共查询到20条相似文献,搜索用时 46 毫秒
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目的探讨基于乳腺动态增强MRI(DCE-MRI)纵向变化的delta影像组学在预测乳腺癌新辅助治疗(NAT)后病理完全缓解(pCR)的价值。方法回顾性分析2019年4月至2021年11月江西省肿瘤医院经手术病理证实为原发性浸润性乳腺癌患者117例的临床及影像资料。患者均为女性, 年龄23~74(48±10)岁, 按照软件中的随机种子数以7∶3比例分成训练集(81例)与测试集(36例)。所有患者均在NAT前、NAT早期(2个疗程)后接受乳腺DCE-MRI, 计算肿瘤NAT前、后最大径相对退缩值(D%), 并构建传统影像模型。基于NAT前、早期DCE-MRI提取delta影像组学特征, 通过冗余性分析、最小绝对收缩与选择算子算法筛选最优特征参数, 以10折交叉验证法构建delta影像组学模型并计算影像组学分数(Radscore)。根据NAT后手术病理结果将117例患者分为pCR组与非pCR(non-pCR)组, 单因素分析两组差异有统计学意义的临床病理指标并通过逐步回归法筛选最终的指标, 并联合D%、Radscore构建联合模型及列线图。采用受试者操作特征曲线及曲线下面积(AUC)评价模型... 相似文献
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【摘要】2021年RSNA大会中关于乳腺影像学方面的研究热点和重点主要包括以下几个方面:①乳腺X线摄影如何提高乳腺癌的检出率及降低召回率,测量乳腺腺体密度并评估乳腺癌患病风险;②超声在乳腺癌诊断、腋窝淋巴结评价方面的应用,引用人工智能辅助系统可提高诊断性能,采用冷冻消融新技术治疗低级别乳腺癌;③探讨简化乳腺MRI序列早期筛查乳腺癌的可行性,乳腺多参数MRI、影像组学及深度学习系统在乳腺癌非肿块病变的诊断、乳腺腺体分类、预测预后和新辅助化疗应答方面的应用。 相似文献
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《中国中西医结合影像学杂志》2015,(3)
随着乳腺癌发病率的逐年上升,乳腺癌的早期筛查及诊断已得到人们的广泛关注。目前,乳腺疾病的常用影像学诊断方法主要有钼靶X线、超声、MRI,通过分析乳腺癌的各种影像诊断方法的表现,兼顾乳腺癌的病因及病理分型,已基本解决乳腺癌的诊断问题,使影像学诊断成为必不可少的、最可靠的乳腺疾病常规检查手段。 相似文献
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目的:探讨基于临床、病理及MRI特征构建的列线图在预测乳腺癌新辅助治疗(NAT)后残余小病灶病理完全缓解(pCR)中的价值。方法:回顾性收集我院2018年1月至2022年5月接受NAT并手术的首诊女性乳腺癌患者,其中2018年1月至2021年5月就诊的患者为建模组,2021年6月至2022年5月为外部验证组。收集患者的临床病理及NAT前、后MRI影像资料,通过logistic回归分析确定残余小病灶pCR的独立预后因素并构建列线图。通过受试者工作特征(ROC)曲线及校准图评估列线图的诊断效能。结果:HER2阳性,Ki-67高表达和较低的早期信号强化率是乳腺癌NAT后残余小病灶pCR的独立预后因素,所构建的列线图在验证组中表现出较高的诊断效能(ROC曲线下面积=0.95,95%CI 0.85~0.99)和校准能力(C指数=0.93,95%CI 0.88~0.98)。结论:基于临床、病理及MRI特征构建的列线图在预测乳腺癌NAT后残余小病灶pCR上显示出较好的预测能力,为临床诊疗提供依据。 相似文献
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<正>乳腺癌已成为全球第一大癌[1],新辅助治疗(NAT)作为乳腺癌综合治疗的一种重要手段,主要包括新辅助化疗、新辅助靶向治疗及新辅助内分泌治疗[2]。《中国乳腺癌新辅助治疗专家共识》(2022版)更新推荐采用超声(US)、乳腺X线、乳腺MRI、胸部CT等影像学检测手段对原发灶、 区域淋巴结、常见转移部位(肝、肺)等进行基线和NAT后的疗效评估[3]。本文着重介绍乳腺癌NAT中评估原发灶及区域淋巴结常用的检查方法:乳腺X线摄影、US及MRI。 相似文献
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Castell L 《Sports medicine (Auckland, N.Z.)》2003,33(5):323-345
In situations of stress, such as clinical trauma, starvation or prolonged, strenuous exercise, the concentration of glutamine in the blood is decreased, often substantially. In endurance athletes this decrease occurs concomitantly with relatively transient immunodepression. Glutamine is used as a fuel by some cells of the immune system. Provision of glutamine or a glutamine precursor, such as branched chain amino acids, has been seen to have a beneficial effect on gut function, on morbidity and mortality, and on some aspects of immune cell function in clinical studies. It has also been seen to decrease the self-reported incidence of illness in endurance athletes. So far, there is no firm evidence as to precisely which aspect of the immune system is affected by glutamine feeding during the transient immunodepression that occurs after prolonged, strenuous exercise. However, there is increasing evidence that neutrophils may be implicated. Other aspects of glutamine and glutamine supplementation are also addressed. 相似文献
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K H Taber P J Migliore J J Pagani J J Ford T McLauren L A Hayman 《Investigative radiology》1990,25(3):240-244
