FasL Expression in Colorectal Carcinoma and Its Significance in Immune Escape of Cancer

It is still unclear howthe colorectal carcinomacells escape from i mmune supervision and pro-gress.Recently,the study concerning the role ofFas and FasL systemin i mmune escape of cancersis becoming a focus[1,2].This study was designedto detect the expression of FasLin colorectal carci-noma tissues andthe apoptosis of tumorinfiltratinglymphocytes(TILs)for exploring the relationshipbetween the up-regulation of the FasL expressionandi mmune evasion of cancer.1MATERIALS AND METHODS1.1…     

Mechanism of Retinoic Acid and Mitogen-activated Protein Kinases Regulating Hyperoxia Lung Injury

Acute and chroniclunginjury are major causesresponsible for the mortality and morbidityin bothpretermand termneonates .Prolonged exposure tohyperoxia inthe developinglungis believedto playcritical roles in the development of acute and chro-nic lung injury[1]. Recent studies demonstratedthat mitogen-activated protein kinases ( MAPKs)play an i mportant role in hyperoxia-induced lunginjury[2]. The processes of lung growth,develop-ment ,injury and repair are extremely complex,in-volving a multit…     

Expression Profile of Metastasis-associated Genes in Esophageal Squamous Cell Carcinoma

Esophageal cancer (EC) is one of the mostcommon fatal cancers in the worldwide , and ischaracterized by its high metastasis ,local lymphnode and blood metastasis at early stage , whichmay be the key factors of its recurrence and poorprognosis[1]. Thus ,better elucidation of molecularmechanism during metastasis is expected to i m-prove prevention and treat ment of EC. Many stud-ies have contributed to advance inits molecular as-pects . This li mited information based on singlegene ,however ,i…     

Evaluation of Normal Fetal Left Cardiac Function by Tissue Doppler Imaging

The fetal and adult heart diastolic functionwas traditionally evaluated by measuring suchindi-ces as spectra of atrioventricular valves . But thesemethods were heavily influenced by heart rates ,preload and so on and they tend to yield errors[1].Previous studies have confirmed the measurementof atrioventricular valve velocity by using TissueDoppler i maging was reliable and accurateinthe e-valuation of myocardial diastolic function in a-dults[2].But the reports concerningits use infetu-ses we…     

Experimental Study of Excitability and Autorhthmicity in Urinary Bladder Detrusor of Diabetes Rats

Urinary bladder function is significantly al-teredin patients with diabetes mellitus[1].The fre-quency of abnormal bladder functionin diabetic pa-tients,occurringin25%to85%of the cases,de-pends on the diagnostic method and duration of di-abetes mellitus.Diabetic cystopathy,the constel-lation of clinical and urodynamic findings associat-ed withlong-termdiabetes mellitus,has been clas-sically described as decreased bladder sensation,increased bladder capacity and i mpaired detrusorcontractility.…     

Expression of CD40 and CD40L on Peripheral Blood Mononuclear Cells in Patients with Condyloma Acuminatum

The initiation,development and transforma-tion of condyloma acuminatum(CA)bear a closerelation to the cellular i mmune function ofhost[1-3].The CD40and CD40ligands,a couple ofi mportant costi mulatory molecules of the specifici mmune systemin vivo,play an i mportant role inthe activation of Tlymphocytes and the secretionof effective cytokines.To obtaintheinformation a-bout the expression level and explore the clinicalsignificance of CD40and CD40L on peripheralblood mononuclear cells(PMBC…     

Effects of Gene Tranfection with CH50 Polypeptide on the Invasion Ability of Bladder Cancer Cell Line BIU-87

Fibronectin(FN) ,a glycoprotein,possesses mul-tiple cell bioactivities such as influencing the cellularmorphology, controlling cellular migration,inducingcellular differentiation and affecting i mmune cell func-tions etc ,whichis closelyrelated withthe carcinogene-sis ,invasion and metastasis[1].CH50 polypeptide is composed of Cell I andHep II bifunctional-domain of human FN, main-tains the function of the original structure and doesnot formnovel function because of deletion of frag-ments a…     

Epidemiology of Hepatitis B, C, D and G Viruses and Cytokine Levels among Intravenous Drug Users

Viral hepatitis presents a major global publichealth concern. HBV and HCV, in particular ,were the causative agents responsible for parenter-ally transmitted diseases[1 ,2]. IVDU represent aspecial subgroup of the population who oftenshared contaminated needles for intravenous drugsinjection[3].Opiate use was knownto alter i mmunefunction and had i mmunosuppressive effects thatmay modify T-lymphocyte subpopulations .IVDUwere subject to transmittable blood-borne patho-gens . The pathogens…     

Experimental Study of Multi-slice Spiral CT Perfusion Imaging in VX2 Soft-tissue Tumor of Rabbits

Malignant tumors are commonly characterizedby neo-vascularity and increased angiogenic activi-ty.As a result,malignant tumors may have ahigher proportion of i mmature and hyper-permea-ble vessels than normal tissues and benigntumors[1].Bothfor the assessment of tumor malig-nancy at initial presentation and for tumor monito-ring during treat ment and follow-up,there is aneed for noninvasive methods to assess tumor biol-ogy in vivo.Especially with the ongoing develop-ment of anti-angiogenic ther…     

Effects of Simvastatin on NF-κB-DNA Binding Activity and Monocyte Chemoattractant Protein-1 Expression in a Rabbit Model of Atherosclerosis

Previous studies have demonstrated that ex-peri mental hypercholesterolemialeads to the ather-oma formation and thus lipid lowering could de-crease the development of atherosclerosis . Recentevidence showed that inflammatory responsesmight play an i mportant role in the process ofatherogenesis[1]. Therefore , anti-inflammatorytherapy has become an i mportant therapeuticmeans for the prevention of atherosclerosis .In re-cent years , 3-hydroxy-3-methylglutaryl coenzymeA ( HMG-CoA) reductase in…