抗痫煎剂治疗特发性全身性强直-阵挛发作型癫痫的临床研究

目的:观察抗痫煎剂对特发性全身性强直-阵挛发作型癫痫的临床疗效、中医辨证分型的疗效差异以及脑电图的改变。方法:对照组:特发性全身性强直-阵挛发作性癫痫口服丙戊酸钠片0.2g次/,3次/日,不能控制者可加量至0.4g次/,3次/日;治疗组:全部患者均在按对照组用药基础上加用抗痫煎剂,两组均连用3个月为1个疗程,1个疗程后进行疗效评定。结果:两组总有效率比较,有显著性差异(P<0.05),治疗组优于对照组;同一证型治疗组与对照组有效率比较,风痰闭阻型非常有显著差异(P<0.01),痰火扰神,有显著性差异(P<0.05),血虚生风,心脾两虚,肝肾阴虚均无显著性差异。在改善脑电图方面治疗组亦优于对照组。结论:抗痫煎剂对特发性全身性强直-阵挛发作型癫痫有较好的抗痫作用,以风痰闭阻、痰火扰神尤佳,对脑电图的改善亦优于对照组。     

穴位埋线加小剂量抗痫西药治疗癫痫全身强直一阵挛发作临床观察

方法 :采用穴位埋线配合小剂量抗痫西药 (治疗组 )治疗癫痫全身强直—阵挛发作 6 4例 ,并与西药抗痫组 (对照组 ) 6 5例进行对照观察。结果 :①治疗组的临床疗效优于对照组 (P <0 0 5) ;②两组治疗后脑电图较治疗前均有改善 (P <0 0 1或P <0 0 5) ,治疗组优于对照组 (P <0 0 5)。③治疗组中原发性与继发性癫痫全身强直—阵挛发作的临床疗效相同 (P >0 0 5)。结论 :穴位埋线加小剂量抗痫西药治疗癫痫全身强直一阵挛发作基本无创伤 ,无局麻药过敏 ,能减轻抗痫西药副作用。     

穴位埋线加小剂量抗痫西药治疗癫痫全身强直——阵挛发作临床观察

方法：采用穴位埋线配合小剂量抗痫西药（治疗组）治疗癫痫全身强直－－阵挛发作64例,并与西药抗痫组（对照组）65例进行对照观察。结果：①治疗组的临床疗效优于对照组（P＜0.05）;②两组治疗后脑电图较治疗前均有改善（P＜0.01或P＜0.05）,治疗组优于对照组（P＜0.05）。③治疗组中原发性与继发性癫痫全身强直－－阵挛发作的临床疗效相同（P＞0.05）。结论：穴位埋线加小剂量亲西药治疗癫痫全身强直一阵挛发作基本无创伤,无局麻药过敏,能减轻抗痫西药副作用。     

柴贝止痫汤加减联合抗癫痫药物治疗难治性癫痫痰气郁滞证70例对照研究

目的观察柴贝止痫汤加减辅助治疗难治性癫痫痰气郁滞证的临床疗效和安全性。方法纳入难治性癫痫痰气郁滞证患者70例作为治疗组,按性别、年龄、病程、发作类型1∶1匹配对照组70例。对照组保持原有抗癫痫药物不变,治疗组在保持原有抗癫痫药物的基础上给予柴贝止痫汤加减辅助治疗。两组疗程均为12周,于治疗前及治疗4周、8周、12周比较两组患者癫痫发作频次、癫痫积分(针对全面性强直-阵挛发作患者)、癫痫发作伴随症状积分及脑电图,记录药物保留率及不良反应,并评价临床疗效。结果两组最终各纳入66例,其中全面性强直-阵挛发作37个匹配组。治疗组患者治疗后不同时间点癫痫发作频次、癫痫积分、癫痫发作伴随症状积分均较治疗前下降(P 0. 01或P 0. 05),且与对照组同时间比较,差异均有统计学意义(P 0. 01或P 0. 05)。治疗4周、8周、12周后,治疗组癫痫发作频次疗效、癫痫积分疗效、癫痫发作伴随症状积分疗效均优于对照组,差异具有统计学意义(P 0. 01或P 0. 05)。仅治疗组1例患者经治疗后脑电图由中度异常变成轻度异常,其余所有患者的脑电图异常程度在治疗前后均未见明显变化;两组均未发现严重不良反应;两组间药物保留率差异无统计学意义(P 0. 05)。结论柴贝止痫汤加减辅助治疗难治性癫痫痰气郁滞证患者可降低癫痫发作频率,改善癫痫发作伴随症状。     

