自身甲状腺球蛋白抗体阳性时甲状腺球蛋白测定方法的评估

应用单克隆固相放免法及双抗体法测定了自身免疫性甲状腺球蛋白抗体(TG-Ab)阳性病人血清中甲状腺球蛋白(TG)浓度。34例慢性淋巴细胞性甲状腺炎病人,TG-Ab阳性及TG-Ab阴性病人的TG值,分别为9.5±4.2ng/ml和10.9±3.7ng/ml(固相法);3.75±0.71ng/ml和4.25±1.1ng/ml(双抗体法)。50例Grave’s病人测定值分别为30.5±18.9ng/ml和41.5±20.5ng/ml(固相法);20.88±10.5ng/ml和27.5±12.5ng/ml(双抗体法)。38例甲状腺癌病人中,无转移灶者,两种方法测定值未见明显差异;8例有转移灶病人中,TG-Ab阳性者其TG值明显低于TG-Ab阴性者(p<0.01)。我们对10例慢性淋巴细胞性甲状腺炎TG-Ab阳性者进行了回收试验,固相法平均为81.6±14.0ng/ml,双抗体法平均为70.8±14.1ng/ml。我们认为,应用单克隆抗体固相法测定的TG值明显高于双抗体法,其回收率也高于双抗体法,但是在TG-Ab阳性病人血清中,TG测定值较TG-Ab阴性者为低,这可能由于在TG-Ab存在的情况下,体内TG代谢清除率增快而使TG浓度下降。因此,对TG-Ab阳性病人TG测定,仍有待于进一步探讨。     

肺癌肿瘤标志物CYFRA21-1的临床应用及其评价

应用免疫放射分析法(IRMA)检测327例肺癌,297例肺部良性疾病患者CYFRA21-1的血清水平,肺癌组水平16.9±8.4ng/ml,非肿瘤组水平1.9±1.6ng/ml(p<0.001)。肺癌阳性率62.4％,良性疾患阳性率5％。测定灵敏度为62.4％,特异性为94.5％,准确率77.9％,结果均好于CEA、NSE、CA-242。肺癌病人随病期的增加,血清CYFRA21-1含量也随之上升(P<0.02)。对8例肺癌手术病人和10例化疗病人含量变化分析,在手术3～5周后,血清含量由术前的6.4±3.1ng/ml,降到1.8±0.6ng/ml,10例化疗病人,其中8例血清含量均有降低,由17.4±9ng/ml降至4.9±2.0ng/ml,临床证实均有良好的治疗效果,另2例临床证实治疗无效,血清CYFRA21-1水平相应增高。     

孕酮及PAPP-A在先兆流产预测中的应用

目的 探讨孕酮及妊娠相关血浆蛋白A(PAPP-A)对先兆流产的预测价值.方法 分别测定96例先兆流产患者血清中孕酮及PAPP-A的含量.结果 患者组孕酮16.24±6.13 ng/ml明显低于正常妊娠组26.30±6.91 ng/ml(P＜0.05),患者组PAPP-A的含量为26.31±9.26IU/L与对照组结果相比32.1±11.2 IU/L具有显著性差异(P＜0.05).结论 孕酮及PAPP-A在对先兆流产的预测上有一定意义.     

1测定醛固酮浓度/肾素活性(SAC/PRA)值在原发性醛固酮增多症中的临床意义

目的:探讨测定SAC/PRA值对原发性醛固酮增多症的诊断价值.方法:采用放射免疫分析法测定48例原发性醛固酮增多症患者和30例正常人的血浆肾素(PRA),血管紧张素Ⅱ(AT-Ⅱ)以及血清醛固酮(Aldo),并计算醛固酮浓度/肾素活性(SAC/PRA)比值.结果:正常组PRA、AT-Ⅱ、Aldo测定值分别为0.57±0.08ng/ml/h,36.03±6.11ng/L,0.33±0.04nmol/L;原醛患者PRA、AT-Ⅱ、Aldo测定值分别为0.14±0.08ng/ml/h,21.21±7.55ng/L,1.07±0.34nmol/L.与正常对照组比较,均有极显著性差异(p＜0.001).SAC/PRA(ng/dl/ng*ml-1*h-1)913±409.结论:合理使用SAC/PRA比值有助于原发性醛固酮增多症的诊断.     

