慢性牙周炎患者血清及龈沟液中炎性细胞因子的变化观察

目的观察牙周炎患者血清及龈沟液中多项炎性细胞因子水平的变化。方法选择慢性牙周炎患者50例作为牙周炎组,纳入同时期口腔健康志愿者50例作为健康对照组。牙周炎组患者进行超声龈上洁治、龈下刮治和根面平整等牙周基础治疗。比较2组患者牙周状态相关指标,包括牙周探诊深度(PD)、龈沟出血指数(SBI)、临床附着水平(CAL),以及血清和龈沟液中炎性因子TNF-α、IL-1β、IL-5、IL-6、IL-8水平差异。结果基线时牙周炎组牙周状态相关指标PD、CAL.、SBI均显著高于健康对照组(P<0.05)。牙周炎组患者治疗后1、3个月PD、CAL.、SBI与基线水平比较均显著下降(P<0.05)。基线时牙周炎组患者血清及龈沟液中炎性细胞因子TNF-α、IL-1β、IL-5、IL-6、IL-8均显著高于健康对照组(P<0.05)。治疗后1、3个月,牙周炎组患者血清及龈沟液中炎性细胞因子TNF-α、IL1β、IL-5、IL-6、IL-8与基线比较均显著降低(P<0.05)。结论牙周炎患者血清及龈沟液中炎性细胞因子明显升高,通过牙周基础治疗能有效下调炎性细胞因子水平,改善其牙周状态。     

牙周炎患者血清及龈沟液中多项炎性细胞因子的变化观察

目的:观察牙周炎患者血清及龈沟液中多项炎性细胞因子水平的变化。方法:选择慢性牙周炎患者50例作为牙周炎组,纳入同时期口腔健康志愿者50例作为对照组。牙周炎组患者进行超声龈上洁治、龈下刮治和根面平整等牙周基础治疗。比较基线时两组患者间和牙周炎组治疗前后牙周状态相关指标(牙周探诊深度(probing depth,PD)、龈沟出血指数(sulcus bleeding index,SBI)、临床附着水平(clinical attachment level,CAL)、血清和龈沟液中炎症因子TNF-α、IL-1β、IL-5、IL-6、IL-8水平差异。结果:基线时牙周炎组牙周状态相关指标PD、CAL、SBI均显著高于对照组(P<0.05)。牙周炎组患者治疗后1、3个月PD、CAL、SBI与基线相比均显著下降(P<0.05)。基线时牙周炎组患者血清及龈沟液中炎症细胞因子TNF-α、IL-1β、IL-5、IL-6、IL-8均显著高于对照组(P<0.05)。治疗后1、3个月,牙周炎组患者血清及龈沟液中炎症细胞因子TNF-α、IL-1β、IL-5、IL-6、IL-8与基线相比均显著降低(P<0.05)。结论:牙周炎患者血清及龈沟液中炎性指标明显升高,通过牙周基础治疗能有效下调炎性细胞因子水平,改善其牙周状态。     

2型糖尿病伴慢性牙周炎牙周基础治疗的疗效

目的:探讨2型糖尿病伴慢性牙周炎牙周基础治疗的疗效。方法:收集2013年1月至2014年1月诊断为2型糖尿病伴慢性牙周炎的患者作为研究对象,按住院单双号顺序分为两组,50例观察组和50例对照组,观察组接受牙周基础治疗,对照组不接受干预。对比观察组和对照组治疗前及治疗后4个月牙周状况、空腹血糖及糖化血红蛋白水平。结果:观察组和对照组治疗前牙周袋探诊深度、菌斑指数、探诊出血指数、空腹血糖及糖化血红蛋白水平差异无统计学意义(P>0.05);观察组和对照组治疗后4个月牙周袋探诊深度、菌斑指数、探诊出血指数均较治疗前降低,且观察组优于对照组(P<0.05),同时空腹血糖、糖化血红蛋白水平均降低,且观察组两指标均低于对照组(P<0.05)。结论:本次研究认为牙周基础治疗后能够降低患者牙周炎症,改善血糖水平。     

