热毒宁注射液联合消旋卡多曲治疗轮状病毒肠炎疗效观察

目的:观察热毒宁注射液联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎的临床疗效.方法:96例小儿轮状病毒肠炎患儿随机分成治疗组和对照组.治疗组用热毒宁注射液静滴,口服消旋卡多曲颗粒治疗;对照组用热毒宁注射液静滴.结果治疗组总有效率91.7%,对照组总有效率81.3%,在临床疗效方面两者对比有统计学学意义(P＜0.01).结论:热毒宁注射液联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎疗效显著.     

热毒宁注射液结合腹泻理疗治疗小儿秋季腹泻52例

目的:观察热毒宁注射液结合腹泻理疗治疗小儿秋季腹泻的临床效果.方法:将92例秋季腹泻患儿随机分为两组.治疗组52例采用常规治疗+热毒宁注射液静滴结合腹泻理疗.对照组40例采用常规治疗+病毒唑静滴,两组均治疗3 d观察疗效.结果:治疗组总有效率为92.31%,对照组总有效率为75.00%,两组结果经统计学处理,差异有高度统计学意义(均P<0.01).结论:热毒宁注射液结合腹泻理疗治疗小儿秋季腹泻具有较好的临床效果,尤其对小儿.具有痛苦小、依从性高的特点,值得临床推广.     

青霉素与热毒宁联合治疗小儿口腔炎120例疗效观察

目的 观察青霉素与热毒宁联合治疗小儿口腔炎的疗效.方法 将小儿口腔炎患儿120例,分为对照组60例:静滴青霉素、病毒唑,观察组60例:静滴青霉素、热毒宁,观察患儿主要症状体征恢复情况,比较两组疗效.结果 观察组和对照组的总有效率分别为 98.3%和 85.0%.两组比较有显著性差异(P<0.01).结论 青霉素与热毒宁联用治疗小儿口腔炎疗效显著,退热效果好,缩短治疗时间.     

热毒宁注射液治疗婴幼儿手足口病60例疗效观察

目的 观察热毒宁注射液对婴幼儿手足口病的临床疗效.方法 将120例婴幼儿手足口病患儿随机化原则分为治疗组和对照组,分别给于热毒宁注射液及利巴韦林注射液静滴.结果 治疗组优于对照组.结论 热毒宁注射液治疗小儿手足口病疗效好,不良反应少.     

热毒宁注射液治疗手足口病56例临床观察

目的:观察热毒宁注射液治疗小儿手足口病的临床疗效.方法:将80例手足口病患儿随机分为治疗组56例和对照组24例.对照组给予头孢呋辛钠(100 mg/kg)加入0.9%氯化钠中稀释后静滴,1次/d;10%葡萄糖加利巴韦林(10 mg/kg)静滴,1次/d(按山东省疾病控制中心诊疗方案).观察组在此基础上再给予热毒宁注射液0.5 ml/kg加入10%葡萄糖中稀释静滴.1次/d,疗程5d,分别观察其治疗效果并进行比较.结果:观察组在退烧时间、疱疹消退时间、咽颊红肿消退时间及止咳时间方面,与对照组比较均有显著性差异(P＜0.05,P＜0.01).结论:热毒宁注射液治疗小儿手足口病疗效显著.     

痰热清注射液治疗小儿流行性腮腺炎疗效分析

目的 观察痰热清注射液治疗小儿流行性腮腺炎临床疗效.方法 45例小儿流行性腮腺炎随机分成两组,治疗组23例,应用痰热清注射液,对照组22例,予利巴韦林静滴,5d为一疗程.结果 治疗组有效率95.7%,而对照组为60.9%,两组比较有显著差异(P＜0.01).结论 痰热清注射液治疗小儿流行性腮腺炎疗效显著.     

热毒宁注射液治疗小儿疱疹性口炎疗效观察

目的观察热毒宁注射液治疗小儿疱疹性口炎的临床疗效.方法选择我院2011年9月至2012年7月82例小儿疱疹性口炎患儿随机分为两组,治疗组给予热毒宁注射液治疗,对照组给予利巴韦林治疗.结果治疗组与对照组总有效率分别为92.6%和75.6%,两组比较差异具有显著性,有统计学意义P<0.05.结论热毒宁注射液治疗小儿疱疹性口炎有较好的疗效而且安全,无明显毒副反应,值得临床推广使用.     

热毒宁注射液联合必奇治疗小儿病毒性肠炎疗效观察

目的观察热毒宁注射液联合必奇治疗小儿病毒性肠炎的临床疗效。方法将150例小儿病毒性肠炎患儿随机分为两组:治疗组75例,对照组75例。治疗组在常规治疗的基础上应用热毒宁注射液静脉点滴,加必奇口服,疗程5～7d。对照组在常规治疗的基础上加用病毒唑静脉点滴。结果治愈率:治疗组为90.66%,对照组为66.67%。在控制主要症状、体征、治愈天数上,治疗组明显优于对照组。结论热毒宁注射液联合必奇治疗小儿病毒性肠炎疗效显著。     

热毒宁治疗小儿急性上感的观察分析

目的 观察分析热毒宁对小儿急性上感的治疗效果.方法 采用半随机分组对照实验:386例急性上感患儿分为两组:观察组192例,对照组194例.观察组用热毒宁注射液,对照组用利巴韦林和双黄连注射液.两组给药方式均为静脉滴注,时间均为3～7d.结果 使用热毒宁的观察组总有效率为93.8%,不良反应率为4.7%;对照组总有效率为75.8%,不良反应率为10.8%,两组总有效率、药物不良反应差异均有显著性(P<0.05).结论 使用热毒宁治疗小儿急性上感有较好的临床效果,且副作用小,值得推广使用.     

热毒宁注射液治疗小儿手足口病的疗效

目的:评价热毒宁注射液治疗小儿手足口病的临床疗效。方法:收治手足口病患儿174例,随机分为治疗组88例和对照组86例。对照组给予5%葡萄糖注射液+利巴韦林10～15mg/(kg·日)静滴,1次/日,疗程5天;治疗组应用热毒宁注射液0.5～1ml/(kg·日),连续应用5天。比较两组在发热消退时间、疱疹消退时间、咽峡部红肿消退时间及总病程等方面的变化和差异。结果:治疗组发热消退时间、疱疹消退时间、咽峡部红肿消退时间及总病程等均较对照组明显缩短,差异有统计学意义(P<0.05)。结论:热毒宁注射液治疗小儿手足口病疗效显著,临床无明显不良反应。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…