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肝硬化是一种以肝组织弥漫性纤维化、假小叶和再生结节形成为特征的慢性肝病[1],是我国常见疾病和主要死亡病因之一。肝硬化分为代偿期和失代偿期,失代偿期以肝功能减退和门脉高压为主要临床表现,常并发食管胃静脉曲张破裂出血、肝性脑病、感染、肝肾综合症、电解质紊乱等并发症,死亡率很高。肝硬化的病理改变,是肝实质的损害,以瘀血阻络为主要矛盾。由于淤结日久、肝脾损伤,其临床表现呈本虚标实,治疗颇为棘手。中医药治疗肝硬化历史悠久,确能改善症状和肝功能[1]。通过临床反复实践,我们自拟软肝散治疗早期肝硬化病人35例,取得一定疗效。 相似文献
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刘平 《中国中西医结合杂志》2015,35(3):0268-0271
肝纤维化是各种慢性肝病向肝硬化发展的必经病理过程,其准确的诊断与有效治疗是改善慢性肝病预后、降低慢性肝病病死率的重要途径之一。近十多年来,随着慢性乙肝(CHB)/丙肝(CHC)抗病毒治疗的研究的发展,对肝纤维化(包括早期肝硬化)病理组织学的可逆性及失代偿期肝硬化的肝功能改善翻开了新篇章;复方中药治疗难治性CHC肝纤维化美国Ⅱ期临床试验的成功实施为发挥中医药在治疗难治性病变 相似文献
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目的探讨轻微型肝性脑病患者的临床特征、发病危险因素及中医证候特点。方法对2017年6月—2018年10月首都医科大学附属北京地坛医院中西医结合中心住院部收治的120例肝硬化患者的临床资料进行分析,并对患者的中医证候特征进行研究。结果轻微型肝性脑病患者52例,占43.3%,其中男32例,女20例;非轻微型肝性脑病患者68例,占56.7%,其中男41例,女27例。与非轻微型肝性脑病组比较,轻微型肝性脑病组失代偿期患者明显增多(P0.05),child分级明显增高(P0.05),白蛋白水平明显降低(P0.05)。经Logistic回归分析发现,白蛋白和child分级是轻微型肝性脑病发生的危险因素(P0.05)。肝肾阴虚证和瘀血阻络证为轻微型肝性脑病患者的最主要证候。结论轻微型肝性脑病患者多发于肝硬化失代偿期,肝脏损害越严重,轻微型肝性脑病发生率越高。 相似文献
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本文介绍采用中医药辨治酒精性肝硬化失代偿期案例,说明部分失代偿期肝硬化经中医辨证治疗后,肝纤维化可有效逆转,肝功能可恢复正常,显示中医治疗肝硬化的优势。 相似文献
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目的:通过对乙肝肝硬化失代偿期患者进行回顾性研究,探索乙肝肝硬化失代偿期的证候特征与客观指标的相关性,为探索乙肝肝硬化失偿期的证候规律提供有力的证据。方法:运用回顾性研究,对373例2002年10月—2010年4月在广东省中医院肝病科、消化科的乙肝肝硬化失代偿期患者的资料,分析患者的中医证型与肝功能、HBV DNA定量、血常规等常见客观指标的相关性。结果:湿热蕴结型中ALT、AST、TBIL值明显高于其他各组,ALB值肝肾阴虚型明显低于肝郁脾虚证型,而GLB值肝肾阴虚型明显高于肝郁脾虚证型,HBV-DNA、AFP、血脂血糖、凝血、血常规进行了分析未发现之间的明显规律性。结论:肝功能是判断疾病变化发展的重要指标之一,对于协助中医辨证判断疾病的阶段及预后评估可起到一定的作用。 相似文献
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目的建立微波消解-电感耦合等离子体质谱(ICP-MS)直接稀释测定脉络宁注射液中25种矿物质元素(Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V、As、Cd和Hg)的方法。方法分别对微波消解条件和测试条件进行考察;样品经微波消解后,采用电感耦合质谱仪测定25种矿物质元素,并对测定方法学进行考察。结果确定最佳消解条件为3步缓慢升温:400 W 80℃升温10 min,保留5 min;600 W 120℃升温10 min,保留5 min;900 W 200℃升温20 min,保留20 min;25种矿物质元素在各自的线性范围内线性关系良好,r≥0.999 6,精密度、稳定性和重复性试验的RSD均符合定量分析要求;加标回收率为94.7%~106.1%,RSD在0.34%~2.79%。脉络宁注射液中检测出Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V,未检出As、Cd和Hg。结论该方法简便、迅速、准确,适用于脉络宁注射液中25种矿物质元素的同时测定。 相似文献
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O. Mastalier 《Deutsche Zeitschrift für Akupunktur (in deutscher Sprache / in German)》2013,56(4):26-29
The disturbance and instability of laterality are obstacles to diagnostics and therapy. Correction prior to starting therapy is required. They also predispose toward defined health problems and unspecific diseases. Numerous research activities provide evidence of the relevance of undisturbed laterality in diagnostics and therapy. Techniques of testing and therapeutic corrections will allow for optimized therapy success. 相似文献
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Chen Han-ping 《针灸推拿医学(英文版)》2014,(5):I0003-I0004
The Journal of Acupuncture and Tuina Science, a journal with an international scope (IS SN 1672-3597, CN 31-1908/R, Bimonthly), is embodied by 'Springer Verlag' Database, Index Copernicus (IC) and Chinese Scientific and Technical Paper and Citations Data (CSTPCD). You can search full text on http://www, springerlink, com/content/1672 -3597. 相似文献
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正Beverages based on Ilex paraguariensis A.St.-Hil.are used in the south Brazil and other Latin American countries located at the so-called southern cone.It is known as chimarro or mate in south and southeast Brazil,tererêin 相似文献
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This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity.