牙周基础治疗对慢性牙周炎伴2型糖尿病患者炎症反应及糖代谢的影响

目的评估牙周基础治疗对慢性牙周炎伴2型糖尿病患者炎症反应及糖代谢的影响。方法选择2011年7月-2014年7月来我院牙周科就诊患者213例,其中单纯慢性牙周炎患者102例(观察组),2型糖尿病伴慢性牙周炎患者111例(试验组);另从体检中心牙周健康人群中选择30名作为对照组。检查基线水平和牙周基础治疗后3个月各组的牙周状况,检测血清炎性细胞因子(CRP、TNF-α及IL-6)和HbA1c含量。结果治疗前,试验组和观察组的PD、CAL及SBI值及血清炎性细胞因子(CRP、TNF-α及IL-6)含量均高于对照组,差异有统计学意义(P0.05)。治疗3个月后,试验组和观察组的PD、CAL及SBI值与治疗前比较均有所减小,差异有统计学意义(P0.05)。治疗3个月后,试验组和观察组的CRP、TNF-α及IL-6含量与治疗前比较均明显下降,差异有统计学意义(P0.05);治疗前,试验组的HbA1c含量明显高于观察组和对照组;治疗3个月后,试验组的HbA1c含量显著下降,且其治疗前后差异有统计学意义(P0.05)。结论牙周基础治疗可有效改善牙周病伴2型糖尿病患者的牙周健康状况,降低血清中炎性细胞因子水平,并可在一定程度上改善代谢状况。     

牙周基础治疗对2型糖尿病伴慢性牙周炎患者血糖代谢指标及血清生化指标的影响

目的：全面评估2型糖尿病伴慢性牙周炎患者牙周基础治疗对牙周临床参数、血糖代谢指标及血清生化指标的影响,探讨牙周基础治疗的干预作用。方法：选择2011年4月至2012年5月来北京大学第三医院口腔科就诊的2型糖尿病伴慢性牙周炎患者40名,于基线水平和牙周基础治疗后3个月时进行牙周临床检查,以及糖化血红蛋白、空腹血糖和其他血清生化指标的检查,比较治疗前、后的差异。结果：牙周基础治疗3个月后,2型糖尿病伴慢性牙周炎患者牙周临床参数（探诊深度、附着丧失、菌斑指数、出血指数、探诊后出血百分数）均有显著改善,差异有统计学意义（P<0.001）。 治疗后糖化血红蛋白水平降低,差异有统计学意义（P=0.014）,但空腹血糖浓度改变,差异无统计学意义（P=0.586）;其他有统计学意义改变的血清生化指标包括：血清磷显著升高、血清钙磷比显著下降、甘油三酯显著下降、载脂蛋白A1显著升高、脂蛋白a显著降低和血清总胆红素显著升高。结论：牙周基础治疗对2型糖尿病伴慢性牙周炎患者牙周临床参数和糖化血红蛋白的控制有显著改善作用,但对空腹血糖的作用不明显。此外,牙周基础治疗还可能影响血清磷的浓度及钙磷比,并影响血脂的代谢。     

牙周基础治疗对2型糖尿病伴牙周炎与超敏C-反应蛋白的影响

目的探讨牙周基础治疗对2型糖尿病伴慢性牙周炎患者超敏C-反应蛋白(hs-CRP)、糖化血红蛋白(Hb A1c)的影响.方法将76例2型糖尿病伴慢性牙周炎患者随机分为治疗组(常规降糖治疗+牙周基础治疗)、对照组(仅采用常规降糖治疗),疗程3月,检测治疗前后血清hs-CRP、Hb A1c水平.结果治疗组患者hs-CRP、Hb A1c、探诊深度(PD)、附着丧失(AL)显著下降(P<0.01).结论牙周基础治疗可以减轻2型糖尿病伴牙周炎患者微炎症及牙周炎病变程度,且对有效控制血糖有帮助.     

