正常小儿和感染性疾病患儿外周血大颗粒淋巴细胞的观察

对５０名正常小儿和１００名感染性疾病患儿进行外周血大颗粒淋巴细胞（ＬＧＬ）的检测。５０名正常小儿的ＬＧＬ，男性为０．１３１０±０．０４８７，女性为０．１３８５±０．０７１６，性别、年龄均无显著性差异。但与１００名感染性疾病患儿的ＬＧＬ比较，感染性疾病患儿的ＬＧＬ为０．２１８７±０．０６１８，ｔ＝８．４６，有非常显著性差异（Ｐ＜０．０１）；在感染性疾病患儿中，白细胞数增高者ＬＧＬ明显较白细胞正常者高（ｔ＝４．６６，Ｐ＜０．０１）。     

新生儿休克时血浆肿瘤坏死因子的测定及其意义

目的：探讨肿瘤坏死因子（ＴＮＦ）在新生儿休克中的作用。方法：应用放射免疫方法检测３６例新生儿休克患儿血浆ＴＮＦ水平。结果：休克组治疗前血浆ＴＮＦ浓度〔（６０４．２６±１．２６）ｎｇ／Ｌ〕显著高于正常对照组〔（３２８．３８±１．１５）ｎｇ／Ｌ〕，Ｐ＜０．０１；感染性休克组〔（６５６．１４±１．４６）ｎｇ／Ｌ〕高于非感染性休克组〔（４６８．７９±１．３２）ｎｇ／Ｌ〕，Ｐ＜０．０５；死亡组〔（６８６．１３±１．１９）ｎｇ／Ｌ〕高于存活组〔（４７１．２３±１．２９）ｎｇ／Ｌ〕，Ｐ＜０．０５。血浆ＴＮＦ浓度与患儿器官损伤数呈正相关趋势，ｒ＝０．３１，Ｐ＞０．０５。结论：ＴＮＦ参与新生儿休克的病理生理过程，且与休克预后有关     

一种新高频通气方法对实验性急性呼吸窘迫综合征的疗效观察

在高频喷射通气（ＨＦＪＶ）治疗犬实验性急性呼吸窘迫综合征（ＡＲＤＳ）时，采用连续ＨＦＪＶ基础上间歇叠加深吸气（ＨＦＪＶ＋ＤＩ）的新通气方法，以期为ＡＲＤＳ的治疗寻找一种新途径。用油酸复制犬ＡＲＤＳ模型，并随机分为３组。ＨＦＪＶ＋ＤＩ组（ｎ＝１０）：在连续ＨＦＪＶ基础上每隔１０分钟加入１次深吸气；常规机械通气组（ＣＭＶ，ｎ＝１０），给予０．７８５ｋＰａ（１ｋＰａ＝１０．２０ｃｍＨ２Ｏ）呼气末正压（ＰＥＥＰ）治疗；对照组（ｎ＝１０），未予通气治疗。每隔１小时测定１次氧合及血流动力学指标，共观察５小时。注射油酸后，动脉氧分压（ＰａＯ２）由１２．４００ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）降至６．５６０ｋＰａ（Ｐ＜０．０１），动脉二氧化碳分压（Ｐａ－ＣＯ２）未见明显变化。通气治疗后，ＣＭＶ和ＨＦＪＶ＋ＤＩ均使ＰａＯ２明显升高，ＰａＣＯ２无明显变化（Ｐ＞０．０５），ＨＦＪＶ＋ＤＩ的氧释放指数（ＤＯ２Ｉ）明显高于ＣＭＶ组（Ｐ＞０．０５），心脏指数（ＣＩ）在ＣＭＶ组及ＨＦＪＶ＋ＤＩ组均明显减低（Ｐ＜０．０５）。提示：ＨＦＪＶ＋ＤＩ时ＰａＯ２的提高大于ＣＩ下降所致的不利影响，在改善组织缺氧方面明显优于ＣＭＶ时加用ＰＥＥＰ     

