频域OCT对正常人和青光眼光感受器细胞层厚度的检测

背景青光眼以视网膜内层的神经节细胞丢失为主要病理特征,但其是否累及视网膜外层尚有争议。部分研究认为青光眼将导致视网膜外层（光感受器）功能的异常,而病理学研究得出了不同的结论。目的用频域OCT测量正常人和青光眼患者光感受器细胞层的厚度,探讨青光眼对光感受器细胞层厚度的影响。方法采用病例对照研究。用频域OCT（SDOCT）对正常人38例38眼和青光眼患者48例48眼的黄斑区进行扫描,由一位检测者采用Sigma图像分析软件盲法测量黄斑中心凹和旁中心凹处（中心凹外1．5mm）视网膜光感受器层的厚度。同时采用时域OCT（Stratus OCT）测量所有检测眼的视盘周围视网膜神经纤维层（RNFL）厚度,比较正常组和青光眼组光感受器细胞核层的平均厚度,分析光感受器细胞层厚度与RNFL厚度的关系。结果正常组和青光眼组在黄斑中心凹光感受器细胞核层厚度分别是（96．7±10．7）μm、（103．7±13．3）μm,差异有统计学意义（P=0．011）;中心凹光感受器内节和外节层厚度分别是（59．3±5．5）μm、（59．5±5．5）μm,差异无统计学意义（P=0．890）。正常组和青光眼组在中心凹外3mm处光感受器细胞核层厚度分别是（70．9±14．0）μm、（68．7±10．7）μm,光感受器内节和外节层厚度分别为（45．2±6．4）μm,（43．6±5．5）μm,差异均无统计学意义（P=0．410,P=0．228）。黄斑中心凹处光感受器细胞核层厚度和RNFL厚度两者有二元线性关系（γ=-0．019X。＋2．73X＋10．34,R^2=0．211,P=0．005）。结论青光眼的黄斑中心凹光感受器细胞核层显著增厚,并随病程的变化而改变。     

黄斑裂孔的光学相干断层成像分析

目的 探讨黄斑裂孔的光学相干断层成像（ｏｐｔｉｃａｌ ｃｏｈｅｒｅｎｃｅ ｔｏｍｏｇｒａｐｈｙ,ＯＣＴ）特征及ＯＣＴ临床应用价值。方法 １９９８年９～１２月临床诊断为黄斑裂孔者共３５例（３８只眼）。经双眼散瞳后进行ＯＣＴ检查,对获取的图像进行分析和测量。结果 １例（１只眼）ＯＣＴ显示为玻璃牵引：１例（１只眼）为黄斑前膜所致的性裂孔：３３例（３６只眼）为黄斑裂孔,其中３例累及双眼。３６只眼中,板层黄     

视网膜中央动脉阻塞的光相干断层扫描 病理形态学改变

目的观察视网膜中央动脉阻塞（CRAO）的光相干断层扫描（OCT）病理形态学改变特征。方法通过检眼镜、荧光素眼底血管造影(FFA)检查确诊的CRAO患者53例（53只眼）进行OCT检查，所有患者发病2周内。OCT检查采用水平或垂直线性扫描，扫描部位为黄斑区、后极部视网膜、视盘及出血、渗出等相应病灶部位。结果CRAO的OCT活体病理改变的图像特征包括黄斑区及后极部全层视网膜厚度增加、反射增强，光感受器暗区增宽（水肿）；黄斑中心凹水肿或囊样水肿；后极部视网膜出血及棉絮斑可有不同的OCT表现；视盘边缘隆起，呈水肿改变；其中4例患者伴有睫状视网膜动脉，在睫状视网视膜动脉供应区视网膜结构正常。结论OCT可以无创伤地在活体上观察CRAO的视网膜组织病理改变，特别适用于不允许进行FFA检查的高龄或合并全身病的CRAO患者，其独特的OCT图像病理改变可以为临床即时诊断提供客观依据。(中华眼底病杂志,2005,21:74-78)     

Adaptive optics and the eye (super resolution OCT)