45例原发性肝细胞肝癌患者血清AFP,SF,RIA的结果观察

我们对45例原发性肝细胞肝癌患者血清进行了AFP、SF的联合测定,并将结果进行分析,现报告如下。 对象和方法 一、对象: (一)正常对照组:系本院血库献血员及本院托儿所工作的健康人员50例。 (二)肝癌组:系本院门诊和住院患者45例,均为放射性核素扫描以及彩超证实肝内占位性病变,临床确诊的肝癌患者。 二、方法: (一)SF(双抗)试剂盒:由上海生物制品研究所供应。 (二)AFP(双抗)试剂盒:巾上海生物制品研究所供应。 (三)仪器:使用上海原子核研究所日环仪器厂生产的SN—682型放射免疫γ计数器。 结果 一、正常组:50例SF测定值为24～162ng/ml,均值为49.64±24.53ng/ml。 二、肝癌组:45例血清标本同时进行SF和AFP测定,其结果分别为200～500↑ng/ml,均值为438.40±80.26ng/ml与42～400↑ng/ml,均值为345.53±115.318ng/ml(表1)。 45例原发性肝细胞肝癌患者血清标本中测定结果,SF含量高于500ng/ml有20例(44.44％)(20/45),300～500ng/ml有21例(46.66％)(21/45),200～250ng/ml有4例(8.88％)(4/5)。且这45例肝癌血清标本同时进行AFP测定,>400ng/ml有34例(75.55％)(31/45),100～400ng/ml有7例(15.55     

人可溶性B7-2分子的定量检测及应用

选取识别不同抗原位点的鼠抗人B7-2单抗1F9和6C8分别作为包被和检测抗体,用生物素(Biotin)标记检测抗体,建立双单抗夹心的sB7-2检测方法。在对其特异性、稳定性和准确性进行分析的基础上,对20例系统性红斑狼疮(SLE)患者及30名健康献血者血清中sB7-2的含量进行了测定。建立的sB7-2检测方法的灵敏度为0.15 ng/ml,具有良好线性关系的检测范围0.31~20.00 ng/ml。单抗1F9包被的测定板,4℃放置30 d内,工作曲线中各测定点的变异系数<5.9%。SLE患者血清中sB7-2的含量为(2.207±0.517)ng/ml,与健康献血者的(1.275±0.263)ng/ml比较具有统计学的显著差异(p<0.01)。本研究中建立的人sB7-2检测方法,能够对血清中sB7-2进行定量分析,可为该分子的基础研究及临床相关疾病的辅助诊断与判断预后提供参数。     

恶性肿瘤患者血清内皮素含量的检测及其临床意义

目的探讨恶性肿瘤患者血清内皮素-1(ET-1)的水平及其临床意义。方法采用放射免疫法,检测了恶性肿瘤患者85例、非肿瘤患者30例和正常人32例血清ET-1的含量。结果正常人和非肿瘤患者血清ET-1的平均含量分别为(46.9±23.1)μg/L和(51.1±30.9)μg/L,不同恶性肿瘤患者为(190.1±135.2～382.4±190.1)μg/L。正常人与非肿瘤患者相比较,血清ET-1的平均含量无明显差异(P＞0.05);而恶性肿瘤患者血清ET-1的含量则明显高于前两者(P＜0.001)。以正常人血清ET-1的平均含量加两个标准差为阳性界值,则不同恶性肿瘤患者的阳性检出率为72％～100％。结论血清ET的含量是筛选和辅助诊断恶性肿瘤的一种良好肿瘤标志物。     