健康男性成人血清α1-酸性糖蛋白浓度及其与年龄的相互关系

研究了成人血清α１－酸性糖蛋白（α１－ＡＧＰ）的浓度范围及其与年龄的关系。采用免疫比浊法，测定了２１３例男性健康成人血清α１－ＡＧＰ浓度。青年组（１８岁～２３岁，ｎ＝１７２）和非青年组（２３～５９岁，ｎ＝４１）男性血清α１－ＡＧＰ浓度分别为５６３．９±２９．５（ｍｇ／Ｌ）（范围４４４．５ｍｇ／Ｌ～６１８．０ｍｇ／Ｌ），５６４．５±３２．７（ｍｇ／Ｌ）（范围４６０．９ｍｇ／Ｌ～６４７．５ｍｇ／Ｌ）。     

各期高血压病的内皮素和血管性血友病因子变化

应用放射免疫法与免疫电泳法同时检测８５例高血压患者的内皮素（ＥＴ）与血管性血友病因子（ｖＷＦ）。结果：①ＥＴ：与正常对照组（６５．５±１４．１μｇ／Ｌ）比较，高血压Ⅰ期ＥＴ大多正常（ｔ＝１．１４，Ｐ＞０．０５），Ⅱ期显著增高（ｔ＝２．８７，Ｐ＜０．０５），Ⅲ期非常显著增高（ｔ＝３．５５，Ｐ＜０．００１）。②ｖＷＦ：与正常对照组（９４．１％±３２．５％）比较，高血压Ⅰ期ｖＷＦ即显著升高（ｔ＝２．９８，Ｐ＜０．０５），Ⅱ期和Ⅲ期均非常显著升高（Ⅱ期ｔ＝３．５７，Ｐ＜０．００１；Ⅲ期ｔ＝４．１２，Ｐ＜０．００１）。③对照组和高血压Ⅰ期、Ⅱ期、Ⅲ期的ＥＴ与ｖＷＦ呈一定正相关性，其ｒ值分别为０．４８９６，０．６００５，０．４１８２和０．３０８７，Ｐ均＜０．０５。作者认为：同时检测ＥＴ与ｖＷＦ有助于判断高血压病情轻重及分期     

哮喘患儿白细胞介素4、γ干扰素水平与IgE的相关性研究

目的了解白细胞介素４（ＩＬ－４）、γ干扰素（ＩＦＮγ）对哮喘患儿ＩｇＥ生成的调节作用。方法应用酶联免疫吸附试验，检测了２２例过敏性哮喘患儿外周血单个核细胞（ＰＢＭＣ）培养上清液中ＩＬ－４和ＩＦＮγ的含量以及血清中ＩＬ－４、ＩＦＮγ和ＩｇＥ的水平，并进行了相关性研究。结果哮喘组患儿ＰＢＭＣ培养上清液中ＩＬ－４与ＩＦＮγ含量分别为２６７．０±１８８．７ｎｇ／Ｌ和０．９７±０．５１μｇ／Ｌ，与对照组（９２．７±１４．７ｎｇ／Ｌ和１．７５±０．８８μｇ／Ｌ）比较，差异有非常显著性（Ｐ＜０．００１，Ｐ＜０．０１）。哮喘组血清中ＩＬ－４和ＩｇＥ含量分别为９０．５±５２．６ｎｇ／Ｌ和９１６．０±５２３．２ｋＵ／Ｌ，而对照组分别为３２．２±２３．０ｎｇ／Ｌ和１８６．６±１２７．７ｋＵ／Ｌ（Ｐ＜０．０１，Ｐ＜０．００１）。哮喘患儿血清中ＩＬ－４与ＩｇＥ浓度呈正相关（ｒ＝０．６１），而ＩＦＮγ与ＩｇＥ呈负相关（ｒ＝－０．４９）。结论提示ＩＬ－４在哮喘患儿ＩｇＥ的产生中起促进作用，而ＩＦＮγ则起抑制作用。     

