镍铬合金和钛合金烤瓷冠修复对牙周组织及龈沟液中细胞因子的影响

目的探讨镍铬合金和钛合金烤瓷冠修复对牙周组织及龈沟液中细胞因子的影响。方法80例共80颗牙按照烤瓷冠金属材料不同分为镍铬合金组（n=40,采用镍铬合金烤瓷冠修复）和钛合金组（n=40,采用钛合金烤瓷冠修复）,以对侧同名健康天然牙作为对照。比较两种烤瓷冠修复后1年对牙龈的影响,检测患牙和对照牙龈沟出血指数（SBI）、菌斑指数（PLI）、探诊深度（PD）;测定并比较龈沟液（GCF）中自细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、天冬氨酸转氨酶（AST）水平。结果镍铬合金组对牙龈外观的影响大于钛合金组（P〈0．01）;修复后1年,镍铬合金组修复牙SBI及PD均显著大于对照牙（P〈0．05）,PLI与对照牙无差异（P〉0．05）;钛合金组修复牙SBI较对照牙增大（P〈0．05）,PLI及PD与对照牙无差异（P〉0．05）;镍铬合金组修复牙GCF量较对照牙增多,IL-1β、TNF-α及AST水平均较对照牙升高（P〈0．05、P〈0．01）,而钛合金组修复牙GCF量、IL-1β、TNF-α及AST水平较对照牙无差异（P〉0．05）。结论镍铬合金烤瓷冠对牙龈和牙周组织有明显不利影响。而钛合金烤瓷冠对牙龈和牙周组织的影响较小。值得临床借鉴。     

镍铬合金镀金烤瓷冠对牙周组织的影响分析

目的:对比分析镍铬合金镀金烤瓷冠对牙周组织的影响。方法:选择临床病例30例,采用镍铬合金烤瓷冠和镍铬合金镀金烤瓷冠修复,分别以修复前和修复6～8个月后,采集龈沟液并分析AST、ALP活性。结果:两种方法修复前,健康状况相似,各指标间无差异(P>0.05),但镍铬合金烤瓷冠修复6～8个月后,GCF量、GCF-AST、GCF-ALP的水平与修复前均有显著差异(P<0.05),而镍铬合金镀金烤瓷冠则无显著差异(P>0.05)。结论:镍铬合金镀金烤瓷冠可以替代贵金属烤瓷冠在临床普及应用。     

不同金属烤瓷冠修复患者龈沟液中IL-6浓度测定及Ni 离子对牙龈的影响

目的：通过龈沟液(GCF)中白细胞介素6(IL-6)浓度的测定,评价不同金属烤瓷冠(PFM)对牙龈组织的刺激性。 方法：欲行PFM修复的牙列缺失患者60例分别采用镍铬合金、镍铬合金镀金及金合金进行修复,每组20例,以修复对侧同名牙或对牙合同名牙为各自对照组。PFM修复6个月后,采集并定量GCF,采用酶联免疫吸附法测定GCF中IL-6的浓度。结果：金合金组GCF分泌量与对照组比较差异无显著性（P>0.05）;镍铬合金镀金组及镍铬合金组GCF分泌量显著高于金合金组及对照组（P<0.05）,而镍铬合金镀金组与镍铬合金组比较差异无显著性（P>0.05）。金合金组、镍铬合金镀金组GCF中IL-6浓度与对照组比较差异无显著性（P>0.05）,镍铬合金组GCF中IL-6浓度显著高于对照组（P<0.05）;金合金、镍铬合金镀金组GCF中IL-6浓度显著低于镍铬合金组（P<0.05）,而金合金与镍铬合金镀金组比较差异无显著性（P>0.05）。结论：含镍金属对牙龈刺激最大,金合金烤瓷冠对牙龈组织刺激性最小,GCF中IL-6的浓度可以作为监测PFM修复效果的理论指标。     

