Early warning signals for Omicron outbreaks in China: A retrospective study

The Omicron variant has become the dominant COVID-19 variant worldwide due to its rapid and cryptic spread. Therefore, successful early warning is of great importance to be able to control epidemics in their early phase, before developing into large outbreaks. COVID-19-related Baidu search index, which reflects human behavior to a certain degree, was used to retrospectively detect the warning signs for Omicron variant outbreaks in China in 2022. The characteristics and effects of warning signs were analyzed in detail. We detected the presence of early warning signs (both high and low thresholds) and found that these occurred 4–7 days earlier than traditional epidemiological surveillance and >20 days earlier than the implementation of the local “lockdown” policy. Compared with the “high threshold” warning, the early warning effect of the “low threshold” is also vital because it indicates a negligence about epidemic prevention and control. However, there is obvious heterogeneity in the optimal threshold for detecting early warning signs and their distribution in different cities. Multi-source and multi-point early warning systems should be established via combining internet-based big data in the future to conduct effective and early real-time warning. This would create precious time for the early control of COVID-19 outbreaks.     

子宫内膜异位症癌抗原(CA125)检测及其临床意义

目的：探讨子宫内膜异位症与ＣＡ１２５有无相关性、提高临床子宫内膜异位症诊断雍诊断最佳途径。方法：用放射免疫测定法（ＲＩＡ）检测７９例子宫内膜异位症、７０例子宫肌瘤、６４例子宫颈癌、８０名正常育龄女性为对照。结果：子宫内膜异位症、子宫肌瘤、子宫颈癌、正常对照组阳性率分别是７９．７５％、８．５７％、１７．１９％、０．００％。前者显著高于后三者（Ｐ〈０．０１）。结论：ＣＡ１２５检测为临床诊断子宫内膜异位     

Direct current pulse elicits basilar membrane vibration in guinea pigs

Since the lagos, the elec~lity of the cochleahas attheted much attention. It has been demonshatedthat the outer air cells (OHCs) Play a key role in theeleC~hty of the COChiea. EvanS et al if] found thatthe OHCs exhiliited in cairo length change in a Voltagedependent manner upon electric stimulation, applying thatOHCs assess electIO~mecbocal ~sduchon ability,which motivates the intwry into the causality betWeenOHC electIDmotility and basilar membrane (BM) vibrationand fulther, into th…     

人乳头瘤病毒16型(湖北株)E7基因在体内和体外的表达

构建人乳头瘤病毒１６型（ＨＰＶ１６）Ｅ７湖北株（ＨＢ）基因真核表达质粒,探讨其在哺乳动物体外,体内表达状况,为本地区ＨＰＶ相关肿瘤的基因治疗提供依据。方法采用分子克隆技术,构建ＨＰＶ１６Ｅ７－ＨＢ重组表达质粒,磷酸钙－ＤＮＡ沉淀技术及基因免疫技术将外源目的基因（ＨＰＶ１６Ｅ７－ＨＢ）导入ＮＩＨ３Ｔ３细胞及大、小鼠体内ＰＣＲ,ＲＴ－ＰＣＲ,免疫荧光染色技术对外源目的基因及其产物（ｍＲ－ＮＡ,蛋白质。     

活血通脉片对实验性SD大鼠急性血瘀证血液流变性的影响

目的　研究中药复方制剂活血通脉片 (HXTMT)对SD大鼠急性血瘀证的影响 .方法　用 HXTMT混悬液给予SD大鼠灌胃 1wk,第 7日同时对大鼠皮下注射 2次 1g·L- 1 肾上腺素 0 .2 m L ,其间进行 1次寒冷刺激 (冰水 ,0℃ ) 5min,于第 8日晨复制成血瘀实验模型 ,并采血测定血液流变学各指标 .结果　 HXTMT能明显降低全血粘度 (ηb)、血浆粘度 (ηp)、纤维蛋白原 (Fib) (P<0 .0 1)及红细胞比容 (HCT) (P<0 .0 5 ) ;缩短红细胞电泳时间 (EET) (P<0 .0 5 ) ,提高红细胞电泳率 (EEM) (P<0 .0 1) ;亦能明显增强红细胞变形性 (DI)(P<0 .0 5 ) ,降低红细胞聚集指数 (AI) (P<0 .0 1) .结论　HXTMT具有改善血液流变性作用 ,能防治高粘血症和缺血性心脏病     

