妊高征患者白细胞介素6与免疫球蛋白的相关性研究

目的　探讨妊高征患者白细胞介素 6 (IL- 6 )与免疫球蛋白 (Ig)的相关性。　方法　用放射免疫法检测妊高征患者 5 0例 (妊高征组 ,其中中度 2 4例 ,重度 2 6例 )及正常足月妊娠 30例 (正常足月妊娠组 )的母血、脐血中的 IL- 6含量 ,采用速率散射比浊法检测同样标本中的 Ig G、Ig M、Ig A的含量。　结果　重度妊高征患者母血中 IL- 6的含量为 (16 7.2 0± 72 .5 2 ) ng/ L,脐血中 IL- 6含量为 (133.2 0±85 .5 5 ) ng/ L,均较正常孕妇显著增高 ,差异显著 (P<0 .0 1,P<0 .0 1) ,中度妊高征患者母血中 IL- 6的含量为 (12 4.40± 86 .37) ng/ L,脐血中 IL- 6含量为 (97.33± 74.16 ) ng/ L,均较正常孕妇显著增高 ,差异显著 (P<0 .0 5 ,P<0 .0 5 )。中度妊高征母血 Ig G含量为 (7.0 1± 2 .0 9) g/ L,而重度妊高征母血 Ig G含量为 (7.43± 1.6 6 ) g/ L,均显著低于正常妊娠组 (P<0 .0 1,P<0 .0 1) ,与母血 IL- 6含量呈显著负相关关系 (r=- 0 .779,P<0 .0 1;r=- 0 .80 6 ,P<0 .0 1)。　结论　 IL- 6与 Ig G协同作用 ,共同参与了妊高征的免疫损伤过程 ,提示 :如能使母血中 IL- 6降低 ,Ig G升高 ,有可能防治妊高征。     

妊娠高血压综合征患者血清β绒毛膜促性腺激素及胎盘催乳素水平测定及其临

目的　探讨血清β绒毛膜促性腺激素 (β hCG)及胎盘催乳素 (HPL)的临床意义及其在妊娠高血压综合征 (妊高征 )发病中的作用。方法　用放射免疫法测定 142例正常妊娠妇女 (正常妊娠组 )及 43例妊高征妇女 (妊高征组 ,其中轻度 16例 ,中度 12例 ,重度 15例 )血清 β hCG及HPL水平。结果　 (1)轻、中、重度妊高征妇女血清 β hCG分别为 (2 5 33± 17 80 ) μg/L、(33 12± 4 91) μg/L、(42 19± 17 47) μg/L ;正常妊娠妇女为 (12 33± 7 92 ) μg/L ,妊高征组与正常妊娠组比较 ,差异有极显著性 (P <0 0 0 1)。β hCG水平与妊高征病情严重程度呈正相关(r=0 6 77,P <0 0 5 )。 (2 )轻、中、重度妊高征妇女血清HPL分别为 (14 73± 3 2 6 )mg/L、(11 44± 4 0 2 )mg/L、(12 73± 4 18)mg/L ;正常妊娠妇女为 (12 78± 4 6 7)mg/L。妊高征组与正常妊娠组比较 ,差异无显著性 (P >0 0 5 )。HPL水平与妊高征病情严重程度无相关 (r=- 0 30 0 ,P >0 0 5 )。结论　β hCG可反映妊高征时滋养细胞功能紊乱的程度及病情严重程度 ,可作为妊高征病情的监测指标之一。HPL水平的变化不能作为妊高征的检测指标。     

可溶性细胞粘附分子1、促肾上腺皮质激素释放激素及白细胞介素6在妊娠高血压综合征发病中的作用

目的　研究可溶性细胞粘附分子 1(soluble intracellular adhesion m olecule- 1,s ICAM-1)、促肾上腺皮质激素释放激素 (cortictropin- releasing horm one,CRH)及白细胞介素 6 (interleukin-6 ,IL- 6 )在妊娠高血压综合征 (妊高征 )发病中的作用。　方法　测定 81例妊娠 2 6～ 37周孕妇血浆s ICAM- 1、CRH、IL- 6水平 ,其中 2 3例 ,为正常孕妇 (正常妊娠组 ) ;5 8例为妊高征孕妇 (妊高征组 ) :包括轻度 2 1例、中度 19例、重度 18例。用酶联免疫法测定 s ICAM- 1及 IL- 6 ,用放射免疫法测定 CRH。　结果　中、重度妊高征患者的血 s ICAM- 1、CRH、IL- 6水平均显著高于正常对照组 (P<0 .0 5 ) ,轻度妊高征患者与正常组相比虽无统计学差异但有升高的趋势。IL- 6水平与 CRH呈正相关 (r=0 .5 1,P<0 .0 5 )。　结论　妊高征患者血 s ICAM- 1升高表明内皮细胞损伤在妊高征的发病中起重要作用。CRH分泌的异常增加可能与内皮细胞的损伤有关 ,该作用可能是通过促进 IL- 6的分泌实现的     