人体25羟维生素D的竞争蛋白结合测定及冬夏季正常值

本文采用二氯甲烷/乙醇粗提血浆,高压液相色谱精分,竞争蛋白结合测定法求得25羟维生素D值,夏季北京居民正常值为13.2±5.9ng/ml(33.0±14.8nmol/L)(n=68),其中男性为13.0±5.7ng/ml(32.5±14.3nmol/L)(n=39),女性为13.5±6.2ng/ml(33.8±15.5nmol/L)(n=29);冬季正常值为10.4±3.8ng/ml(26.1±9.6nmol/L)(n=45),其中男性为10.2±4.2ng/ml(25.4±10.4nmol/L)(n=22),女性为10.7±3.6ng/ml(26.6±8.9nmol/L)(n=23),性别间无显著性差异,夏冬季P值均大于0.5;夏季值之间差异显著(P<0.01)。 文中还对响影测定的有关问题作了讨论。     

CEA,CYFRA21-1和NSE联检在肺癌诊治中的应用

目的 :探讨CEA、CYFRA2 1- 1和NSE 3种肿瘤标志物联检在肺癌诊治中的应用及胸水与血清水平同时测定在肺癌诊断中的差异。方法 :放免法测定CEA、CYRFA2 1- 1和NSE。共测定 37例健康成人、2 6例肺良性疾病及 5 3例肺癌患者的血清 ,并对 5 3例肺癌患者中的 33例同时进行了胸水 3项标志物的测定。结果 :健康成人组CEA为 (2 6 8± 1 75 )ng/ml,CYFRA2 1- 1为 (1 5 2± 0 86 )ng/ml,NSE为 (8 77± 4 13)ng/ml。肺良性疾病组CEA为 (5 4 8± 3 2 6 )ng/ml,CYFRA2 1- 1为 (5 32± 2 2 7)ng/ml,NSE为 (15 2 1± 11 36 )ng/ml,肺癌组CEA为 (2 4 95± 18 36 )ng/ml,CYFRA2 1- 1为 (17 81± 11 35 )ng/ml,NSE为 (19 85± 14 2 2 )ng/ml。肺癌组 3项标志物均较健康成人组有显著增高 (P <0 0 1) ,敏感性分别为 2 4 5 %、71 7%、35 8% ,3项联检敏感性为 83 0 % ,较肺良性疾病组CEA、CYFRA2 1- 1两项有显著增高 (P <0 0 1) ,NSE增高不明显 (P >0 0 5 ) ,肺良性疾病组较健康成人组均有显著性增高 (P <0 0 5及P <0 0 1)。同时测定 33项肺癌患者的胸水标本 ,胸水 3项标志物中的CEA、NSE水平较血清增高 ,但无显著性差异 (P >0 0 5 ) ,CYFRA2 1- 1显著增高(P <0 0 1) ,3项标志物水平与血清相比敏感性均增高     

儿童肾脏病患者血清白介素-2、白介素-6和胰岛素样生长因子-Ⅱ检测及其临床意义

为观察儿童肾脏病患者血清白介素 - 2 (IL - 2 )、白介素 - 6 (IL - 6 )、胰岛素样生长因子 -Ⅱ (IGF -Ⅱ )的含量 ,探讨细胞因子与肾脏病的关系 ,采用RIA法检测了不同肾脏病儿童患者血清IL - 2、IL - 6、IGF -Ⅱ的水平。结果显示 ,正常儿童血清IL - 2含量为 1 .6 0± 0 .32 μg/L、IL - 6为 37.0± 6 .0ng/L、IGF -Ⅱ为 0 .30±0 .1 5μg/L。正常男女性儿童之间血清三个细胞因子含量无显著性差异 (P >0 .0 5 )。正常儿童与成年人之间三个细胞因子有显著性差异 (P <0 .0 1 )。慢性肾小球肾炎血清IL - 2含量为 1 .96± 0 .4 4 μg/L、IL - 6为 5 4 .9± 2 0 .9ng/L、IGF -Ⅱ为 0 .5 2± 0 .1 5 μg/L ;急性肾炎血清IL - 2含量为 1 .92± 0 .4 7μg/L、IL - 6为 76 .3± 36 .2ng/L、IGF -Ⅱ为 0 .6 2± 0 .2 2 μg/L ;紫癜性肾炎血清IL - 2含量为 1 .91± 0 .33μg/L、IL - 6为 5 5 .5± 1 5 .1ng/L、IGF -Ⅱ为 0 .5 0± 0 .1 9μg/L ;肾病血清IL - 2含量为 1 .96± 0 .6 5 μg/L、IL - 6为 5 6 .2± 2 8.4ng/L、IGF -Ⅱ为 0 .5 9±0 .2 8μg/L ;不同肾脏病儿童三个细胞因子与正常人相比有显著差异 (P <0 .0 1 )。提示 :不同肾脏病儿童血清IL- 2、IL - 6、IGF -Ⅱ含量升高表明 ,这三个细胞因子均积极参与     

