补肾益气中药对运动大鼠心脏内分泌影响

目的 探讨补肾益气中药和游泳训练对运动大鼠心脏内分泌的影响.方法 将64只大鼠,随机分为8组,每组8只,训练组和药物组分别进行为期5周的游泳运动和灌胃补肾益气煎剂;5周后,观察不同状态下大鼠心脏心钠素和血管紧张素Ⅱ的变化.结果 给药、训练和给药训练组大鼠的力竭游泳时间分别延长了37.2%,90.18%和145.55%;安静状态下,给药组心钠素含量[(215.883±14.445)pg/mgprot]明显高于对照组[(146.133±41.766)pg/mgprot](P＜0.01);力竭运动后,给药组、训练组和给药训练组心钠素含量分别为(264.257±53.644),(219.06±32.966),(459.687±159.869)pg/mgprot,明显升高(P＜0.01),给药组、训练组和给药训练组血管紧张素Ⅱ分别为(181.730±30.247),(173.5601±23.779)和(251.275±64.926)pg/mgprot,明显高于对照组(P＜0.01).结论 补肾益气中药具有增加大鼠心肌收缩力,改善冠脉循环,提高运动能力作用.     

慢性镉中毒小鼠肾小球超微结构观察和形态计量研究

为了全面、客观地反映慢性镉中毒时肾脏的病理学改变、本实验用透射电镜观察并结合形态计量法研究了慢性镉中毒小鼠肾小球的超微结构。结果表明：肾小球（特别是滤过屏障三层结构）明显受损。包括毛细血管内皮细胞肿胀、增厚；血管系膜增生；血管球基膜增厚、基膜和内皮细胞之间有电子致密物沉积；足细胞次级突起间裂孔缩小、裂孔膜变薄。从形态学方面考虑，认为慢性镉中毒时肾小球超微结构的改变与膜性增生肾小球肾炎的病理特征相似。     

低浓度铅对大鼠血脑屏障超微结构的损害

目的观察低浓度铅暴露对动物神经系统的影响。方法以硝酸镧为示踪物，观察分别给饮用铅（乙酸铅溶液，以Ｐｂ２＋计）１０和３０ｍｇ／Ｌ３个月的大鼠血脑屏障超微结构和通透性的变化，及其有关的血铅和脑铅浓度。结果当染毒大鼠血铅浓度为对照组的１．６５倍时，脑铅浓度无明显增加，可见镧盐颗粒沿着毛细血管内皮细胞膜整齐排列，基膜处没有镧盐颗粒；当染毒大鼠血铅浓度为对照组的２．４５倍时，脑铅浓度明显增高，在血管腔大而内皮细胞质复盖管腔面较薄的毛细血管的某些部位可见镧盐颗粒渗到基膜。结论神经细胞受损与血脑屏障的通透性增高有关，血管腔较大的毛细血管的某些部位通透性增加是低浓度铅对大脑损害的较早期指标     

亚慢性镉染毒致大鼠心脏损伤探讨

目的 观察氯化镉(CdC12)亚慢性染毒对大鼠心脏组织的损伤作用.方法 96只SD大鼠随机分成镉高剂量组、中剂量组、低剂量组和生理氯化钠对照组,每组24只,雌雄各半,给予CdCl2腹腔注射,每天1次,每周5d,连续14周.测定大鼠心脏组织中镉水平和脏器系数的变化,现察其心肌组织病理学改变.结果 镉染毒雄性大鼠心脏镉水平在高剂量组、中剂量组和低剂量组分别为5.764、2.450和0.789 μg/g,分别是对照组的 115.28、49.00和15.78倍;而雌性大鼠心脏镉水平在上述3个剂量组分别为5.147、2.180和1.219μg/g,分别是对照组的102.94、43.60和24.38倍,差异均有统计学意义(P<0.01).两性大鼠心脏脏器系数均随着镉染毒水平的增加而有不同程度的升高,有明显的剂量依赖关系(P<0.01)0所有染毒大鼠心脏组织出现不同程度的形态结构改变,主要有心肌纤维排列疏松,间陈增宽,细胞核固缩、碎裂、崩解,甚至心肌坏死,这些病理学改变随着镉染毒水平的增加而更加明显.结论　亚慢性镉染毒可引起大鼠心脏组织内镉蓄积,导致染毒大鼠心肌坏死等明显的组织病理学改变.     