The combination of adaptive optics (AO) and optical coherence tomography (OCT) was first reported 8 years ago and has undergone tremendous technological advances since then. The technical benefits of adding AO to OCT (increased lateral resolution, smaller speckle, and enhanced sensitivity) increase the imaging capability of OCT in ways that make it well suited for three-dimensional (3D) cellular imaging in the retina. Today, AO-OCT systems provide ultrahigh 3D resolution (3 × 3 × 3 μm3) and ultrahigh speed (up to an order of magnitude faster than commercial OCT). AO-OCT systems have been used to capture volume images of retinal structures, previously only visible with histology, and are being used for studying clinical conditions. Here, we present representative examples of cellular structures that can be visualized with AO-OCT. We overview three studies from our laboratory that used ultrahigh-resolution AO-OCT to measure the cross-sectional profiles of individual bundles in the retinal nerve fiber layer; the diameters of foveal capillaries that define the terminal rim of the foveal avascular zone; and the spacing and length of individual cone photoreceptor outer segments as close as 0.5° from the fovea center.     

Multifocal electroretinogram in diabetic subjects

PurposeTo identify local retinal abnormalities and evaluate the nature and extent of retinal dysfunction in diabetics using full field electroretinogram (ERG) and multifocal ERG (MF-ERG) and to determine the correlation between features of optical coherence tomography (OCT) and MF-ERG.MethodsTwenty-eight normal subjects (Control Group; 56 eyes) and 37 patients (72 eyes) with diabetes mellitus (DM Group) were evaluated. In the DM Group, 17 eyes had no retinopathy (grade 1), 18 eyes had early non proliferative diabetic retinopathy (NPDR) (grade 3), 16 eyes had late NPDR (grade 4), 21 eyes had proliferative diabetic retinopathy (PDR) (grade 5). Full field ERG and MF-ERG, were used to assess the effects of diabetic retinopathy on retinal function. OCT and fluorescein angiography were used to assess and compare morphological changes with functional changes in diabetes mellitus.ResultsIn diabetic patients without retinopathy (17 eyes), the amplitudes of the second order component of MF-ERG were reduced and implicit times were delayed, while only implicit times of first order component of MF-ERG were delayed but the amplitudes of first order component were normal. In diabetic patients with retinopathy (55 eyes), the overall amplitudes were reduced and peak implicit time increased in the first order component and second order component.OCT of the DM Group showed the fovea of eyes with edema were thicker than the Normal Group. The fovea of eyes with cystoid macular edema (CME) were significantly thicker than the fovea of eyes with diffuse swelling. The implicit times of MF-ERG were directly correlated with foveal thickness.ConclusionMF-ERG reveals local retinal dysfunction in diabetic patients. MF-ERG offers the advantage of topographic mapping of retinal dysfunction. The magnitude of delay of MF-ERG implicit time reflects the degree of local clinical abnormalities in eyes with retinopathy. Local response delays found in eyes without retinopathy detects subclinical local retinal dysfunction in diabetics. The combination of OCT and MF-ERG may provide objective criteria for evaluation and assessment of diabetic retinopathy.     

视网膜分支动脉阻塞的光相干断层扫描病理形态学改变

目的 观察视网膜分支动脉阻塞（BRAO）的光相干断层扫描（OCT）病理形态学改变特征。 方法 对2002年12月至2005年6月在本中心确诊的BRAO患者26例（26只眼）进行OCT检查，所有患者发病2周内。OCT检查采用水平或垂直线性扫描，扫描部位为黄斑区、后极部视网膜，测量黄斑中心小凹视网膜厚度，用方差分析比较不同阻塞部位黄斑区视网膜厚度，用Pearson相关分析分析视网膜厚度与视力的关系。 结果 26只BRAO眼中，9只眼为颞上支动脉阻塞，8只眼为颞下支动脉阻塞，7只眼为小动脉阻塞，2只眼为睫状视网膜动脉阻塞；OCT活体病理改变的图像特征表现为受阻塞动脉供应的视网膜部位全层视网膜厚度增加、反射增强，光感受器暗区增宽（水肿）；黄斑中心凹水肿不明显；其余部位视网膜OCT图像正常；视网膜颞上支动脉阻塞、视网膜颞下支动脉阻塞和视网膜小动脉阻塞黄斑中心小凹视网膜平均厚度分别是(161.11±17.66)、(148.38±18.48)、(136.29±14.94) μm（F＝4.137，P＝0.031）。24只眼黄斑中心小凹视网膜厚度与视力进行相关分析，r＝0.285，P＝0.176。 结论 OCT可以无创伤地在活体上观察BRAO的视网膜组织病理改变，BRAO黄斑中心小凹视网膜厚度增加不明显且与视力无相关关系。OCT适用于不允许进行FFA检查的高龄或合并全身病的BRAO患者，其独特的活体病理形态改变可以为临床即时诊断提供客观依据。 (中华眼底病杂志，2007，23：173-176)     

