全文获取类型
收费全文 | 2756篇 |
免费 | 148篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 141篇 |
妇产科学 | 45篇 |
基础医学 | 352篇 |
口腔科学 | 111篇 |
临床医学 | 352篇 |
内科学 | 413篇 |
皮肤病学 | 45篇 |
神经病学 | 312篇 |
特种医学 | 58篇 |
外科学 | 419篇 |
综合类 | 11篇 |
预防医学 | 232篇 |
眼科学 | 26篇 |
药学 | 142篇 |
中国医学 | 3篇 |
肿瘤学 | 239篇 |
出版年
2023年 | 12篇 |
2022年 | 15篇 |
2021年 | 77篇 |
2020年 | 32篇 |
2019年 | 70篇 |
2018年 | 99篇 |
2017年 | 55篇 |
2016年 | 50篇 |
2015年 | 62篇 |
2014年 | 95篇 |
2013年 | 135篇 |
2012年 | 212篇 |
2011年 | 221篇 |
2010年 | 101篇 |
2009年 | 99篇 |
2008年 | 181篇 |
2007年 | 170篇 |
2006年 | 165篇 |
2005年 | 166篇 |
2004年 | 150篇 |
2003年 | 144篇 |
2002年 | 119篇 |
2001年 | 51篇 |
2000年 | 38篇 |
1999年 | 32篇 |
1998年 | 18篇 |
1997年 | 18篇 |
1996年 | 21篇 |
1995年 | 18篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 22篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 14篇 |
1988年 | 16篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 17篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1976年 | 9篇 |
1973年 | 5篇 |
1972年 | 6篇 |
1970年 | 6篇 |
1969年 | 5篇 |
1966年 | 13篇 |
1965年 | 5篇 |
排序方式: 共有2915条查询结果,搜索用时 15 毫秒
1.
Robert J. Motzer MD Bernard Escudier MD Saby George MD Hans J. Hammers MD PhD Sandhya Srinivas MD Scott S. Tykodi MD PhD Jeffrey A. Sosman MD Elizabeth R. Plimack MD Giuseppe Procopio MD David F. McDermott MD Daniel Castellano MD Toni K. Choueiri MD Frede Donskov MD PhD Howard Gurney MD Stéphane Oudard MD Martin Richardet MD PhD Katriina Peltola MD PhD Ajjai S. Alva MD Michael Carducci MD John Wagstaff MD Christine Chevreau MD Satoshi Fukasawa MD Yoshihiko Tomita MD PhD Thomas C. Gauler MD Christian K. Kollmannsberger MD Fabio A. Schutz PhD James Larkin MD PhD David Cella PhD M. Brent McHenry PhD Shruti Shally Saggi BEng Nizar M. Tannir MD 《Cancer》2020,126(18):4156-4167
2.
Toni Kulju Joonas Haapasalo Ryan Verner Maxine Dibu‐Adjei Kai Lehtimki Sirpa Rainesalo Jukka Peltola 《Neuromodulation》2020,23(6):852-858
BackgroundIn vagal nerve stimulation (VNS) therapy, the release of VNS model 106 (AspireSR) allowed for responsive VNS (rVNS). rVNS utilizes a cardiac-based seizure detection algorithm to detect seizure-induced tachycardia to trigger additional stimulation. There are some studies suggesting clinical benefits of rVNS over traditional VNS, but the performance and significance of autostimulation mode in clinical practice are poorly understood.ObjectivesTo assess the effect of initiation of rVNS therapy and altered stimulation settings on the number of daily stimulations and energy consumption in VNS therapy and to compare autostimulation performance in different epilepsy types.Materials and MethodsRetrospective follow-up of 30 patients with drug-resistant epilepsy treated with rVNS including 17 new implantations and 13 battery replaces at a single center in Finland. Our data consist of 208 different stimulation periods, that is, episodes with defined stimulation settings and both autostimulation and total stimulation performance-related data along with clinical follow-up.ResultsThe variation in autostimulation frequency was highly dependent on the duration of the OFF-time and autostimulation threshold (p < 0.05). There was a large additional effect of autostimulation mode on therapy time and energy consumption with longer OFF-times, but a minor effect with shorter OFF-times. Significantly more autostimulations were triggered in the temporal lobe and multifocal epilepsies than in extratemporal lobe epilepsies.ConclusionsThe initiation of autostimulation mode in VNS therapy increased the total number of stimulations. Shortening the OFF-time leads to a decreased number and share of automatic activations. Epilepsy type may affect autostimulation activity. 相似文献
3.