小儿定风汤剂治疗小儿原发性癫痫强直一阵挛性发作(痰热挟惊证)30例临床观察

目的 观察小儿定风汤剂治疗小儿原发性癫痫强直一阵挛性发作(痰热挟惊证)的有效性和安全性.方法 90例患儿随机分为3组,即定风汤剂组、抗痫胶囊组及熄风胶囊组.分别予小儿定风汤剂、抗痫胶囊及熄风胶囊治疗,12个月后观察其发作频率、发作持续时间、脑电图变化,评价其临床疗效及安全性.结果 小儿定风汤剂组总有效率达86.67%,优于抗痫胶囊组(P＜0.05),与熄风胶囊组比较差异无统计学意义(P＞0.05).小儿定风汤剂能显著减少癫痫患儿发作频率,缩短发作持续时间,改善脑电图.结论 小儿定风汤剂是治疗小儿原发性癫痫强直一阵挛性发作(痰热挟惊证)安全、有效的中药.     

小儿定风汤剂治疗小儿原发性癫痫强直-阵挛性发作（痰热挟惊证）30例临床观察

目的观察小儿定风汤剂治疗小儿原发性癫痫强直一阵挛性发作（痰热挟惊证）的有效性和安全性。方法90例患几随机分为3组，即定风汤剂组、抗痫胶囊组及熄风胶囊组。分别予小儿定风汤剂、抗痫胶囊及熄风胶囊治疗，12个月后观察其发作频率、发作持续时间、脑电图变化，评价其临床疗效及安全性。结果小儿定风汤剂组总有效率达86．67％，优于抗痫胶囊组（P〈0．05），与熄风胶囊组比较差异无统计学意义（P〉0．05）。小儿定风汤剂能显著减少癫痫患儿发作频率，缩短发作持续时间，改善脑电图。结论小儿定风汤剂是治疗小儿原发性癫痫强直一阵挛性发作（痰热挟惊证）安全、有效的中药。     

熄风定痫汤治疗卒中后迟发型癫痫40例临床观察

目的:观察熄风定痫汤治疗卒中后迟发型癫痫风痰闭阻证的临床疗效。方法:选择卒中后迟发型癫痫风痰闭阻证患者75例,将其随机分为治疗组40例和对照组35例。对照组给予卡马西平治疗,治疗组在对照组治疗的基础上给予熄风定痫汤治疗。2组疗程均为6个月,比较2组综合疗效、癫痫发作频率以及认知功能评分。结果:总有效率治疗组为92. 50%,对照组为74. 29%,2组比较,差异有统计学意义(P 0. 05);治疗后2组癫痫发作频率均较治疗前显著降低、MoCA评分均较治疗前显著升高,且治疗组均优于对照组,差异有统计学意义(P 0. 05)。结论:熄风定痫汤可有效提高卒中后迟发型癫痫风痰闭阻证疗效,减少癫痫发作频率,并改善患者认知功能,值得临床推广。     

加味镇心定痫汤对小儿癫痫痰火扰神证认识功能和生活质量的影响

目的:探讨加味镇心定痫汤对小儿癫痫(痰火扰神证)认识功能和生活质量的影响及其抗炎、抗氧化应激作用。方法:将124例患者采用SAS软件生成,随机按数字表法分为对照组和观察组各62例。对照组口服左乙拉西坦片,起始治疗剂量是10 mg·kg~(-1),根据临床效果及耐受性,剂量可以增加至30 mg·kg~(-1),2次/d。观察组在对照组治疗的基础上采用加味镇心定痫汤内服,1剂/d,每周服药5 d,停药2 d。两组疗程均连续治疗12个月。记录癫痫发作次数和持续时间,进行治疗前后脑电图检测和痰火扰神证评分;进行治疗前后癫痫患者生活质量问卷(QOLIE-AD-48)和韦氏儿童智力量表中国修订版(WISC-CR)评价;检测治疗前后高迁移率族蛋白B1(HMGB1),白细胞介素-6(IL-6),肿瘤坏死因子-α(TNF-α),超氧化物歧化酶(SOD)和丙二醛(MDA)水平。结果:观察组临床疗效总有效率为92.86%,高于对照组的78.18%(χ~2=4.844,P0.05);观察组脑电图疗效总有效率为96.43%,高于对照组的81.82%(χ~2=6.143,P0.05);治疗后观察组癫痫发作次数少于对照组,持续时间短于对照组,痰火扰神证评分低于对照组(P0.01);治疗后观察组QOLIE-AD-48量表癫痫态度、躯体功能、学校表现、健康观念、羞耻感、记忆注意力、癫痫影响等因子评分均高于对照组(P0.01);治疗后观察组患者WISC-CR量表中言语智商(VIQ),操作智商(PIQ),总智商(FIQ)均高于对照组(P0.01);治疗后观察组患者HMGB1,IL-6,TNF-α和MDA水平均低于对照组,SOD水平高于对照组(P0.01)。结论:加味镇心定痫汤联合左乙拉西坦片治疗儿童癫痫(痰火扰神证),能控制癫痫的发作,改善临床症状,提高患儿的生活质量和认识能力,并具有一定的抗炎症反应和抗氧化损伤作用,临床疗效优于单纯的西医治疗。     

