银屑病发病中角质形成细胞的增殖和凋亡与端粒酶的表达

银屑病是一种常见的慢性炎性、增殖性皮肤病,主要表现为角质形成细胞的增殖和分化异常,同时其发病过程中伴有细胞端粒酶活性的增高。现将近年来银屑病发生发展过程中角质形成细胞的增殖和凋亡异常与端粒酶表达的研究进展综述如下。一、银屑病中角质形成细胞的增殖异常银屑病的主要表现为角质形成细胞的过度增殖,其增殖活化过程在很大程度上受T细胞的影响。首先,T细胞可通过其所分泌的TNF-α、IFN-γ、IL-2、IL-3、IL-5等与局部微环境其他细胞分泌的细胞因子如转化生长因子α/β(TGFα/β)、TNF-α、IL-6/IL-8和粒细胞-巨噬细胞刺…     

弱极性色谱柱的拓展使用探讨

色谱工作者在选择色谱柱的固定液时，大都遵循下述原则：对于非极性物质一般选用非极性固定液；对于中等极性物质选用中等极性固定液；对于强极性物质选用强极性固定液〔１〕。然而，在实际的卫生检验工作中，由于被分析物质复杂多样，千差万别，检验人员常因手中色谱柱种...     

广州市食用植物油煎炸后极性组分含量调查

广州市食用植物油煎炸后极性组分含量调查高燕红１９８６年国家标准规定了食用煎炸油的理化指标为酸价和羰基价，１９９４年又增加了极性组分。因为酸价和羰基价只能分别衡量存在于煎炸油中含有羧基的化合物和含有羰基的化合物，而极性组分是指食用油在煎炸的高温氧化条件...     

银屑病发病中角质形成细胞的增殖和凋亡与端粒酶的表达

银屑病是一种常见的慢性炎性、增殖性皮肤病，主要表现为角质形成细胞的增殖和分化异常，同时其发病过程中伴有细胞端粒酶活性的增高。现将近年来银屑病发生发展过程中角质形成细胞的增殖和凋亡异常与端粒酶表达的研究进展综述如下。     

广州市食用植物油煎炸后极性组分含量调查

1986年国家标准规定了食用煎炸油的理化指标为酸价和羰基价，1994年又增加了极性组分。因为酸价和羰基价只能分别衡量存在于煎炸油中含有羧基的化合物和含有羰基的化合物．而极性组分是指食用油在煎炸的高温氧化条件下发生劣变．包括热氧化产物、热聚台产物、热氧化聚合产物、水解化产物的总称，它比酸价和羰基价所包括的范围更大，因此测定食用植物油煎炸后的极性组分更有综合意义。     

煎炸油食品卫生指标研究——煎炸油中极性化合物的实验研究

本实验研究对豆油、葵花油分别在240℃、180℃条件下连续煎炸,按时间梯度采样,进行极性化合物检验。结果表明,极性化合物的含量随煎炸时间的延长而有规律的升高,认为此项指标既灵敏又有规律性可寻,是评价煎炸油卫生质量的较好指标。     

2007年盐城市区部分煎炸油极性组分含量的检测

目的了解江苏省盐城市区油炸食品生产中的煎炸油极性组分含量，为卫生监督执法、保障消费者的健康提供依据。方法依据GB／T5009．202—2003食用植物油煎炸过程中极性组分的测定方法进行检验，评价标准按GB7102．1—2003食用植物油煎炸过程中的卫生标准，极性组分〉27％判为不合格。结果2007年共检测106份，合格94份，合格率88．7％，极性组分含量9．0％-45．1％，不同类别煎炸油极性组分检测结果无统计学意义（Χ^2=4．58，P〉0．05）；煎炸油不同煎炸时间对极性组分含量影响较大，随煎炸时间的延长极性组分含量增高。结论盐城市区煎炸食品烹饪过程中，煎炸油存在长时间反复使用的情况，个体早餐点尤为严重，应加强监督检测频次和范围，保障市区人群的饮食安全。     