糖尿病并发牙周炎的临床研究

目的:观察糖尿病伴有牙周炎患者经过牙周治疗后,对患者空腹血糖(FPG)、肿瘤坏死因子(TNF-α)和糖化血红蛋白(HbAlc)的影响。方法:选择糖尿病伴牙周炎患者50例,随机分为观察组和对照组,分析治疗后1个月、3个月、6个月的空腹血糖、糖化血红蛋白及肿瘤坏死因子的水平。结果:牙周炎观察组FPG、TNF-α和HbAlc治疗后较治疗前有明显降低,与对照组比较差异有统计学意义(P<0.05)。结论:糖尿病伴牙周炎患者行牙周炎治疗对血糖控制有益。     

2型糖尿病伴慢性牙周炎42例牙周基础治疗效果观察

目的探讨并评价牙周基础治疗2型糖尿病伴慢性牙周炎患者的临床效果。方法随机将42例2型糖尿病伴慢性牙周炎患者分为两组(每组21例)。观察组行牙周基础治疗加药物治疗,对照组仅行药物治疗。分别记录两组患者治疗前后各项牙周临床指标和糖化血红蛋白水平。结果观察组治疗后12周,各项临床指标和糖化血红蛋白水平有显著降低,与治疗前相比差异有高度显著性(P均<0.01)。结论2型糖尿病伴慢性牙周炎患者接受牙周基础治疗,在短期内有良好的效果。     

双花薄荷饮对2型糖尿病合并牙周炎的临床研究

目的：：应用双花薄荷饮治疗2型糖尿病合并牙周炎展开临床研究。方法：将112例患者随机分成两组，基础治疗组给予降糖药物常规治疗和牙周基础治疗；中医治疗组在基础治疗组的基础上口服双花薄荷饮。两组均治疗1个月，对比组间糖化血红蛋白、空腹血糖水平及治疗前后牙龈出血指数、牙周袋深度指标。结果：中医治疗组在改善糖化血红蛋白、空腹血糖水平、牙龈出血指数、牙周袋深度指标方面优于基础治疗组( P<0.05)。结论：双花薄荷饮治疗2型糖尿病合并牙周炎疗效确切。     

牙周炎治疗对2型糖尿病病人牙周状况及代谢指标的影响

[目的]探讨牙周炎治疗对2型糖尿病病人的牙周状况及代谢指标的影响.[方法]将42例2型糖尿病合并牙周炎病人进行牙周炎治疗,观察牙周炎治疗后牙周状况及血糖、血脂及糖化血红蛋白指标的变化.[结果]2型糖尿病合并牙周炎患者经牙周炎治疗后除血脂无显著变化外(P＞0.05),其余各项较治疗前相比显著性下降(P＜0.01或P＜0.05).其中龈沟出血指数由(3.38±0.59)降至(1.85±0.26)、探诊深度由(5.63±0.85)mm降至(3.76 0.67)mm(均P＜0.01),空腹血糖由(8.23±1.52)mmol/L降至(7.71±1.03)mmol/L,餐后2 h血糖由(14.71±4.22)mmol/L降至(12.90±2.34)mmol/L,糖化血红蛋白指标由(8.50±1.64)%降至(7.94±0.92)%(均P＜0.05).[结论]通过牙周炎治疗可以在一定程度上改善糖尿病患者糖代谢水平及降低糖化血红蛋白的水平,改善牙周状况.     

芪明颗粒对糖尿病患者血脂的影响

目的：研究分析芪明颗粒对糖尿病患者血脂的影响。方法：选取本院收治的90例糖尿病患者为研究对象,将90例患者随机分为对照组（常规糖尿病治疗组）45例和观察组（常规糖尿病治疗加芪明颗粒组）45例,然后将两组治疗前后的血脂、血糖、糖化血红蛋白、C肽及血流变指标进行检测与比较。结果：观察组治疗后6周及12周的血脂水平均好于对照组,血糖、糖化血红蛋白、C肽及血流变指标均低于对照组,差异具有统计学意义（P〈0.05）。结论：芪明颗粒可有效控制糖尿病患者的血脂水平,且对于糖尿病患者其他疾病相关指标也发挥着较佳的改善作用。     

