全文获取类型
收费全文 | 2832篇 |
免费 | 252篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 122篇 |
妇产科学 | 44篇 |
基础医学 | 340篇 |
口腔科学 | 180篇 |
临床医学 | 219篇 |
内科学 | 594篇 |
皮肤病学 | 57篇 |
神经病学 | 150篇 |
特种医学 | 118篇 |
外科学 | 367篇 |
综合类 | 175篇 |
一般理论 | 1篇 |
预防医学 | 182篇 |
眼科学 | 136篇 |
药学 | 166篇 |
中国医学 | 3篇 |
肿瘤学 | 252篇 |
出版年
2023年 | 29篇 |
2022年 | 22篇 |
2021年 | 83篇 |
2020年 | 59篇 |
2019年 | 80篇 |
2018年 | 88篇 |
2017年 | 68篇 |
2016年 | 81篇 |
2015年 | 79篇 |
2014年 | 98篇 |
2013年 | 106篇 |
2012年 | 180篇 |
2011年 | 147篇 |
2010年 | 100篇 |
2009年 | 85篇 |
2008年 | 113篇 |
2007年 | 133篇 |
2006年 | 112篇 |
2005年 | 106篇 |
2004年 | 137篇 |
2003年 | 76篇 |
2002年 | 86篇 |
2001年 | 80篇 |
2000年 | 80篇 |
1999年 | 73篇 |
1998年 | 59篇 |
1997年 | 56篇 |
1996年 | 51篇 |
1995年 | 30篇 |
1994年 | 38篇 |
1993年 | 30篇 |
1992年 | 38篇 |
1991年 | 37篇 |
1990年 | 59篇 |
1989年 | 45篇 |
1988年 | 36篇 |
1987年 | 41篇 |
1986年 | 36篇 |
1985年 | 44篇 |
1984年 | 29篇 |
1983年 | 22篇 |
1982年 | 17篇 |
1981年 | 13篇 |
1980年 | 9篇 |
1979年 | 33篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1975年 | 10篇 |
1972年 | 11篇 |
1971年 | 9篇 |
排序方式: 共有3118条查询结果,搜索用时 187 毫秒
71.
72.
Bodagh Neil Yap Reuben Kotadia Irum Sim Iain Bhalla Ajay Somerville Peter O’Neill Mark Williams Steven E. 《Journal of interventional cardiac electrophysiology》2022,65(1):271-286
Journal of Interventional Cardiac Electrophysiology - Atrial fibrillation is associated with an increased risk of cognitive impairment. It is unclear whether the restoration of sinus rhythm with... 相似文献
73.
Yap Sing-Chien Anic Ante Breskovic Toni Haas Annika Bhagwandien Rohit E. Jurisic Zrinka Szili-Torok Tamas Luik Armin 《Journal of interventional cardiac electrophysiology》2022,64(3):565-565
Journal of Interventional Cardiac Electrophysiology - 相似文献
74.
75.
Yap S Naughten ER Wilcken B Wilcken DE Boers GH 《Seminars in thrombosis and hemostasis》2000,26(3):335-340
Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency leads to severe hyperhomocysteinemia (HHcy). Vascular events (VE) remain the major cause of morbidity and mortality in the untreated patients with HCU. The study on the natural history of untreated HCU disclosed that, at the time of maximal risk, in other words beyond 10 years old, there was one event per 25 years. Recent studies from Australia (n = 32), The Netherlands (n = 28), and Ireland (n = 24) have documented the effects of long-term treatment on the vascular outcome of a total of 84 patients with 1314 patient-years of treatment for HCU. The mean (range) age was 27.8 (2.5 to 70) years. Five VE were recorded during treatment; one pulmonary embolism, two myocardial infarctions, and two abdominal aneurysms. All five VE occurred in B6-responsive patients at a mean (range) age of 48.8 (30 to 60) years. In 1314 patient-years of treatment, 53 VE would have been expected if they remained untreated; instead only 5 were documented, relative risk = 0.091 (95% confidence interval [CI] 0.043 to 0.190; p < 0.001). Appropriate homocysteine-lowering therapy for severe HHcy significantly reduced the vascular risk in patients with HCU. VE were rare with treatment despite the fact that the post-treatment homocysteine levels were several times higher than the cutoff point for homocysteine in the normal population. The present findings may have relevance to the current concept of "mild HHcy" as a risk factor for vascular disease, with elevated plasma homocysteine levels considerably lower than that of the post-treatment levels in this group of reported patients. 相似文献
76.