妊高征患者血浆和胎盘中环磷酸鸟苷浓度的变化及其意义

目的　探讨环磷酸鸟苷 (c GMP)在妊高征发病中的作用。　方法　采用放射免疫法测定 12 4例正常妊娠各期、32例妊高征患者及 30例健康对照者血浆 c GMP浓度。其中 32例正常足月孕妇和 32例妊高征患者于剖宫产时取胎盘组织测其匀浆 c GMP浓度。　结果　 (1)正常妊娠各期血浆 c GMP(2 6 .2 5± 4.30 )、(2 3.40± 4.5 4)、(2 6 .2 0± 6 .6 0 )、(34 .14± 8.41)、(32 .32± 8.11) nm ol/ L 显著高于健康对照者 (2 0 .2 2± 3.44 ) nm ol/ L (P均 <0 .0 5 )。 (2 )妊高征血浆及胎盘 c GMP(2 8.49± 8.98) ) nmol/ L与 (2 .76± 0 .49) nmol/ g均显著低于正常足月孕妇 (34 .14± 8.41) nmol/ L与(3.78± 0 .81) nmol/ g(P<0 .0 5 ,P<0 .0 0 1)。轻度妊高征患者血浆及胎盘 c GMP显著高于中度及重度患者 (P<0 .0 0 5 ,P<0 .0 5及 P<0 .0 5 ,P<0 .0 0 1)。妊高征患者血浆及胎盘 c GMP与舒张压均呈负相关 (P<0 .0 5 ,P<0 .0 5 )。 (3)妊高征患者胎盘 c GMP显著低于其血浆 c GMP(P<0 .0 0 1)。　结论　妊娠期间胎盘产生的 c GMP可能在妊高征的发病中起重要作用     

妊高征孕妇血清β-HCG及HPL水平测定

目的 :探讨血清 β绒毛膜促性腺激素 (β HCG)及胎盘泌乳素 (HPL)水平与妊娠高血压综合征 (妊高征 )之间的关系。方法 :用放射免疫法测定 1 1 8例正常妊娠妇女及 42例妊高征妇女血清 β HCG及HPL水平。结果 :正常妊娠妇女血清 β HCG为 1 2 .0 4± 5.62 μg/L ,妊高征妇女血清 β HCG为 2 2 .32± 9.40 μg/L,两组比较差异有显著性 (P <0 .0 5)。β HCG水平与妊高征病情严重程度呈正相关 (γ=0 .56P <0 .0 5) ;正常妊娠妇女血清HPL为 6.1 8± 3 .2 7mg/L ,妊高征妇女为 6 .35± 2 .79mg/L ,妊高征组与正常妊娠妇女组比较 ,差异无显著性 (P >0 .0 5)。结论 :β HCG可反映妊高征时胎盘滋养细胞功能紊乱程度及病情的严重程度     

妊高征患者血清瘦素水平变化的研究

目的 :探讨妊娠高血压综合征 (妊高征 )患者血清瘦素 (leptin)水平的变化及其与妊高征发病的关系。方法 :采用放射免疫分析法测定了 36例妊高征患者 (妊高征组 )和 30例正常孕妇 (正常妊娠组 )产前及产后血清瘦素水平。结果 :中、重度妊高征患者产前瘦素水平为 15 .19± 6 .74 ng/ ml明显高于正常妊娠组的 10 .11± 2 .80 ng/ m l(P<0 .0 5 ) ;轻度妊高征组患者产前瘦素水平 12 .77± 4 .6 8ng/ ml与正常妊娠组比较 ,差异无显著性 (P>0 .0 5 )。妊高征患者产后瘦素水平为 5 .91± 2 .6 8ng/ ml,与产前 14 .5 6± 6 .30 ng/ ml相比 ,差异显著 (P<0 .0 5 )。妊高征组产后瘦素水平与正常妊娠组 5 .74± 2 .38ng/ ml相比 ,差异无显著性。结论 :妊高征患者血清瘦素水平升高 ,与妊高征的发生有关     