THERAPEUTIC EFFECT OF NON-SURGICAL TREATMENT OF CHRONIC PERIODONTITIS IN DIABETIC CHINESE

Objective To observe the therapeutic effect of non-surgical treatment on diabetic Chinese with chronic periodontitis. Methods Moderate to advanced chronic periodontitis (CP) was studied in 36 diabetes mellitus （DM) patients ctassified as 20 with hihg and fluctuating blood glucose level (DM-H) and 16 with relatively low and stable blood glucose level (DM-L). 28 non-DM CP patients acted as controls (Non-DM). Plaque index (PII), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss ( AL ) of all patients were recorded at 6 sites on each tooth at the baseline and 1,3 and 6 months after oral hygiene instruction ( OHI) , scaling and root planing. Results It was found that the short-term effect of non-surgical periodontal procedure had resulted in significant resolution of gingival inflammation and pronounced reduction in pocket depth and gain of attachment loss in both DM and Non-DM CP patients. Conclusion The pilot study suggested that non-surgical periodontal treatment allowed for favorable treatment responses in a group of Chinese diabetic subjects with chronic periodontitis and that their various profiles of blood glucose did not influence the short-term healing response to OHI, scaling and root planning.     

牙周炎与糖尿病的关系

牙周病是口腔的两大疾病之一,我国成人的患病率高达80％～90％。其中牙周炎是成人失牙的主要原因。近年来医学研究的重大发现是牙周炎不仅累及牙周组织,而且严重危害人们的全身健康,是糖尿病和心、脑血管疾病、呼吸系统疾病发病的危险因素,并与妊娠早产低体重儿有密切关系;而系统性疾病如糖尿病、免疫功能紊乱、骨质疏松症等也会增加患牙周炎的风险,并影响牙周治疗的效果。目前,牙周炎与全身健康的关系已是国内外医学专家和口腔医学专家的关注热点,此综述将根据近年来北京大学口腔医学院牙周实验室的相关工作进一步阐述牙周炎与糖尿病的关系。     

牙周炎伴2型糖尿病患者牙周基础治疗效果研究

目的探讨2型糖尿病与牙周炎在疾病发展过程中的相互影响。方法选择2型糖尿病的牙周炎患者（观察组）与不伴糖尿病的牙周炎患者（对照组）各30例行牙周基础治疗,记录并比较两组患者在治疗前后的牙周袋探诊深度（PD）、牙周附着丧失（AL）、血糖（GLU）及糖化血红蛋白（HbAlc）的变化。结果牙周基础治疗后,两组PD与AL与治疗前相比明显下降,差异有统计学意义（P〈0.05）。GLU与HbAlc指标也明显下降,差异有统计学意义（P〈0.05）。结论糖尿病和牙周炎之间存在着双向关系,牙周基础治疗可缓解牙周炎患者的局部牙周炎症状态,同时在一定程度上缓解糖尿病症状。     

牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响

目的 探讨牙周非手术治疗对肥胖大鼠血清炎症因子及代谢水平的影响.方法 选取16只已成功建立肥胖复合牙周炎模型的大鼠,随机分为治疗组及未治疗组(对照组),治疗组大鼠接受牙周非手术治疗,对照组未做任何处理,所有大鼠于牙周治疗后2周处死.牙周治疗前及治疗后2周两组大鼠均行口服糖耐量试验,眼眶静脉取血、检测空腹血糖及空腹胰岛素,运用酶联免疫吸附法检测血清C-反应蛋白(CRP).结果 牙周治疗后2周,治疗组的空腹血糖(t=2.445,P=0.034)及β细胞功能指数显著低于对照组(t=-2.543,P=0.027);经牙周治疗后,治疗组CRP水平显著降低,并低于对照组(t=2.388,P=0.028);口服糖耐量试验中,曲线下面积显著下降,并低于对照组(t=12.053,P=0.000).结论 牙周非手术治疗可以下调肥胖复合牙周炎大鼠的CRP水平,改善肥胖大鼠的糖代谢状况.     

Short term effects of periodontal therapy on inflammatory markers in patients with type-2 diabetes

Objectives:

To evaluate the influence of periodontal therapy on glycosylated hemoglobin and fasting blood glucose and serum levels of interleukin (IL)-4, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α) in chronic periodontitis (CP) patients with type-2 diabetes mellitus (T2DM) and in controls.

Methods:

A total of 30 periodontal patients, 15 of which were systemically healthy (control group), and 15 were T2DM patients (test group) were included in this study. This prospective study was carried out at Istanbul University, Istanbul, Turkey between February 2011 and December 2013. Plaque index, gingival index, bleeding on probing, periodontal probing depth, and clinical attachment level were assessed and recorded at baseline, one, and 3 months after therapy. Serum samples were collected at the same time-points and analyzed using Luminex assay for the levels of IL-4, IL-6, IL-8, IL-10, and TNF-α. The change in the metabolic control was also monitored.