不同金属烤瓷冠修复对牙周组织及龈沟周围细胞因子的影响

目的探究不同金属烤瓷冠修复对牙周组织及龈沟周围细胞因子的影响。方法选择90例患者共90颗牙按照烤瓷冠金属材料不同分为三组:镍铬合金组、钴铬合金组和钛合金组,每组各30例。以自身对侧同名健康的天然牙作为基准进行对照。比较三种烤瓷冠修复后12个月对牙龈组织的影响情况,检测患者修复牙和对照牙龈沟菌斑指数、龈沟出血指数、龈沟探诊深度及龈沟液中血管内皮生长因子(VEGF)、白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平,并进行比较。结果在修复后12个月三组修复牙与对照牙比较,菌斑指数、龈沟出血指数、龈沟探诊深度升高,镍铬合金组和钴铬合金组龈沟出血指数与龈沟探诊深度高于钛合金组,差异均有统计学意义(P<0.05);三组患牙VEGF、IL-1β、TNF-α水平均较对照牙升高(P<0.05),钛合金组修复牙VEGF、IL-1β、TNF-α水平低于镍铬合金组和钴铬合金组,差异均有统计学意义(均P<0.05)。结论镍铬合金烤瓷冠对牙周组织和牙龈有比较明显的不利影响,而钛合金烤瓷冠对牙周组织和牙龈的影响较小。     

不同烤瓷冠对牙周组织影响的临床观察

目的：观察不同类型的烤瓷冠对牙周组织的影响。方法：对352颗临床上常用的七种不同类型的烤瓷冠（镍铬合金烤瓷冠、镍铬镀金烤瓷冠、钴铬烤瓷冠、钛合金烤瓷冠、纯钛烤瓷冠、金合金烤瓷冠、全瓷冠）修复1年后的牙龈变化、牙龈出血指数（GBI）、菌斑指数（PLI）、牙周袋深度（PD）进行检测,并与对侧或相邻近的健康天然牙进行对照。结果：镍铬合金烤瓷冠出现明显牙龈变化9/51;其中5例出现龈缘黑线;与健康牙和其他烤瓷牙相比,差异显著（P〈0.05）;镍铬合金烤瓷冠GBI、PLI、PDL分别增加了0.45、0.53、0.17,镍铬镀金烤瓷冠GBI增加了0.05,与健康牙相比均有明显差异（P〈0.05）。结论：镍铬合金烤瓷冠对牙龈和牙周健康有明显影响,做烤瓷牙修复时应尽量采用处理措施或采用其他高耐腐蚀性材料和贵金属材料。     

镍铬合金与镍铬合金全瓷肩台烤瓷冠对牙周组织影响的研究

目的:观察镍铬合金烤瓷冠与镍铬合金全瓷肩台烤瓷冠对牙周组织的影响。方法:选择镍铬合金烤瓷冠与镍铬合金全瓷肩台烤瓷冠烤瓷冠修复后6～8个月的临床病例,对所选病例进行牙周状况检查,即测定龈沟液(CCF)量,观察牙龈出血指数(GBl)、菌斑指数(PLl)、探诊深度(PD)。镍铬合金烤瓷冠51例,镍铬合金全瓷肩台烤瓷冠44例。结果:镍铬合金全瓷肩台烤瓷冠牙周各项指标均无显著性差异(P>0.05),镍铬合金烤瓷冠的GC阳和GBI均有高度显著性差异(P<0.01),PLI和PD均有显著性差异(P<0.05)。结论:两种烤瓷冠对牙周组织的影响不同。     

镀金合金、镍铬合金和高金合金烤瓷冠的龈缘美学研究

目的：分析非贵金属烤瓷冠引起牙龈变色、炎症的原因,对镀金方法作出改进,为临床应用镀金烤瓷冠提供参考。方法：选择2005年6月?006年12月来本科就诊的患者240例,介绍镍铬合金、镀金镍铬合金、以及高金合金烤瓷冠的区别,按患者自愿选择烤瓷冠（PFM）类型的要求分为3组。镀金组: 镀金烤瓷冠80例;镍铬合金组:镍铬合金烤瓷冠80例;高金合金组：高金合金烤瓷冠80例。对3组烤瓷冠的牙龈变色及牙龈健康情况进行观察、比较。结果：初戴时,镍铬合金组有3例出现牙龈变色,而镀金组和高金合金组均无1例出现牙龈变色,但组间比较差异无显著性(P>0.05)。3组烤瓷冠均无牙龈炎症出现。1年后,镍铬合金组共出现12例牙龈变色,与镀金组及高金合金组(无1例) 比较差异有显著性 (P<0.01)。镍铬合金组出现13例、镀金组出现3例牙龈红肿现象,经秩和检验,镍铬合金组与镀金组、高金合金组比较差异有显著性(均P<0.01),镀金组与高金合金组比较差异无显著性(P>0.05)。结论：从龈缘的美学效果和适中的价格来看,高度抛光镀金烤瓷冠是临床修复比较理想的选择。     

