经皮经肝胆囊引流：重症胆囊炎患者通往腹腔镜胆囊切除之桥

目的:探讨重症胆囊炎患者行经皮经肝穿刺胆囊引流及二期腹腔镜胆囊切除的可行性和安全性?方法:重症胆囊炎患者包括入院时胆囊三角炎症极重而难以一期切除胆囊者以及因全身情况差而难以耐受胆囊切除的胆囊炎患者?2007~2011年对这两类共18例患者行经皮经肝穿刺胆囊置管引流术及二期气腹或免气腹腹腔镜胆囊切除术?结果:全组患者成功行经皮经肝胆囊引流术,无明显腹腔出血?胆瘘等并发症;除1例患者引流后失访,其余17例患者均成功行腹腔镜胆囊切除术?结论:对难以一期切除胆囊的重症胆囊炎患者,经皮经肝胆囊引流能在有效缓解急性期症状的基础上有利于二期微创切除胆囊,减少了手术创伤并规避了胆囊炎急性期强行切除胆囊的风险?     

经皮经肝胆囊穿刺置管引流治疗合并肝硬化的急性胆囊炎

目的 探讨经皮经肝胆囊穿刺置管引流治疗对合并肝硬化门静脉高压症的急性胆囊炎患者的安全性及疗效。方法 回顾性分析于2013年9月到2014年12月进行经皮经肝胆囊穿刺置管引流术治疗的合并肝硬化高压症急性胆囊炎患者12例。其中,肝功能Child-pugh A级7例,Child-pugh B级5例,分析12例患者经皮经肝穿刺胆囊置管引流术后并发症发生情况、术后炎症消退情况、术前后肝功能变化情况。结果 12例患者均通过皮经肝胆囊穿刺置管引流术治疗后胆囊炎症消退,并择期成功行腹腔镜下胆囊切除术。其中,有2例患者因穿刺出现腹腔内出血,后经保守治疗后出血停止。无胆瘘发生。术后部分患者肝功能有所改善。结论 经皮经肝穿刺胆囊置管引流治疗对合并肝硬化的急性胆囊炎是一种安全的治疗方法 ,可作为后续安全地施行腹腔镜下胆囊切除术的过渡。     

经皮经肝胆囊穿刺引流联合延期腹腔镜胆囊切除术治疗老年急性胆囊炎疗效观察

目的探讨经皮经肝胆囊穿刺引流联合延期腹腔镜胆囊切除术治疗老年急性胆囊炎(AC)的临床效果。方法选取南阳市第一人民医院49例老年急性胆囊炎患者,随机分组,对照组24例,观察组25例,对照组予以腹腔镜胆囊切除术治疗,观察组予以经皮经肝胆囊穿刺引流联合延期腹腔镜胆囊切除术治疗,观察比较两组术中出血量、住院时间、凝血功能恢复时间及并发症发生情况。结果观察组凝血功能恢复时间、住院时间及术中出血量均优于对照组(P<0.05);两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论对老年急性胆囊炎患者给予经皮经肝胆囊穿刺引流联合延期腹腔镜胆囊切除术治疗,疗效显著,安全性高。     

经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除治疗急性危重胆囊炎的临床研究

目的:探究经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术在治疗急性危重胆囊炎中的临床效果。方法:回顾分析我院肝胆科2013年1月至2014年12月期间60例急性危重胆囊炎患者行经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术的临床资料。结果:60例患者均成功接受经皮肝胆囊穿刺引流,患者在穿刺后2-4h腹部疼痛明显缓解,术后2-3d体温降至正常。所有患者在术后1个月行二期腹腔镜胆囊切除术,无一例出现胆汁漏及胆管损伤的等严重并发症。结论:急性危重胆囊患者经皮肝胆囊穿刺引流后可以缓解临床症状,术后1个月给予腹腔镜胆囊切除安全系数较高,可行性好,中转开腹率较低,值得临床治疗借鉴使用。     

经皮经肝胆囊穿刺引流术在老年急性结石性胆囊炎中的应用

目的研究经皮经肝胆囊穿刺引流术在治疗老年急性结石性胆囊炎中的应用效果。方法选取急性结石性胆囊炎老年患者72例,将其按双盲随机方法平均分为观察组与对照组（n=36）。对照组患者行胆囊造瘘术;观察组患者首先行经皮经肝胆囊穿刺引流术,择期再行胆囊造瘘或胆囊切除术,对比2组患者治疗效果。结果观察组患者治疗成功率为97.2%,对照组患者治疗成功率为86.1%,2组对比差异具有统计学意义（P〈0.05）。观察组患者术后并发症发生率为27.8%,对照组患者术后并发症发生率为5.6%,观察组显著低于对照组（P〈0.05）,差异具有统计学意义。结论经皮经肝胆囊穿刺引流术治疗老年急性结石性胆囊炎,能够快速缓解症状,有效控制感染,避免了急症情况下行胆囊造瘘或胆囊切除手术风险,是一种安全、有效的治疗方法,值得临床推广与应用。     

