枢丹预防术后恶心呕吐的临床观察

枢丹预防术后恶心呕吐的临床观察代志刚许航艾永凯魏国华王百胜作者单位：８３２００８新疆石河子医学院第一附属医院麻醉科（代志刚、许航、艾永凯、魏国华）；新疆伊犁州奎屯医院麻醉科（王百胜）枢丹是一种新型强效具有高度选择性的５－Ｈ３受体拮抗药，已广泛地应用于...     

浅谈冠心病旁路手术麻醉处理

严重冠状动脉阻塞的患者需行主动脉冠状动脉分路手术．减少对药物的依赖，缓解心绞痛．以改善生活质量。我院近期首次成功施行此类手术4例．皆麻醉成功，现报告如下：临床资料有关病史：4例病人，男性2例．女性2例，年龄4O～67岁，3例病人有心绞痛病史问～5年），ECG示心肌缺血     

超声波治疗瘢痕增生10例报告

<正>近年我们应用超声波治疗10例瘢痕增生,取得一定疗效,现报告如下。 1.临床资料 本组10例,男7例,女3例,年龄24～45岁,病程4周至3年。发病<1月1例,1～6月6例,1～2年2例,3年1例。瘢痕增生9例,瘢痕疙瘩1例,其中2例曾作过超短波、红外线治疗。 疗法与标准 采用C_2—Ⅰ型超声波治疗机,频率800kHz,连续式输出0.75～1.5W/cm~2,液体石腊作接触剂,直接接触移动法。患者取舒适体位,操作者手持声头稍加压力于瘢痕组织,以3～6cm/s的速度在瘢痕部位作直线式或上下左右往复移动,每日一次,每次15min,10次为一疗程。     

普腰改腰麻醉后头痛分析

腰麻是临床常用的麻醉方法,腰麻后继发头痛是最常见的并发症,发生率为3%～30%。为减少这一并发症的发生,麻醉界的同道们进行了很多的研究、探讨。我院从1964年以来共做腰麻4.284例。其中改良腰麻(简称改腰)2.347例。为叙述方便我们将常规腰麻简称普腰,现将两种方法并发头痛的情况进行总结、分析。     

皱折对高密度聚乙烯膜特性的影响

HDPE（高密度聚乙烯）膜在铺设、使用过程中不可避免会产生皱折，研究说明，皱折对膜的拉伸强度没有显著影响，对抗应力开裂性能的影响在正常值范围。填埋场铺设HDPE膜时，应尽可能减少皱折，对于严重的皱折须及时、妥善地处理。     

绒毛膜癌肺转移致大咯血1例并文献复习

绒毛膜癌肺转移是咯血少见病因,经常以弥漫性肺泡出血首诊呼吸科,常规的咯血救治方法效果不佳.本文回顾性分析我科诊治的1例绒毛膜癌肺转移致大咯血的病例资料,并复习相关文献,探讨该病的临床特点及诊治关键.     

3D可视化技术在骨科教学中的应用

近年来可视化技术在各领域中得到广泛应用,在教学过程中通过引入可视化技术,可显著提高课堂的教学效率。近年来,随着3D可视化技术和骨科教学的不断发展和改进,大量的教育工作者将3D可视化技术运用到骨科教学研究中,旨在探讨更好的教学模式。本文通过总结前人开展3D可视化技术教学的经验,探讨如何通过3D可视化技术提高骨科教学的效率和水平,并提高年轻骨科医学生的空间思维能力和手术操作能力。     

重症监护病房细菌耐药性分析

目的 了解重症监护病房（ICU）细菌耐药趋势以指导抗感染治疗。方法 取1999-2000年2年内ICU患者分离所得细菌720株,用纸片扩散法进行药敏试验。结果 耐苯唑西林的金黄色葡萄球菌、表皮葡萄球菌和溶血葡萄球菌耐药率分别为29%、100%和100%,并发现耐万古霉素的金黄色葡萄球菌和表皮葡萄球菌菌株,大肠埃杀菌对哌拉西林,庆大毒素和环丙沙星的耐药率达60%以上,铜绿钾单胞菌对头孢他啶和亚胺培南的耐药率为22%和31%。结论 ICU细菌耐药性别严重。须合理使用抗菌药物。     

