THE CORRELATIONS OF CLINICOPATHOLOGIC FEATURES, HORMONE RECEPTOR LEVEL WITH THE PROGNOSIS OF BREAST CANCER：REPORT OF 308 CASES IN ELDERLY WOMEN

1NTRoDUCTIONBreastcancerisamostcommoncancerinwomen.Theincidenceofbreastcancerinelderlywomenisin-creasingwiththeincreasinglong-livedsubjectsofpopu-lation(1).Thepurposeofthisstudyistoexplorethecorrelationshipofclinicopathologicfeatures,hormonere-ceptor(HR)levelwiththeprognosisofbreastcancerinelderlywomen.PATIENTSANDMETHODSFrom1973to1989,atotalof1644womenwithpathologicallyprovenprimarybreastcarcinomaweretreatedwithoperationinourhospital.Forallcasesthefollow-upstatuswereobtained.Ofthe…     

直肠癌癌旁粘膜HIO/AB染色与肿瘤浸润范围的关系

本研究是对手术切除标本的回顾性研究,用HIO/AB粘液组织化学染色方法,观察癌旁粘膜粘液分泌物的性质与肿瘤浸润范围的关系,以期建立一个能够在术前判断肿瘤侵袭能力和浸润范围的参考指标,为临床确     

AGE AND SITES-SPECIFIC PREVALENCE RATES OF PRECANCEROUS GASTRIC LESIONS AT A HIGH-RISK POPULATION OF STOMACH CANCER

A population-based screening for stomach cancer (SC) and its precancerous lesions was conducted in Linqu County, Shandong, China, one of the highest SC rates found in China and the world. An analysis of precancerous stomach lesions revealed that chronic atrophic gastritis (CAG) was a universal common among people aged 35-64 (96-98%). For 52% and 20% of the residents in this age group had Intestinal metaplasia (IM) or dysplssia (DYS). These more advanced lesions were more pronounced in the antrum for both males and females. Age-specific prevalence rates in different anatomic locations sshowed that CAG, developed in the antrum, particularly along the lesser curvature earter than other sites and spread to fundus. IM and DYS accrued under the background of CAG with a leading time in the antrum than the other part of the stomach. Although CAG, IM and DYS prevalence rates were higher in the antrum than In the fundus, the prevalence rates showed a similar smoothly slope, a result of accumulated somatic genetic     

GASTROINTESTINAL STROMAL TUMORS OF THE ANORECTUM——A SPECIAL ENTITY： GISTs OF THE ANORECTUM

Objective： Until recently gastrointestinal stromal tumor （GIST） has been separated from other mesenchymal neoplasms and categorized as a special entity. Morphology of tumor cells and immunohistochemical findings with CD117 are crucial in the pathological diagnosis of GISTs. Newly developed drug imatinib mesylate （formerly called STI571） has been proved effective for GISTs. The distinction of GISTs and other mesenchymal tumors has great clinical significance, especially for lesions located in the anorectum. Methods： The authors searched the database of Peking University, School of Ontology for patients with anorectal neoplasms treated from January 1995 to June 2002. Information of 12 patients with anorectal mesenchymal tumors was collected. The patients were reevaluated and discussed according to current criteria of GISTs with clinical data and immunohistochemical findings. Results： Six patients （including 3 males） were finally diagnosed as anorectal GISTs. The median age of those patients was 59.5 years （27～69）. The symptoms were not specific. Three cases with original diagnosis of leiomyoma or leiomyosarcoma were actually GISTs. A total of six anorectal GISTs was found comprising about 1.06% of patients with anorectal neoplasmas in the same period. Besides CD117, CD34 and vimentin were also expressed in majority of these patients. Five of the six patients underwent surgical resection one of which received neoadjuvant chemotherapy before resection Conclusion： Anorectal GISTs should be considered as a special entity using current diagnostic criteria. Surgical resection remains the primary therapeutic strategy. Neoadjuvant imatinib mesylate may be helpful in sphincter-sparing operations and improvement of the quality of life for these patients.     