小儿抗痫胶囊治疗儿童癫痫及其神经生化机制的研究

本课题在930例儿童癫痫证候学研究基础上，提出“健脾顺气、豁痰熄风”法应视为小儿癫痫的基本治疗法则。通过其代表方剂“小儿抗痫胶囊”治疗儿童癫痫930例临床观察及小儿抗痫胶囊、鲁米那对照治疗儿童癫痫风痰闭阻证(强直-阵挛性发作)401例临床研究，表明小儿抗痫胶囊对风痰闭阻证、痰阻气逆证的疗效较好，惊痫痰聚证次之，对痰瘀交     

中西医结合治疗月经性癫痫1例

患者于月经初潮后首次出现癫痫发作,多于排卵前出现全面强直-阵挛发作,属于排卵期月经性癫痫。结合患者的发作特点、症状、体征,辨证属肾精不足,风痰闭阻证,治以益肾填精、豁痰息风。患者既往服用拉莫三嗪、丙戊酸钠疗效欠佳,添加中药治疗后发作得到控制。     

微波消解-电感耦合等离子体质谱法测定脉络宁注射液中25种矿物质元素

目的建立微波消解-电感耦合等离子体质谱(ICP-MS)直接稀释测定脉络宁注射液中25种矿物质元素(Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V、As、Cd和Hg)的方法。方法分别对微波消解条件和测试条件进行考察;样品经微波消解后,采用电感耦合质谱仪测定25种矿物质元素,并对测定方法学进行考察。结果确定最佳消解条件为3步缓慢升温:400 W 80℃升温10 min,保留5 min;600 W 120℃升温10 min,保留5 min;900 W 200℃升温20 min,保留20 min;25种矿物质元素在各自的线性范围内线性关系良好,r≥0.999 6,精密度、稳定性和重复性试验的RSD均符合定量分析要求;加标回收率为94.7%~106.1%,RSD在0.34%~2.79%。脉络宁注射液中检测出Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V,未检出As、Cd和Hg。结论该方法简便、迅速、准确,适用于脉络宁注射液中25种矿物质元素的同时测定。     

Die Lateralität und Lateralitätsinstabilität in der Diagnostik und Therapie

The disturbance and instability of laterality are obstacles to diagnostics and therapy. Correction prior to starting therapy is required. They also predispose toward defined health problems and unspecific diseases. Numerous research activities provide evidence of the relevance of undisturbed laterality in diagnostics and therapy. Techniques of testing and therapeutic corrections will allow for optimized therapy success.     

Journal of Acupuncture and Tuina Science Instructions for Authors

The Journal of Acupuncture and Tuina Science, a journal with an international scope （IS SN 1672-3597, CN 31-1908/R, Bimonthly）, is embodied by ＇Springer Verlag＇ Database, Index Copernicus （IC） and Chinese Scientific and Technical Paper and Citations Data （CSTPCD）. You can search full text on http：//www, springerlink, com/content/1672 -3597.     

Yerba Mate or Paraguay Tea

正Beverages based on Ilex paraguariensis A.St.-Hil.are used in the south Brazil and other Latin American countries located at the so-called southern cone.It is known as chimarro or mate in south and southeast Brazil,tererêin     

Ethnopharmacologic study of chinese rhubarb

This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity.

It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata e.g. Rheum palmatum R. palmatum var. tanguticum R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity.     

Wirksamkeit der Akupunktur bei der Therapie von idiopathischen Schmeckstörungen: Eine randomisierte Placebo-kontrollierte Studie

Background

At present, the state-of-the-art medication in treating idiopathic taste disorder (gustatory dysfunction) is zinc. If zinc medication was unsuccessful, not tolerated or if it is contraindicated the persons affected can hardly be helped.

Objectives

In a randomized placebo-controlled clinical trial an attempt was made to determine the efficacy of acupuncture.

Methods

The treatment group was treated with acupuncture needles, the placebo group with an inactive acupuncture-laser. Endpoints of the study were changes in the taste test, the quality of life and the severity of symptoms of depression (BDI) as well as mood changes (ZMS). Satisfaction with the success of the respective therapy was also evaluated. Data were collected before and after therapy and again for the treatment group 10 weeks after completion of the treatment period.

Findings

Treatment with real acupuncture showed a significant improvement in gustatory function as well as a significant improvement in psychological symptoms. Greater satisfaction with the treatment results was evident in the treatment group. The treatment results of acupuncture remained stable over a period of ten weeks after completion of the treatment.

