急性胰腺炎合并多脏器功能衰竭26例报告

急性胰腺炎(AP)以发病急、症状重、变化快和并发症多为其特征。本文重点分析与探讨AP合并多脏器功能衰竭(MOF)的临床特点和治疗。 资料来源 自1975年9月～1986年3月,我院共收治AP患者118例,其中合并MOF者26例(占22.03％)对26例患者多次进行白细胞计数,血尿淀粉酶、血清电解质和脏器功能检查。此外,还作了动脉血气分析。胸部X线摄片和胰脏B型超声等特殊检查。     

Dual Exposure to Sevoflurane Improves Anesthetic Preconditioning in Intact Hearts

Background: Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevoflurane would achieve an outcome similar to that associated with a single exposure to a higher (H) concentration.

Methods: Langendorff-prepared guinea pig hearts were exposed to 0.4 mm sevoflurane once for 15 min (H1-15; n = 8) or 0.4 mm (H2-5; n = 8) or 0.2 mm sevoflurane (L2-5; n = 8) twice for 5 min, with a 5-min washout period interspersed. Sevoflurane was then washed out for 20 min before 30 min of global no-flow ischemia and 120 min of reperfusion. Control hearts (n = 8) were not subjected to APC. Left ventricular pressure was measured isovolumetrically. Ventricular infarct size was determined by tetrazolium staining and cumulative planimetry. Values are expressed as mean +/- SD.

Results: The authors found a better functional return and a lesser percentage of infarction on reperfusion in H2-5 (28 +/- 9%) than in H1-15 (36 +/- 8%; P < 0.05), L2-5 (43 +/- 6%; P < 0.05), or control hearts (52 +/- 7%; P < 0.05).     

尿脱落细胞特异性荧光染色法在膀胱肿瘤诊断等方面的应用

[收集尿脱落细胞并进行特异性荧光染色和先进的细胞检测法是诊断早期膀胱肿瘤的一种新途径]从尿脱落细胞中查找癌细胞作为膀胧肿瘤的辅助诊断方法已有近百年的历史。近年来,由于新的特异性荧光染料不断发现,以及流式细胞检测仪器的应用,标本收集方法的改进     

葛根素联合中药治疗糖尿病周围神经病变

近年来,笔者使用葛根素氯化钠注射液静脉点滴联合中药治疗糖尿病周围神经病变32例,取得了较好的效果。现报告如下。     

Effect of water restrictions on the physiological parameters,psychological behavior and brain c-Fos expression in rat

1 Introduction Exposure to hostile stressors causes a series of coor- dinated responses in the body, such as alterations of neu- roendocrine secretion, immune reaction and behavioral manifestation to maintain homeostasis stability and sur-vival of the organisms. Stressors are divided into two main categories: physical, or systemic, and psychological, or emotional / processive. Each stressor might activate a spe- cific central pathway to induce a special neuroendocrine response, even cause stre…     

静脉动脉化再植拇指完全离断

目的 报道静脉动脉化再植拇指完全离断的新方法。方法 1999—2002年在5例拇指完全离断再植手术中，因指动脉严重损伤或多次吻合指动脉失败后，将近侧动脉与断指的一条静脉吻合作为供血通路，近侧的静脉与断指的另几条静脉吻合作为回血通路。结果 5例再植拇指全部成活，早期病例完全恢复了良好的功能。结论 静脉动脉化是一种拇指离断再植的新方法，操作简便，效果可靠，值得推广应用。     

天然生化适应剂增强人体耐力效应的研究

<正> 通过在体动物实验及体外试验,证明“适应剂”能提高动物机体的耐力和智力、改善心功能等功效。在大量的动物实验基础上,我们选择了耐力负荷极大,处于高度疲劳状态下的越野滑雪运动员与竞跑田径运动员为试验对象,分别进行了为期6个月与1个月服药后的人体耐力效应评价。服用后,若干运动心功能指标与疲劳代谢产物有显著变化,竞赛成绩亦有明显提高,并且无不良反应。方法与结果如下:一、实验材料1 实验仪器(1)XF-5型心率发射器上海体育技术研究所(2)RDH-2000型氧与二氧化碳分析仪南京分析仪器厂(3)XY-1型动态心功能测量仪海军医学研究所(4)μ-80型微型计算机上海计算机研究所     

Morphine Preconditions Purkinje Cells against Cell Death under In Vitro Simulated Ischemia-Reperfusion Conditions

Background: Morphine pretreatment via activation of [delta]1-opioid receptors induces cardioprotection. In this study, the authors determined whether morphine preconditioning induces ischemic tolerance in neurons.

Methods: Cerebellar brain slices from adult Sprague-Dawley rats were incubated with morphine at 0.1-10 [mu]m in the presence or absence of various antagonists for 30 min. They were then kept in morphine- and antagonist-free buffer for 30 min before they were subjected to simulated ischemia (oxygen-glucose deprivation) for 20 min. After being recovered in oxygenated artificial cerebrospinal fluid for 5 h, they were fixed for morphologic examination to determine the percentage of undamaged Purkinje cells.

Results: The survival rate of Purkinje cells was significantly higher in slices preconditioned with morphine (>= 0.3 [mu]m) before the oxygen-glucose deprivation (57 +/- 4% at 0.3 [mu]m morphine) than that of the oxygen-glucose deprivation alone (39 +/- 3%, P < 0.05). This morphine preconditioning-induced neuroprotection was abolished by naloxone, a non-type-selective opioid receptor antagonist, by naltrindole, a selective [delta]-opioid receptor antagonist, or by 7-benzylidenenaltrexone, a selective [delta]1-opioid receptor antagonist. However, the effects were not blocked by the [mu]-, [kappa]-, or [delta]2-opioid receptor antagonists, [beta]-funaltrexamine, nor-binaltorphimine, or naltriben, respectively. Morphine preconditioning-induced neuroprotection was partially blocked by the selective mitochondrial adenosine triphosphate-sensitive potassium channel antagonist, 5-hydroxydecanoate, or the mitochondrial electron transport inhibitor, myxothiazol. None of the inhibitors used in this study alone affected the simulated ischemia-induced neuronal death.