支原体感染与肿瘤的发生

一直被视为抗肿瘤单抗的PD4在对其抗原进行纯化、测序后被证实为抗猪鼻支原体抗体。用单抗PD4通过免疫组化检测发现，胃癌、大肠癌有较高的支原体感染等。细胞学实验表明，猪鼻支原体可提高胃癌细胞MGC803在软琼脂上克隆形成能力，单抗PD4则能够抑制这种作用。作者在回顾相关文献的基础上结合自己实验室的上述工作得出结论：支原体感染和肿瘤发生可能存在被人们忽视的某种相关性，需要进一步予以系统研究。     

人胃粘膜上皮细胞系GES－1的建立及其生物学特性

原代培养的胎儿正常胃粘膜上皮细胞用ＳＶ４０病毒感染，３周左右分离出了转化细胞克隆，并建立了可在体外长期稳定传代的细胞系ＧＥＳ－１。对此细胞的生物学特性分析表明：细胞的基因组中整合了ＳＶ４０Ｔ基因，并在细胞核中表达。染色体为近三倍体（５０～６０之间）。除了转化特性之外，ＧＥＳ－１细胞基本保留了正常的细胞骨架结构（微丝、微管、角蛋白），粘蛋白反应阳性。接种在裸鼠中６个月观察无致瘤性。此细胞系将为深入研究胃上皮细胞癌变提供重要的模式系统。     

三苯氧胺对乳腺癌患者宫颈的影响

目的：探讨三苯氧胺（TAM）对乳腺癌患者宫颈细胞形态学的影响。方法：选取233例乳腺癌术后服用TAM患者（TAM组）及106例无TAM服药史的乳腺癌术后患者（对照组），所有患者均行宫颈检查，ThinPrep液基薄层制片，观察其细胞形态学改变。结果：TAM组宫颈上皮细胞异常的发生率为11．6％（27／233），明显高于对照组4．7％（5／106）（P〈0．05）；两组霉菌感染的发生率分别为4．72％和0．9％，差异无统计学意义（P〉0．05）。TAM组绝经前后宫颈上皮细胞异常及霉菌感染的发生率分别为15．4％、8．5％、5．8％和3．9％，均无显著差异。结论：乳腺癌患者服用TAM后宫颈上皮细胞异常的发生率增高，与绝经状态无关。对乳腺癌术后服用三苯氧胺患者应进行规律的宫颈涂片检查。     

针刺髓核构建退行性变椎间盘模型

背景：目前对椎间盘退行性变尚无有效治疗方法，实验性椎间盘退行性变模型的建立，是研究椎间盘退行性变病理过程和尝试基因治疗等的基础，建立的动物模型要求与人类的椎间盘退行性变具有相似性和可比拟性。目的：拟建立一种稳定、重复性强的椎间盘退行性变动物模型。设计、时间及地点：随机对照动物实验，于2005—10／2006-03在哈尔滨医科大学附属第一临床医院中心实验室完成。材料：选用健康成年新西兰大白兔30只，按随机数字表法分为2组，手术组15只，对照组15只。方法：手术组以18#腰穿针针刺L1～5节段椎间盘，至少穿刺5次，直至胶冻样髓核组织出现为止：对照组做同样皮肤切口，拨开肌肉，暴露椎间盘后即缝合。主要观察指标：手术8周以后通过MRI和组织病理学检查观察腰椎间盘退行性变情况。结果：①对照组腰椎MRI检查未见异常；手术组L1～2腰椎间盘则相继出现T2加权像低信号、T1加权像信号无明显改变等变化。②组织学切片显示，手术组椎间盘髓核纤维软骨样变性。结论：针刺髓核的方法可以成功构建椎间盘退行性变新西兰大白兔模型。     

直肠癌的病理特点与临床关系(附50例分析)

本文将我所50例直肠癌外检病例,结合临床资料,重点探讨其肉眼类型、组织学类型、肿瘤向旁侧浸润深度,纵轴下断端浸润距离以及浸润方式淋巴结转移等,以便提供给临床外科医师进行直肠癌低位切除