黄斑水肿的光相干断层扫描分析

目的 观察黄斑水肿的光相干断层扫描（OCT）图像特征；探讨黄斑中心凹厚度与最佳矫正视力之间的关系。 方法 对50例正常对照者以及47例54只经直接、间接检眼镜、三面镜及荧光素眼底血管造影（FFA）诊断为黄斑水肿的患眼进行OCT检查，通过黄斑中心凹的水平或垂直方向线性扫描，测量黄斑中心凹的厚度，对比分析两组受检者的黄斑形态及中心凹厚度值，根据形态学特点对黄斑水肿者的OCT图像进行分类并将其中心凹厚度与其最佳矫正视力进行相关分析。 结果 正常对照组与黄斑水肿组黄斑形态及中心凹厚度差异有显著性的意义。黄斑水肿患眼的OCT图像表现为3种特征，20只眼表现为黄斑区视网膜海绵样肿胀，占37.1%；26只眼表现为黄斑囊样水肿，占48.1%；8只眼表现为浆液性视网膜神经上皮脱离，占14.8%。黄斑水肿者黄斑中心凹厚度与其最佳矫正视力呈负相关（r=－0.569, P=0.000）。 结论 黄斑水肿的OCT图像主要包括视网膜海绵样肿胀、黄斑囊样水肿及神经上皮浆液性脱离。黄斑水肿患者的黄斑中心凹厚度明显增厚，黄斑中心凹厚度越厚，视力越差。 （中华眼底病杂志，2004，20：152-155）     

Optical coherence tomography findings in idiopathic juxtafoveal retinal telangiectasis

Purpose To describe optical coherence tomography (OCT) findings in patients with juxtafoveal retinal telangiectasis (JRT). Methods Fourteen consecutive patients (28 eyes) with JRT (12 patients with JRT type II, one with JRT type I and one with JRT type III) were examined using fluorescein angiography (FA) and OCT. Results Despite prominent leakage in FA, macular oedema was absent in all 26 eyes with type II JRT. In contrast to that, in patients with type I and type III JRT, cystoid macular oedema was evident. In 14 of 28 eyes (all with type II JRT), a single foveal cyst was found in OCT. It varied significantly in size and was associated with visual acuity decrease. An intraretinal hyperreflective lesion was seen in eight of 28 eyes and flattening of the fovea in three eyes. Conclusions Foveal cyst, absent macular oedema, intraretinal hyperreflective lesions and foveal flattening were the most common OCT findings in patients with JRT type II. These may represent progressive loss of retinal tissue, possibly due to Müller cells degeneration, and provide additional diagnostic criteria for JRT.     

Macular gradient measurement in myopic posterior staphyloma using optical coherence tomography

Purpose

To evaluate clinical characteristics and the macular gradient in myopic posterior staphyloma with time domain (TD) optical coherence tomography (OCT).

Methods

Sixty-four staphyloma eyes of 40 patients were examined. Macular gradient (tangent θ) and the location of staphyloma were assessed with OCT imaging. The macular gradient was measured at points 1 mm and 2 mm distant from the fovea. The relationships of the macular gradient with age, axial length, and spherical equivalent were analyzed.

Results

In 8 eyes (12.5%), the bottoms of the staphylomas were in the fovea, and there was no macular gradient. However, in the other 56 eyes (87.5%), the bottoms of the staphylomas were not in the foveal area, and macular gradients existed. Staphylomas were commonly located in the infero-nasal retinal area. The mean macular gradient (tangent θ) was 0.26 ± 0.08 at 1 mm distance from the fovea and 0.28 ± 0.10 at 2 mm. No significant relationships were observed between macular gradient and axial length, patient age, or spherical equivalent.

Conclusions

TD OCT reveals staphyloma location. If the location is outside of the fovea, a macular gradient exists and can be measured by OCT. Axial length measurement error may occur in eyes with poor visual fixation and steep macular gradients.     