Renal dysplasia and asplenia in two sibs

A family is reported in which two sibs, one male and the other female, both died within 24 hours of birth with enlarged polycystic kidneys. Postmortem histology in the second child showed gross renal dysplasia. In both children the pancreas was enlarged, nodular and cystic but the liver appeared macroscopically normal. In the second child, histological examination confirmed pancreatic fibrosis with cystic dilation of ducts, but showed portal fibrosis with bile duct proliferation in the liver.
This combination of findings is very reminiscent of those in a girl and her brother reported by Ivemark et al. (1959). The children reported here also showed absence or hypoplasia of the spleen, cardiac anomalies and other features of the Ivemark syndrome (Ivemark 1955), a quite different, usually sporadic, congenital disorder. It is suggested that the children described here have a distinct lethal congenital disorder, probably inherited in an autosomal recessive manner.     

Schizophrenia in a North Swedish geographical isolate, 1900–1977. Epidemiology, genetics and biochemistry

Over 200 schizophrenic patients belonging to three major and interrelated pedigree complexes have been investigated over the past 30 years in a North Swedish geographically isolated population, presently numbering about 6,000. An intensive investigation of a number of biochemical correlates and genetic markers in a few selected families belonging to one of the major pedigrees has indicated new strategies for the current research program.
Schizophrenia, as defined operationally, is significantly associated with decreased activities of two enzymes (1) blood platelet monoamine oxidase, (2) plasma dopamine-β-hydroxylase, and (3) with the genetic marker Gc² (group specific antigen). Both enzymes are subject to genetic variation. A positive score for linkage between schizophrenia and low plasma DBH activity has been calculated, but, so far, available data are insufficient for discrimination between linkage and partial contribution of genetically controlled low plasma DBH to the pathogenesis of the disease. Alternatively, both mechanisms could be involved.
As a model for continued research, schizophrenia is explained as based on a double dominant-recessive genotype (Aabb), representing a vulnerability which in about 50 % of cases develops into clinical schizophrenia. It is suggested that the dominant mutation (A) operates on or affects MAO activity, and that the recessive genotype (bb) is instrumental in low variates of DBH activity and very likely such variates within the normal range of physiological variation. Moreover, it is suggested that the combined effects of MAO- and DBH-reduced efficiency on the metabolism of e.g. dopamine could be an essential pathogenic mechanism for the schizophrenic illness which is segregating in this population.     

What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?

There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children with Plasmodium falciparum infection in sub-Saharan Africa. Successes are largely attributed to malaria prevention strategies, such as insecticide-treated mosquito nets and indoor spraying, as well as improved access to existing treatments. One important hurdle to new approaches for the treatment and prevention of malaria is our limited understanding of the biology of Plasmodium infection and its complex interaction with the immune system of its human host. Therefore, the elimination of malaria in Africa not only relies on existing tools to reduce malaria burden, but also requires fundamental research to develop innovative approaches. Here, we summarize our discoveries from investigations of ethnic groups of West Africa who have different susceptibility to malaria.     

