全文获取类型
收费全文 | 3336篇 |
免费 | 173篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 241篇 |
妇产科学 | 213篇 |
基础医学 | 271篇 |
口腔科学 | 99篇 |
临床医学 | 281篇 |
内科学 | 829篇 |
皮肤病学 | 78篇 |
神经病学 | 252篇 |
特种医学 | 136篇 |
外科学 | 537篇 |
综合类 | 41篇 |
一般理论 | 1篇 |
预防医学 | 98篇 |
眼科学 | 88篇 |
药学 | 127篇 |
中国医学 | 5篇 |
肿瘤学 | 163篇 |
出版年
2024年 | 2篇 |
2023年 | 37篇 |
2022年 | 35篇 |
2021年 | 105篇 |
2020年 | 76篇 |
2019年 | 89篇 |
2018年 | 107篇 |
2017年 | 91篇 |
2016年 | 138篇 |
2015年 | 142篇 |
2014年 | 176篇 |
2013年 | 187篇 |
2012年 | 246篇 |
2011年 | 193篇 |
2010年 | 150篇 |
2009年 | 133篇 |
2008年 | 210篇 |
2007年 | 265篇 |
2006年 | 241篇 |
2005年 | 227篇 |
2004年 | 184篇 |
2003年 | 143篇 |
2002年 | 132篇 |
2001年 | 62篇 |
2000年 | 44篇 |
1999年 | 41篇 |
1998年 | 10篇 |
1997年 | 10篇 |
1996年 | 14篇 |
1995年 | 10篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有3533条查询结果,搜索用时 22 毫秒
51.
Factor V Leiden mutation and other thrombophilia markers in childhood ischemic stroke. 总被引:4,自引:0,他引:4
Ridvan Duran Betül Biner Muzaffer Demir Co?kun Celtik Serap Karasaliho?lu 《Clinical and applied thrombosis/hemostasis》2005,11(1):83-88
The aim of this study was to evaluate the association between ischemic childhood stroke and thrombophilia. The prevalence of thrombophilia risk factors in 30 unrelated children with ischemic stroke were compared with 33 age-matched control subjects. Patients and control group were tested for the presence of activated protein C (APC) resistance, antiphospholipid antibodies (APLA), increased factor VIII levels, and for the deficiency of protein C (PC), protein S (PS), and antithrombin. When APCR was detected in patients or in controls, factor V Leiden (FVL) mutation was also tested. Seventeen of 30 patients (56.6%) had at least one thrombophilia marker compared with only 5 of 33 control subjects (15.1%). Three children with ischemic stroke (10%) were affected with a combination of two or more thrombophilia markers whereas none of the children in the control group had a combination of risk factors. Seven of 30 children with ischemic stroke (23.3%) and one of 33 control subjects (3.03%) had APC resistance and in all of them FVL mutation were found. The prevalence of FVL mutation was higher among pediatric stroke patients than among control subjects (p < 0.05). None of the patients but one child from the control group (3.03%) had PS deficiency. Antithrombin and PC deficiencies and the presence of APLA and increased factor VIII levels were more frequent in the pediatric stroke patients than in controls but the difference was not statistically significant (p > 0.05). These data confirm that stroke in children is commonly associated with a combination of multiple risk factors and especially the prevalence of FVL mutation is increased in children with ischemic stroke compared with control subjects. 相似文献
52.
Accumulation and toxicity of CuO and ZnO nanoparticles through waterborne and dietary exposure of goldfish (Carassius auratus) 下载免费PDF全文
Mehmet Ates Zikri Arslan Veysel Demir James Daniels Ibrahim O. Farah 《Environmental toxicology》2015,30(1):119-128
Dietary and waterborne exposure to copper oxide (CuO) and zinc oxide (ZnO) nanoparticles (NPs) was conducted using a simplified model of an aquatic food chain consisting of zooplankton (Artemia salina) and goldfish (Carassius auratus) to determine bioaccumulation, toxic effects, and particle transport through trophic levels. Artemia contaminated with NPs were used as food in dietary exposure. Fish were exposed to suspensions of the NPs in waterborne exposure. ICP‐MS analysis showed that accumulation primarily occurred in the intestine, followed by the gills and liver. Dietary uptake was lower, but was found to be a potential pathway for transport of NPs to higher organisms. Waterborne exposure resulted in about a 10‐fold higher accumulation in the intestine. The heart, brain, and muscle tissue had no significant Cu or Zn. However, concentrations in muscle increased with NP concentration, which was ascribed to bioaccumulation of Cu and Zn released from NPs. Free Cu concentration in the medium was always higher than that of Zn, indicating CuO NPs dissolved more readily. ZnO NPs were relatively benign, even in waterborne exposure (p ≥ 0.05). In contrast, CuO NPs were toxic. Malondialdehyde levels in the liver and gills increased substantially (p < 0.05). Despite lower Cu accumulation, the liver exhibited significant oxidative stress, which could be from chronic exposure to Cu ions. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 119–128, 2015. 相似文献
53.