吸入一氧化氮对犬烟雾吸入性损伤血液流变学的影响

目的评价犬烟雾吸入性损伤吸入一氧化氮（ＮＯ）对血液流变学的影响。方法１７只犬随机分二组，烟雾吸入后，对照组（ｎ＝８）单纯吸氧（ＦｉＯ２，０４５），治疗组（ｎ＝９）吸氧（ＦｉＯ２，０４５）＋０００４５％ＮＯ，连续监测血液流变学有关参数，数据行多个样本均数间方差分析和相关分析。结果治疗组ＲＢＣ数和ＲＢＣ压积（Ｈｃｔ）比对照组显著降低（Ｐ＜００５）；ＲＢＣ聚集指数（ＥＡＩ）比对照组降低而ＲＢＣ刚性指数（ＥＲＩ）则升高（Ｐ＜００５～００１）；低切全血粘度（Ｌηｂ）、全血还原粘度（Ｌηｈ）和血浆粘度（ηＰ），治疗组比对照组明显降低（Ｐ＜００５～００１）；治疗组ＮＯ含量升高与ＥＡＩ、Ｌηｈ和ηＰ降低呈显著负相关（ｒ值分别为－０９４，－０９５，－０９３，Ｐ均＜００１）。结论吸入性损伤后血液粘度也有不同程度升高，吸入ＮＯ有不同程度降低吸入性损伤血液的高凝趋势，值得进一步研究     

人凝血因子Ⅸ∶Ag酶联免疫测定法的建立

采用抗人凝血因子Ⅸ单克隆和多克隆两种抗体，建立了人凝血因子Ⅸ抗原（ＦⅨ∶Ａｇ）酶联免疫测定法（ＥＬＩＳＡ）。标准曲线相关系数为０．９９３（Ｐ＝０．００１，ｎ＝５），测定范围（６．２５～１００）Ｕ／Ｌ，最低检测量１．５Ｕ／Ｌ；批内及批间变异系数分别为７．２５％和４．７３％，回收率９９．７％；与人血浆中其它蛋白质未见交叉反应。测得２０人份正常人血浆中ＦⅨ∶Ａｇ为（１０２７±１７２）Ｕ／Ｌ，与ＦⅨ促凝活性（ＦⅨ∶Ｃ）测得值比较，差异无显著性（Ｐ＞０．５）。重症乙型血友病人血浆ＦⅨ∶Ａｇ测得值与临床诊断相符。     

纤维连接蛋白对创伤后脓毒症多器官损害的保护效应

目的：探讨纤维连接蛋白（Ｆｎ）在创伤后脓毒症多器官损害（ＭＯＤ）中的作用与机制，为临床应用Ｆｎ制剂防治创伤后ＭＯＤ提供理论依据。方法：在创伤后３小时输注Ｆｎ治疗，观察创伤后脓毒症小鼠和用Ｆｎ治疗后小鼠的血浆Ｆｎ、肿瘤坏死因子α（ＴＮＦα）水平和肝、肾、小肠的组织病理变化。结果：创伤后３小时血浆Ｆｎ水平（９２．１７±１０．１２ｍｇ／Ｌ）较正常对照（１２８．１７±１０．２５ｍｇ／Ｌ）显著降低（Ｐ＜０．０５）；脓毒症小鼠肝、肾、小肠均出现明显病理损害，肝小叶Ｆｎ聚集沉着；Ｆｎ治疗组血浆Ｆｎ水平（２１６．００±２４．５０ｍｇ／Ｌ）明显高于脓毒症组（１９９．４０±１６．９０ｍｇ／Ｌ），Ｐ＜０．０５；而其血浆ＴＮＦα水平（０．７７±０．０３μｇ／Ｌ）低于脓毒症组水平（０．８０±０．０４μｇ／Ｌ），肝、肾、小肠组织病理损害明显减轻，肝组织Ｆｎ与正常相似。结论：Ｆｎ治疗能有效防止创伤后脓毒症ＭＯＤ发生，可能与单核巨噬细胞廓清功能改善和ＴＮＦα释放减少的双重效应有关。     

抗栓酶Ⅲ号对烫伤大鼠血液流变学和氧自由基的影响

以烫伤大鼠为模型，观察蝮蛇抗栓酶Ⅲ号对烫伤大鼠休克期血液流变学和氧自由基的影响。实验结果：用药组伤后１２小时纤维蛋白原（Ｆｇ）即明显降低（Ｐ＜０．０５），较烫伤对照组下降４２．９％；全血粘度伤后２４小时呈现明显下降趋势（Ｐ＜０．０１）；血小板消耗明显减少（Ｐ＜０．０１），并与Ｆｇ呈负相关性变化（ｒ＝０．６０００，Ｐ＜０．０１）；肝组织丙二醛明显低于烫伤对照组（Ｐ＜０．０１）。提示：抗栓酶Ⅲ号在一定程度上可降低烫伤大鼠的血液粘度，减少血小板消耗，有助于烧伤休克期组织器官的保护     

Human fibronectin metabolism.

