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22.
Wei Han Ming-Xing Xie Qing Lv Xin-Fang Wang Li Zhang 《Frontiers of Medicine in China》2010,4(1):71-76
The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular
(LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients
with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their
ejection fraction (EF) values (group A: LVEF ⩾ 50%; group B: LVEF < 50%), and 35 normal people served as the control group.
Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared
with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26±1.89
vs 10.74±2.67; 9.71±1.71 vs 11.36±2.29, both P < 0.05), but the radial displacement and global twist were maintained (P > 0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly,
especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both P < 0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop
was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification
of left ventricular global and segment twist and radial displacement in patients with coronary artery disease. 相似文献
23.
TNF-α在沙漠干热环境下猪腹部肠管火器伤后肝组织中的表达 总被引:3,自引:3,他引:0
目的探讨沙漠干热环境下猪腹部肠管火器伤后肝脏组织TNF-α的表达和肝功能的变化。方法沙漠干热环境组和常温环境组健康长白仔猪各42头随机等分为对照组和伤后1、2、4、8、12 h和24 h组,实验组建立腹部火器伤肠管穿透模型后,用免疫组化及图像分析法测定各组肝脏组织内TNF-α的表达,同时测定血清中AST水平。结果伤后各组肝组织TNF-α表达明显高于对照组,沙漠干热环境组于伤后2 h和8 h出现2个高峰;常温环境组于伤后2 h和12 h出现2个高峰。血清AST水平于伤后显著增高,并于伤后2 h出现第1个高峰,沙漠干热环境组和常温环境组分别于伤后8 h和12 h出现第2个高峰。结论沙漠干热环境下腹部肠管火器伤后肝脏TNF-α的表达增加并与AST的变化趋势一致,而且峰值较常温组提前出现,提示TNF-α在腹部肠管火器伤后肝损伤过程中可能起重要作用。 相似文献
24.
25.
个性化护理干预对妇科恶性肿瘤手术后生活质量的影响 总被引:2,自引:0,他引:2
[目的]探讨个性化护理干预对妇科恶性肿瘤手术后生活质量的影响。[方法]将46例在我科因妇科恶性肿瘤手术的患者随机分为实验组和对照组,通过实施个性化护理干预,对两组患者进行SF-36量表和Olson婚姻质量问卷进行测评。[结果]对妇科恶性肿瘤手术后患者进行个性化护理干预后其生活质量明显提高,差异有显著性意义(P〈0.01)。[结论]个性化护理干预能提高妇科恶性肿瘤手术后生活质量。 相似文献
26.
摘要:目的:探究苯并芘(benzo[a]pyrene,BaP)通过芳香烃受体(aryl hydrocarbon receptor,AhR)和核因子E2相关因子(subcellular localization of nuclear factor?E2-related factor 2,Nrf2)信号通路对HepG2细胞中谷胱甘肽-S-转移酶P1(glutathione S-transferase P1,GSTP1)的影响。方法:将体外培养HepG2细胞分为Control组、BaP(10μmol/L)组、BaP(10μmol/L)+AhR抑制剂(1μmol/L)组和BaP(10μmol/L)+Nrf2抑制剂(1μmol/L)组,BaP组给予10μmol/LBaP培养24小时,抑制剂组给予1μmol/L抑制剂半小时后,加入10μmol/L BaP培养24小时,Western Blot和qPCR实验方法检测各组AhR、Nrf2、细胞色素P450s(cytochrome P450s,CYPs)、血红素加氧酶-1(heme oxygenase-1,HO-1)及GSTP1基因和蛋白的表达。结果:与Control组相比,BaP组中AhR、Nrf2、GSTP1、CYP1A1及HO-1的mRNA和蛋白表达均升高(P<0.05);与BaP组相比,BaP+AhR抑制剂组中AhR、GSTP1和CYP1A1的mRNA和蛋白表达均降低(P<0.05),BaP+Nrf2抑制剂组中Nrf2、GSTP1和HO-1的表达均降低(P<0.05);与BaP+AhR抑制剂组相比,BaP+Nrf2抑制剂组GSTP1 mRNA和蛋白的表达降低(P<0.05)。结论:BaP通过AhR和Nrf2两条信号通路增加GSTP1的表达,以Nrf2信号通路为主导影响GSTP1的表达。 相似文献
27.