Ali Emre Senol Carilli Hovsep Hazar Umit Ince Semra Calangu 《Journal of hepato-biliary-pancreatic sciences》1997,4(3):337-339
A 35-year-old woman was admitted for weight loss, fatigue, and epigastric and back pain. She had undergone uterine myomectomy 6 weeks previously, and light microscopic examination revealed actinomycosis. Radiologic examination showed 5×4×4 cm and 2×2×2 cm solid lesions in the left liver lobe. Ultrasound-guided fine-needle aspiration biopsy could not exclude the possibility of malignancy. We decided to perform an explorative laparotomy. Frozen sections indicatedEchinococcus alveolaris infection or granulomatous inflammatory disease, and left hepatic lobectomy was performed. Histologic examination revealed hepatic actinomycosis. After 6 months' penicillin treatment, there was no sign of recurrence. This case of hepatic actinomycosis following uterine infection without gross involvement of any other abdominal organ raises questions on the dissemination pathway. The other interesting feature of this case is the short interval from the presumed initiatory event to the presence of the hepatic deposits. 相似文献
54.
Pamuk GE Turgut B Vural O Demir M Tek M Altaner S 《Clinical and laboratory haematology》2003,25(5):329-331
Hydroxyurea is a ribonucleotide diphosphate reductase inhibitor used in the treatment of patients with myeloproliferative disorders. Hydroxyurea has some dermatological side-effects. It has recently been recognized that hydroxyurea can induce squamous cell and basal cell carcinomas of skin. We present the case of an elderly man with chronic myeloid leukaemia who was treated with hydroxyurea for 4 years, with good control of his disease. However, in addition to the appearance of various skin lesions and cutaneous squamous cell carcinoma after 3 years of therapy, he was found to have a metastatic squamous cell carcinoma after 4 years. Hydroxyurea was discontinued, and he underwent surgery and radiotherapy. The patient subsequently died of ventricular fibrillation. We present this case to draw attention to the association between hydroxyurea and secondary skin cancers and to emphasize the need for dermatological examination before and during the course of hydroxyurea therapy. 相似文献
55.
Nedim Durmus Sefa Gültürk Tijen Kaya Tuncer Demir Mesut Parlak Ahmet Altun 《Indian journal of pharmacology》2015,47(1):34-38
Objectives:It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model.Results:Beta and delta recording ratios in 1 μM/5 μl mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 μM/5 μl w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups.Conclusions:We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects.KEY WORDS: Epilepsy, mibefradil, T and N type calcium channels, Wistar Albino Glaxo/Rij rats, w-Conotoxin MVIIA 相似文献
56.
Demir Arzu Meltem Aydin Fatma Acar Banu Kurt Tuba Poyraz Aylar Kiremitci Saba Gülleroglu Basak Azili Müjdem Nur Bayrakci Umut Selda 《Clinical rheumatology》2021,40(9):3817-3825
Clinical Rheumatology - Autoimmune pancreatitis (AIP) type 1 is an IgG4-related disease (IgG4-RD), characterized by inflammatory pseudotumors and histologically by dense lymphoplasmacytic... 相似文献
57.
Cebi Alper Han Demir Ferhat Ikbal Mevlit Kalyoncu Mukaddes 《Clinical rheumatology》2021,40(5):1975-1981
Clinical Rheumatology - Immunoglobulin A vasculitis (IgAV) is the most common form of childhood systemic vasculitis. It is mostly self-limiting and characterized by skin, joint, gastrointestinal... 相似文献
58.
Clinical Rheumatology - To compare the effectiveness of cyclophosphamide and rituximab in the treatment of patients with systemic sclerosis with pulmonary involvement (SSc-ILD). Symptoms and the... 相似文献
59.
Sahin Serdar Gundogdu Aycan Nalbantoglu Ufuk Kadioglu Pinar Karaca Zuleyha Hacioglu Aysa Urhan Muhammed Emre Unluhizarci Kursad Demir Ahmet Numan Hora Mehmet Durcan Emre Elbüken Gülsah Dokmetas Hatice Sebile Zuhur Sayid Shafi Kelestimur Fahrettin 《Pituitary》2022,25(3):520-530
Pituitary - Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal... 相似文献
60.