The metabolic behavior of fibronectin (Fn), a highly adhesive glycoprotein (440,000 mol wt), was studied in eight healthy control subjects and in 11 patients, six of whom were critically ill. Fn was purified from fresh human plasma, radiolabeled, and shown to retain function both in vitro and in vivo. Results showed that, in normal controls, Fn is a rapidly catabolized protein with a fractional catabolic rate (FCR) of 4.81%/h (range, 4.00-6.27), a half-life (t1/2) of 25 h (20-30), extravascular/intravascular diffusion ratio (EV/IV) of 2.04 (1.52-3.30), and a synthesis rate (SR) of 0.71 mg/kg body weight per h (0.61-0.87). There was evidence for extravascular catabolism in each subject. Plasma levels correlated with SR but not with t1/2 or FCR. Patients had a lower EV/IV ratio, and in two critically ill patients with low plasma Fn concentration the SR was markedly depressed. These findings suggest that reduced synthesis of Fn, rather than increased FCR or increased extravascular distribution, is responsible for Fn deficiency in critically ill patients.     

Admission angiopoietin levels in children with septic shock

Angiopoietin (angpt) 1 and angpt-2 are circulating proteins first ascribed opposing roles in embryonic angiogenesis. Both bind the tyrosine kinase with immunoglobulin-like loop and epidermal growth factor homology domains (Tie) 2 receptor on endothelial cells, but angpt-1 is a Tie-2 agonist, whereas angpt-2 antagonizes Tie-2 signaling. In the developed vasculature, angpt-1 protects against vascular leak, whereas angpt-2 promotes increased vascular permeability. Because alterations in vascular permeability are common in septic shock, we obtained plasma from critically ill children within 24 h of diagnosis of the systemic inflammatory response syndrome (SIRS, n = 20), sepsis (n = 20), or septic shock (n = 61), as well as 15 healthy controls. Plasma levels of angpt-1 and angpt-2 were measured via a commercially available enzyme-linked immunosorbent assay. Plasma angpt-2 levels were significantly elevated in children with septic shock when compared with healthy children, as well as critically ill children with either SIRS or sepsis, and circulating angpt-2 levels seemed to correlate with disease severity and outcome. In addition, plasma angpt-1 levels were significantly decreased in critically ill children with septic shock compared with critically ill children with either SIRS or sepsis. Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted.     

危重症患者血清胰岛素、C肽及血浆皮质醇与血镁关系的临床研究

对ＩＣＵ８０例患者血清镁与血清胰岛素、Ｃ肽和血浆皮质醇之间关系进行研究。发现血镁与胰岛素呈正相关（ｒ＝０．４０７，Ｐ＜０．０１）；而与血清Ｃ肽和血浆皮质醇无关。低血镁组血清胰岛素浓度低于正常血镁组（Ｐ＜０．０１）；两组间血Ｃ肽及皮质醇浓度无显著差异。高血糖组患者血胰岛素浓度较正常血糖组低（Ｐ＜０．０５）。作者认为：危重症患者血镁浓度受血清胰岛素影响较大，胰岛素与Ｃ肽均为胰岛素原的分解产物，而本结果血镁仅与血清胰岛素有关，故危重症患者体内可能存在胰岛素抗体或胰岛素拮抗物，干扰血清胰岛素测定，也影响了胰岛素的正常生物活性，而这些胰岛素抗体或拮抗物并不影响Ｃ肽的测定     

休克患者血浆肾上腺髓质素与血管阻力变化的关系

目的：观察休克患者血浆肾上腺髓质素（ＡＤＭ）与血管阻力变化,探讨其在休克病理生理过程中的作用。方法：应用放射免疫方法检测４６ 例休克患者血浆ＡＤＭ 浓度,无创胸导生物电阻抗方法测定平均动脉压（ＭＢＰ）、全身血管阻力（ＳＶＲＩ）和心排指数（ＣＩ）。结果：休克组治疗前血浆ＡＤＭ 浓度明显高于正常对照组（Ｐ＜０．０１）;感染性休克组高于非感染性休克组（Ｐ＜ ０．０５）;死亡组高于存活组（Ｐ＜ ０．０５）;感染性休克组ＳＶＲＩ较其他组明显降低,而ＣＩ较正常组略高,其他休克组则明显降低（Ｐ＜ ０．０５）。结论：ＡＤＭ 与血管阻力变化相关,并参与了休克的病理生理过程。     