煎炸油中极性组分含量的调查

煎炸果子是我市居民广泛食用的早餐之一,目前我市生产油炸果子的店铺数量之多,分布也很广,为了更好地掌握我市当前煎炸油卫生状况,我所对市内六区炸果子店、铺的煎炸油中极性组分含量进行一次监测。     

高血压患者U波极性的变化观察

近年来 ,研究发现Ｕ波的改变时对某些心血管疾病有着重要的诊断价值。而Ｕ波极性的改变在高血压病患者中的诊断价值 ,尚未引起足够的重视。我们对 146例高血压患者进行Ｕ波极性改变的分析观察 ,发现Ｕ波极性的变化对高血压患者具有不同的临床意义。1　资料与方法1·1　对象　 1999年 5月～ 1999年 12月门诊诊断高血压病患者 ,男性 86例 ,女性 6 0例 ,年龄 2 8岁～ 75岁(平均 5 6 4岁 )。高血压病史 1～ 30年 ,排除心肌硬死、心肌炎、糖尿病、左室肥厚、低血钾。对照组 5 5例均为 2 8岁～ 6 7岁的体检健康正常人。1·2　方法　所有的高血压…     

竹黄颗粒剂对培养人角朊细胞增殖的影响

竹黄颗粒剂是治疗银屑病的经验方一竹黄汤经剂型改革研制而成，临床运用疗效甚佳，鉴于表皮角朊细胞过度增殖是银屑病重要的病理改变，我们将竹黄颗粒剂制成内提取液，研究其对体外培养的人角朊细胞增殖的影响，从而阐明竹黄颗粒剂治疗银屑病的机制。     

Polarity effect on surface dose measurement for an attix parallel plate ionisation chamber

The effects of chamber polarity have been investigated for the measurement of 6MV and 18MV x-ray surface dose using a parallel plate ionization chamber. Results have shown that a significant difference in measured ionization is recorded between polarities at 6MV and 18MV at the phantom surface. A polarity ratio ranging from 1.062 to 1.005 is seen for 6MV x-rays at the phantom surface for field sizes 5 cm x 5 cm to 40 cm x 40 cm when comparing positive to negative polarity. These ratio's range from 1.024 to 1.004 for 18MV x-rays with the same field sizes. When these charge reading are compared to the Dmax readings of the same polarity it is found that these polarity effects are minimal for the calculation of percentage dose results with variations being less than 1% of maximum.     

Childhood linear psoriasis

Linear distribution of psoriasis is rare. This presentation offers to physicians some diagnostic difficulty, especially in the absence of a history of pre-existing psoriasis or in the presence of any other linear dermatosis. In this study, we report cases of 3 girls, ages 4 yr, 5 yr and 10 yr, admitted to our dermatology department. The clinical features and differential diagnosis of this skin disease which, in children, can be easily mistaken for inflammatory verrucous epidermal nevus, are discussed.     

银屑病患者皮损中磷酸化表皮生长因子受体的表达及意义

目的 检测银屑病患者皮损中磷酸化表皮生长因子受体（p-EGFR）表达的改变,探讨其相关的临床意义.方法 入选寻常型银屑病患者64例（银屑病组）,其中轻度20例,中度28例,重度16例,另取健康皮肤标本30例作为对照组.免疫组织化学法检测p-EGFR蛋白的表达.结果 对照组和银屑病组p-EGFR蛋白的吸光度值分别为42.53±14.54,95.56±33.28,两组比较差异有统计学意义（P＜0.01）.轻度、中度和重度银屑病患者p-EGFR蛋白的吸光度值分别为67.26±21.33,92.45±31.64,136.37±40.51,三者间比较差异有统计学意义（P＜0.05）.头面部、四肢和其他部位取材检测p-EGFR蛋白的吸光度值分别为97.54±32.62,93.28±33.71,96.35±32.47,三者间比较差异无统计学意义（P＞0.05）.结论 表皮生长因子受体信号通路的激活可能参与了银屑病的发生、发展过程.     