Jinyi Yuan Biwen Mo Zhuang Ma Yuan Lv Shih-Lung Cheng Yanping Yang Zhaohui Tong Renguang Wu Shenghua Sun Zhaolong Cao Jufang Wu Demei Zhu Liwen Chang Yingyuan Zhang 《Journal of microbiology, immunology, and infection》2019,52(1):35-44
Background/Purpose
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens in community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety of nemonoxacin compared with levofloxacin in patients with CAP.Methods
A phase 3, multicenter, randomized (2:1) controlled trial was conducted in adult CAP patients receiving nemonoxacin 500 mg or levofloxacin 500 mg orally once daily for 7–10 days. Clinical, microbiological response and adverse events were assessed. Non-inferiority was determined in terms of clinical cure rate of nemonoxacin compared with that of levofloxacin in a modified intention-to-treat (mITT) population. NCT registration number: NCT01529476.Results
A total of 527 patients were randomized and treated with nemonoxacin (n = 356) or levofloxacin (n = 171). The clinical cure rate at test-of-cure visit was 94.3% (300/318) for nemonoxacin and 93.5% (143/153) for levofloxacin in the mITT population [difference (95% CI), 0.9% (?3.8%, 5.5%)]. The microbiological success rate was 92.1% (105/114) for nemonoxacin and 91.7% (55/60) for levofloxacin in the bacteriological mITT population [difference (95% CI), 0.4% (?8.1%, 9.0%)]. The incidence of adverse events (AEs) was comparable between nemonoxacin (33.1%, 118/356) and levofloxacin (33.3%, 57/171) (P > 0.05).Conclusion
Nemonoxacin 500 mg once daily for 7–10 days is as effective and safe as levofloxacin for treating adult CAP patients in terms of clinical cure rates, microbiological success rates, and safety profile.ClinicalTrials.gov identifier: NCT01529476. 相似文献28.
In order to substantiate the concept that cocaine behavioral effects may be influenced by histone modification, rats were trained to self-administer cocaine intravenously (0.75 mg/(kg injection)), and were systemically pretreated with sodium butyrate (NaBu), a potent histone deacetylase inhibitor, before the test session during the maintenance phase. The effect of NaBu on a control reinforcer (sucrose)-induced self-administration was also assessed. NaBu (100–200 mg/kg) was inactive in altering the cocaine (0.75 mg/(kg injection))-maintained responding and at the highest dose (400 mg/kg) it did increase cocaine-induced lever presses during the maintenance phase. On the other hand, sucrose-reinforcing potential was not altered when NaBu was given at the highest dose (400 mg/kg). These findings extend previous observations that changes in histone acetylation are relevant to cocaine-induced behavioral effects. Given that histone acetylase inhibitor enhances cocaine-induced behavioral plasticity, the therapeutic benefits of histone acetyltransferase inhibitors warrant further investigation in the experimental models of cocaine abuse. 相似文献
29.
Li Zhihai Gao Qixue Tao Baohong Lv Jingyao Cai Zhiyi 《Anatomical record (Hoboken, N.J. : 2007)》2008,291(12):1662-1672
Decompression operation of the optic canal via the nasal path under endoscope is widely used, but it is both a challenging and controversial method. Unsatisfactory results were largely associated with otolaryngologists' limited understanding of the real anatomical situations of the optic canal before operation. To provide otolaryngologists with the real situations and data preoperation, multislice helical CT was used to reconstruct the images of the optic canal. Using multislice helical CT‐aided three‐dimensional reconstructive methods in combination with direct anatomic measurement, we dissected and analyzed the shape of the optic canal and its anatomic relationship with the adjoining structures in 40 intact postmortem skull samples. The In‐Space technique clearly showed the structure and the related region of the optic canal. The virtual endoscopy technique showed superbly the spatial appearance and topography of the inner optic canal and also gave the inner structure of the optic canal optically. There was no statistic difference in three‐dimensional reconstructive data with that obtained by anatomical measurements and thus can be used to directly instruct the clinic operation. These results demonstrate that a combined In‐Space technique with virtual endoscopy can accurately define the subtle structure and the related region of the optical canal. In conclusion, multislice helical CT‐based three‐dimensional reconstruction is of important value for clinical operations. Anat Rec, 2008. © 2008 Wiley‐Liss, Inc. 相似文献
30.
A novel human leukocyte antigen (HLA)-DQB1 allele, DQB1*020102, was detected in a 28-year-old woman of Han ethnic in Guangzhou, China. Compared with HLA-DQB1*020101 and HLA-DQB1*0202, they differed in only one nucleotide at the position 167 (C to T) of exon 2, which was a highly conserved position. This is a synonymous mutation, which does not cause any change in the amino acid sequence of mature protein. 相似文献