Conclusion

Acupuncture was effective in the therapy of idiopathic taste disorders and therefore it is an effective alternative when zinc medication is not tolerated or unsuccessful. But it is also suitable as a therapy of first choice. Acupuncture can be considered as an extension of the therapeutic spectrum in the difficult treatment of taste disorders.     

Veränderungen der Herzratenvariabilität (HRV) während Low Level Lasernadelakupunktur: Placebokontrollierte Studie an 19 herzgesunden Probanden

Background

Experimental and clinical studies postulate a neurobiological mechanism of acupuncture by modulating central pain systems, neurohormones and -transmitters. It seems to be quite likely that the autonomic nervous system (ANS) plays an important mediating role in this neuromodulation.

Aim

In measuring heart rate variability (HRV), as a non-invasive approach to the ANS-function, the object of this study was to monitor probable acupuncture-induced changes of autonomic balance. The innovative technology of laser-needle acupuncture offers for the first time a stimulation method which fulfils the demands on a placebo-controlled acupuncture trial not requiring controversial sham acupuncture.

Method

19 healthy voluntary subjects underwent 3 treatments in randomized sequence, consisting of placebo-, 1-point- (PC 6) and simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle-stimulation over 20 minutes. Before, during and after placebo-/verum laser-needle acupuncture, HRV-data for normalized HF(high frequency)- and LF(low frequency)-Power (nHF, nLF) and their quotient nLF/nHF obtained by power spectrum analysis (FFT), were measured and analyzed statistically at 5 different time points (ANOVA repeated measures, p < 0,05).

Results

During both verum applications, the 1-point- (PC 6) as well as the simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle stimulation, significant changes of the ANS-activity were found in comparison to the placebo application. The most significant modification of HRV was an increase of nHF (p < 0,05 (PC 6), p < 0,0001 (PC 6, LR 3, SI 3)) as an expression of growing vagal activity during acupuncture.

Conclusion

Laser-needle acupuncture causes in 1-point-stimulation (PC 6) as well as in simultaneous 3-point-stimulation (PC 6, LR 3, SI 3) significant changes in HRV in comparison to placebo application. HRV-monitoring seems to be a suitable approach in exploration of acupuncture-induced changes of ANS and could possibly be established in combination with laser needle acupuncture as a standard for further scientific and clinical acupuncture investigations which are greatly needed.     

瑞香科五属植物中酚性聚合物的结构特征、分布及药理活性研究进展

瑞香科植物广泛分布于世界热带和温带地区,其中多种植物可供药用。在对该科植物的研究中发现,黄酮类、木脂素和香豆素等酚性化合物的低聚体为其重要的特征性成分,药理活性主要表现在抗肿瘤、抗炎、抗氧化、抗菌和抗病毒等方面。对已发现的酚性聚合体的化学结构、植物来源及药理活性进行综述,为瑞香科植物今后的研究和开发利用提供参考。     

HPLC法同时测定沉香化滞丸中11种成分

目的采用HPLC梯度洗脱法同时测定沉香化滞丸中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚11种成分。方法采用Thermo Syncronis C18色谱柱(250 mm×4.6 mm,5μm),流动相为水-乙腈,梯度洗脱:0～10 min,20%乙腈;10～20 min,20%～40%乙腈;20～24 min,40%乙腈;24～26 min,40%～52%乙腈;26～30 min,52%乙腈;30～31 min,52%～90%乙腈;31～35 min,90%乙腈;35～40 min,90%～100%乙腈;40～43min,100%乙腈;43～45min,100%～20%乙腈;检测波长215nm,体积流量1.0m L/min,柱温30℃,进样量20μL。结果各成分在43 min内分离良好,沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚的线性范围分别为1.4～13.6、10.0～200.0、31.5～315.0、1.0～120.1、1.8～50.6、0.93～10.1、1.8～30.0、0.2～40.3、1.8～18.1、1.7～25.0、0.45～10.70μg/mL;样品中各成分的平均回收率均在98.90%～100.87%;11种成分精密度RSD在0.55%～1.54%;供试品溶液在30 h内稳定性良好,RSD在0.75%～1.94%;重复性RSD在0.39%～1.73%。6批次样品中沉香四醇、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、大黄素、厚朴酚、木香烃内酯、去氢木香内酯、大黄酚、大黄素甲醚质量分数分别为92.0～201.0、511.5～9 033.0、5 475.0～12 635.5、54.5～5 095.5、192.0～2 137.5、117.0～391.5、106.5～1 281.5、13.0～136.5、93.5～199.0、177.0～1 207.0、33.5～251.5μg/g。结论本方法准确、快速、简便,重复性好,精密度高,适用于沉香化滞丸中多种活性成分的定量分析。