妊娠高血压综合征患者血栓前状态功能指标的检测及其意义

目的　探讨妊娠高血压综合征 (妊高征 )患者的血小板活化状态、血管内皮损伤、止血及凝血系统部分功能指标的变化 ,对妊高征患者血栓前状态 (PTS)的诊断意义。方法　检测正常非孕妇女 3 0例 (正常非孕组 )、正常晚孕妇女 3 0例 (正常晚孕组 )和妊高征患者 5 0例 (妊高征组 )的血管性血友病因子 (vWF)、血小板α 颗粒膜蛋白 (GMP 140 )、蛋白C依赖的活化部分凝血酶原时间 (PCAT)、抗凝血酶 Ⅲ (AT Ⅲ )、纤维蛋白原 (Fbg)、纤溶酶原 (PLG)、组织纤溶酶原激活物 (t PA)及其抑制物 (PAI)、D 二聚体 (D Dimer)含量。结果　妊高征组GMP 140、vWF含量 [( 2 3 9± 3 6) μg/L ,( 15 6± 2 3 ) % ]与正常非孕组 [( 8 7± 2 5 ) μg/L ,( 82± 11) % ]及正常晚孕组 [( 11 9± 4 1) μg/L ,( 12 3± 2 7) % ]比较 ,均显著增高 (P <0 0 1) ,并随病情加重而呈增高趋势 ;而AT Ⅲ、蛋白C活性均显著下降 (P <0 0 1) ,且病情越重下降越明显 ;妊高征组与正常非孕组比较 ,Fbg、PLG、D Dimer、PAI含量均显著增高 (P <0 0 5 ) ,中、重度患者增高尤其明显 ,而t PA含量无显著性改变 (P >0 0 5 )。结论　正常晚期妊娠妇女存在PTS ,而妊高征患者存在明显的PTS。     

重度妊娠高血压综合征患者表皮生长因子及其受体水平的研究

目的　研究孕晚期重度妊娠高血压综合征 (妊高征 )并发及未并发胎儿生长受限(FGR)者的血浆表皮生长因子 (EGF)水平、胎盘组织 EGF受体 (EGFR)表达情况 ,探讨 EGF与妊高征的关系、EGF在妊高征及 FGR发生中的作用、EGF对妊高征胎儿生长发育的影响 ,为妊高征及FGR的病因研究及治疗提供依据。　方法　血浆 EGF及血清胎盘生乳素 (HPL )采用放射免疫分析法测定 ,胎盘组织 EGFR采用免疫组织化学方法测定。　结果　 (1)血浆 EGF浓度 ,重度妊高征组为(96± 46 ) ng/L ,明显低于对照组 (144± 36 ) ng/L ,(t=4.16 9,P<0 .0 1)。重度妊高征并发 FGR组为(89± 37) ng/L ,重度妊高征未并发 FGR组为 (10 1± 5 4) ng/L ,均明显低于对照组 ,Dunnett t=3.94、3.2 0 ,P<0 .0 1,但此二者之间差异无显著性 ,(t=0 .792 ,P>0 .0 5 )。(2 )血清 HPL与血浆 EGF呈正相关。(3)胎盘 EGFR染色情况。重度妊高征胎盘 EGFR的表达比对照组强 ,妊高征组染色通光度为 114± 8,对照组为 12 5± 9(t=4.74,P<0 .0 1) ,且无论妊高征并发或未并发 FGR,其胎盘 EGFR的表达都比对照组强 ,FGR组为 115± 8,NFGR组为 114± 7,Dunnett t值分别为 3.6 4、4.35 ,P值均 <0 .0 1。但在妊高征者 FGR组与 NFGR组之间差异无显著性 ,(t=0 .5 5 ,P>0 .0 5 )。     

