细胞黏附分子与白癜风

白癜风是一种色素脱失性疾病，临床上表现为以皮肤黑素细胞破坏缺失而出现色素脱失斑为特征。导致白癜风黑素细胞破坏的分子机制目前尚未阐明。近年来有关细胞黏附分子在白癜风发病中的作用研究日益增多。研究细胞黏附分子与白癜风发病的相互关系，可以对白癜风的发病机制进行更深入的探讨。     

中西医结合治疗慢性肺心病心功能不全临床观察

笔者采用中西医结合治疗慢性肺源性心脏病合并心功能不全33例，并与单纯西药治疗的28例进行疗效对比，现报道如下。     

头体针与腹针交替应用治疗中风后上肢功能障碍疗效

目的:观察头体针、腹针交替应用对中风后上肢功能障碍的临床疗效。方法:222例中风后上肢功能障碍患者按入院先后随机分为治疗组(133例)与对照组(89例),治疗组使用头针、体针与腹针交替治疗,对照组使用体针治疗,治疗5周后观察疗效,并比较治疗结束后1、3个月后疗效。对治疗前后Fugl-Meyer运动功能评分、Barthel指数评定进行观察。结果:Fugl-Meyer运动功能评分、Barthel指数评定结果显示:治疗组治疗5周,治疗后1、3个月后与治疗前比较,积分明显升高而且差异有统计学意义(P<0.01);与对照组比较,治疗组积分升高,差异有统计学意义(P<0.01)。对照组治疗5周后与治疗前比较差异无统计学意义(P>0.05),治疗后1、3个月与治疗前比较差异有统计学意义(P<0.01)。结论:头针、体针、腹针交替应用治疗中风后上肢功能障碍疗效优于单纯体针治疗。     

胃癌组织中S100P表达的临床意义及其机制探讨

Objective To investigate the impact of the expression of S100P on the prognosis and tumor chemosensitivity in patients with resectable gastric cancer and its mechnisms. Methods The expression of S100P was analyzed in 121 resected primary gastric cancer tissues by using tissue array of immunohistochemistry excised from January 2003 to December 2007. The patients received adjuvant chemotherapy with oxaliplatin. The pEGFP-SlOOP plasmid was constructed and was transfected into BGC823 cell line to establish gastric cancer cell line with over-expression of human S100P, BGC823-S100P. The expression level of S100P was determined by real-time PCR and Western blot assay. The chemosensitivity of BGC823-S10OP cell line to oxaliplatin was detected by 3-( 4, 5-Dimethylthiazol-2-yl )-2, 5-diphenyltetrazolium (MTT) assay. Results The S100P was positively expressed in 64 tumors(52. 9% , 64/ 121). Although there was no significant relation between the expression of S100P and tumor T staging( P = 0. 683), N staging( P = 0. 472), M staging (P = 0. 770 ) and differentiation (P = 0. 553), Wilcoxon test showed that the 5-year cumulative survival rate of patients with positive S100P expression was significantly higher than that of patients with negative expression (20.3% vs. 3.5%, P =0.034). Furthermore, overexpressed of S100P was found in the BGC823 cell line, BGC823-S100P. The mRNA and protein level of S1O0P in pEGFP transfected BGC823-S100P cell lines were significantly higher than those in control group (8.42±1.38 ra. 0.83±0.11 and 3. 52±0.48 vs. 0. 97±0. 19,all P <0. 05). It indicated with MTT assay that the half-inhibitory concentration(IC50) to oxaliplatin decreased in BGC823-S1OOP cells, and was significantly lower than that in vector-only transfected cells[ ( 142±16) mg/L vs. (266± 11 ) mg/L,P = 0. 032]. Conclusions S100P may also be a potentially novel independent prognostic factor in gastric cancer patients following curative resection. And it could improve the cumulative survival of the patients through enhancing the chemosensitivity of tumor cell line to oxaliplatin.     

丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮疗效观察

目的观察丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮的疗效。方法76例患者随机分为应用丹参酮胶囊联合维胺酯维E乳膏治疗（治疗组）40例和应用罗红霉素胶囊治疗（对照组）36例，并进行疗效观察，两组均14天为一个疗程。结果治疗组治疗2周后总有效率为90.0％，对照组为72.3％，两组比较差异有显著性（X^2=5.76，P〈0.05）。结论丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮有较好的疗效。     

软组织病小铍针疗法临床应用举要

近年来，笔者采用小铍针治疗部分软组织劳损性疾病，取得了良好疗效。该疗法将针刺、手术和局部封闭有机地结合起来，取长补短，有效地解决了部分软组织病的治疗难题，现报道如下。     

人参三醇皂甙促进人白细胞介素6转译的生物学效应

将PHA激活淋巴结细胞作为研究对象,观察了人参三醇皂甙(PTGS)对人白细胞介素6(IL-6)分泌的促进效应。应用同位素示踪技术观察细胞RNA合成和蛋白质合成与IL-6分泌的关系,结合IL-6mRNA体外转译体系,探讨了PTGS促IL-6诱生的机理。结果表明PTGS对IL-6基因的转录环节无明显作用,但对IL-6基因的转译环节具明显促进效应。     

胃囊肿与溃疡并存一例报告

患者,男,47岁。中上腹无规律疼痛2年余,加重1周,伴恶心、嗳气、反酸。临床检查:心肺正常,中上腹部压痛明显,无反跳痛,未扪及肿块。实验室检查无特殊。X线钡餐检查:胃内有少量空腹潴留液,胃体小弯侧见约0.8×1 cm的突出     

~(32)P治疗4247例皮肤血管瘤临床分析

皮肤血管瘤分草莓状、海绵状和混合性血管瘤,发生于皮肤血管及其附属结构组织的良性肿瘤,是一种主要表现为病损区血管的数量、结构及功能显著异常性疾病.我们用32P治疗皮肤血管瘤共4 247例,疗效明显,现报告如下.