Results:

All clinical parameters were significantly improved after the periodontal therapy in both groups (p<0.001). Glycosylated hemoglobin levels were decreased; however, the difference was not significant (p>0.05). Fasting blood glucose levels were decreased one month after therapy, and increased at 3 months. Patients with T2DM had significantly higher levels of circulating IL-8 at each time point, and TNF-α (p<0.05) at baseline. The IL-4 and IL-10 levels were decreased at one month after therapy (p>0.05).

Conclusion:

Periodontal therapy has limited impact on the serum levels of IL-4, IL-6, IL-8, IL-10, and TNF-α. Metabolic control levels were not influenced by periodontal therapy.Chronic periodontitis (CP) is an infectious disease resulting in inflammation in periodontal tissues, progressive attachment, and bone loss. Chronic periodontitis is the most common type of periodontitis, and its prevalence and severity increases with age.1 Microbial dental plaque is the main etiological agent; however, progression from gingivitis to periodontitis is associated with host response and immunity. Presence of systemic disease such as diabetes, stress, and genetic factors are among the factors related to host response.2 Bone loss occurs with the influence of local factors, which are expressed from inflammatory mediators. Interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), IL-6 are the cytokines favoring bone loss around the teeth. It has been reported that patients with chronic periodontitis present with increased systemic inflammation and raised levels of various inflammatory markers compared with healthy controls.3 The local tissue produces inflammatory cytokines, as well as elevates their systemic circulating levels. Type-2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism. Defects in insulin secretion (b-cell dysfunction), insulin action (insulin resistance), or both cause T2DM.4 Type-2 diabetes is regarded as a low-grade inflammatory disease because some inflammatory cytokines are involved in the mechanism. Functions of specific immune system cells are impaired in patients with DM. Diabetes mellitus causes dysfunction in the adhesion, chemotaxis, and phagocytosis capacity of neutrophils. As a result, they cannot kill periodontopathogens, and cannot destroy their toxins resulting in the destruction of periodontal tissues,5-7 which may explain in part the increased incidence of periodontitis among diabetic patients. The glycosylated hemoglobin (HbA1c) levels reflect the glycemic level over the previous one to 3 months. Whether periodontal therapy reduces HbA1C levels in periodontitis patients remains controversial.8-14 In patients with periodontitis, diabetes is associated with elevated levels of several cytokines and other mediators in serum, saliva, and gingival crevicular fluid (GCF). It was reported that monocytes in peripheral blood of patients with DM produce higher amounts of TNF-α when encountered with Porphyromonas gingivalis.15The TNF-α, which is a pro-inflammatory cytokine was first reported by Hotamisligil et al16 to cause insulin-resistance. The TNF-α produced by the adipose tissues acts as a risk factor for periodontal disease; likewise, TNF-α produced due to periodontal inflammation may be an additional risk factor influencing insulin sensitivity.17 The TNF-α, IL-6, resistin, and other pro-, and anti-inflammatory cytokines activate intracellular pathways, which causes the development of insulin resistance and T2DM.18 Interleukin-4 reduces secretion of IL-1, IL-6, and TNF-α from monocytes.19 It was reported by a series of studies that patients with diabetes have a lower concentration of GCF IL-4 compared with healthy subjects.20-22 It was indicated that periodontal therapy reduces serum IL-6 concentration significantly in patients with CP.23 Interleukin-8 is a chemo attractive proinflammatory cytokine that affects neutrophil migrations in thetissue and circulation. Interleukin-1β and TNF-α has a role on IL-8 production.24 Substantial data has been accumulated on metabolic measures and serum levels of cytokines on T2DM patients with periodontitis. A systematic review has shown that non-surgical periodontal treatment results in a mean reduction in HbA1C of 0.36% (95% confidence interval [CI]: 0.19-0.54) at 3 months.25 However, the results from different reports are not consistent to demonstrate the potential effects of non-surgical periodontal therapy on Hba1C and specific cytokines in T2DM patients with CP.9-14We hypothesized that non-surgical periodontal therapy will reduce the levels of proinflammatory cytokines, HbA1c, and fasting blood glucose (FBG) levels in T2ßDM patients with CP, and this group of patients can benefit from periodontal therapy, as well as non-diabetics. Thus, the aim of this study was to evaluate the influence of periodontal therapy on HbA1C and FBG and serum levels of IL-4, IL-6, IL-8, IL-10, and TNF-α in CP patients with T2DM and in controls.     

