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31.
Peng Li Sha-Sha Tao Meng-Qin Zhao Jun Li Xiu Wang Hai-Feng Pan 《Immunological investigations》2015,44(7):603-615
Objective: Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.Methods: We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).Results: A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR?=?0.813, 95%CI?=?0.694–0.953, p?=?0.010) in overall populations.Conclusions: The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions. 相似文献
33.
【摘要】 目的 评估超声引导下前锯肌平面阻滞(SAPB)与胸段硬膜外阻滞治疗胸廓切开术后急性疼痛的有效性和安全性。 方法 该研究在2017年2月至2018年12月期间进行全身麻醉下计划进行胸廓切开术的61例患者被随机分配两组,前锯肌阻滞组32例,胸段硬膜外阻滞组29例。前锯肌阻滞组患者在术后气管导管拔除前进行超声引导下前锯肌浅层肌间隙注射0.25%左旋布比卡因30 mL,而后在肌间隙泵注0.125%左旋布比卡因5 mL / h;胸段硬膜外阻滞组通过术前清醒状态置入胸段硬膜外导管,在术后气管导管拔除前在导管内推注0.25%左布比卡因15 mL,随后泵注的0.125%左旋布比卡因5 mL/h。在术后24 h内记录患者平均动脉压和VAS疼痛评分以及使用吗啡的剂量。 结果 前锯肌阻滞组术前与术后相比,患者平均动脉血压没有显著变化(P = 0.147),而胸段硬膜外阻滞组则显著下降(P = 0.002);两组的VAS评分以及消耗吗啡的总剂量没有显著统计学差异。 结论 前锯肌平面阻滞相对于胸段硬膜外阻滞是治疗急性胸廓切开术后疼痛安全有效的镇痛方案。 相似文献
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35.
Peng‐fei Lei Shi‐long Su Ling‐yu Kong Cheng‐gong Wang Da Zhong Yi‐he Hu 《Orthopaedic Surgery》2019,11(5):914-920
Three‐dimensional (3D) printing technology, virtual reality, and augmented reality technology have been used to help surgeons to complete complex total hip arthroplasty, while their respective shortcomings limit their further application. With the development of technology, mixed reality (MR) technology has been applied to improve the success rate of complicated hip arthroplasty because of its unique advantages. We presented a case of a 59‐year‐old man with an intertrochanteric fracture in the left femur, who had received a prior left hip fusion. After admission to our hospital, a left total hip arthroplasty was performed on the patient using a combination of MR technology and 3D printing technology. Before surgery, 3D reconstruction of a certain bony landmark exposed in the surgical area was first performed. Then a veneer part was designed according to the bony landmark and connected to a reference registration landmark outside the body through a connecting rod. After that, the series of parts were made into a holistic reference registration instrument using 3D printing technology, and the patient's data for bone and surrounding tissue, along with digital 3D information of the reference registration instrument, were imported into the head‐mounted display (HMD). During the operation, the disinfected reference registration instrument was installed on the selected bony landmark, and then the automatic real‐time registration was realized by HMD through recognizing the registration landmark on the reference registration instrument, whereby the patient's virtual bone and other anatomical structures were quickly and accurately superimposed on the real body of the patient. To the best of our knowledge, this is the first report to use MR combined with 3D printing technology in total hip arthroplasty. 相似文献
36.
周世繁 《中国中医药现代远程教育》2020,(4):J0147-J0148,I0009
目的分析PBL教学法在中医急诊学教学中的运用效果。方法2018年3月-2018年6月选取本校2016级针推专升本学生68名进行调查,采用随机数字表法将其分为2组,各34名,观察组采取PBL教学法,对照组采取传统讲授法,对比2组学生的理论、实践考核成绩,并通过调查问卷评价学生对教学方法的认可程度。结果实施教学后,观察组学生理论、实践考核成绩较对照组学生明显提高(P<0.05)。相比于对照组,观察组学生在培养学习兴趣、提升学习技巧、增强合作能力、创新思维方式的层面上对教学方法的认可程度普遍较高(P<0.05)。结论采取PBL法实施中医急诊学教学有助于提升临床教学效果和质量。 相似文献
37.