远视性单眼弱视患者黄斑区视网膜厚度的研究

目的通过检测远视性单眼弱视者弱视眼黄斑区视网膜厚度（MRT）,研究弱视眼视网膜神经上皮层厚度的特征。方法远视性单眼弱视患者42例,正常组单眼远视但无弱视者20例。采用光学相干断层扫描仪（OCT）测量弱视眼和正常眼的MRT。结果弱视眼黄斑中心凹厚度比正常眼厚（P=0．005）,对于黄斑部位的分区测量,黄斑中心区厚度弱视眼比正常眼厚（P=0．010）,而黄斑周围外环及内环各象限弱视眼和正常眼相比差异均无统计学意义（P〉0．05）。不同程度弱视患者问黄斑中心凹及黄斑各分区的视网膜厚度差异均无统计学意义（P〉0．05）。结论远视性单眼弱视眼黄斑中心区视网膜厚度增厚,不同程度弱视眼间的视网膜厚度差异无统计学意义。     

Macular thickness and systemic markers for diabetes in individuals with no or mild diabetic retinopathy

Background:  The relationship between diabetic risk factors and macular thickness in individuals without clinically detectable diabetic macular oedema has yet to be formally explored. The purpose of this study was to assess the correlation between macular thickness and diabetes control and duration.
Methods:  This was a prospective, cross-sectional study. All subjects underwent digital retinal imaging and Stratus OCT macular thickness scanning both eyes. Mean retinal thickness was determined for quadrants, rings, hemispheres, and for the central fovea (CFT), total fovea (TFT) and total macula (TMT).
Results:  We evaluated 92 non-diabetic controls, 92 diabetic subjects with no diabetic retinopathy (DR) and 24 subjects with mild DR at the Veteran's Hospital in Jamaica Plain, MA. In subjects with diabetes, there was a significant negative correlation between retinal thickness and diabetes duration in all macular quadrants, rings and hemispheres, and for CFT, TFT and TMT (CFT: P  = 0.0025, r  = −0.28; TFT: P  = 0.0062, r  = −0.25; TMT: P  = 0.0026, r  = −0.28). There was no significant relationship between retinal thickness and HbA1c level (average of last three readings), systolic or diastolic blood pressure, or triglyceride levels. Additionally, no significant differences in retinal thickness were found between controls, subjects with no DR and subjects with mild DR.
Conclusions:  In subjects with no or mild DR, macular and foveal thickness is significantly thinner with longer duration of disease. This may reflect neurodegenerative changes in the diabetic retina.     

Correlation between foveal structure and visual outcome following macular hole surgery: a spectral optical coherence tomography study

PURPOSE: The aim of this paper is to evaluate the retinal structure after macular hole surgery and to study the correlation of structural findings with final functional outcomes, using high-speed, high-resolution spectral optical coherence tomography (SOCT). METHODS: Sixty-eight eyes of 60 patients with full-thickness macular holes were included in the study. All patients underwent pars plana vitrectomy with trypan blue staining and internal limiting membrane (ILM) peeling. Patients were evaluated by SOCT, with 6 mum axial and 12-18 mum transverse resolution and three-dimensional images of the retina. RESULTS: There were four different types of macular hole closure: U-shape, V-shape, irregular and flat/open. The following retinal abnormalities were observed in postoperative scans: photoreceptor irregularities, lack of photoreceptors (photoreceptor defect), cysts in outer retinal layers, nerve fiber layer defects, lesion of all retinal layers, and RPE defects. It was possible to evaluate photoreceptor defects on a three-dimensional image. Retinal thickness in the fovea was also measured. CONCLUSIONS: Because of excellent resolution, SOCT is capable of visualization of retinal defects after macular hole surgery. Three-dimensional examination is adequate for evaluation of photoreceptor defects. Good postoperative visual acuity is correlated with U-shape closure, normal foveal thickness and absence of photoreceptor layer defects.     

视网膜脱离手术前后黄斑区光学相干断层成像图形特征观察

目的 :观察孔源性视网膜脱离手术前后黄斑区光学相干断层成像 (OCT)的形态特征及临床应用价值。方法 :对 2 8例 2 8眼孔源性视网膜脱离PVRB级以下的患者手术前后黄斑区中心凹进行OCT检查 ,对其图像及与手术前后视力进行分析。结果 :根据 2 8例患者术前临床观察及OCT扫描图像可分为两组四型 ;术后OCT检查显示有 11例 (3 9 2 9% )患者视网膜下仍有微量积液 ;两组四型黄斑中心凹平均RNFL比较无显著性差异 (P >0 0 5 )。结论 :OCT作为一种高分辨率的在眼内获得活体组织横断面的检查仪器 ,能直观、清晰地显示视网膜脱离手术前后黄斑区视网膜横断面的形态特征 ,发现一些临床不易观察的眼底细微改变 ,如黄斑区视网膜神经上皮下微量的积液、视网膜的水肿、囊腔样改变等     

