsA retrospective review of 68 patients with humerus split type greater tuberosity fractures treated with open reduction and internal fixation using anatomic locking plates between January 2014 and October 2016. Postoperatively, patient radiographs, functional results, and complications were reviewed.ResultsAll patients got a mean follow-up of 30.5 months (range 14–46 months). Average fracture healing time was 9.4 weeks (range, 8–14 weeks). Overall mean Constant score was 86.8% (range, 70%–96%). The result was rated as excellent in 25 patients (Constant score: 92.1%), good in 38 patients (Constant score: 85.3%) moderate in 5 patients (Constant score: 71.8%) and poor in 0 cases. The excellent-good rate was 92.6%. No recurrence of dislocation occurred in the 30 cases with shoulder dislocation. All fractures healed without the complications of wound infection, subacromial impingement syndrome, nonunion, secondary displacement, and implant loosening.ConclusionPre-contoured anatomic locking plate is a reliable option in treating humerus split type greater tuberosity fractures as it provides stable fixation with an early return to function. The surgical technique is easy and efficient.     

血必净、乌司他丁联合治疗对老年重症急性胰腺炎患者动脉血乳酸水平和预后影响的临床研究

目的:观察血必净、乌司他丁联合治疗对老年重症急性胰腺炎患者动脉血乳酸和预后的影响。方法:58例老年重症急性胰腺炎患者随机分为2组,A组(28例)进行常规治疗+静脉滴注血必净100 mL,bid,连用10 d;B组(30例)在A组治疗的基础上加用乌司他丁60万U,静脉滴注,bid,连用10 d,2组患者分别于治疗前及治疗后第3,7,10天行动脉血乳酸检测,并于治疗后第10天进行APACHEⅡ评分、观察10 d内死亡率。结果:2组患者治疗后动脉血乳酸水平与同组治疗前比较显著降低,差异有显著性(P<0.01),治疗7 d后B组动脉血乳酸水平与A组比较下降更加明显,差异有显著性(P<0.05),治疗后第10 d APACHEⅡ评分及10 d内死亡率比较,B组显著优于A组,差异有显著性(P<0.05)。结论:血必净、乌司他丁联合治疗可以显著降低老年重症急性胰腺炎患者动脉血乳酸水平,改善预后。