高功率微波辐照对大鼠睾丸形态和超微结构的影响

目的 观察高功率微波(HPM)辐照后大鼠睾丸病理形态变化特征。方法 健康成年雄性SD大鼠45只,随机分为8个实验组和1个对照组。以S波段功率密度分别为20 mW·cm-2、40mW·cm-2的HPM辐照实验组大鼠,辐照时间分别为1、5、10和20 min。于辐照后6 h取材,以透射电镜和光镜观察其病理形态变化。结果 光镜下与对照组相比,20 mW·cm-25 min组开始出现轻度炎细胞浸润、组织充血,水肿;10 min组出现生精上皮细胞排列紊乱,畸形精子增多;20 min组和40 mw·cm-21 min组可见大鼠睾丸部分曲细精管管腔断裂,生精细胞明显坏死脱落。上述改变随功率密度增加,照射时间延长而加重。40 mW·cm-2 5 min组部分曲细精管内几乎无细胞,损伤达坏死极限;电镜下超微结构发生轻度线粒体水肿和内质网扩张是从20 mW·cm-25 min组开始,10 min组可见精原细胞水肿变性,20 min组毛细血管内皮细胞肿胀,基底膜分层,断裂。精原细胞凋亡增多,线粒体呈空泡化。功率增高后的各组均可见部分间质细胞发生变性、凋亡和坏死崩解。对照组无改变。结论 高功率微波辐照可导致大鼠睾丸形态发生明显的病理性改变,当达到20 mW·cm-2 20 min或40mW·cm-21 min后,对大鼠睾丸组织细胞有致死作用。     

规律运动对慢性心理应激大鼠海马锥体细胞形态的影响

目的探讨规律运动对慢性心理应激大鼠海马锥体细胞形态的影响。方法建立慢性心理应激模型结合6周游泳训练后,采用HE染色和透射电镜技术观察海马锥体细胞形态和结构变化。结果应激组大鼠海马CA3区锥体细胞胞浆凝固、胞核固缩、染色质边集,核膜皱褶,核内外可见空泡变性,线粒体变性、嵴数量明显减少,粗面内质网模糊不清、网腔局部扩张;30min运动组与对照组相似,60min运动组较对照组轻度改变,应激+30min运动组变化介于对照组和应激组之间;应激+60min运动组与应激组相似。结论心理应激导致大鼠海马CA3区锥体细胞形态和超微结构改变,适量运动调节可减缓慢性心理应激引起的损伤,对海马锥体细胞有保护作用。     

烟碱提取物对心肌梗死大鼠心室重构的影响

目的：建造大鼠心肌梗死模型，分析烟碱提取物对梗死后心肌纤维化及心室重构的影响。方法：将选取的30只SPF级雄性SD成年大鼠随机分作对照组(Ctrl组)、梗死组(AMI组)、烟碱提取物组。各组大鼠按实验设计同时给予4周持续灌胃治疗后，测定各项指标变化。其中，肌酸激酶-同工酶(CK-MB)、B型利钠肽(BNP)经ELISA法测得；运用四维彩超反应心功能，记录数据参数变化。测定左室收缩期内径(LVIDs)、左室舒张期内径(LVIDd)、左室内径缩短率(FS)、射血分数(EF)数据。并依据公式计算出肺、体质量比(L/BW)和右心室、体质量比(RVW/BW);HE染色观察心肌病理改变；用Masson染色观察心肌组织纤维化程度，并代入公式算出胶原纤维的容积分数(CVF)。结果：烟碱提取物治疗组的心功能明显改善；经ELISA测定的BNP及CK-MB均下降；梗死区心肌细胞胶原纤维沉积明显变少；HE染色可见心肌纤维化得到了显著控制。结论：烟碱提取物能够明显改善心梗大鼠的心功能，并且可以通过降低心肌纤维化来减缓心室重构而达到心脏保护作用。     