高度近视眼黄斑区神经上皮层厚度的OCT检测研究

目的探讨高度近视眼黄斑区视网膜神经上皮层厚度的变化。方法选取200／年5月至2007年12月在我院就诊并行光学相干断层扫描（OCT）检查的高度近视眼患者64例（64只眼）和正常对照者铝例（48只眼），分为高度近视组和正常对照组，测量其黄斑中心凹、中心凹上下方及颞侧、鼻侧各750μm处的视网膜神经上皮层厚度，比较两组有无显著性差异。结果高度近视组的黄斑区视网膜神经上皮层厚度均低于正常对照组，二者差异有显著意义（P〈0．01）。结论高度近视眼黄斑区视网膜神经上皮层厚度明显低于正常眼，OCT能够精确量化测定该厚度变化。     

Stargardt病的频域相干光断层扫描图像分析

目的 应用频域相干光断层扫描(OCT)技术评价Stargardt病患者黄斑区视网膜容积与中心视力之间的关系.方法 回顾性病例系列研究.收集10例(20只眼)Stargardt病的临床资料进行回顾性分析.所有患者均使用频域OCT分别测量黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积.运用线性回归分析法,比较最小分辨角对数(logMAR)视力与黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节(IS/OS)缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内视网膜容积的关系.结果 18只眼的logMAR视力为0.30～1.22,黄斑中心凹区光感受器细胞内外节缺失宽度为847～5306μm,黄斑中心凹区视网膜厚度为20～126 μm,黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积分别为1.06～1.76 mm3、0.06～0.13 mm3.logMAR视力与黄斑中心凹区光感受器细胞内外节缺失宽度呈正相关(r=0.695,P＜0.05),与黄斑中心凹区视网膜厚度呈负相关(r=-0.601,P＜0.05),与黄斑中心凹区直径3 mm范围内的视网膜容积呈负相关(r=-0.725,P＜0.05),与黄斑中心凹区直径1 mm范围内的视网膜容积无相关性(r=-0.364,P＜0.05).结论 频域OCT技术可以清晰观察Stargardt 病患者各层视网膜结构,频域OCT检测获得的黄斑区视网膜容积与中心视力间存在一定的相关性.

Abstract：

Objective To assess the relationship between central visual acuity and retinal volume of macular fovea in patients with Stargardt disease by spectral-domain optical coherence tomography ( SD OCT). Methods It was a retrospective case series study. Twenty eyes of 10 patients with Stargardt disease were investigated by three-dimensional spectral-domain optical coherence tomography. SD OCT images were obtained and retrospectively analyzed. The retinal volumes of macular fovea were measured by SD OCT,whose diameters were set as 3 mm and 1 mm separately ( volume 3 and volume 1). The retinal thickness of macular fovea (macular thickness) and the width of IS/OS conjunction loss of macular fovea (IS/OS loss)were also measured by SD OCT. We correlated the logMAR BCVA with IS/OS loss, macular thickness,volume 3 and volume 1 by linear regression analysis. Results LogMAR BCVA was from 0. 3 to 1. 22.IS/OS loss was from 847 μm to 5306 μm. Macular thickness was from 20 μm to 126μm. Volume 3 and volume 1 was from 1. 06 to 1. 76 mm3 and 0. 06 to 0. 13 mm3. LogMAR BCVA correlated with the IS/OS loss (r = 0.695,P＜0. 05) , macular thickness (r= - 0. 601 ,P ＜ 0. 05), and volume 3 ( r = -0.725,P＜0. 05 ). LogMAR BCVA did not correlate with volume 1 ( r = - 0. 364, P ＞ 0. 05). Conclusions SD OCT could demonstrate the retinal structure of Stargardt disease clearly. The retinal volume of macular fovea accessed by SD OCT correlated with the visual acuity of Stargardt disease.     

Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT)

ABSTRACT

Amblyopia refers to visual impairment resulting from perturbations in visual experience during visual development, typically secondary to strabismus, uncorrected refractive error, and/or deprivation. Amblyopia has traditionally been considered a cortical disease, but the depth of our understanding of this complex neurodevelopmental condition is limited by our ability to appreciate structural pathophysiology in the visual pathway. Recent advances in Optical Coherence Tomography (OCT) have facilitated numerous studies of the structural changes in the retina and optic nerve, thereby expanding our appreciation for the pathogenesis of this condition. In this review, we summarize findings from studies evaluating retinal, retinal nerve fiber layer, and choroidal thickness changes in patients with amblyopia. Focusing on the largest and most recent studies, we discuss common limitations and confounding variables in these studies. We summarize recent advances in ocular imaging technology and reconcile the findings of early histological reports with those of structural OCT in amblyopia.     

糖尿病性黄斑水肿的光学相干断层扫描与荧光血管造影图像的对比分析

目的对比分析糖尿病视网膜病变患者的光学相干断层扫描(optical coherence tomography,OCT)与荧光血管造影(fluorescein angiographic,FA)图像。方法回顾性分析不同阶段糖尿病视网膜病变70例患者95眼的OCT和FA图像。结果OCT图像显示视网膜水肿占70.5%,囊样黄斑水肿(cystoid macular edema,CME)占13.7%,浆液性黄斑脱离并发水肿占4.2%,浆液性黄斑脱离并发水肿和CME占2.1%,正常黄斑结构占9.5%。结论OCT为糖尿病视网膜病变黄斑结构的变化提供了依据,特别是对FA未能发现的早期黄斑结构改变的诊断具有重要意义。     

玻璃体视网膜术后黄斑区视网膜光学相干断层扫描图像意义探讨

目的 探讨光学相干断层扫描图像(OCT)在玻璃体视网膜术后黄斑形态检测中的意义。方法应用zeissHumphrey OCT检查仪对48例(48眼)，经玻璃体视网膜术后临床检查为复位成功的患者黄斑区进行经中心凹水平和垂直扫描，观察黄斑形态，并测量中心凹神经上皮层厚度。结果 48眼接受检查，黄斑结构正常10眼；黄斑水肿12眼；黄斑变薄6眼；神经上皮下积液8眼；视网膜色素上皮脱离3眼；黄斑前膜7眼；黄斑裂孔2眼。术后黄斑的形态及中心凹神经上皮层厚度与术后视力存在一定关系。结论 OCT能精确探查玻璃体视网膜术后黄斑结构变化，并且在病变的定量随访中有重要意义。     

病理性近视黄斑部脉络膜新生血管光动力疗法治疗后光相干断层扫描观察结果分析

目的评价光相干断层扫描(OCT)检查在病理性近视(PM)所致的黄斑部脉络膜新生血管(CNV)光动力治疗(PDT)中的临床应用价值。方法对比分析25例PM患者28只患眼PDT治疗前后OCT图像中黄斑区视网膜高度及CNV复合体厚度,观察CNV与黄斑中心凹的关系。结果治疗前22只眼表现为CNV伴视网膜神经上皮水肿;2只眼为CNV合并神经上皮浆液性浅脱离;6只眼为CNV合并有视网膜层间出血。17只眼CNV位于中心凹处,11只眼位于中心凹旁。治疗后CNV强反光团逐渐缩小,神经上皮水肿或出血吸收,黄斑视网膜高度和CNV复合体厚度均显著降低(P值分别为0.02、0.03)。CNV复发表现为OCT图像中强反光团扩大,神经上皮水肿增厚,伴或不伴视网膜层间出血。结论OCT检查对于判定PM所致CNV的活动性以及决定是否进行PDT治疗和重复治疗有重要的辅助作用。     

急性视网膜坏死光相干断层扫描图像分析

目的 分析OCT对急性视网膜坏死的诊断价值.方法 回顾分析急性视网膜坏死的眼底照相和OCT图像特征,进行分析总结.结果 炎症急性期OCT显示黄白色视网膜病变的区域视网膜弥漫性水肿渗出呈高反射信号,其下结构反射信号屏蔽;神经上皮层下液体积存,视网膜各层组织结构紊乱.黄斑区OCT图像表现为弥漫性水肿,神经上皮层厚度增加,可见高反射渗出物.炎症消退期坏死区域视网膜与正常视网膜相比厚度明显减少,色素上皮破坏.结论 OCT能提供急性视网膜坏死患者视网膜精细的形态学特征,结合眼底彩照、眼部荧光造影检查对该病能进行较全面而精细的评估.