浅析金属烤瓷桥应用于慢性牙周病治疗中的临床效果

目的：探讨金属烤瓷桥治疗慢性牙周病的临床效果。方法利用不同材质的金属烤瓷冠修复临床患有牙周炎的患者,其中镍铬合金烤瓷桥冠159颗牙,金合金烤瓷桥冠61颗牙,镍铬合金镀金烤瓷桥冠172颗牙,共计392颗牙。1年后观察牙周组织的变化,定期随访,并与健康天然牙进行比较。结果经过金属烤瓷桥冠修复1年后,复查牙龈颜色、牙周探诊深度、牙龈指数及菌斑指数。发现应用三种金属烤瓷桥冠修复后PD和PLI分别与健康天然牙对比,差异均无统计学意义。与健康天然牙对比,镍铬合金烤瓷桥冠GBI平均增加0.95,差异具有统计学意义（P<0.05）;与健康天然牙对比,金合金烤瓷桥冠GBI平均增加0.15,镍铬合金镀金烤瓷桥冠GBI平均增加0.17,差异均无统计学意义。结论镍铬合金烤瓷桥冠、金合金烤瓷桥冠和镍铬合金镀金烤瓷桥冠作为修复体,对慢性牙周炎患者的牙周组织具有良好的改善效果,在口腔医学领域具有良好的应用前景,值得临床推广应用。     

不同金属烤瓷全冠对龈沟液内可溶性细胞间黏附分子-1及白细胞介素-1β水平的影响

目的通过观察不同合金烤瓷冠修复前后龈沟液(GCF)中可溶性细胞间黏附分子-1(sICAM-1)及白细胞介素-1β(IL-1β)水平变化,探讨不同金属基底烤瓷冠对牙周组织的影响。方法将45颗牙分为镍铬合金组、钴铬合金组和金铂合金组,每组15颗,分别进行镍铬合金、钴铬合金和金铂合金PFM全冠修复。在治疗前及治疗后6个月检测受试牙菌斑指数(PLI)、龈沟出血指数(SBI)、龈沟探诊深度(GCD)、龈沟内GCF量和sICAM-l、IL-1β水平。结果镍铬合金组修复后6个月,SBI、GCD和GCF量和sICAM-l、IL-1β水平[(3.72±0.33)mm、(1.62±0.24)mm、(0.691±0.112)mg、(94.12±25.14)ng/mL、(8.49±3.22)ng/mL]与钴铬合金组[(3.03±0.35)mm、(1.18±0.18)mm、(0.419±0.131)mg、(74.20±26.34)ng/mL、(5.72±3.06)ng/mL]、金铂合金组[(2.21±0.27)mm、(1.42±0.21)mm、(0.325±0.115)mg、(64.89±24.01)ng/mL、(4.24±2.18)ng/mL]相比,差异均有统计学意义(均P<0.05)。且钴铬合金组修复后6个月,SBI、GCD和GCF量和sICAM-l、IL-1β水平与金铂合金组相比,差异有统计学意义(P<0.05)。结论金铂合金烤瓷全冠对牙周组织的不利影响小于镍铬合金、钴铬合金,钴铬合金优于镍铬合金。     

烤瓷熔附金属全冠不同边缘位置对牙周组织的影响

目的 观察烤瓷熔附金属全冠不同边缘位置对牙周组织的影响.方法 选择行镍铬合金烤瓷全冠修复后3个月的临床病例20例,按冠边缘位置分为冠边缘平齐龈缘组(A组)10例,冠边缘位于龈下0.5～1 mm组(B组)10例,以A组和B组对侧或对颌健康同名牙做对照组.记录试验组和对照组牙龈指数(GI)、探诊深度(PD),并采用滤纸条法收集龈沟液,测定龈沟液量.结果 A组在临床牙周指标(GI、PD)与其对照组无统计学差异(P＞0.05),而GCF量变化上有统计学差异(P＜0.05).B组各项指标与其对照组比较均有统计学差异(P＜0.05).A组与B组之间比较各指标也均有统计学差异(P＜0.05).结论 不同牙冠边缘位置对牙周组织的影响不同.与对照组健康牙比较,冠边缘平龈边缘对牙周组织健康影响较小,龈下边缘较平龈边缘对牙周组织的影响大.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.