The universal muscular chain reaction,muscle spasm,Torsions, ruptures and extravasations. Chameleons of pathology and some manifestations of simple muscular disorders

Most bodily functions require the coordinated actions of complementary and supplementary paired muscle groups. Where this essential muscular cooperation is lacking, hollow organs may burst and others become literally screwed up, giving rise to many similar spastic diseases such as Torticollis, Twisted ovarian cyst, Torsion of the Testis, Volvulus of the intestines, Varicose Veins, Megacolon, Aortamegaly, Scoliosis, Erb's Palsy, Peyronie's Disease, Main-en-Griffe, Undescended Foot (Pes Cavus), Talipes, Strabismus. Spasm is “panenepidemic” and unclassified examples of Torsion Dystonia and Dyskinesia really are as common as debt and taxes.     

Hypo- und Hypermagnesämie aus kardiologischer Sicht

Zusammenfassung Eine Reihe pathologischer Zustände bedingen Magnesiummangel. Zustände mit Hypermagnesämie sind ebenfalls bekannt, doch wesentlich seltener. Für den Kardiologen beachtenswert ist, daß unter Therapie mit bestimmten Diuretica bei Herzinsuffizienz, bei Herzinfarkt, Kardiomyopathie, Digitalisintoxikation und bestimmten Herzrhythmusstörungen Hypomagnesämie beobachtet wurde. Leider kann in der klinischen Routine nur ein extracelluläres Magnesiumdefizit durch Serumbestimmungen gemessen werden; über Magnesiummangel einzelner Organe kann nichts ausgesagt werden. Hinweise für Magnesiummangel geben aber neben der Messung des Serumspiegels Anamnese, klinischer Befund, bestimmte EKG-Veränderungen wie auch evtl. Hypokalämie, ein Zustand, bei dem sich oft — besonders bei Aldosteronismus — parallele Veränderungen zeigten.Tierexperimente deuten darauf hin, daß infarktähnliche Läsionen unter Magnesiummangel entstehen, doch ob Herzinfarkt beim Menschen durch Magnesiummangel ausgelöst werden kann, ist noch ungeklärt. In Leichenherzen zeigte sich im Infarktgebiet neben Calciumakkumulation signifikanter Magnesiumverlust, wobei unklar blieb, ob sich Ursache oder Folge des Infarktes widerspiegelten. Falls ein ursächlicher Zusammenhang besteht, ist er im Myokardstoffwechsel selbst zu suchen, wie bei der Alkoholkardiomyopathie, wo myokardialer Magnesiummangel zumindest als pathogenetischer Teilfaktor anerkannt wird. Andererseits versucht man aber auch Beziehungen zwischen Atherosklerose, Blutgerinnung und Hypomagnesämie herzustellen, in der Meinung, daß Magnesiummangel auch über den coronaren Pathomechanismus des Herzinfarktes wirken könnte. Sicher scheint, daß gewisse EKG-Veränderungen und Herzrhythmusstörungen durch einen irritierten Magnesiumhaushalt bedingt sein können, da sie bei Gabe bzw. Entzug von Magnesium verschwinden. Daß Magnesiummangel die Glykosidtoleranz verringert, wird tierexperimentell bestätigt. Unter Hypomagnesämie bewirkt Acetylstrophanthidin eher und länger Rhythmusstörungen als ohne, außerdem lassen diese sich durch Magnesiumgaben eliminieren. Da in gewissen Fällen spontane und digitalisinduzierte Herzrythmusstörungen durch Magnesiuminjektionen beseitigt wurden, scheint Magnesium als Therapeuticum angebracht. Einsatz verschiedener Magnesiumsalze bei Angina pectoris, degenerativen Herzerkrankungen und Herzinsuffizienz ohne geprüften und offensichtlich gestörten Magnesiumhaushalt ist fragwürdig, weil keine eindeutigen klinischen Erfolgsbeweise vorliegen. Immerhin mag es aber larvierte, durch Serumbestimmungen nicht erfaßbare Mangelzustände geben. Allgemein erscheint es aus kardiologischer Sicht ratsam, den Magnesiumhaushalt zu überwachen und in entsprechenden Fällen auszugleichen, um möglichen Myokardläsionen oder fatalen Herzrhythmusstörungen entgegenzuwirken.     