The rates at which the paramagnetic compounds deoxyhemoglobin (Hb) and methemoglobin (MHb) form in vivo within an area of hemorrhage are unknown. The present experiment establishes the baseline concentrations and rates of change in paramagnetic hemoglobin concentrations, as well as the pH in normal heparinized and clotted human blood maintained in vitro at 37 degrees C under anaerobic conditions over 30 hours. There was a moderate increase in Hb concentration in normal heparinized blood (average increase was 15.5%, rate = 0.50%/hour) and a slight increase in MHb concentration in the heparinized blood and clots (average increase was 1.4%, rate = 0.044%/hour). A second experiment was done to verify the activity of the RBC systems responsible for maintaining the hemoglobin molecule in the reduced state. Conversion of MHb to Hb in these samples proceeded at a rate of 5.6%/hour. In a third experiment, blood from 11 normal subjects maintained at 4 degrees C 25 degrees C was analyzed for MHb concentration over the course of 28 days. The level of MHb formation remained in the range of normal for at least 11 days in all subjects. The authors conclude that at basal conditions created in vitro, the blood levels of both Hb and MHb remain at relatively low levels. Therefore, if the accumulation of Hb and/or MHb occurs in acute in vivo hematomas it must be driven by intrinsic tissue factors. 相似文献
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M Radojkovi? S Ili? 《Vojnosanitetski pregled. Military-medical and pharmaceutical review》1992,49(5):493-497
The pathohistologic analysis of testis sections of 37 postpuberty patients with different types of cryptorchism is performed. The tissue samples were taken during orchiopehy, fixed in Bouin's solution and treated by the standard histologic techniques. The morphologic criteria are presented for identification of the presence of the so called carcinoma in situ cells found in two cases. Besides, in 13 patients rare, mainly single, atypical germinative cells were found in a smaller number of the seminiferous tubules. It has been concluded that the presence of carcinoma in situ cells in undescended testes of some patients and considering the simple way of sampling, lack of complications and high reliability of the diagnostic procedure, it is absolutely justified to take routine biopsy of testes during orchiopexy in each postpuberty and perhaps prepuberty patient. 相似文献
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新时期军医学院人才培养的思考 总被引:1,自引:0,他引:1
在新的历史条件下 ,军医学院迎接未来高技术局部战争的挑战 ,适应部队武器装备的不断更新以及医学科技、社会发展对人才素质提出的新要求 ,必须在更为广阔的时空背景下找准人才培养的着眼点 ,科学确立人才培养方向 ,提高人才培养质量。现就人才培养思考如下 :1 改变教育观念 , 相似文献
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P Gavarry 《Schweizerische Zeitschrift für Sportmedizin》1989,37(2):77-9; discussion 99-102
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成批煤气爆燃烧伤的救治体会 总被引:1,自引:0,他引:1
张骏 《中国烧伤创疡杂志》1998,(3):17-18
报道治疗因煤气泄漏爆炸烧伤病员7例,经应用MEBT技术积极救治,其中6例于伤后17天痊愈出院,另一例特重伤员也于伤后30天康复出院。作者认为:应严格按照MEBT/MEBO要求进行规范治疗,正确处理生命体征、休克、感染、脏器功能和创面的辨证关系。同时,不能忽视外科营养在过程中的重要作用,它是创面修复的物质保证。 相似文献
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我国医用辐射防护研究概况 总被引:8,自引:0,他引:8
张景源 《中华放射医学与防护杂志》1998,18(5):305-309
医学放射学技术的迅速发展及介入放射学在临床广泛应用,使更多的人受到电离辐射的照射,同时也促进了医疗照射防护工作的发展。文中重点综述了我国医用辐射防护工作者近年来在X射线CT的医疗照射防护、对介入放射学工作者的剂量监测以及应用医疗照射防护体系,降低医疗照射剂量等方面所作出的成绩和研究进展 相似文献