It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata e.g. Rheum palmatum R. palmatum var. tanguticum R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity. 相似文献
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H. Brandt B. Hauswald H. Langer J. Gleditsch Th. Zahnert 《Deutsche Zeitschrift für Akupunktur (in deutscher Sprache / in German)》2008
Background
At present, the state-of-the-art medication in treating idiopathic taste disorder (gustatory dysfunction) is zinc. If zinc medication was unsuccessful, not tolerated or if it is contraindicated the persons affected can hardly be helped.Objectives
In a randomized placebo-controlled clinical trial an attempt was made to determine the efficacy of acupuncture.Methods
The treatment group was treated with acupuncture needles, the placebo group with an inactive acupuncture-laser. Endpoints of the study were changes in the taste test, the quality of life and the severity of symptoms of depression (BDI) as well as mood changes (ZMS). Satisfaction with the success of the respective therapy was also evaluated. Data were collected before and after therapy and again for the treatment group 10 weeks after completion of the treatment period.Findings
Treatment with real acupuncture showed a significant improvement in gustatory function as well as a significant improvement in psychological symptoms. Greater satisfaction with the treatment results was evident in the treatment group. The treatment results of acupuncture remained stable over a period of ten weeks after completion of the treatment.Conclusion
Acupuncture was effective in the therapy of idiopathic taste disorders and therefore it is an effective alternative when zinc medication is not tolerated or unsuccessful. But it is also suitable as a therapy of first choice. Acupuncture can be considered as an extension of the therapeutic spectrum in the difficult treatment of taste disorders. 相似文献18.
Background
Experimental and clinical studies postulate a neurobiological mechanism of acupuncture by modulating central pain systems, neurohormones and -transmitters. It seems to be quite likely that the autonomic nervous system (ANS) plays an important mediating role in this neuromodulation.Aim
In measuring heart rate variability (HRV), as a non-invasive approach to the ANS-function, the object of this study was to monitor probable acupuncture-induced changes of autonomic balance. The innovative technology of laser-needle acupuncture offers for the first time a stimulation method which fulfils the demands on a placebo-controlled acupuncture trial not requiring controversial sham acupuncture.Method
19 healthy voluntary subjects underwent 3 treatments in randomized sequence, consisting of placebo-, 1-point- (PC 6) and simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle-stimulation over 20 minutes. Before, during and after placebo-/verum laser-needle acupuncture, HRV-data for normalized HF(high frequency)- and LF(low frequency)-Power (nHF, nLF) and their quotient nLF/nHF obtained by power spectrum analysis (FFT), were measured and analyzed statistically at 5 different time points (ANOVA repeated measures, p < 0,05).Results
During both verum applications, the 1-point- (PC 6) as well as the simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle stimulation, significant changes of the ANS-activity were found in comparison to the placebo application. The most significant modification of HRV was an increase of nHF (p < 0,05 (PC 6), p < 0,0001 (PC 6, LR 3, SI 3)) as an expression of growing vagal activity during acupuncture.Conclusion
Laser-needle acupuncture causes in 1-point-stimulation (PC 6) as well as in simultaneous 3-point-stimulation (PC 6, LR 3, SI 3) significant changes in HRV in comparison to placebo application. HRV-monitoring seems to be a suitable approach in exploration of acupuncture-induced changes of ANS and could possibly be established in combination with laser needle acupuncture as a standard for further scientific and clinical acupuncture investigations which are greatly needed. 相似文献19.
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目的采用HPLC梯度洗脱法同时测定沉香化滞丸中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚11种成分。方法采用Thermo Syncronis C18色谱柱(250 mm×4.6 mm,5μm),流动相为水-乙腈,梯度洗脱:0~10 min,20%乙腈;10~20 min,20%~40%乙腈;20~24 min,40%乙腈;24~26 min,40%~52%乙腈;26~30 min,52%乙腈;30~31 min,52%~90%乙腈;31~35 min,90%乙腈;35~40 min,90%~100%乙腈;40~43min,100%乙腈;43~45min,100%~20%乙腈;检测波长215nm,体积流量1.0m L/min,柱温30℃,进样量20μL。结果各成分在43 min内分离良好,沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚的线性范围分别为1.4~13.6、10.0~200.0、31.5~315.0、1.0~120.1、1.8~50.6、0.93~10.1、1.8~30.0、0.2~40.3、1.8~18.1、1.7~25.0、0.45~10.70μg/mL;样品中各成分的平均回收率均在98.90%~100.87%;11种成分精密度RSD在0.55%~1.54%;供试品溶液在30 h内稳定性良好,RSD在0.75%~1.94%;重复性RSD在0.39%~1.73%。6批次样品中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚质量分数分别为92.0~201.0、511.5~9 033.0、5 475.0~12 635.5、54.5~5 095.5、192.0~2 137.5、117.0~391.5、106.5~1 281.5、13.0~136.5、93.5~199.0、177.0~1 207.0、33.5~251.5μg/g。结论本方法准确、快速、简便,重复性好,精密度高,适用于沉香化滞丸中多种活性成分的定量分析。 相似文献