亚临床型糖尿病性心肌病变的结构与功能改变

对50例无临床心脏病表现的Ⅱ型糖尿病者,用心电图、心音图、颈动脉图及超声心动图等方法进行心脏结构和功能的测定,并与20例正常人对照。结果发现糖尿病组较正常组有心室肥厚、质量增加、收缩功能减退及舒张期顺应性下降等改变。其中合并高血压者影响更大。提示:糖尿病可引起一种功能减退性(收缩力下降,僵硬度增加)肥厚性心肌病变。     

铵梯炸药车间扩建职业危害控制效果评价

某化工厂在 1996年完成铵梯炸药车间改建工程后 ,又于去年进行车间生产线扩建改造。为了全面、正确评估扩建改造后生产环境各作业岗位工人对ＴＮＴ的接触水平 ,预测新ＴＮＴ生产线对接毒工人的健康损害程度 ,综合、客观地评价卫生防护设施的性能、效果和使用情况 ,同时也为该车间的正式投产前的竣工验收提供技术依据 ,我们于2 0 0 2年 4月受该厂委托 ,对该厂生产现场进行劳动卫生监测与作业环境的安全性评价。内容与方法1　采样点的选择　根据 84 #产品生产工艺和生产性有害因素的发生源及其分布情况 ,设立 11个采样点。2　采样数量和时间的…     

模拟调强技术照射鼻咽低分化鳞癌细胞的生物效应机制研究

Objective To study the altered radiobiological effect of simulative intensity-modulated radiotherapy (SIMR) in cultured human nasopharyngeal carcinoma (NPC) cells and the related mechanism. Methods Single cell suspension of exponentially growing CNE-2 cells, a poor differentiated NPC cell line, was seeded and cultured for 12 hours, then the cells were irradiated in two different models by 6 MV X-ray beams at 3 Gy/min. In single fraction irradiation (SFR) model, cells were irradiated a single fraction of 0, 2, 4, 6 or 8 Gy within 0 to 3 minutes. In S1MR model, cells were irradiated 0, 2, 4, 6 or 8 Gy in 5 frac-tions with interval of 8.0-8.5 minutes between. Clonogenic assay was performed to determine the radiosen-sitivity. Cellular apoptosis was measured by flow cytometry. RT-PCR was used to detect mRNA expressions of Bax and Bcl-2, Respectively. Results Compared with SFR group, the survival fraction in SIMR group was higher at all the dose levels. The values of α, β, D0 and Dq were higher in SIMR group than in SFR group. At dose levels of 2 Gy, 4 Gy and 6 Gy, The early and late apoptotic cells in SIMR group were lower than in SFR group (21.20%: 15.89%, F=18.51, P=0.020;13.00%: 10.20, F=15.67, P=0.040).The mRNA expression of Bax was upregulated in a dose-dependent manner in the both groups. Compared with SFR group, the mRNA expression of Bax in SIMR group was lower at all the dose levels (Mean value of 76.75% : 62.50%, F =36.57, P =0.000). Bcl-2 mRNA expression at every dose level had no significant difference between the two groups (Mean value of 29.25% : 29.75%, F=0.74, P=0.800). Conclusions Prolonged delivery time in SIMR model can decrease the radiobiological effects.     

消化道大出血急诊剖腹探查术中内镜的价值

目的 探讨内镜在急性消化道大出血行急诊剖腹探查术中的应用价值.方法 回顾性分析2005年始我科配合急诊手术治疗26例消化道大出血患者的临床资料,评估术中内镜价值.结果 26例均查出出血部位,25例为单一出血灶,1例有2处血管畸形;术中平均内镜检查时间15min.所有患者均根据术中内镜诊断进行了相关手术治疗,术中无死亡病例,术后随访3个月无再出血,1例死于多脏器功能衰竭.结论 对不明原因消化道大出血患者,术中内镜检查是安全有效的手段.     

成人隐睾症腹股沟情况评估与一期行无张力修补术

目的 探讨成人隐睾症术中腹股沟管情况评估的方法及一期无张力修补术的必要性.方法 选取我院收治的成人腹股沟管隐睾186例,年龄18～32岁,分成两组,观察组94例,对照组92例,术中评估腹股沟情况,观察组对内环口扩张及腹横筋膜病例一期进行无张力疝修补术,对照组对单纯内环扩张病例进行单纯疝囊高位结扎术、对腹横筋膜薄弱或内环...     