骨骼肌卫星细胞移植治疗心功能衰竭的实验研究

目的：移植骨骼肌卫星细胞（SC）修复受损心肌，治疗心功能衰竭。方法：雄性苏中幼猪23头，随机分为实验组与对照组。结扎对角支制作急性心肌梗死模型，造成心衰。实验组采用改良Dorfman法培养SC，心肌内注射种植；对照组注射等量细胞培养液。通过病理形态观察探讨SC移植对心衰的治疗作用。结果：（1）存活10头猪，实验组5头，对照组5头。总制模成功率43．5％；（2）SC贴壁生长，延尺分瓶或降低培养液中胎牛血清（FBS）浓度，SC生长停滞，相互融合形成肌管；（3）实验组梗死区内见新生的横纹肌纤维，细胞间无闰盘，毛细血管密度明显高于对照组。结论：自体SC移植后可在心肌内存活，可能通过改变心肌顺应性、心脏构型，或通过局部的促毛细血管增生作用提高心功能。     

心律失常的食疗辅治法

正常心脏跳动由窦房结控制，当心脏内兴奋波发放或传导发生障碍或潜在起搏点兴奋性增高时，就可引起心跳过快、心跳过缓或心动不规则等变化，称为心律失常。器质性心脏病是老年人产生心律失常的主要原因，如冠心病多引起室性心律失常，肺原性心脏病可导致多源性房性早搏、心动过速，风湿性心脏病则常有心房颤动，心肌炎、心包炎致心肌受损缺血时易引起反复发作或持续的窦性心动过速。常见的心外因素有：情绪激动、紧张、过度疲劳、饮浓茶或大量饮酒；急性感染性疾病，如上呼吸道感染、扁桃体炎、细菌性痢疾等；颅内病变，如脑瘤、脑外伤等；…     

Effects of Sulfur Dioxide Inhalation on Myocardial Collagen Fiber Morphology and Collagen Content in Exercising Rats

目的 探讨SO2吸入对运动大鼠心肌胶原纤维形态及胶原蛋白含量的影响.方法 24只雄性SD大鼠随机分为空白对照组、单纯运动组、单纯SO2污染组、SO2污染运动组,每组6只.单纯运动组、空白对照组大鼠置于自然环境中,单纯SO2污染组、SO2污染+运动组置于人工模拟的SO2污染环境中(10 mg/m3,1 h/d,连续4周),单纯运动组、SO2污染+运动组大鼠进行跑轮运动(8 m/min,1 h/d,连续4周).采用胃酶酸解法测定大鼠心肌羟脯氨酸的含量,并计算胶原浓度.采用苦味酸-天狼猩红染色法检测大鼠心肌、小动脉周围胶原容积分数.结果 单纯运动组、单纯SO2污染组和SO2污染+运动组大鼠心肌胶原纤维较空白对照组增生,且SO2污染+运动组大鼠心肌胶原纤维过度堆积.SO2污染+运动组、单纯SO2污染组、单纯运动组大鼠心肌羟脯氨酸含量、胶原浓度较空白对照组升高(P＜0.05),SO2污染+运动组升高更明显(P＜0.01)；单纯SO2污染组、SO2污染+运动组心肌、小动脉血管周围胶原容积分数较空白对照组大鼠升高(P＜0.05),SO2污染+运动组大鼠升高更明显(P＜0.01).结论 SO2吸入和运动双重刺激作用下,大鼠心肌胶原纤维过度增生,胶原蛋白合成与降解失衡,从而影响心肌细胞间力的传递及心脏的正常舒缩功能.     

有氧健身操对亚健康中老年女性健身作用的探讨

目的 通过自行设计的有氧健身操,观察对亚健康中老年女性的健身作用。方法 采用改良Bruce方案功率车 运动试验,观察锻炼组30例,对照组30例在运动前中后的心电变化来确定有氧健身操的最佳负荷,探讨有氧健身操对心脏功 能、体重指数、脂肪百分比的影响及腰臀围之比(WHR)与运动功能的关系。结果 锻炼组安静时心率明显低于对照组,最高 心率及心率储备两组间差异具显著性(P<0.05),锻炼组与对照组间WHR差异也具显著性(P<0.05)。锻炼组锻炼前后 血压、体重指数、脂肪百分比均有明显降低。结论 锻炼对心血管系统有良好的治疗作用,有氧健身操锻炼可改善中老年女 性WHR,减少腰部的脂肪堆积,降低血压、体重指数、脂肪百分比,增强运动能力。中老年女性WHR与运动能力呈负相关。     

Metabolic effects of the addition of resistive to aerobic exercise in older men

The metabolic changes associated with the addition of 4 months of resistive exercise to an existing aerobic exercise program (AEX+RT, n = 7) were compared to a maintenance aerobic exercise program (AEX, n = 8) in overweight, older men. The subjects in this study had recently completed a 6-month aerobic exercise program (treadmill walking, 45 min/d, 2 d/wk). The AEX+RT group added 6 exercises on upper- and lower-body pneumatic-resistance machines (2 sets, 15 repetitions each, 2 d/wk) to an aerobic exercise program at > or = 70% heart rate reserve for 30-40 min, 2 d/wk on treadmill, while the AEX group continued the same maintenance treadmill AEX program. There were no baseline differences in body weight, VO2max, or glucose metabolism between groups. The AEX+RT group increased upper- and lower-extremity strength by 28 +/- 4% and 46 +/- 6%, respectively (p < .05), despite a 9% decrease in VO2max (p < .05). VO2max did not change in the AEX group. There was no change in the fasting glucose or insulin levels, or the 3-h glucose responses to an oral glucose load in either group. The insulin responses decreased by 25 +/- 4% in the AEX+RT group (p < .01) but did not change in the AEX group. In conclusion, the addition of resistive exercise training to an existing aerobic exercise program may improve insulin sensitivity in overweight, older men, and thus prevent the development of type 2 diabetes.     

体力运动对慢性疲劳综合征大鼠不同脑区5-HT含量的影响

[目的]探讨慢性疲劳综合征的神经机制及运动的干预作用。[方法]40只健康雄性SD大鼠随机分为正常对照组、模型组、运动+模型组及运动组,每组10只。采用睡眠剥夺加负重力竭性游泳方式建立慢性疲劳综合征模型。采用8周跑轮运动作为自动体力运动模型。实验结束后处死各组大鼠,用高效液相色谱法检测海马、枕叶皮层5-羟色胺(5-HT)含量。[结果]与正常对照组比较,模型组不同脑区5-HT含量明显降低(P﹤0.01)。与模型组比较,运动+模型组5-HT含量明显增加。与对照组比较,运动组不同脑区5-HT升高,差异有统计学意义(P﹤0.05)。[结论]长期体力运动可作为一种有效的防护措施,通过调节神经递质的紊乱,从而降低慢性疲劳对机体神经功能的损害。     

运动对慢性疲劳综合征大鼠神经免疫功能影响

目的探讨慢性疲劳综合征的神经免疫机制及运动的干预作用。方法40只雄性Sprague-Daw ley大鼠随机分为对照组,模型组、运动+模型组及运动组;采用睡眠剥夺加负重力竭性游泳方式建立慢性疲劳综合征模型;采用8周跑轮运动作为自动体力运动模型;用高效液相色谱法检测海马、枕叶皮层5-羟色胺(5-HT)含量,应用酶联免疫吸附(ELISA)法检测血清干扰素-γ(IFN-γ)和白细胞介素-4(IL-4)水平以及IFN-γ/IL-4比值变化。结果模型组海马、枕叶皮层5-HT(11.28±5.13),(1.15±0.34)ng/g较对照组(33.56±6.42),(3.49±0.42)ng/g明显降低(P0.01);血清IFN-γ(19.36±4.34)pg/mL及IFN-γ/IL-4比值(0.96±0.62)较对照组明显下降(P0.01);与模型组比较,运动+模型组5-HT(23.35±4.36),(2.67±0.51)ng/g明显增加;IFN-γ水平(37.58±5.13)pg/mL和IFN-γ/IL-4比值(2.65±0.91)明显增高(P0.05);与对照组比较,运动组5-HT水平(54.27±5.31),(5.87±0.63)ng/g升高(P0.05)。结论长期体力运动可作为一种有效的防护措施,可降低慢性疲劳对机体神经免疫功能的损害。     

Beneficial effects of gradual intense exercise in tissues of rats fed with a diet deficient in vitamins and minerals: A pilot study

ObjectiveThis study evaluated the preliminary effects of intense physical training (swimming) on oxidative stress in rats with nutritional deficiencies.MethodsRats were fed with a standard diet or a diet deficient in vitamins and minerals for 4 months. The deficient diet contained one-fourth of the recommended vitamin and mineral levels for rats. From the second month, half of the animals were subjected to a swimming exercise in a plastic container with water maintained at 34 ± 1°C for 1 h/d, five times per week, for 11 wk. The rats were subjected to swimming exercise with loads attached to the dorsal region, which were progressively increased according to their body weight (1% to 7%). Sedentary rats were transported to the experimental room and handled as often in a similar way as the exercise group, except that they were not put in water.ResultsIn the exercised group, blood lactate levels were significantly lower and the heart weight/body weight ratio was significantly higher than in the sedentary group (P < 0.05). Increased lipid peroxidation was observed in the liver, heart, and skeletal muscle of rats fed with the deficient diet, but it was completely reversed by exercise. Exercise also decreased lipid peroxidation levels in the heart and skeletal muscle of rats fed with the standard diet (P < 0.05).ConclusionThis pilot study leads to the continuity of the studies, because the partial results observed suggest that inadequate nutrition may enhance oxidative stress, and that intense chronic physical training may activate antioxidant defenses, possibly by hormesis.     

Effects of exercise on emerging and traditional cardiovascular risk factors

BACKGROUND: Common cardiovascular disease risk factors (e.g., insulin and aerobic fitness) are improved with exercise; however, few studies have addressed the potential for training to modify emerging cardiovascular disease risk factors such as homocysteine and high-sensitivity C-reactive protein. METHODS: Sedentary adults (n = 324, 48.9 +/- 8.4 years) were randomized to four groups differing in training intensity (moderate = 45-55% or high = 65-75% of heart rate reserve) and frequency (low = 3-4, 30-min sessions/week or high = 5-7, 30 min-sessions/week). RESULTS: Within-group changes in homocysteine, insulin, and aerobic fitness were significant (all P < 0.0125). Furthermore, homocysteine increased in the high-intensity-low-frequency (0.98 +/- 2.32 micromol/L) and high-intensity-high-frequency (0.93 +/- 2.56 micromol/L) groups, while aerobic fitness increased in the moderate-intensity-high-frequency (0.99 +/- 2.01 mL min(-1) kg(-1)) and high-intensity-high-frequency (1.77 +/- 2.97 mL min(-1) kg(-1)) groups (all P < 0.003). The change in aerobic fitness was greater in the high-intensity-high-frequency compared to the moderate-intensity-low-frequency group (1.77 +/- 2.97 vs. 0.36 +/- 2.10 mL min(-1) kg(-1), P = 0.0014) (effect size estimate = 0.60 mL min(-1) kg(-1)). The main effects for intensity, with respect to the change in insulin (effect size estimate = 0.46 microU/mL), and frequency, with respect to the change in aerobic fitness (effect size estimate = 0.38 mL min(-1) kg(-1)), were significant (P < 0.0125). CONCLUSION: Although frequent bouts of higher intensity exercise were particularly effective in reducing fasting insulin and improving fitness, they resulted in slightly increased homocysteine levels.     

支链氨基酸提高大鼠游泳耐力作用探讨

目的 :　探讨支链氨基酸 (BCAA)对提高大鼠运动耐力的作用。方法 :　取雄性Wistar大鼠 2 1只 ,随机分为三组 :正常组、游泳对照组及游泳补充 5% BCAA饲料组。两个游泳组每天游泳训练 1 h,1 0 d后 ,游泳 6h,观察游泳大鼠的存活率 ,测定血乳酸和尿素氮水平 ,血清和骨骼肌乳酸脱氢酶 (LDH)活力 ,线粒体脂质过氧化物 (LPO)水平和线粒体膜的粘度系数。另取昆明种小鼠 ,随机分为三组 ,用实验一相同的饲料喂养 ,两周后 ,于每只小鼠尾静脉注射 15N-甘氨酸 (15N-Gly) 1 .0 mg,注射后 和 组立即游泳 ,分别于注射后的 1、2、3及 4h,测定各组骨骼肌蛋白质中15N-甘氨酸 (15N- Gly)的丰度。结果 :　BCAA可明显提高大鼠游泳存活率 ,抑制游泳运动后大鼠的血乳酸浓度、LDH活力、骨骼肌 LPO的升高幅度 ,抑制骨骼肌 LDH活力和膜流动性下降的趋势。并且 BCAA还可增加 15N- Gly在骨骼肌蛋白质中的滞留时间。结论 :　BCAA可改善运动后骨骼肌线粒体功能 ,改善运动性疲劳 ,提高大鼠的运动耐力     

运动和表没食子儿茶素没食子酸酯对糖尿病大鼠心肌间质蛋白表达的影响

目的观察游泳训练和/或表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)对2型糖尿病大鼠心肌间质蛋白表达的影响及其与心肌TGF-β/Smads信号通路的关系。方法6周龄SPF级雄性SD大鼠,采用6周高脂饲料喂养加腹腔注射链脲佐菌素(STZ,30 mg/kg)复制2型糖尿病大鼠模型,随机分为糖尿病模型组(D组)、糖尿病(EGCG)组(DG组)、糖尿病运动组(DE组)、糖尿病运动EGCG组(DEG组),每组8只,另增设同批次雄性SD大鼠6只为正常对照组(C组)。运动组大鼠进行无负重游泳训练,游泳时间为第1周15 min/d,时间以每周15 min递增延长,直到延长至90 min/d,每周运动5天,休息2天。EGCG给药组(100 mg/kg BW)大鼠每天灌胃,连续7天。游泳训练和/或EGCG干预共12周。干预实验结束48小时后,过夜禁食12 h后麻醉处死大鼠,取部分左心室采用免疫组化法检测心肌多克隆抗体Ⅰ型胶原(Col Ⅰ)、Ⅳ型胶原(ColⅣ)、纤维连接蛋白(FN)蛋白表达,另取部分左心室采用碱水解法检测心肌羟脯氨酸(Hyp)含量、免疫印迹检测转化生长因子-β1(TGF-β1)蛋白表达、RT-PCR检测Smad2和Smad7 mRNA基因表达。结果与C组相比,D组大鼠血糖、心肌TGF-β1、Smad2 mRNA表达和心肌Hyp含量、Col Ⅰ、Col Ⅳ、FN蛋白表达均显著升高(P<0.01),Smad7 mRNA表达显著下降(P<0.01)。与D组相比,DG组、DE组、DEG组大鼠血糖、心肌TGF-β1、Smad2 mRNA表达和心肌Hyp含量、Col Ⅰ、Col Ⅳ、FN蛋白表达均显著下降(P<0.05或P<0.01),DG组、DEG组大鼠心肌Smad7 mRNA表达显著上升(P<0.05或P<0.01)。与DG组比较,DEG组大鼠血糖、心肌Smad2 mRNA表达和心肌Hyp含量、Col Ⅰ、Col Ⅳ蛋白表达均显著下降(P<0.05或P<0.01),心肌Smad7 mRNA表达显著上升(P<0.05)。与DE组比较,DEG组大鼠血糖、心肌TGF-β1、Smad2 mRNA表达和心肌Hyp含量、Col Ⅰ、Col Ⅳ蛋白表达均显著下降(P<0.05或P<0.01),心肌Smad7 mRNA表达显著上升(P<0.05)。DEG组大鼠血糖、心肌Smad2 mRNA表达和心肌Hyp含量、Col Ⅰ、Col Ⅳ、FN蛋白表达仍显著高于C组(P<0.05或P<0.01)。结论12周的游泳训练和/或EGCG给药均不同程度的降低了2型糖尿病大鼠心肌间质蛋白的表达,且二者联合干预效果更佳。     