4.
5.
Erik W. Martin Marguerite S. Buzza Kathryn H. Driesbaugh Shihui Liu Yolanda M. Fortenberry Stephen H. Leppla Toni M. Antalis 《Oncotarget》2015,6(32):33534-33553
The membrane-anchored serine proteases are a unique group of trypsin-like serine proteases that are tethered to the cell surface via transmembrane domains or glycosyl-phosphatidylinositol-anchors. Overexpressed in tumors, with pro-tumorigenic properties, they are attractive targets for protease-activated prodrug-like anti-tumor therapies. Here, we sought to engineer anthrax toxin protective antigen (PrAg), which is proteolytically activated on the cell surface by the proprotein convertase furin to instead be activated by tumor cell-expressed membrane-anchored serine proteases to function as a tumoricidal agent. PrAg''s native activation sequence was mutated to a sequence derived from protein C inhibitor (PCI) that can be cleaved by membrane-anchored serine proteases, to generate the mutant protein PrAg-PCIS. PrAg-PCIS was resistant to furin cleavage in vitro, yet cytotoxic to multiple human tumor cell lines when combined with FP59, a chimeric anthrax toxin lethal factor-Pseudomonas exotoxin fusion protein. Molecular analyses showed that PrAg-PCIS can be cleaved in vitro by several serine proteases including the membrane-anchored serine protease testisin, and mediates increased killing of testisin-expressing tumor cells. Treatment with PrAg-PCIS also potently attenuated the growth of testisin-expressing xenograft tumors in mice. The data indicates PrAg can be engineered to target tumor cell-expressed membrane-anchored serine proteases to function as a potent tumoricidal agent. 相似文献
6.
Ian Glynn Davies Toni Blackham Agnieszka Jaworowska Catherine Taylor Matthew Ashton Leonard Stevenson 《International journal of food sciences and nutrition》2016,67(3):217-224
The aim of the study was to analyze the saturated fatty acid (SFA) and trans-fatty acid (TFA) contents of popular takeaway foods in the UK (including English, pizza, Chinese, Indian and kebab cuisine). Samples of meals were analyzed by an accredited public analyst laboratory for SFA and TFA. The meals were highly variable for SFA and TFA. English and Pizza meals had the highest median amount of SFA with 35.7?g/meal; Kebab meals were high in TFA with up to 5.2?g/meal. When compared to UK dietary reference values, some meals exceeded SFA and TFA recommendations from just one meal. Takeaway food would be an obvious target to reduce SFA and TFA contents and increase the potential of meeting UK recommendations. Strategies such as reformulation and smaller takeaway portion sizes warrant investigation. 相似文献
7.
Robert J. Motzer MD David F. McDermott MD Bernard Escudier MD Mauricio Burotto MD Toni K. Choueiri MD Hans J. Hammers MD PhD Philippe Barthélémy MD PhD Elizabeth R. Plimack MD Camillo Porta MD Saby George MD Thomas Powles MD Frede Donskov MD PhD Howard Gurney MD Christian K. Kollmannsberger MD Marc-Oliver Grimm MD Carlos Barrios MD Yoshihiko Tomita MD PhD Daniel Castellano MD Viktor Grünwald MD PhD Brian I. Rini MD M. Brent McHenry PhD Chung-Wei Lee MD PhD Jennifer McCarthy MA Flavia Ejzykowicz PhD Nizar M. Tannir MD 《Cancer》2022,128(11):2085-2097
8.
9.
Sarah M. Coyne Toni Liechty Kevin M. Collier Aubrey D. Sharp Emilie J. Davis Savannah L. Kroff 《Health communication》2018,33(7):793-799
Much research has found that exposure to certain types of media portrayals of women can be related to body image concerns among women. The current paper focuses on the impact of certain messages on pregnant and postpartum women. These women are rarely examined in a media research context but are particularly vulnerable to body image concerns. This experimental study involved 192 pregnant or postpartum women who read a magazine containing glamorized media portrayals of pregnant/postpartum women or a control magazine. Pregnant women reported lower body image after only five minutes of exposure to the magazine with pregnant/postpartum women compared to the control group. There was no immediate effect on postpartum women. Implications for the media industry, health professionals, and women are discussed. 相似文献
10.