胃黏膜下囊状淋巴管瘤

患者男,46岁,因反酸、上腹部间断隐痛半年,胃窦隆起病变1 d来我院诊治.患者半年前出现反酸、上腹部间断隐痛,在外院行胃镜检查提示十二指肠球部溃疡,予抑酸等治疗后症状稍有缓解,1 d前在外院复查胃镜提示胃隆起性病变性质待定.体检:腹平软,无压痛及反跳痛,肝脾未触及,腹部未触及异常包块.入院后行胃镜检查:胃窦小弯侧见一处黏膜略隆起,直径约1.8 cm,表面呈淡蓝色,光滑,质软,充气后可变平坦.     

女性腹股沟疝无张力修补术原则探讨

目的通过三种无张力疝修补术疗效分析探讨女性腹股沟疝无张力修补术的原则。方法选取我院2001年1月至2007年5月行腹股沟斜疝或直疝无张力修补术的女性患者54例进行回顾性分析,应用Lichtenstein平片无张力修补术16例,应用疝修补装置(PHS)无张力修补术20例,应用疝环充填式(Mesh plug)无张力修补术18例。结果应用疝装置修补术效果好,无复发及遗漏疝病例,平片无张力修补术及网塞修补术较疝修补装置,遗漏股疝的发生率高。结论女性腹股沟疝应当选用全耻骨肌孔修补的无张力修补术式。     

模拟调强技术照射鼻咽低分化鳞癌细胞的生物效应机制研究

Objective To study the altered radiobiological effect of simulative intensity-modulated radiotherapy (SIMR) in cultured human nasopharyngeal carcinoma (NPC) cells and the related mechanism. Methods Single cell suspension of exponentially growing CNE-2 cells, a poor differentiated NPC cell line, was seeded and cultured for 12 hours, then the cells were irradiated in two different models by 6 MV X-ray beams at 3 Gy/min. In single fraction irradiation (SFR) model, cells were irradiated a single fraction of 0, 2, 4, 6 or 8 Gy within 0 to 3 minutes. In S1MR model, cells were irradiated 0, 2, 4, 6 or 8 Gy in 5 frac-tions with interval of 8.0-8.5 minutes between. Clonogenic assay was performed to determine the radiosen-sitivity. Cellular apoptosis was measured by flow cytometry. RT-PCR was used to detect mRNA expressions of Bax and Bcl-2, Respectively. Results Compared with SFR group, the survival fraction in SIMR group was higher at all the dose levels. The values of α, β, D0 and Dq were higher in SIMR group than in SFR group. At dose levels of 2 Gy, 4 Gy and 6 Gy, The early and late apoptotic cells in SIMR group were lower than in SFR group (21.20%: 15.89%, F=18.51, P=0.020;13.00%: 10.20, F=15.67, P=0.040).The mRNA expression of Bax was upregulated in a dose-dependent manner in the both groups. Compared with SFR group, the mRNA expression of Bax in SIMR group was lower at all the dose levels (Mean value of 76.75% : 62.50%, F =36.57, P =0.000). Bcl-2 mRNA expression at every dose level had no significant difference between the two groups (Mean value of 29.25% : 29.75%, F=0.74, P=0.800). Conclusions Prolonged delivery time in SIMR model can decrease the radiobiological effects.     

微粒子活性炭在腹腔镜结直肠癌手术中的定位作用

目的:探讨微粒子活性炭用于腹腔镜结直肠癌手术中定位的有效性。方法:21例结直肠癌患者,术前常规纤维结肠镜检查找到肿瘤部位,然后让患者取俯卧位,向肿瘤附近肠腔内注入生理盐水,生理盐水滞留处是大肠后侧,水面的正对侧则是大肠的腹腔侧,腹腔侧的大肠粘膜是注射微粒子活性炭的目标位置,先向此处的粘膜下注射生理盐水,形成粘膜膨疹,再向膨疹内注射微粒子活性炭,腹腔镜手术中寻找大肠浆膜黑染位置。结果:21例患者腹腔镜手术中均清晰见到大肠浆膜被微粒子活性炭黑染的标记,并以此为依据确定了手术切除范围,所有病变均行腹腔镜手术切除。结论:在腹腔镜结直肠癌手术前注射微粒子活性炭具有定位作用,此法简单、实用、节省手术时间,具有良好的应用前景。     

腹膜透析引起胆囊水肿2例报告

可持续性非卧床式腹膜透析(CAPD)是血液净化疗法的另一种重要技术.由于很少限制饮食、符合人体生理、心血管稳定、利于保护残存肾功能,且安全、操作简单等优点,被广泛用于肾脏替代治疗.笔者在临床工作中遇到2例因腹膜透析引起胆囊水肿,现报道如下.