Guo-Chao Zhong Yang Peng Kang Wang Lun Wan You-Qi-Le Wu Fa-Bao Hao Jie-Jun Hu Hai-Tao Gu 《International journal of cancer. Journal international du cancer》2020,147(6):1577-1586
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs. 1: 0.44; 95% confidence interval: 0.24, 0.80; ptrend = 0.0065) and mortality (subdistribution hazard ratiotertile 3 vs. 1: 0.37; 95% confidence interval: 0.19, 0.71; ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Nonlinear inverse dose–response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all pnonlinearity < 0.05). In summary, in the US population, a high magnesium intake is associated with decreased risks of PLC incidence and mortality in a nonlinear dose–response manner. These findings support that increasing the consumption of foods rich in magnesium may be beneficial in reducing PLC incidence and mortality. 相似文献
38.
背景与目的:CD44分子是众多肿瘤细胞的标志分子,其表达水平与肿瘤细胞的恶性程度有关。该研究探讨CD44基因中的单核苷酸多态性(single nucleotide polymorphism,SNP)位点与云南汉族人群宫颈癌和非小细胞肺癌(nonsmall cell lung cancer,NSCLC)易感性的相关性。方法:选取了CD44基因中的两个SNP位点rs13347和rs8193,采用TagMan基因分型的方法,分析这两个多态性位点在497例宫颈癌患者和500例健康对照个体以及483例NSCLC患者和471例健康对照个体中的分布特征,并分析CD44基因中的多态性位点与云南汉族人群宫颈癌和NSCLC的相关性。结果:rs13347和rs8193位点等位基因和基因型在宫颈癌组和对照组中的分布频率的差异无统计学意义(P>0.05)。而在NSCLC组和对照组的比较中:rs13347和rs8193位点等位基因在NSCLC组和对照组中的分布频率的差异有统计学意义(P=0.020和P=0.004);这两个位点基因型在NSCLC组和对照组中分布频率的差异有统计学意义(P=0.027和P=0.020);其中rs13347位点等位基因C在NSCLC组中的分布频率显著高于对照组,可能是NSCLC发生的风险因素(OR=1.250,95% CI:1.035~1.509),rs8193位点等位基因C在对照组中的分布频率显著高于NSCLC组,可能是NSCLC发生的保护性因素(OR=0.768,95%CI:0.641~0.921)。单倍型分析结果显示,rs13347C-rs8193T和rs13347T-rs8193C在NSCLC组和对照组中的分布频率差异有统计学意义(P=0.003和0.022);该结果说明单倍型rs13347C-rs8193T可能是云南汉族人群NSCLC发生的风险性因素(OR=1.316,95%CI:1.096~1.579)。结论:CD44基因中的两个SNP位点rs13347和rs8193可能与云南汉族人群宫颈癌发病风险无关,而可能与云南汉族人群NSCLC具有相关性。 相似文献
40.
异常毒性最初是一种确保复杂成分制剂生产工艺一致性及安全性的辅助检测手段,后来成为针对外源性毒性污染物的通用安全性检测项,曾在世界范围内被各国药典收载。由于该检测与药品质量、安全性之间的关联性受到质疑,各国药典逐渐在各论及通则中删除该检测项,目前仅《中国药典》保留异常毒性。由于该检测存在设定限值难以统一、给药体积及给药剂量不合理、结果易受干扰且缺乏明确的判定标准等试验原理及设计上的缺陷,导致其试验结果没有实际参考意义。基于对历史数据的回顾分析,国际监管机构及卫生组织对异常毒性有了更为科学的认知,并已逐渐形成统一的监管共识:严格的生产控制措施和有效的质量检测手段,比异常毒性检测更为重要;异常毒性检测结果或与产品质量及污染不具相关性;在异常毒性检查中使用大量动物不符合动物福利和“3R”原则。本文从科学角度试论异常毒性作为药品质量控制指标的合理性,并总结异常毒性修订的科学原则,希望能为我国监管机构、制药行业修订异常毒性相关内容提供思考角度。 相似文献