自组装DEAC-PNAG@miR-150纳米体系制备及其血管保护机制研究

目的 研究自组装技术制备脱乙酰化聚N-乙酰氨基葡萄糖(DEAC-PNAG)-miR-150纳米靶向体系,并对其血管保护机制进行探讨.方法 通过自组装技术制备纳米聚合物,通过透射电镜和DLS进行表征,凝胶位移法用于评价封装效率.通过荧光显微镜检测细胞摄取,RT-PCR用于检测转染细胞中miR-150的表达,Western blot用于检测纳米纳聚合物对HUVECs细胞中血管紧张素Ⅱ(Ang-Ⅱ)和DLK-1表达影响.结果 DEAC-PNAG聚合物具有纳米尺寸和阳性表面电势,可保护miRNA不被RNase A降解.此外,DEAC-PNAG@miRNA能促进miRNA的细胞摄取,通过抑制HU-VECs细胞中Ang-Ⅱ和DLK-1的表达发挥血管保护作用.结论 DEAC-PNAG@miR-150是一个有效的miRNAs递送平台,可能对脓毒症治疗有积极意义.     

Role and mechanism by which long non-coding RNAs regulate subchondral bone homeostasis in knee osteoarthritis北大核心

BACKGROUND: The important role of subchondral bone adjacent to the cartilage layer in the knee osteoarthritis progression has been widely recognized and the factors interfering with subchondral bone homeostasis are gradually becoming a research hotspot. Current studies have revealed that long-stranded non-coding RNAs have highlighted certain advantages and values in regulating bone homeostasis. OBJECTIVE: To understand the working mechanism of long non-coding RNAs in the subchondral bone homeostasis, thereby providing evidence for exploring new prevention and treatment methods for knee osteoarthritis. METHODS: CNKI, WanFang, VIP, PubMed, Medline, Embase, and Web of Science databases were searched with the search terms of “Long non-coding RNA, Knee osteoarthritis, Subchondral bone, Osteoblasts, Osteoclasts, Mesenchymal stem cells, Signal pathway” in Chinese and English. Literature retrieval time was from inception to July 2022, and a total of 65 articles were included in accordance with the inclusion and exclusion criteria. RESULTS AND CONCLUSION: (1) Subchondral bone homeostasis is closely related to the proliferation, differentiation, and apoptosis of mesenchymal stem cells, osteoblasts and osteoclasts, and peripheral cytokines, and angiogenesis. (2) Long non-coding RNAs can modulate various factors affecting subchondral bone homeostasis, mainly through the Wnt/β-catenin, TGF-β/BMPs/Smad, PI3K/AKT, and SDF-1/CXCR4 signaling pathways, which thereby promote or inhibit bone formation by modulating the proliferation, differentiation and apoptosis of bone marrow mesenchymal stem cells, osteoblasts and osteoclasts. It can also modulate cytokines and inhibit angiogenesis. These findings provide a theoretical basis for balancing subchondral bone homeostasis and a potential target site for the prevention and treatment of subchondral osteosclerosis in knee osteoarthritis. (3) Long non-coding RNAs are important for modulating bone formation, bone resorption, and angiogenesis. How this type of RNAs can play a role in modulating the abnormal subchondral bone in knee osteoarthritis will be a key research focus in the future. (4) Given that it is difficult to collect samples of normal human subchondral bone, there is no report on the long non-coding RNAs in normal human subchondral bone. There is still a lack of clinical studies on the direct effects of long non-coding RNAs on subchondral bone and the mechanisms of their effects on modulating subchondral bone homeostasis are not fully understood. These remain to be studied in greater depth in the future. (5) This review can preliminarily reveal the mechanism of long non-coding RNAs on subchondral bone homeostasis and summarize the relevant potential targets, which are expected to promote long non-coding RNA as a biomarker and therapeutic target for the regulation of subchondral bone in the future, thus providing new ideas for the prevention and treatment of knee osteoarthritis. © 2023, Publishing House of Chinese Journal of Tissue Engineering Research. All rights reserved.