慢性肾功能不全患者不同病期血浆白细胞介素-8的含量及其临床意义

目的：了解慢性肾功能不全患者不同病期血浆白细胞介素８（ＩＬ８）的含量及其临床意义。方法：用双抗夹心酶联免疫吸附法分别测定慢性肾功能不全患者不同病期血浆ＩＬ８含量，并与正常对照组比较。结果：慢性肾功能不全代偿期及氮质血症期患者血浆ＩＬ８略低于正常对照组，但差异无显著性（Ｐ均＞０．０５）。肾功能衰竭期患者血浆ＩＬ８含量显著低于正常对照组（Ｐ＜０．０１）。在慢性肾功能不全病程中，血浆ＩＬ８含量与血肌酐、尿素氮呈显著负相关（ｒ＝－０．５８，Ｐ＜０．０１；ｒ＝－０．５１，Ｐ＜０．０１）。结论：慢性肾功能不全患者肾功能衰竭期机体全身免疫功能低下，急性炎症反应减弱。     

Plasma fibronectin levels in sepsis: influencing factors

Low plasma levels of the opsonic glycoprotein fibronectin (Fn) have been suggested to imply an impaired host defense against sepsis. However, the mechanism(s) behind Fn depletion in sepsis are obscure. We measured the Fn plasma concentration in 32 patients 12 to 24 h after the diagnosis of septic shock. Although the average plasma level was low (214 +/- 80 [SD] mg/L) compared to that of a reference material (p less than .001), the range was great (60 to 403 mg/L). A multivariate analysis of some possible influencing factors showed significant (p less than .01) positive correlations to the prothrombin level (r = .62) and the amount of insulin infused per 24 h (r = .63). The relationships to disseminated intravascular coagulation-related variables, hemodilution, and outcome were weak. Cryoprecipitate was infused into 16 patients; Fn levels increased by 52 +/- 18% of the expected increase. The most severely ill patients displayed the lowest rates of increase. The postinfusion decrease in Fn plasma concentration indicated that the plasma half-life of cryoprecipitate Fn was about 25 h. The results support the concept that decreased Fn synthesis, probably in the liver, is the major reason for Fn depletion in sepsis, rather than an increased rate of consumption.     

危重病患者全身应激对机体内环境的影响

目的 :探讨危重病患者应激状态下内环境的变化规律、代谢支持选择的最佳时机。方法 :12 7例因各种原因所致的全身炎症反应综合征 (SIRS)和多器官功能障碍综合征 (MODS) ,ICU危重病患者入院后 1、3、5、7、14日进行电解质、血糖、晶体渗透压监测 ,入院后第 2、5、10日检测血皮质醇。 38例接受重组人生长激素治疗。结果 :死亡组 (35例 )患者入院时表现为高钠血症和晶体渗透压升高 ,而存活组 (92例 )入院时出现低钠血症和晶体渗透压偏低 (P均 <0 .0 0 1)。死亡组患者血糖一直维持于较高水平 ,对胰岛素存在一定的耐受性 ;存活组患者治疗后血糖和胰岛素用量进行性下降 (P均 <0 .0 1)。生长激素能明显提高 2组患者血糖水平 (P均 <0 .0 1) ,增加危重病患者内环境紊乱。死亡组患者血皮质醇浓度一直处于较高水平 ,而存活组呈进行性下降至生理范围 (P<0 .0 1)。结论 :危重病患者应激反应可使内环境紊乱 ,这种紊乱与血皮质醇浓度及疾病的严重程度变化一致。血糖可作为危重症患者应激反应过程的一个监测指标。     