同型半胱氨酸、叶酸、维生素B12与妊娠高血压综合征发病的关系

目的探讨同型半胱氨酸(Hcys)、叶酸、维生素B12与妊娠高血压综合征(妊高征)发病的关系. 方法采用荧光偏振免疫分析法检测59例妊高征患者(妊高征组)和60例正常晚期妊娠妇女(对照组)血清中Hcys水平;并同时用微粒子酶联免疫分析法检测两组孕妇血清中叶酸、维生素B12水平. 结果 (1)妊高征组孕妇血清Hcys水平为(13.1±3.7) μmol/L,对照组孕妇为(10.4±3.9) μmol/L, 两组比较,差异有显著性( P <0.05).(2)妊高征组孕妇血清叶酸、维生素B12水平分别为(12.9±4.0) μmol/L及(339.5±115.6) μmol/L; 对照组孕妇叶酸、维生素B12水平分别为(13.7±2.5) μmol/L及(350.1±153.0) μmol/L.两组比较,差异无显著性( P >0.05). 结论 Hcys代谢异常在妊高征发病中起重要作用,叶酸、维生素B12水平与妊高征发病无直接关系.     

妊娠高血压综合征患者血浆止凝血分子标志物水平变化的意义

目的探讨妊娠高血压综合征(妊高征)患者血浆止凝血分子标志物水平变化的意义.方法对45例妊高征孕妇(妊高征组,其中轻度20例、中度15例、重度10例)及20例正常孕妇(正常妊娠组)分娩前后的血浆止凝血分子标志物进行检测.其中,采用酶联免疫吸附试验(ELISA)检测两组孕妇分娩前后的P-选择素、凝血酶原片段1+2(F1+2)、D-二聚体、纤溶酶抗纤溶酶复合物(PAP);采用发色底物法检测两组孕妇分娩前后的抗凝血酶活性.结果 (1)P-选择素妊高征组中、重度孕妇分娩前分别为(66±24)μg/L、(80±30)μg/L,正常妊娠组为(49±15)μg/L,两组比较,差异有显著性(P<0.05).分娩后妊高征组重度孕妇为(65±34)μg/L,正常妊娠组为(40±12)μg/L,两组比较,差异有显著性(P<0.05).(2)F1+2妊高征组轻、中、重度孕妇分娩前分别为(2.2±0.2)nmol/L、(2.3±0.4)nmol/L、(2.2±0.2)nmol/L,均明显高于正常妊娠组的(1.2±0.3)nmol/L,两组比较,差异有显著性(P<0.05).(3)D-二聚体妊高征组轻、中、重度孕妇分别为(0.7±0.1)mg/L、(0.7±0.3)mg/L、(0.8±0.2)mg/L,正常妊娠组为(0.4±0.1)mg/L,妊高征组显著高于正常妊娠组(P<0.05),且妊高征组重度孕妇D-二聚体水平高于中度及轻度孕妇.(4)PAP妊高征组轻、中、重度孕妇分娩前分别为(0.7±0.4)mg/L、(0.8±0.4)mg/L、(0.8±0.4)mg/L,均高于正常妊娠组的(0.7±0.3)mg/L(P<0.05),且妊高征组轻、中、重孕妇PAP的升高水平与疾病的严重程度呈正相关(P<0.05).两组孕妇分娩后PAP水平比较,差异无显著性(P>0.05).(5)抗凝血酶活性正常妊娠组为(108±17)%,而在妊高征组则显著降低,其中重度孕妇为(44±37)%、中度孕妇为(64±25)%、轻度孕妇为(83±39)%,两组比较,差异有极显著性(P<0.01).妊高征组中、重度孕妇又显著低于轻度孕妇(P<0.01).结论 P-选择素及 F1+2可用于高危妊娠的筛查,D-二聚体可作为妊高征孕妇早期DIC的监测,抗凝血酶活性是反映妊高征疾病严重程度的有效指标.以上这些止凝血分子标志物可作为妊高征患者血栓前状态的监测指标.     

Endothelin-1 (ET-1) as a mediator of pregnancy induced hypertension (PIH)

Pregnancy induced hypertension (PIH) is accompanied by injury and further activation of placental endothelial cells. Activated endothelial cells produce several mediators, among them endothelin-1 (ET-1)--one of the most potent vasoconstrictors. The aim of the study was to examine the ET-1 level in serum of 18 women with PIH and compare it to the group of 16 normotensive pregnant women. ET-1 level, as evaluated by ELISA test, was significantly higher in PIH than in normotensive pregnancy, 33.00 +/- 12.07 vs. 25.00 +/- 5.69 pg/mL (p = 0.005), respectively. It might be concluded, that ET-1 level is a prognostic parameter, indicating the possibility of PIH development.     

