环维黄杨星干预高血压大鼠脑组织NPY与超微结构的研究

目的观察中药单体环维黄杨星(CVB)对易卒中型肾血管性高血压大鼠(RHRSP)脑缺血-复流不同时间脑组织神经肽Y(NPY)表达与细胞超微结构的干预作用。方法采用环形银夹使SD大鼠的双侧肾动脉狭窄,制成RHRSP模型,再用线栓法制成一侧大脑中动脉闭塞(MCAO)脑缺血-复流实验组;观察CVB对脑缺血6h后再灌注6、72、168h不同时间点大鼠脑组织NPY表达、含水量、梗死面积百分率、行为学评分及细胞超微结构的干预作用(治疗组),并与生理盐水处理者(对照组)及假手术组对照。结果对照组脑缺血-复流6h后脑组织NPY、含水量与假手术组相比均明显升高,72h上升至高峰,脑梗死面积百分率亦急剧增加,168h开始下降,但仍高于假手术组。电镜显示,对照组脑缺血-复流上述不同时间分别出现不同程度神经元和血管壁的超微结构损害,脑缺血-复流72h后治疗组较对照组大鼠脑NPY、含水量及梗死面积显著降低,受损脑组织神经元和血管壁的超微结构亦明显改善。结论NPY可能参与了RHRSP急性缺血-复流性脑损伤病理过程,CVB对脑缺血脑损伤RHRSP大鼠NPY、水肿与超微结构有一定的干预作用。     

主动脉、桡动脉和内乳动脉粥样硬化与微生物感染的关系

目的：探讨人主动脉、桡动脉和内乳动脉粥样硬化与微生物感染的关系。方法：搭桥手术中成功取得主动脉碎片（全层）30例、桡动脉30例和内乳动脉20例，组织行PCR检测及病理学分析，评估血管病变程度并分级。结果：30例主动脉、30例桡动脉、20例内乳动脉其轻度病变组与重度病变组肺炎衣原体（CPn）、幽门螺旋杆菌（HP）、巨细胞病毒（CMV）的PCR检测阳性率比较，差异均无统计学意义（P〉0．05）。结论：CPn、HP、CMV感染与动脉硬化有关，但与主动脉、桡动脉、内乳动脉的动脉病理改变程度无关。     

糖尿病患者为什么必须测定糖化血红蛋白

糖尿病是终身需要治疗的疾病.治疗效果的判定需要系统地监测.这是控制糖尿病进展的重要环节.控制的效果好可以避免或减缓并发症的发生.可最大限度地减少不必要的痛苦和经济负担.我国对1型和2型糖尿病患者进行了大量研究,证实了血糖控制良好就可明显减少慢性并发症发生的危险性.     

艾滋病的检验诊断

1981年,在美国首先发现了由人类免疫缺陷病毒(HIV)感染的疾病,将其命名为获得性免疫缺陷综合征(AIDS),即艾滋病。至今,全球已有六千多万人感染了HIV,造成2500万人死亡。我国在1985年发     

现代检验诊断新技术(三十九)“流脑“的检验诊断

"流脑"是流行性脑脊髓膜炎的简称,其病原是脑膜炎奈瑟氏菌。此菌依其荚膜多糖的差别可分为13型,主要的流行菌为A,B,C,Y,W135型,90％的"流脑"是由A,B,C型引起的。我国今年的流行菌株为C型菌。此菌经呼吸道进人体内,突破血脑屏障进     

血液葡萄糖含量多少正常

刘先生在一家大医院验过血液葡萄糖（以下简称血糖），一次是6．0毫摩／升，一次是6．4毫摩／升，有的医生告诉他，没事，不要紧，不是糖尿病。有的医生说，血糖已经超标了，并告知他很可能是得了糖尿病，应如何注意等等。     

高尿酸血症和痛风

赵先生在体检中发现血中的尿酸升高，为458微摩／升，其他血液化验的指标没有什么异常。有人说赵先生得了痛风病。赵先生很紧张，但也没有什么症状，要求了解是什么原因引起了尿酸升高。     

细菌耐药性机制的研究进展

本文对细菌耐药机制中的染色体介导的AmpC酶、金属酶、膜耐药、抗生素多耐药Aar基因以及生物膜等内容进行了综述以便增强对耐药机制及其检测方法的了解。     

Effect of electro-acupuncture combined with early rehabilitation on motor function and expressions of CD11b/CD18 and tumor necrosis factor-α in patients with acute cerebral infarction

Objective To observe the effect of electro-acupuncture combined with early rehabilitation on the motor function and expressions of the adhesion molecules CD11b and CD18 in the polymorphonuclear leucocytes (PMN) and monocytes and serum tumor necrosis factor-α (TNF-α) levels in patients with acute cerebral infarction (ACI). Methods A total of 165 ACI patients were randomly divided into control group (group A, n=50), conventional rehabilitation group (group B, n=50) and comprehensive rehabilitation group (group C, n=65). The expressions of CD11b and CD18 in the PMN and monocytes and serum TNF-α levels were determined before and at 1, 2, and 4 weeks after the treatment. Thirty-two healthy subjects were also recruited as the normal control group (group N). The neurological function of the subjects was evaluated by modified Edinburgh-Scandinavia stroke scale (MESSS) and Fugi-Meyer Assessment (FMA), and their activity of daily living (ADL) was assessed using Barthel index (BI). Results The CD11b/CD18 expression in the PMN and MN and serum TNF-α level in groups A, B and C were significantly higher than those in group N before and 1 week after the treatment (P<0.05). CD11b/CD18 expression and serum TNF-α level were significantly lower in groups B and C than in the group A at 1 week after the treatment, and significantly lower in group C than in group B (P<0.05). At 2 weeks of treatment, CD11b/CD18 and TNF-α were significantly lower in groups B and C than in the group A, being the lowest in group C (P<0.05). The scores of mESSS in both groups B and C were lower than that in group A, and the scores were lower in group C than in group B. Group C showed higher FMA scores than group B, both having higher scores than group A. At 4 weeks of treatment, the mESSS scores were significantly lower, hut the FMA and ADL score significantly higher in groups B and C than in the control group (P<0.05), and the differences were more obvious in group C. Groups B and C had greater effective rate than group A (P<0.05), and the rate was the highest in group C (P<0.05). Conclusion Electro-acupuncture combined with early rehabilitation promotes the recovery of motor function in ACI patients probably by regulating the expressions of the adhesion molecules CD11b and CD18 on the PMN and monocytes and the serum levels of TNF-α.