极性蛋白Par3在小鼠胚胎着床子宫内膜中的表达

目的：探讨极性蛋白Par3在不同小鼠模型子宫内膜中的表达水平及其在小鼠胚胎着床过程中的作用。方法：建造妊娠1～8 d（早孕组）、假孕1～5 d（假孕组）、卵巢切除后类固醇激素注射（类固醇激素处理组）小鼠模型,应用免疫组织化学方法检测各种模型中小鼠子宫内膜腔上皮中Par3的表达情况,并使用Image-Pro Plus（IPP）图像分析系统进行半定量分析。结果：早孕组妊娠1～4 d小鼠内膜腔上皮中持续表达Par3并于妊娠4 d达高峰,于妊娠5 d明显减弱,妊娠6～8 d围绕胚胎初级蜕膜区域阴性表达并于次级蜕膜区域阳性表达;假孕组Par3表达趋势与早孕组类似,趋势变化幅度较早孕组小;类固醇激素处理组中,注射雌二醇（E2）组、孕酮（P4）组以及同时注射E2+P4组的Par3表达水平均明显低于注射芝麻油对照组。结论：雌、孕激素可下调Par3表达,Par3表达水平下降引起子宫内膜腔上皮极性短暂下调有利于胚胎着床。     

The pathogenesis of inflammatory dermatoses, especially psoriasis

The skin contains a variety of cell types and mediators, which together constitute the skin's immune system and play a key role in protecting the human body against dangers from outside. Dysregulation of the skin's immune system, however, frequently occurs and can result in undesirable inflammatory processes in the skin. A typical example of an undesirable inflammation in the skin is the chronic inflammatory skin disease psoriasis. In the pathogenesis of psoriasis, both genetic and environmental factors play a key role. In psoriasis, the complex interactions between T-lymphocytes, antigen-presenting cells, keratinocytes and pro-inflammatory cytokines and chemokines are disturbed. The two most widely accepted hypotheses are: (a) psoriasis is a T-cell mediated autoimmune disease, and (b) psoriasis is the result of a too finely adjusted system for regulating inflammation in the skin. The result of both mechanisms is a chronic inflammatory reaction fuelled by pro-inflammatory type-I cytokines that lead to the psoriasis-skin phenotype. With the development ofbiologicals, it has become feasible to target specific molecules in the immune process, for example type-I cytokines and the molecules present on pathogenic T-cells. This approach has already proved successful in the treatment of rheumatoid arthritis and Crohn's disease, creating novel therapeutic options for psoriasis and other inflammatory dermatoses.     

The treatment of psoriasis in a day care center

We describe the treatment of 196 patients with psoriasis, in the psoriasis day care centre at Ede. Treatments involve salt water baths followed by radiation of UVB, additional radiation of the scalp and therapy-resistant parts of the skin and anthralin 'short contact therapy'. During the anthralin therapy the hairy scalp is treated with liq. carb. dexerg. 5% in soya oleum. The results were evaluated by means of the psoriasis area and severity index (PASI) and of a questionnaire which was completed by 144 patients. In an average course of 28.4 treatment sessions (range 9-51), the PASI decreased by 84.3%. Evaluation of the PASI included the hairy scalp, the axillae and the inguinal region. The answers to the questionnaire indicated a risk of rather rapid relapse however, according to many patients, only a small part of the skin surface was affected. The additional value of the treatment is attributed to the setting of the psoriasis day care centre and the relatively safe therapeutic possibilities offered there.     

The influence of skin disorders on sexual expression

This article documents the profound effect skin disorders can have on sexual expression and responsiveness. The role of health care providers in uncovering and dealing with the sexual difficulties of dermatologic patients is discussed. For illustrative purposes, the social and psychological consequences of psoriasis are considered, as well as clinical and research data related to this condition.     