Increased maternal plasma levels of soluble vascular cell adhesion molecule-1 (VCAM-1) in pregnancy induced hypertension (PIH)

One of the reason of PIH problems may be due to the presence of increased circulating levels of cell adhesion molecules, markers of endothelial damage and leukocyte activation. The objective was to evaluate the plasma levels of soluble vascular cell adhesion molecule in maternal peripheral blood of patients with PIH (pregnancy induced hypertension) and compared to those of normal healthy women with uncomplicated pregnancy. Maternal plasma samples were prepared from peripheral venous blood collected from 10 patients with PIH and 10 matched normotensive patients with uncomplicated pregnancies. Samples were assayed for soluble VCAM-1 by specific enzyme-linked immunosorbent assay (ELISA). Women with PIH had significantly higher plasma level of soluble VCAM-1 as compared with healthy pregnant women without PIH (653.50 vs. 456.39 ng/mL, respectively, p < 0.005). Our results on the increased plasma levels of soluble VCAM-1 in patients with PIH provide evidence for endothelial activation of PIH. It suggest that increased plasma level of soluble VCAM-1 could be an early marker of the maternal syndrome of PIH.     

妊高征患者抗中性粒细胞胞浆抗体的检测

目的　探讨抗中性粒细胞浆抗体 (ANCA)在妊高征患者内皮细胞损伤中的作用及可能机理。方法　采用间接免疫荧光法 (IIF)和酶联免疫吸附试验 (ELISA)对 32例中、重度妊高征患者作血中ANCA的定性和定量检测 ,并以 44例正常孕妇作对照。结果　 32例妊高征患者ANCA阳性者 13例 (胞浆型ANCA阳性 9例 ,核周型ANCA阳性 4例 ) ,正常孕妇无一例ANCA阳性。妊高征患者ANCA含量 (0 45± 0 18) g/L ,正常孕妇为(0 2 3± 0 0 9) g/L ,两组间定性及定量均有显著性差异 (P <0 0 5 )。结论　ANCA可能参与妊高征患者血管内皮细胞损伤机制     

Calcium supplementation in pregnancy to prevent pregnancy induced hypertension (PIH)

Calcium supplementation during pregnancy has been studied since the 80's, epidemiologically and experimentally through laboratory animals and clinical trials. The findings showed the lowering of blood pressure and prevention of PIH in those receiving Calcium Supplementation. There were 22 clinical trials on Calcium supplementation since 1983; there were 5 trials added since Bucher et al made a meta-analysis on 14 of these trials in 1996. Three trials from Japan were added to the trials under study. A review of calcium homeostasis during normal pregnancy and PIH was added to allow a better understanding of physiologic and pathologic processes and how calcium supplementation works. The objective of this review is to show the rationale for supplementation of calcium during pregnancy to prevent PIH, hence the discussion on the latest investigations regarding etiology of PIH and the relation of Calcium to this causation. The USA large multicenter trial reported by Levine in 1997 contradicted the findings of all the previous random placebo controlled trials. Analysis of these trials showed that subjects were different; Levine trial used healthy nulliparas. The studies done in Japan, China and Philippines used a lower dose of Calcium but were effective. The conclusion of this review is Calcium supplementation helps those with high risk to develop PIH especially in countries where the calcium intake is low. Healthy nulliparas residing in countries with high Calcium intake will benefit less.     

Rheological analysis of suppressed leukocytosis in patients with pregnancy induced hypertension (PIH)