经皮经肝胆囊穿刺引流术序贯腹腔镜胆囊切除术治疗老年急性重症胆囊炎

目的 探讨经皮经肝胆囊穿刺引流(PTGD)序贯腹腔镜胆囊切除术(LC)在老年重症胆囊炎治疗中的应用和体会。方法 回顾性分析60例老年重症胆囊炎行PTGD序贯LC治疗的临床资料。结果 60例先行经皮胆囊穿刺置管并带管出院,4~5周后胆囊炎症消退后行腹腔镜胆囊切除术,术中证实为结石性胆囊炎,手术均顺利完成,术后恢复良好,无严重手术并发症。结论 PTGD序贯LC治疗老年重症胆囊炎风险较低,安全可行。     

经皮经肝胆囊穿刺序贯腔镜胆囊切除治疗老年急性重症胆囊炎效果比较

目的分析经皮经肝胆囊穿刺序贯腔镜胆囊切除与单纯腹腔镜胆囊切除治疗老年急性重症胆囊炎的效果。方法选择53例患者,随机分为2组,观察组27例实施经皮经肝胆囊穿刺序贯腔镜胆囊切除,对照组26例则实施急诊腹腔镜胆囊切除,比较2组患者术中治疗情况、临床症状改善时间以及治疗期间所发生的并发症。结果观察组入院至接受手术治疗时间和手术时间均短于对照组(P0.05),术中出血少于对照组(P0.05),总住院时间短于对照组(P0.05),凝血功能恢复、白细胞恢复、体温恢复以及休克纠正快于对照组(P0.05),观察组发生胆漏和术后多器官功能衰竭的比率低于对照组(P0.05)。结论经皮经肝胆囊穿刺序贯腔镜胆囊切除能第一时间解除胆囊炎症、胆管梗阻,对患者影响小,为Ⅱ期实施腹腔镜下胆囊切除术提供条件。     

中心静脉导管经皮经肝胆囊穿刺引流治疗老年急性胆囊炎

①目的 观察应用中心静脉导管经皮经肝胆囊穿刺置管引流治疗老年急性胆囊炎的临床疗效.②方法 76例急性胆囊炎患者在B超引导下于右侧第6、7肋间或右肋缘下经皮经肝穿刺胆囊后,在导丝引导下置入中心静脉导管行胆囊外引流,观察其临床表现.③结果 76例患者穿刺置管均成功,经引流1～5天后症状完全消失,无1例发生出血、胆漏等并发症.④结论 对老年急性胆囊炎患者,应用中心静脉导管超声引导经皮经肝胆囊穿刺置管引流是一种简单、安全、可靠、有效的治疗方法.     

经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术治疗老年急性胆囊炎效果分析

目的分析经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术治疗老年急性胆囊炎(AC)的临床效果。方法抽取2014年10月至2016年3月宜阳县中医院收治的74例老年急性胆囊炎患者,随机数表法分为两组,各37例。研究组采用经皮经肝胆囊穿刺引流联合腹腔镜胆囊切除术,对照组仅实施腹腔镜胆囊切除术。对比两组围术期相关指标水平,并统计并发症发生率。结果研究组腹腔引流时间、开始进食时间、肛门排气时间、下床活动时间及住院时间均较对照组短,差异有统计学意义(P<0.05);研究组并发症发生率(10.81%)与对照组(8.10%)对比,差异无统计学意义(P>0.05)。结论联合采用经皮经肝胆囊穿刺引流术及腹腔镜胆囊切除术治疗老年急性胆囊炎效果显著,可减少术后机体功能康复用时,且安全性较高,具有推广价值。     

经皮经肝胆囊穿刺造瘘术在老年重症结石性胆囊炎患者治疗中的效果

目的研究经皮经肝胆囊穿刺造瘘术在老年重症结石性胆囊炎患者治疗中的效果。方法选取我院2014年6月至2015年12月收治的老年重症结石性胆囊炎患者86例为研究对象,将其随机分为观察与对照两组,对照组患者急诊行腹腔镜下胆囊切除术治疗,观察组采用经皮经肝胆囊穿刺造瘘术联合腹腔镜下胆囊切除术治疗,对比分析两组治疗效果。结果观察组患者凝血功能恢复时间、白细胞恢复时间、体温恢复时间、休克纠正时间、手术时间与住院时间显著短于对照组,术中出血量显著少于对照组(P0.05)。结论经皮经肝胆囊穿刺造瘘术在老年重症结石性胆囊炎患者治疗中的效果显著,在临床上值得广泛推广。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…