伴有2型糖尿病牙周炎患者牙周基础治疗后血糖水平和疗效观察

目的研究伴有2型糖尿病的牙周炎患者在牙周基础治疗后的血糖水平变化和临床疗效。方法选取泰安市口腔医院伴有2型糖尿病的牙周炎患者51例作为研究组,另选取无糖尿病史牙周炎患者50例作为对照组,两组均行牙周基础治疗,研究组同时行良好糖尿病治疗。对比观察两组在治疗前和治疗后1、8、12周的斑菌指数（PLI）、探针深度（PD）、附着丧失（CAL）、龈沟出血指数（SBI）变化,以及研究组的糖化血红蛋白（HbA）和空腹静脉血糖（FPG）变化。结果两组患者的各牙周临床指标（PLI、PD、CAL、SBI）在牙周基础治疗后均得到明显改善（P〈0．05）,两组间比较差异无统计学意义（P〉0．05）;研究组在治疗后1周的HbA和FPG无显著改善（P〉0．05）,治疗后8周显著降低（P〈0．05或P〈0．01）;治疗后12周有所反弹但差异无统计学意义（P〉0．05）。结论伴有2型糖尿病的牙周炎患者在良好糖尿病治疗基础上应用牙周基础治疗．短期疗效与无糖尿病史患者疗效相当,确切而稳定,并能显著改善血糖,可在临床推广应用及进一步研究。     

黄连素对2型糖尿病患者血清IL-10、IL-6及CRP水平的影响

目的 探讨黄连素(小檗碱)对2型糖尿病患者血清IL-10、IL-6及CRP水平的影响.方法 选取2型糖尿病患者182例,按随机数字表法分为2组,对照组91例予以二甲双胍治疗,研究组91例在对照组基础上予以黄连素(小檗碱)治疗,观察并记录2组间血清脂联素及炎症因子水平、血糖、胰岛素、血脂指标,同时对比不良反应发生率.结果 与对照组比较,研究组治疗后血清IL-6、CRP、TNF-α 水平较低,血清ADPN、IL-10水平较高,治疗后FPG、2hPG、HbA1c水平较低,治疗后FINS、HOMA-IR水平较低,ISI水平较高,治疗后TC、TG、LDL-C水平较低,HDL-C水平较高,具有统计学意义(P<0.05);研究组和对照组不良反应发生率比较无统计学意义(P>0.05).结论 黄连素(小檗碱)能够有效降低2型糖尿病患者血清IL-6、CRP、TNF-α水平,提高血清IL-10、ADPN水平,减轻炎症反应,改善糖脂代谢及胰岛素抵抗,有效降低血糖.     

慢性牙周炎伴2型糖尿病患者牙周基础治疗对牙周状况及血清C反应蛋白水平的影响

目的探讨牙周基础治疗对慢性牙周炎伴2型糖尿病患者牙周状况及血清C反应蛋白的影响。方法选择该院2009年1月—2011年12月慢性牙周炎伴2型糖尿病患者26例作为观察组,同期慢性牙周炎患者26例作为对照组,两组均行牙周基础治疗。观察比较两组患者治疗前、后探诊出血（BOP）、牙周探诊深度（PD）、附着丧失（AL）以及血清CRP水平的变化情况。结果治疗后1个月,两组患者BOP阳性率、PD、AL、血清CRP水平跟治疗前比较均明显下降,差异有统计学意义（P〈0.05）。观察组牙周指数BOP阳性率、PD、AL与CRP水平呈正相关（r=0.879,r=0.531,r=0.585,P〈0.05）,对照组BOP阳性率、PD、AL与CRP水平呈正相关（r=0.782,r=0.720,r=0.690,P〈0.05）。结论牙周基础治疗能够明显改善慢性牙周炎伴2型糖尿病患者牙周状况,有效降低患者血清CRP水平。