Dr. P.E. Williams P.L. Yap J. Gillon R.J. Crawford S.J. Urbaniak and G. Galea 《Vox sanguinis》1989,57(1):15-18
Four patients (2 with X-linked, one with common variable hypogammaglobulinaemia, and 1 with ulcerative colitis) developed non-A, non-B hepatitis (NANBH) following administration of a specific batch of intravenous immunoglobulin (IV IgG) manufactured by the Scottish National Blood Transfusion Service using the pH4/mild pepsin method. Each patient had normal serum ALT levels over a preceding period of 12-67 months, with raised values developing within 4-18 weeks of first administration of the implicated batch. Two patients had very mild symptoms of hepatitis, the other 2 being asymptomatic. Over a follow-up period of 8-12 months, ALT levels returned to normal in 3 patients, but biopsy-proven chronic NANBH developed in the fourth. The level of NANBH virus in the starting plasma used to manufacture this batch may have exceeded the capacity of the process to inactivate the virus. The transmission of NANBH by one of approximately 110 batches administered demonstrates the importance of continued close surveillance of recipients of IV IgG, even if asymptomatic, by regular monitoring of liver function tests and recording of all batches received. 相似文献
77.
Alan H. Lockwood Kathryn E. Peek Marc Berridge Linda Bogue Eddy Yap 《Metabolic brain disease》1987,2(1):47-60
We developed a double-isotope autoradiographic method for the simultaneous measurement of the local cerebral metabolic rate for glucose (1CMRG) and index of regional acid-base status (rABI) in single brain slices using [2-14C]deoxy-D-glucose (DG) and 5,5-dimethyl-[2-14C]oxazolidine-2,4, dione (DMO). After iv isotope administration, paper chromatography separates plasma DMO from DG activity using a methanol-methylene chloride solvent system. Initial tissue autoradiograms depict regional DMO plus DG and DG metabolite distribution. After 14 days in a well-ventilated hood, 97.5 ±0.5% of all DMO is lost from tissue sections by sublimation, and a second autoradiogram depicts DG plus DG metabolite distribution. Retention of brain lipids does not alter beta-particle self-absorption, avoiding problems associated with isotope extraction with solvents. Autoradiograms are digitized and converted to isotope-content images. The second autoradiogram is used for lCMRG computation. After subtracting the second regional isotope-content value from the first, the DMO content is obtained and used to compute rABI. Application of this method to normal animals yields expected values for lCMRG and rABI. This method is amenable to whole-slice digitization and creation of functional images of lCMRG and ABI followed by pixel-by-pixel correlations of the two variables, making this a potentially valuable tool for the investigation of the relationships between glucose metabolism and brain acid-base balance. 相似文献
78.
79.
KA Hodgkinson SP Connors N Merner A Haywood T‐L Young WJ McKenna B Gallagher F Curtis AS Bassett PS Parfrey 《Clinical genetics》2013,83(4):321-331
To determine the phenotype and natural history of a founder genetic subtype of autosomal dominant arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by a p.S358L mutation in TMEM43. The age of onset of cardiac symptoms, clinical events and test abnormalities were studied in 412 subjects (258 affected and 154 unaffected), all of which occurred in affected males significantly earlier and more often than unaffected males. Affected males were hospitalized four times more often than affected females (p ≤ 0.0001) and died younger (p ≤ 0.001). The temporal sequence from symptoms onset to death was prolonged in affected females by 1–2 decades. The most prevalent electrocardiogram (ECG) manifestation was poor R wave progression (PRWP), with affected males twice as likely to develop PRWP as affected females (p ≤ 0.05). Left ventricular enlargement (LVE) occurred in 43% of affected subjects, with 11% fulfilling criteria for dilated cardiomyopathy. Ventricular ectopy on Holter monitor was common and occurred early: the most diagnostically useful clinical test. No symptom or test could rule out diagnosis. This ARVC subtype is a sex‐influenced lethal arrhythmogenic cardiomyopathy, with a unique ECG finding, LV dilatation, heart failure and early death, where molecular pre‐symptomatic diagnosis has the greatest clinical utility. 相似文献
80.
Noor H. A. Suaini Evelyn Xiu-Ling Loo Rachel L. Peters Gaik Chin Yap Katrina J. Allen Hugo Van Bever David J. Martino Anne Eng Neo Goh Shyamali C. Dharmage Marjorelee T. Colega Mary Foong Fong Chong Anne-Louise Ponsonby Kok Hian Tan Mimi L. K. Tang Keith M. Godfrey Bee Wah Lee Lynette Pei-Chi Shek Jennifer J. Koplin Elizabeth Huiwen Tham 《Allergy》2021,76(10):3171-3182