Environmental risk factors and their role in the management of atopic dermatitis

Introduction: The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.

Areas covered: We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.

Expert commentary: The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.     

Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry: The Usko Mediterranean languages

Georgia (or Sakartvelo in its own language) is a South Caucasus Mts. country with its easternmost part is enigmatically named Iberia, like the Iberian Peninsula, which may refer to rivers “Kura” and “Ebro” or their valleys respectively. Most of their inhabitants speak Georgian which is included within Dene-Caucasian group and Usko-Mediterranean subgroup of languages. The latter includes Basque, Berber, ancient Iberian-Tartessian, Etruscan, Hittite, Minoan Lineal A and others. In the present paper, HLA class II -DRB1 and -DQB1 alleles has been studied and extended haplotypes calculated. Most frequent haplotypes are also of Mediterranean origin (i. e.: (A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*51)-DRB1*13:01-DQB1*06:03, or (A*24-B*35)-DRB1*01:01-DQB1*05:01) and DA genetic distances show that closest world populations to Georgians are Mediterraneans. Georgians also show common extended haplotypes ((A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*13)-DRB1*07:01-DQB1*02:01 and (A*03-B*35)-DRB1*11:01-DQB1*03:01) with Svan people, a secluded population in North Georgia mountains. We can conclude that Georgians belong to a very old Mediterranean substratum according to both linguistics (Usko Mediterranean languages) and HLA genetics.     

HLA genes in Amerindians from Mexico San Vicente Tancuayalab Teenek/Huastecos

Huastecos or Teenek Amerindians are presently living at North East Mexico (San Luis Potosi State). They have probably one of the most ancient culture of Mexico and Central America together with Mayas and Olmec groups with which also show close relationships. Proximity to Atlantic Ocean/Mexican Gulf originated that Spaniards had very early contact with them at about 1519 CE or before. In the present paper we have aimed to study HLA gene profile which may be useful for HLA and disease epidemiology and transplant programs in Teeneks. HLA-DRB1*04:07, -DRB1*14:06 and -DRB1*04:11 have been found in high frequency like in other Amerindian groups. High frequency typical Amerindians HLA extended haplotypes have been found, such as A*02-B*35-DRB1*04:07-DQB1*03:02; A*68-B*39-DRB1*04:07-DQB1*03:02 and A*02-B*39-DRB1*04:07-DQB1*03:02; also new haplotypes have been described, like A*02-B*52-DRB1*04:11-DQB1*03:02, A*68-B*35-DRB1*14:02-DQB1*03:01 and A*68-B*40-DRB1*16:02-DQB1*03:01. Genetic proximity is observed not only to linguistically close Mayans, but also to Mazatecans, Mixtecans and Zapotecans, who speak an altogether different languages; it shows once more that genes and languages do not correlate. This population was greatly diminished after European contact between 1500 and 1600 years CE; in fact, North and South America First Inhabitants population was brought from 80 down to 8 million people because of diseases (i.e.: measles, smallpox or influenza), slavery and war.     

État de l’art : nouveaux anticoagulants et transfusion

Direct oral anticoagulants (DOAC) are indicated for stroke prevention in atrial fibrillation and for the prevention and treatment of venous thromboembolism. As any anticoagulant, they are associated with a bleeding risk. Management of DOAC-induced bleeding is challenging. Idarucizumab, antidote for dabigatran, is currently available and is part of the therapeutic strategy, whereas antidotes for anti-Xa agents are under development. Activated or non-activated prothrombin concentrates are proposed, although their efficacy to reverse DOAC is uncertain. We propose an update on DOAC-associated bleeding management, integrating the availability of idarucizumab and the critical place of DOAC concentration measurements.     

HLA in North Colombia Chimila Amerindians

HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci.