丁苯酞氯化钠注射液对进展性脑梗死患者双抗血小板疗效及神经缺损功能恢复的影响

目的 研究丁苯酞氯化钠注射液对进展性脑梗死患者双抗血小板疗效及神经缺损功能恢复的影响.方法 纳入106例进展性脑梗死患者为治疗对象,根据治疗用药不同,随机分为对照组(n=53)和治疗组(n=53),对照组给予氯吡格雷片+阿司匹林肠溶片双重抗血小板治疗,治疗组在对照组治疗基础上加用丁苯酞氯化钠注射液治疗,比较两组NHISS评分与Barthel指数、治疗疗效和不良反应.结果 治疗后,两组NHISS评分显著降低(P<0.01),Barthel指数显著上升(P<0.01),且治疗后治疗组下降或上升幅度显著高于对照组(P<0.01);治疗组治疗总有效率86.79%,对照组67.92%,两组差异显著(P<0.05);两组均未出现不良反应.结论 丁苯酞氯化钠注射液联合双抗血小板治疗进展性脑梗死,可显著改善患者神经功能缺损状态,提高生活质量,治疗效果显著,具临床推广意义.     

丁苯酞联合阿司匹林和氯吡格雷治疗高龄脑梗死患者的临床安全性及疗效研究

目的:观察丁苯酞联合阿司匹林和氯吡格雷治疗高龄脑梗死患者的临床安全性及疗效。方法:选取362例高龄脑梗死患者,依据给药方式的不同分为对照组(176例)和观察组(186例)。对照组患者行氯吡格雷联合阿司匹林治疗;观察组患者行丁苯酞联合阿司匹林和氯吡格雷治疗。比较两组患者的血小板及凝血指标;治疗前后,两组患者的NIHSS评分与Barthel指数及不良反应情况。结果:治疗前,两组患者的NIHSS评分、Barthel指数及不良反映均无显著差异(P>0.05);治疗后,观察组患者的血小板及凝血指标、NIHSS评分与Barthel指数均优于对照组(P<0.05)。结论:丁苯酞联合阿司匹林和氯吡格雷治疗高龄脑梗死患者安全,其疗效优于氯吡格雷联合阿司匹林。     

丁苯酞氯化钠注射液联合双重抗血小板治疗进展性脑梗死合并睡眠障碍及对睡眠结构的影响

目的  探讨丁苯酞氯化钠注射液联合阿司匹林、氯吡格雷双重抗血小板治疗进展性脑梗死患者睡眠障碍的疗效及对睡眠结构的影响。方法  选取2013年4月-2015年12月于保定市第二医院神经内科住院患者共206例,均符合进展性脑梗死合并睡眠障碍,随机分为治疗组（加用丁苯酞氯化钠注射液治疗）103例及对照组103例（不加用丁苯酞氯化钠注射液治疗）,发病时间在48 h内,匹兹堡睡眠质量指数（PSQI）≥8分。分别于治疗前、治疗后第8、15及30天进行PSQI、NIHSS评分和Barthel评分,入组第１及30天进行多导睡眠监测,对PSQI、美国国立卫生研究院卒中量表（NIHSS）评分、日常生活能力评定量表（Barthel）评分、睡眠结构及进程参数进行分析。结果  治疗后第15和30天,治疗组与治疗前同组及同期对照组比较,PSQI、NIHSS评分及Barthel评分,差异有统计学意义（P <0.05）。治疗组与对照组治疗后30 d比较,总睡眠时间、睡眠效率及深睡眠比例增加,夜间觉醒次数、睡眠呼吸暂停低通气指数减少（P <0.05）。治疗组治疗后30 d与治疗前比较,总睡眠时间、睡眠效率、深睡眠比例及REM期睡眠比例增加,入睡潜伏期、夜间觉醒次数及睡眠呼吸暂停低通气指数减少（P <0.05）。结论  丁苯酞氯化钠注射液联合阿司匹林、氯吡格雷对进展性脑梗死后睡眠障碍可进行有效干预,并改善睡眠结构。

     

替罗非班联合丁苯酞注射液治疗进展性脑梗死

目的观察替罗非班联合丁苯酞注射液治疗进展性脑梗死的疗效。方法进展性脑梗死患者120例,随机分为对照组(n=60)及观察组(n=60),对照组给予阿司匹林、氯吡格雷等药物的常规治疗,观察组在对照组基础上加用替罗非班及丁苯酞注射液,观察两组患者治疗前后的神经功能缺损程度(NIHSS)评分及生活自理能力Barthel指数(BI),并监测治疗前后的血液学指标变化,观察临床疗效。结果观察组疗效优于对照组,观察组治疗后的血小板聚集率及血浆炎症因子水平优于对照组,两组均无明显出血。结论替罗非班联合丁苯酞注射液能够提高进展性脑梗死的疗效。     

丁苯酞氯化钠注射液辅助治疗急性期脑梗塞的近期疗效观察

目的:观察丁苯酞氯化钠注射液辅助治疗急性期脑梗塞患者的近期疗效。方法:将40例急性脑梗塞患者随机分为对照组(20例)和丁苯酞组(20例),对照组予常规予阿司匹林肠溶片抗血小板聚集;阿托伐他汀钙片调脂稳定斑块;银杏达莫针改善循环;依达拉奉针清除氧自由基护脑等治疗,疗程14天。丁苯酞组在对照组治疗的基础上加上丁苯酞氯化钠注射液100ml每天2次静滴,静滴间隔6小时,共14天。两组分别于治疗前/治疗后第8天和第15天进行神经功能缺失评分(NIHSS评分)。结果:治疗前对照组和丁苯酞组NIHSS评分比较差异无显著性,经治疗后第8天及15天两组患者的NIHSS评分比较改善明显。丁苯酞组总有效率明显高于对照组。结论:丁苯酞氯化钠注射液治疗急性期脑梗塞的近期疗效确切。     

丁苯酞注射液联合双抗对急性脑梗死患者神经功能及血液流变学的影响

目的分析丁苯酞注射液联合双抗对急性脑梗死患者神经功能及血液流变学的影响。方法选取2014年3月至2019年2月于本院接受诊疗的急性脑梗死患者78例,根据随机数字表法分为对照组和观察组,各39例。两组患者均予以常规治疗,对照组予以阿司匹林联合氯吡格雷双抗治疗,观察组在对照组基础上加入丁苯酞注射液治疗。分析两组神经功能、日常生活能力与血液流变学指标。结果与对照组比较,观察组治疗后NIHSS评分较低,Barthel指数较高,治疗后血浆黏度、全血低切黏度及纤维蛋白原值均较低,差异有统计学意义(P<0.05)。结论对急性脑梗死患者予以丁苯酞注射液联合双抗治疗能明显改善神经功能与血液流变学指标,可提升患者的日常生活能力。     

丁苯酞联合阿司匹林和氯吡格雷治疗进展性缺血型脑梗死的临床疗效及安全性分析

目的:观察进展性缺血型脑梗死患者采用丁苯酞胶囊联合阿司匹林与氯吡格雷治疗的安全性及临床疗效。方法:选取进展性缺血型脑梗死患者189例,依照随机数字表法分为阿司匹林与氯吡格雷治疗的对照组(96例)和丁苯酞胶囊联合阿司匹林与氯吡格雷治疗的研究组(93例)。将两组临床疗效、神经功能损伤情况及安全性进行对比分析。结果:2周治疗过程中,研究组发生不良反应7例,低于对照组的13例,但差异无统计学意义(P>0.05)。疗程结束后,研究组的凝血功能明显优于对照组,血小板水平也明显低于对照组,差异均有统计学意义(P<0.05);研究组总有效率为96.77%,高于对照组的80.21%,差异有统计学意义(P<0.05)。治疗1周及2周后两组ESS评分比较,研究组明显优于对照组,差异有统计学意义(P<0.05)。结论:进展性脑梗死患者采用丁苯酞胶囊联合阿司匹林与氯吡格雷治疗,比阿司匹林和氯吡格雷临床疗效更为显著,可较好的保护神经功能,安全性更高。     

丁苯酞联合氯吡格雷治疗急性脑梗死的效果及对患者免疫能力的影响

目的：探究丁苯酞联合氯吡格雷治疗急性脑梗死的效果及对患者免疫能力的影响。方法：选取2019年3月-2020年3月于苏州市相城人民医院接受治疗的急性脑梗死患者120例,按照随机双盲法分为氯吡格雷组、联合组,各60例,氯吡格雷组使用氯吡格雷进行治疗,联合组使用丁苯酞联合氯吡格雷进行治疗。使用PL-12血小板分析仪对两组患者二磷酸腺苷诱导血小板最大聚集率(MARADP)、花生四烯酸诱导血小板最大聚集率(MARAA)水平进行检测,测试巴氏量表(Barthel指数)、美国国立卫生研究院卒中量表(NIHSS)评分,使用流式细胞仪检测患者的免疫能力,酶联免疫吸附法检测白细胞介素-10(IL-10)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,对比两组患者的治疗效果。结果：治疗后,联合组的MARADP、MARAA水平均低于氯吡格雷组(P<0.05)。治疗后,联合组NIHSS评分低于氯吡格雷组,Barthel指数评分高于氯吡格雷组(P<0.05)。治疗后,联合组CD8⁺水平低于氯吡格雷组,CD4⁺、C...     

丁苯酞氯化钠注射液联合依达拉奉治疗急性进展性脑梗死临床观察

目的观察丁苯酞氯化钠注射液联合依达拉奉治疗急性进展性脑梗死的临床疗效.方法将65例进展性脑梗死患者随机分为单独使用依达拉奉治疗组(对照组,30例)和依达拉奉联合丁苯酞氯化钠注射液治疗组(治疗组,35例),比较两组治疗后14d的NIHSS评分和BI评分.结果两组治疗后NHISS评分、BI评分均较治疗前明显改善(P<0.05),且治疗组的治疗效果改善更明显.结论丁苯酞联合依达拉奉治疗急性进展性脑梗死疗效确切.     

丁苯酞氯化钠注射液对急性脑梗死患者血清NSE、S100β水平及神经功能的影响

目的研究丁苯酞氯化钠注射液对急性脑梗死患者血清神经元特异性烯醇化酶(NSE)水平、血清S100β蛋白水平及神经功能的影响。方法选取2015年9月至2018年5月淇县人民医院86例急性脑梗死患者,按随机数表法分为对照组和丁苯酞组,各43例。对照组接受阿替普酶静脉溶栓治疗,丁苯酞组于对照组基础上加用丁苯酞氯化钠注射液治疗,两组均治疗2周。对比两组美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血清神经元特异性烯醇化酶(NSE)水平、血清S100β蛋白水平、不良反应发生率。结果治疗后,两组患者Barthel指数均较前提高,NIHSS评分及血清NSE、S100β水平均较前降低,丁苯酞组Barthel指数较对照组高,NIHSS评分及血清NSE、S100β水平均较对照组低,差异有统计学意义(均P<0.05)。对照组和丁苯酞组不良反应发生率分别为6.98%(3/43)、11.63%(5/43),差异无统计学意义(P>0.05)。结论阿替普酶联合丁苯酞氯化钠注射液可有效减轻急性脑梗死患者神经损伤,改善其神经功能,提高其日常生活能力。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.