脑外伤患者血浆一氧化氮合酶与T淋巴细胞亚群的变化

目的 :通过检测急性脑损伤患者血浆一氧化氮合酶 (NOS)与 T淋巴细胞亚群 (CD 4 /CD 8)含量变化 ,探讨其临床意义。方法 :采用酶法检测 NOS,应用单克隆抗体 APAAP法检测 45例脑损伤患者的 T淋巴细胞亚群。结果 :脑损伤患者血浆中 NOS与 CD 8细胞含量均较对照组升高 ,中、重型组差异有显著性 (P<0 .0 5或 P<0 .0 1) ;而脑损伤患者的 CD 4 较对照组下降 ,中、重型组差异有显著性 (P<0 .0 5或 P<0 .0 1)。 NOS与CD 8间呈正相关关系 (r=0 .36 7,P<0 .0 1)。CD 4 /CD 8比值与对照组比较差异均显著 (P均 <0 .0 1)。结论 :血浆中 NOS、CD 8升高水平与脑损伤程度有关 ,临床检测 NOS与 T淋巴细胞亚群的含量有助于评价脑损伤患者的病情及预后     

Antithrombin III in critically ill patients

To assess the role of antithrombin III (ATIII) in the thrombotic complications of acutely ill patients who suffered from septicemia or trauma, with or without evidence of acute lung injury, we measured the plasma concentration of ATIII-related antigen (ATIII:Ag) in 146 patients with acute lung injury and in 43 critically ill patients without lung injury. We found plasma ATIII:Ag levels of both groups of acutely ill patients to be significantly lower than those of normal subjects (n = 21). The plasma ATIII:Ag levels of patients with acute lung injury, however, were significantly higher than those without lung injury (P < .01). By separating post-trauma acutely ill patients with lung injury from those with septicemia, we noted that their plasma ATIII:Ag levels were identical to those of normal subjects despite activation of blood coagulation. This finding led us to examine ATIII functional activity (ATIII:Fn) and search for ATIII-enzyme(s) complexes in 46 patients with acute lung injury (30 patients with sepsis and 16 post-trauma patients) and in 12 acutely ill patients without lung injury (eight patients with sepsis and four post-trauma patients). These 58 patients were representative of the groups studied and had no evidence of hepatic or renal dysfunction. We found significantly reduced ATIII:Ag and ATIII:Fn in septic patients, with or without lung injury, as compared with the normal levels (P < .05). After trauma, patients with or without lung injury had normal ATIII:Ag, but the ATIII:Fn levels were disproportionately lower. Following trauma, the ATIII:Ag/ATIII:Fn ratio was significantly higher than in septicemia patients or in normal patients. Patients who died from septicemia and post-trauma had higher ATIII:Ag to ATIII:Fn ratios, while surviving patients had ATIII:Ag to ATIII:Fn ratios closer to normal. In addition, in all post-trauma or septicemia patients, there was evidence of ATIII-enzyme(s) complex formation by cross-immunoelectrophoresis despite ATIII levels and the presence or absence of acute lung injury. High ATIII:Ag to ATIII:Fn ratios and the presence of circulating ATIII:enzyme(s) complexes were associated with high mortality. The ATIII alterations, however, did not allow us to determine the presence of acute lung injury. The ATIII changes observed in our patients appeared to be primarily influenced by the differing pathways of blood activation that occurred in septicemia and trauma.     

多发性创伤后单核细胞功能变化的实验研究

背景血浆纤维结合蛋白(Fn)是单核吞噬细胞吞噬功能的调节剂.多发伤后,血浆Fn发生明显有规律改变.有报道体外循环犬中外周血单核细胞活性增加.而多发伤后细胞Fn变化不清楚.目的检测多发伤犬外周血单核细胞其表面纤维结合蛋白(Fn)和吞噬功能. 设计随机对照实验研究.地点和对象对随机造模的多发伤犬16只进行实验,年龄1～4年,平均为2.5年.干预用梯度离心法收集16例犬外周血单核细胞.主要观察指标多发伤犬单核细胞吞噬功能,表面Fn及血浆Fn水平变化.结果多发伤犬单核细胞吞噬功能在伤后第1,3,7天分别为(0.263±0.048),(0.388±0.087),(0.472±0.137)A,单核细胞吞噬功能7 d显著性增强(t=1.07,P＜0.05);血浆Fn水平在伤后第3天(0.144±0.002)g/L和7天(0.152±0.003)g/L较第1天(0.125±0.009)g/L显著升高.单核细胞吞噬功能与血浆Fn水平显著相关(r=0.099,P=0.05).单核细胞表面Fn变化无显著性意义.结论多发伤后单核细胞表面Fn呈动态变化,与其吞噬功能和血浆变化相一致,其对评价创伤后单核细胞功能变化具有重要价值.