甘草黄酮对运动训练大鼠睾酮、 皮质酮及血脂代谢的影响

摘要:目的　研究运动前补充甘草黄酮对力竭运动大鼠血清睾酮、皮质酮、FFA含量及血脂代谢的影响。方法　通过建立灌服甘草黄酮大鼠的力竭游泳运动模型,测定大鼠血清睾酮、皮质酮、TC、TG、LDL- C、HDL- C 和FFA的含量。结果　血清睾酮水平在力竭游泳运动后低于安静对照组,补充甘草黄酮组大鼠血清睾酮水平低于安静对照组而高于运动对照组（P＜0.05）。而血清皮质酮水平在力竭游泳运动后有所上升,补充甘草黄酮组大鼠血清皮质酮水平高于安静对照组（P＞0.05）而低于运动对照组（P＜0.05或P＜0. 01）;各组间血清睾酮与皮质酮比值变化与睾酮变化程度相一致。力竭游泳运动后大鼠血清TC,TG,FFA 和 LDL-C含量都有所升高,而HDL- C含量有所下降;通过补充不同剂量的甘草黄酮后,能够降低大鼠血清TC,TG和LDL-C的含量,FFA和HDL- C的含量有所升高。结论　在大强度运动中通过灌注甘草黄酮可以降低大鼠的血睾酮和皮质酮水平,改善大鼠的血脂水平和肌内脂肪氧化,提高运动能力。     

The effect of soccer training on the levels of atherosclerotic lipids in the blood of obese subjects

Aerobic exercise may modify lipid levels in obese subjects. The resulting change in lipid profile reduces the risk of atherosclerosis. The aim of this study was to investigate the impact of soccer training on lipid parameters in obese individuals playing soccer for recreation. Thirty obese subjects aged 25 to 55 years participated in the study. Twenty-two of the subjects played soccer recreationally for two hours per week over a four-month period and the remaining eight constituted the control group. Before and after the study period, we collected anthropometric data and capillary blood samples for the analysis of lipid parameters. All subjects had mixed obesity and lipid parameters showed that all were at risk of cardiovascular disease. The lipid profiles of the individuals in the training group did not become less atherosclerotic. Thus, soccer training without intensive coaching did not affect the weight or lipid profiles of these obese recreational soccer players. Such training is therefore less effective than appropriate therapeutic agents for reducing the risk of atherosclerosis in obese subjects. We suggest that regular individual aerobic exercise associated with dietetic advice is probably the best way to manage the risks of atherosclerosis.