加杨雄花序的化学成分研究

首次对加杨雄花序了条统从其撮物的石油醚（６０～９０℃）部分,乙酸乙酯部分分离并鉴定了１５个化合物,本语文报道８个黄酮类成分,乔松酮（ｐｉｎｏｓｔｒｏｂｉｎ,１）,高良姜素－３－甲氧基（ｇａ／ｌａｎｇｉｎ ３ ｍｅｔｈｏｘｙ,２）,乔松索（ｐｉｎｏｃｅｒｍｂｉｎ,２）,白杨素（ｃｈｒｙｓｉｎ,４）槲皮素－３,７－二甲氧基（ｑｕｅｒｃｅｔｉｎ０－３,７－ｄｉｍｅｔｈｏｘｙ,５）,鼠李素（ｒｈａｍｍｅｔ     

杨属植物中酚甙类含量的HPLC法测定

采用ＨＰＬＣ法,对１８种杨属植物树中酚甙类成分含量进行了测定。所建立的方法「采用Ｓｈｉｍ－ｐａｃｋＯＤＳ柱,以甲醇（Ａ）和水－四氢呋喃（９９：１）（Ｂ）为流动相」确实可靠,具良好的线性关系,精密度ＲＳＤ〈２％,加样回收率ｓａｌｉｒｅｐｏｓｉｄｅ为９９．２％,ＲＳＤ＝１．７７％,ｄａｖｉｄｉａｎｉｎ为９８．６％,ＲＳＤ＝３．０１％,ｇｒａｎｄｉｄｅｎｔａｔｉｎ为１０２．１％,ＲＳＤ＝０．９１％。ＳＧ     

四类新药盐酸格拉司琼注射液预防抗肿瘤药物所致呕吐的Ⅱ期临床观察

目的在肿瘤的治疗中化疗药物所引起的恶心、呕吐是极为常见的,通过对盐酸格拉司琼注射液预防肿瘤化疗所致呕吐的Ⅱ期临床研究,探讨该药的止吐疗效及毒性反应.方法对31例病人的观察,采用自身对照新药盐酸格拉司琼与恩丹西酮预防抗肿瘤药物(DDP及蒽环类药物)所致呕吐进行比较.结果格拉司琼对强致吐剂顺铂所引起的呕吐其总的缓解率＞90%,恩丹西酮对顺铂引起的呕吐其缓解率＞85%.两止吐药毒性反应主要为便秘,恩丹西酮致便秘发生率高达41%,而格拉司琼所致便秘发生率为16%.结论两药预防呕吐的疗效相当,但格拉司琼的副反应明显低于恩丹西酮     

茜草多糖对肾缺血再灌注损伤的保护作用

目的 :观察茜草多糖对肾缺血再灌注损伤的保护作用。方法 :通过建立大鼠急性肾缺血再灌注损伤模型 ,测定了茜草多糖对肾缺血再灌注后 ,MDA、SOD以及肾组织中Na ,K ATP酶及Ca2 ATP酶活性的变化。结果 :使用茜草多糖后 ,与对照组比较MDA明显降低。SOD、Na 、K ATP酶及Ca2 ATP酶的活性显著上升。结论 :茜草多糖对急性肾缺血再灌注损伤肾脏有显著的保护作用。     

低分子肝素治疗急性脑梗死的临床观察

目的 观察低分子肝素治疗急性脑梗死的临床疗效及对出凝血时间、凝血酶原时间、血小板的影响。方法 ６０例急性脑梗死患者,分为治疗组、对照组各３０例。治疗组采用低分子肝素静滴,对照组用低分子右旋糖酐治疗。结果 治疗组总有效率９３．３％,显效率６３．３％,明显优于对照组（７３．３％,４６．６％）。有显著性差异（Ｐ〈０．０１）;对出凝血时间、凝血酶原时间、血小板无显著性差异（Ｐ〉０．０５）,无１例继发出血。结论 低分子肝素治疗急性脑梗死是安全有效的。