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71.
72.
用反向点杂交法(RDB)对临床诊断的1例重症β-地中海贫血患儿及其家庭成员进行了基因分析。在该家庭中检出两种中国人罕见的β-地贫突变,基因型分别为:先证者,CD27-28(+c)/CD43(G→T);父,CD43(G→T)/N;母,CD27-28(+c)/N;胞姐,N/N(正常)。这两种突变经PCR-限制酶谱分析法进一步证实;CD27-28(+C)突变为国内首次报道。 相似文献
73.
344 cases of Heart-Qi Deficiency Syndrome (HQDS) including 19 Kinds of disease were observed to explore the rule of differentiation of symptoms and signs for HQDS. The results showed that the common symptoms of HQDS were weakness, shortness of breath, and palpitation, etc. According to with or without complicated cardiovascular diseases, the patients were divided into two groups: group A with cardiovascular diseases, group B without that. In group A, the symptoms and signs of HQDS were the most frequent and early clinical manifestations, the associated symptoms and signs were blood stasis and attack of water-evil, etc. In group B, in whom often associated with nervous and emotional symptoms such as insomnia, dreamfulness, and amnesia, etc., which was due to the disturbance of emotional activities of heart. In order to avoid diagnostic confusion, the authors suggest that the HQDS patients with cardiovascular diseases would be diagnosed as HQDS; on the other hand, the HQDS patients without cardiovascular diseases would be diagnosed as disturbance of emotional activities of heart. 相似文献
74.
Summary From 1987 to 1990 the authors treated 20 cases of spondylolisthesis by an improved operative procedure including excision
of the medial part of the superior articular processes of the slipped vertebra, excision of the soft tissue between the ununited
isthmi, and excision of the ligamentum flavum between the intervertebral space above the slipped segment. In some instances
the lower portion of the lamina over the slipped vertebra should be resected. A U-shaped rod was used to hold sublaminar fixation
of two segments above and below the slipped vertebra, with the slipped vertebra spared. Utilizing the U-shaped rod as support,
bone strips were placed along the lateral and anterior sides of the rod to bridge the gap between the laminae of the displaced
vertebra. Other bone grafts were focused on the facet joints. The patients were allowed ambulation early postoperatively.
19 cases could be evaluated at preliminary follow-up. All showed satisfactory results. 相似文献
75.
Xuyu Zu Ruilan Yan Sarah Robbins Paulette A Krishack Duan-Fang Liao Deliang Cao 《Toxicological sciences》2007,97(2):562-568
Acrolein is a highly reactive alpha,beta-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats to human health if not properly metabolized. In this study, we report aldose reductase-like-1 (ARL-1) as a novel enzyme that catalyzes the reduction of acrolein and protects cells from their toxicity. Using purified ARL-1 protein, we determined its enzymatic activity in response to acrolein and defined its steady-state kinetics with K(m) and V(max) at 0.110 +/- 0.012 mM and 3122.0 +/- 64.7 nmol/mg protein/min, respectively. By introducing a functional Enhanced Green Fluorescent Protein (EGFP)/ARL-1 fusion protein into 293T cells, we demonstrated that plating efficiency in liquid culture and focus formation in soft agar increased by more than 60% (p < 0.05), compared to the vector control cells. More significantly, at a low dose of 5 microM acrolein, EGFP/ARL-1 expression enhanced both plating efficiency and focus formation by more than threefold, and the foci (in soft agar) of 293T cells expressing EGFP/ARL-1 were significantly larger than those of the vector control cells. At high concentrations of acrolein (25 and 50 microM), EGFP/ARL-1 protein prevented oncotic death of 293T cells induced by acrolein. In summary, our data demonstrated for the first time that the ARL-1 protein protects 293T cells from acrolein toxicity. Due to the high toxicity and wide distribution of acrolein, this finding is important to the understanding of its detoxification mechanisms. 相似文献
76.
重视介入性肺减容术的研究 总被引:5,自引:2,他引:3
介入性肺减容术是在外科切除肺减容术和内镜下非外科切除肺减容术的基础上发展起来的。它是一项X线导引下的经导管治疗技术,在靶肺叶经支气管行博来霉素(或无水乙醇)碘油乳剂栓塞的同时并对其近端支气管用骨水泥封堵,可获得稳定的肺纤维化和肺减容,即所谓的功能性肺叶切除。虽然此项介入治疗技术目前仍处于动物实验阶段,但已经显露出其临床应用潜力和广阔的前景。 相似文献
77.
胃癌双对比造影表现与血5‘—核苷酸酶相关性的研究 总被引:1,自引:0,他引:1
目的 初步探讨胃癌影像学表现与 5′-核苷酸酶 (5′- NT)活性的变化关系。方法 经病理证实的 4 1例胃癌 ,均行 X线双对比造影摄片 ,并采用分光光度法测其治疗前血清 5′- NT活性。以 4 0例健康人作对照组。结果 胃癌组 5′- NT活性 (1.14± 0 .16 u/ ml)较正常健康人明显减低 (2 .6 0± 0 .10 u/ m l) (P<0 .0 5 )。解剖部位上 ,从贲门、胃体到胃窦部胃癌 ,其 5′- NT活性分别为 0 .98、1.2 0、1.2 8u/ m l,呈逐渐升高的趋势。溃疡型胃癌 5′- NT活性(0 .96 u/ ml)低于肿块型 (1.12 u/ m l)和浸润型 (1.4 0 u/ ml)。 期胃癌 5′- NT(1.5 3u/ ml)高于 期 (0 .83u/ m l)、 期 (0 .98u/ ml)和 期 (1.0 3u/ m l) (P<0 .0 5 )。结论 胃癌患者血清 5′- NT活性明显较正常人降低 ,其酶活性的变化与胃癌的形态、生长部位及进展程度有一定的相关 相似文献
78.
本文以体外红系祖细胞培养方法。观察白血病细胞相关抑制物对正常红系祖细胞(CFU-E)的抑制作用。10/10例初发未治急性白血病病人的白血病细胞培养液对CFU-E的生长均有抑制,抑制率25.4~67.4%,平均抑制率为44.35%。结果提示,白血病细胞相关抑制物对正常红细胞系造血也有抑制作用。 相似文献
79.
肝动脉化疗栓塞治疗难治性肝癌的若干问题 总被引:7,自引:2,他引:5
肝动脉化疗栓塞(transcatheter hepatic artery chemoembolization,TACE)已成为非手术治疗肝癌的首选方法。但是,遇到有些情况,TACE仍然比较难治。难治性肝癌应该包括:肿块较大;病灶较多;肝功能较差;伴有门静脉癌栓;伴有门脉高压、脾功能亢进;或伴有肝动脉-门静脉分流、肝动脉-肝静脉分流;或伴有糖尿病、高血压、冠心病等情况。这些情况都必须慎重处理,采取相应措施,才能延长患者生命。 相似文献
80.
重症急性胰腺炎并发上下消化道出血的病因和处理 总被引:3,自引:0,他引:3
重症急性胰腺炎(SAP)是临床常见的病死率很高的急腹症。病人主要死于早期的休克、多脏器功能衰竭和全身感染,以及残余感染期的出血和感染相关的并发症。SAP并发致死出血的发生率在1.2%~14.5%,主要表现为消化道、腹腔以及腹膜后出血。SAP病人消化道出血可表现为突发腹痛、腹胀、心动过速和低血压,但有时也表现为慢性间断性出血。SAP并发消化道出血的常见病因包括:应激性溃疡出血、胰源性门静脉高压症出血、胰腺脓肿或假性囊肿穿破消化道引发的出血。 相似文献