It is documented that the number of leukocytes in peripheral blood increases considerably during pregnancy. We observed that the range of leukocytosis differs in normal pregnancy differs from that in cases with severe pregnancy induced hypertension (PIH). The data obtained in our university hospital, for example, give the number of leukocytes after twenty-four weeks of gestation as 9,000 +/- 1,600/mm3 (mean +/- SD) for normal cases (93 measurements in 37 cases) and 6,600 +/- 1,100/mm3 for PIH (72 measurements in 18 cases; p less than 0.001). To elucidate the cause and relation to PIH, we studied changes in the activity of leukocytes during pregnancy by means of a modified Nuclepore filtration method (Kikuchi et al., 1983). The time required for leukocytes to squeeze through filter pores under constant suction varies greatly depending on their active states; more active cells show greater resistance to pore passage, which can be clearly shown by exposing cells to various stimuli. The filtration time for 0.5ml blood containing 5,000/mm3 leukocytes minus that of leukocyte poor blood with the same hematocrit was taken as an index of the activity, which we called the rheological activity of leukocytes (RAL). RAL values for blood taken at delivery were 3.4 +/- 1.5 sec for normal cases and 5.0 +/- 2.1 sec for PIH (N.S.). RAL values obtained after the addition of a chemotactic stimulant FMLP (formyl-methionyl-leucyl-phenylalanine) (10nM) to the same samples were 21 +/- 10 sec for normal cases and 405 +/- 265 sec for PIH (p less than 0.001). Leukocyte activity, particularly, response to chemotactic stimulation, was the before thought to be considerably increased in PIH.(ABSTRACT TRUNCATED AT 250 WORDS)     

肿瘤坏死因子对妊高征的致病作用及与内皮素的关系

目的：探讨肿瘤坏死因子在妊高征发病中的作用及与内皮素的关系。方法：采用放射免疫法测定了４６例妊高征患者（妊高征组）和２０例正常晚期妊娠妇女（对照组）血浆肿瘤坏死因子（ＴＮＦ）和内皮素（ＥＴ－１）的质量浓度。结果，妊高征组中，重度患者ＴＮＦ和ＥＴ－１质量浓度明显高于对照且和轻度患者（Ｐ〈０．０５及Ｐ〈０．０１）；产后７２小时两者质量浓度均明显下降。对照组血浆ＴＮＦ与ＥＴ－１质量浓度无相关性，而妊高征     

妊高征患者胎盘滋养细胞中转化生长因子β1的表达及意义

目的 :探讨胎盘组织中转化生长因子 β1 (TGF β1 )的定位 ,检测滋养细胞中TGF β1mRNA的表达水平 ,评估TGF β1在妊娠高血压综合征 (妊高征 )中的作用。方法 :用免疫组化法对 30例正常孕妇、2 5例妊高征孕妇的胎盘组织进行TGF β1定位 ;用逆转录 聚合酶链反应 (RT PCR)检测正常妊娠滋养细胞 6例、妊高征滋养细胞 6例中TGF β1mRNA表达水平 ,并进行定量分析。结果 :(1 )胎盘TGF β1主要位于绒毛小叶的合体滋养细胞及细胞滋养细胞 ;(2 )与正常组比较 ,妊高征组胎盘TGF β1的平均光密度显著增加(P <0 .0 5) ;(3)与正常滋养细胞比较 ,妊高征滋养细胞TGF β1mRNA的表达强度显著增强(P <0 .0 5)。结论 :胎盘组织中TGF β1主要位于胎盘小叶的合体滋养细胞、细胞滋养细胞 ,胎盘滋养细胞合成TGF β1的增多与妊高征的发生有关     

心钠素治疗妊高征的临床研究

目的：探索心钠素治疗妊高征的临床效果及机理。方法：心钠素治疗妊高征病人６０例，硫酸镁治疗妊高病人３０例。观察治疗前后血压、尿蛋白、血心钠素、超氧化物岐化酶、肾素、血管紧张素、醛固酮的变化。结果：病人经心钠素治疗后，血压明显下降，尿蛋白转阴，水肿消退，血中超氧化物岐化酶、肾素、血管紧张素、醛固酮减少。结论：心钠素可有效地纠正妊高征病人的病理生理变化，达到降压、利尿、消除尿蛋白的效果。近期、远期未发现     

2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature

To summarize the literature regarding 2009 H1N1 influenza A during pregnancy, we conducted a systematic literature review using a PubMed search and other strategies. Studies were included if they reported 2009 H1N1 influenza in pregnant women as original data. In all, 2153 abstracts were reviewed, and a total of 120 studies were included. Data were extracted regarding number of cases, additional risk factors for influenza-associated complications, treatment, and maternal and pregnancy outcomes. Authors were contacted to determine the extent of overlap when it was suspected. Pregnancy was associated with increased risk of hospital and intensive care unit admission and of death. Pregnant women who received delayed treatment with neuraminidase inhibitors or who had additional risk factors were more likely to develop severe disease. Preterm and emergency cesarean deliveries were frequently reported. These results reinforce the importance of early identification and treatment of suspected influenza in this high-risk population.