Oral Vitamin D Therapy in Patients with Psoriasis

Vitamin D treatment is effective when applied topically to the skin for plaque-type psoriasis. Oral vitamin D supplementation might be effective as an adjuvant treatment option in psoriasis. This umbrella review aimed to highlight the current knowledge regarding the use of oral vitamin D for treatment of patients with psoriasis. We performed a literature search and identified 107 eligible full-text articles that were relevant to the research interest. Among these, 10 review articles were selected, and data were extracted. A data synthesis showed that only a few studies monitored oral vitamin D efficacy in patients with psoriasis. No studies investigated the optimal dose of systemic vitamin D in psoriasis. However, most studies did not observe side effects for doses within a relatively narrow range (0.25 to 2 μg/day). These results suggest that more large-scale studies are needed to determine the efficacy, optimal dose, and adverse effects of vitamin D administration in patients with psoriasis.     

胃黏膜EGF及PEG2与肝源性溃疡患者的相关研究

目的探讨胃黏膜EGF(表皮生长因子)及PEG2(前列腺素E2)与肝源性溃疡患者的相关研究。方法本实验选取了160例在2010年8月份～2011年12月份在某医院进行治疗的患者为对象进行研究,其中38例肝硬化肝源性溃疡患者(A组),42例肝硬化非肝源性溃疡患者(B组),35例慢性胃炎患者(C组),45例非溃疡性消化不良(D组),统计及比较A组和B组的胃黏膜表皮生长因子含量和前列腺素E2含量情况以及A组、C组和D组的胃黏膜表皮生长因子含量和前列腺素E2含量情况。结果 A组患胃黏膜表皮生长因子含量为(0.521±0.292)pg/mg,前列腺素E2含量为(519±294)pg/mg;B组患者胃黏膜表皮生长因子含量为(0.911±0.507)pg/mg,前列腺素E2含量为(908±532)pg/mg。两组数据均进行比较,得出P﹤0.05,差异有统计学意义。A组患者胃黏膜表皮生长因子含量(0.521±0.292)pg/mg,前列腺素E2含量为(519±294)pg/mg;C组患者胃黏膜表皮生长因子含量(1.853±0.751)pg/mg,前列腺素E2含量为(1749±638)pg/mg;D组患者胃黏膜表皮生长因子含量(1.871±0.746)pg/mg,前列腺素E2含量为(1707±616)pg/mg。A组与C组相比较,P﹤0.01;A组与D组相比较,P﹥0.05。结论肝源性溃疡患者的胃黏膜表皮生长因子和前列腺素E2不明显与肝硬化患者的肝功能分级相互关系,也就是说不会影响到肝功能变化对肝源性溃疡患者胃黏膜的保护作用。     

The relationship between demographic and clinical variables,and quality of life aspects in patients with psoriasis

There is a strong need for health care programmes to promote functioning and quality of life in patients suffering from psoriasis. The aim of the present study is to highlight the relationships between demographic and clinical variables and disease-specific disability, health status, the perception of living with a chronic disease and the overall quality of life in patients suffering from psoriasis. A further aim is to examine the extent to which the effects of demographic and clinical variables on mental health and the overall quality of life are mediated by disability, physical health and the perception of living with psoriasis. The sample examined in this study comprised 334 patients (20% in-patients and 80% out-patients) who were treated consecutively at three dermatology departments in eastern Norway. A total of 282 patients completed the testing procedures, yielding a response rate of 85%. The following questionnaires were used: The Psoriasis Disability Index, the Sf-36 and the Quality of Life Scale. Correlation and multiple linear regression analyses were performed to address the core issue. Results show that demographic and clinical variables combine to explain variance in health status, the perception of living with psoriasis and overall quality of life. While most of the variance is explained by the clinical variables, the disease-specific disability variable seems to be an important mediating factor.