Peripheral blood lymphocyte/monocyte ratio predicts outcome for patients with diffuse large B cell lymphoma after standard first-line regimens

To determine whether peripheral blood absolute lymphocyte/absolute monocyte counts ratio (ALC/AMC ratio) at diagnosis predicts survival of diffuse large B cell lymphoma (DLBCL) patients treated with standard first-line regimens, we retrospectively analyzed 244 patients with DLBCL who were treated with standard cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone, or rituximab–cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone. Progression-free survival and overall survival (PFS and OS) were estimated using the Kaplan–Meier method and two-tailed log-rank; The Cox proportional hazards model was used to evaluate ALC/AMC ratio as prognostic factors when adjusting for the International Prognostic Index (IPI). On univariate and multivariate analyses performed with factors included in the IPI, the ALC/AMC ratio at diagnosis remained an independent predictor of OS and PFS (OS: P?<?0.001; PFS: P?<?0.001). Patients with lower ALC/AMC ratio (<3.8) seemed to have lower complete remission rate, 2-year PFS and 3-year OS when compared to patients with ALC/AMC ratio ≥3.8, respectively (26 versus 90 %, P?<?0.001; 18 versus 82 %, P?<?0.001; 24 versus 86 %; P?<?0.001, respectively). Moreover, the ALC/AMC ratio was able to further risk-stratify IPI 0-2 and three–five risk patient groups, respectively. The ALC/AMC ratio at the time of diagnosis may provide additional prognostic information beyond that of the IPI for patients with DLBCL who receive standard first-line regimens.     

Serum/plasma homocysteine levels in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Clinical Rheumatology - Published studies have shown contradictory results in the association of serum/plasma levels of homocysteine (HCY) with systemic lupus erythematosus (SLE). This study is to...     

以应对为焦点的乳腺癌患者家庭韧性干预方案构建

目的 构建以应对为焦点的乳腺癌患者家庭韧性干预方案。方法 理论及文献研究形成干预方案框架;对相关科室护理人员、患者及家属进行结构式访谈形成干预方案初稿;对17名相关领域专家进行2轮德尔菲专家函询,进一步完善干预方案,最终形成乳腺癌患者家庭韧性干预方案终稿。结果 理论及文献研究结果初步确定以应对为焦点的3个系统、6个主题干预方案;结构式访谈和专家函询明确了1对1网络家庭会议干预形式及内容;2轮专家函询专家权威系数分别为0.822、0.840,协调系数Kendall’s W分别为0.061(P>0.05)、0.146(P<0.01)。最终形成以应对为焦点的乳腺癌患者家庭韧性干预方案。结论 本研究构建的乳腺癌患者家庭韧性干预方案具有科学、实用和可行性,可用于乳腺癌患者的家庭护理。     

Online computing of non-stationary distributions velocity fields by an accuracy controlled growing neural gas

This paper presents a vector quantization process that can be applied online to a stream of inputs. It enables to set up and maintain a dynamical representation of the current information in the stream as a topology preserving graph of prototypical values, as well as a velocity field. The algorithm relies on the formulation of the accuracy of the quantization process, that allows for both the updating of the number of prototypes according to the stream evolution and the stabilization of the representation from which velocities can be extracted. A video processing application is presented.     

高危肾盂癌患者的简化手术治疗

目的:探讨高危肾盂癌患者的治疗方法。方法:自2009年7月~2012年12月对14例高龄且伴有严重并发症的肾盂癌患者行经腹膜后途径腹腔镜下肾脏+中上段输尿管切除术,术后正规膀胱灌注表柔比星注射液,以预防再发膀胱癌,并定期进行影像学及膀胱镜检查。结果:14例手术全部成功,手术时间63~105min,平均78.3min。术后24~48小时恢复饮食,5~9天出院。术后病理检查2例为鳞状细胞癌,12例为尿路上皮细胞癌;其中2例为浸润性肾盂癌伴肾门处淋巴结转移。术后13例得到随访,1例失访;随访8~36个月,平均21.4个月。1例术后13个月死于肺部转移,2例术后21个月因心肺疾病死亡;2例术后再发膀胱癌,行根治性全膀胱切除。结论:对于高危肾盂癌患者,简化手术,腹腔镜下切除肾脏+中上段输尿管,术后配合正规膀胱灌注化疗是一种有效安全的治疗方法。     

临床学习环境对实习护生关爱能力影响的研究

目的 探讨临床学习环境对实习护生关爱能力的影响,为营造良好的临床学习环境、提高护生关爱能力提供依据.方法 以方便整群抽样方法抽取合肥市6所综合性教学医院的346名临床实习护生,采用实习护生一般情况调查表、关爱能力评价量表和护理临床学习环境评价量表进行调查.结果 实习护生关爱能力总分为（203.40±14.25）分,各维度得分为理解（78.88±8.37）分、勇气（66.43±5.75）分、耐心（58.09±4.37）分.实习护生关爱能力各维度及总分与临床学习环境各维度及总分呈正相关（均P＜0.01）,工作氛围和团队文化、人际关系、创新性、个性化及任务定位对关爱能力总分有积极影响（P＜0.05,P＜0.01）.结论 实习护生关爱能力较以往有进步,但仍需进一步提升.良好的临床学习环境有利于提高实习护生的关爱能力.     

综合性医院实施目标管理的理论与实践探索

目标管理是现代化医院管理的重要方法之一.结合医院目标管理的实践,系统介绍了医院目标管理的设定原则、体系构成、考核形式、结果评价等内容,客观回顾了医院目标管理取得成绩,并阐述了对目标管理工作的体会及思考,旨在为综合性医院实施目标管理及持续改进提供参考.     

伊曲康唑预防急性白血病患儿侵袭性真菌感染的临床研究

目的：评价伊曲康唑口服液在急性白血病（AL）患儿化疗后粒细胞缺乏伴感染时侵袭性真菌感染（IFI）预防性治疗的效果。方法回顾性分析2009年6月-2013年6月我院收集的AL化疗后伴粒细胞缺乏的213例患儿,将其分为伊曲康唑早期预防组和晚期预防组。伊曲康唑早期预防组（330例次）在粒细胞缺乏伴发热应用广谱抗生素同时服用伊曲康唑口服液;对照组（191例次）在粒细胞缺乏出现发热、经广谱抗生素应用72 h 后发热无改善者加用伊曲康唑口服液,比较两组患儿IFI发生率。结果伊曲康唑早期预防组和对照组各有7例和18例发生IFI,发生率分别为2.12％和9.42％,两组IFI发生率差异有显著性（P＜0．01）。结论 AL化疗后粒细胞缺乏患儿在发热早期进行预防性口服伊曲康唑可以有效降低IFI的发生率。     

强化降糖治疗对老年2型糖尿病患者生活质量的影响

目的 分析强化降糖治疗对老年2型糖尿病患者生活质量的影响.方法 97例老年2型糖尿病患者随机分为强化治疗组及标准治疗组,平均随访5年,随访中检测FBG、HbA1c等指标,填写欧洲五维度生活质量调查表（EQ-5D）并收集相关的研究结果.结果 强化组与标准组相比生活质量及VAS评分均无显著性差异.Logistic回归分析显示,血管并发症、低血糖发作、女性、高龄、长病程、低教育程度及高体质量指数均显著影响糖尿病患者生活质量.结论 强化降糖治疗对患者生活质量无显著影响,而血管并发症、低血糖发作显著降低患者生活质量,女性、高龄、病程长、受教育程度低及高体质量指数的患者生活质量更差,对这类患者应加强心理支持治疗.