胆道阻塞的CT诊断—与直接胆管造影的比较研究

本文对８２例手术病理证实的阻塞性黄疸作前瞻性ＣＴ诊断，并与直接胆道造影比较研究。发现胆管逐渐尖削，明显的肝外胆管壁环状增厚是良性阻塞可靠且特异的ＣＴ征象。肝内外胆管不一致扩张（内轻外重），扩张胆管腔内ＣＴ值大于２０ＨＵ对良性阻塞的判断有一定帮助。管突断伴或不伴肿块，胆管壁局根不规则增厚是恶性阻塞相对可靠且特异的ＣＴ征象。ＣＴ能清楚显示肝内胆管扩张及它们汇合处解部剖及变异。比较直接胆管造影，ＣＴ对肝     

Radiologic diagnosis and staging of pancreatic ductal adenocarcinoma

IBD CT is the single best modality for diagnosis and staging of patients with suspected pancreatic carcinoma. While carefully performed real-time US is an excellent technique for determining the level and etiology of bile duct obstruction, it is of more limited value for diagnosis of tumors in the body and tail of the gland, and is less accurate than IBD CT for assessment of tumor resectability. Thus, most patients require IBD CT for accurate, nonoperative staging. ERCP and angiography continue to be useful adjunctive procedures for evaluation of patients with suspected pancreatic carcinoma, particularly for evaluation of equivocal CT or US findings. An isolated pancreatic mass, that is, a mass with no ancillary CT or US findings of carcinoma (local extension, distant metastases), is a non-specific finding and requires further evaluation with either ERCP or angiography, and perhaps most importantly, with FNAB. Other neoplasms may mimic pancreatic ductal carcinoma, particularly islet cell carcinoma and lymphoma. Pancreatitis also can result in a focal pancreatic mass, simulating a neoplasm. These diseases usually respond to therapy and thus it is essential to confirm the radiologic diagnosis of pancreatic carcinoma with biopsy, particularly if surgery is not planned or if chemoradiation therapy is anticipated.     

Echography in jaundice caused by primary neoplasms of the bile ducts

A retrospective study is reported, carried out on 45 patients with primary carcinoma of the biliary tree. The purpose of the study was to test the effectiveness of US in accurately demonstrating the kind of jaundice (diagnostic level I), the site (diagnostic level II) and etiology of the biliary obstruction (diagnostic level III). A carcinoma of the gallbladder with common bile duct infiltration was found in 23 patients, while 22 were affected by primary bile duct carcinoma. In the 23 patients with carcinoma of the gallbladder, the kind of jaundice was correctly diagnosed in 100% of cases, while the site and cause of obstruction were detected in 18 (78%) and 10 (43%) cases respectively. In the 22 cases of primary bile duct carcinoma, the kind of jaundice was accurately demonstrated in 21 cases (95%); the site and etiology of the obstruction in 19 (86%) and 11 (50%) patients respectively. Therefore, in a total number of 45 patients examined, success rate was 98% in diagnostic level I, 80% in diagnostic level II, and 47% in diagnostic level III. Ultrasonography proves thus to be almost completely reliable in diagnostic level I, and very reliable in diagnostic level II; so much so that it can, alone, direct the surgeon in case of an emergency. Results are less satisfactory in diagnostic level III. Therefore, if details of the obstructive lesion and of the biliary tree are required for the planning of definitive treatment, either PTC, ERCP, or CT should be performed.     

恶性胆管梗阻的磁共振胰胆管造影与手术病理对照研究

目的探讨磁共振胰胆管造影（ＭＲＣＰ）诊断恶性胆管梗阻的价值。方法３２例临床怀疑梗阻性黄疸的病人进行了ＭＲＣＰ检查，并全部经手术病理证实。结果ＭＲＣＰ对恶性胆管梗阻部位诊断的准确率为９６．９％，而ＣＴ为８８．５％，超声为７６．０％。ＭＲＣＰ的定性诊断准确率为９６．９％。结论ＭＲＣＰ在恶性胆管梗阻的定位诊断上明显高于超声     

胰胆管水成像对梗阻性黄疸的诊断价值

目的 探讨胰胆管水成像(MRCP)对梗阻性黄疸的诊断价值。方法 回顾分析47例经手术、病理证实的梗阻性黄疸患者的影像表现。并与B超、CT、PTC相比较。结果 MRCP能清晰显示胰胆管的梗阻部位,对梗阻性黄疸的定位诊断率100％,定性诊断率93.6%。结论 MRCP是阻性黄疸的首选和最佳检查方法。     

Comparative evaluation of plain films, ultrasound and CT in the diagnosis of intestinal obstruction.

BACKGROUND: There are limited studies in the literature comparing plain radiography, US and CT in the evaluation of intestinal obstruction. We carried out this prospective study to compare the relative efficacies of these three imaging techniques in patients with intestinal obstruction. MATERIAL AND METHODS: Thirty-two patients presenting with clinical suspicion of intestinal obstruction were subjected to plain radiography, US and CT and the findings were compared with reference to the presence or absence of obstruction, the level of obstruction and the cause of obstruction. The final diagnosis was obtained by surgery (n=25), or by contrast studies and/or clinical follow-up in those who were treated conservatively (n=7). RESULTS: Out of 32 patients, 30 had mechanical intestinal obstruction (22 had small bowel obstruction and 8 had large bowel obstruction). Of the remaining 2 patients, 1 had adynamic ileus and the other had a mesenteric cyst. CT had high sensitivity (93%), specificity (100%) and accuracy (94%) in diagnosing the presence of obstruction. The comparable sensitivity, specificity and accuracy were, respectively. 83%, 100% and 84% for US and 77%, 50% and 75% for plain radiography. The level of obstruction was correctly predicted in 93% on CT, in 70% on US and in 60% on plain films. CT was superior (87%) to both US (23%) and plain radiography (7%) in determining the aetiology of obstruction. CONCLUSION: CT is a highly accurate method in the evaluation of intestinal obstruction especially for determining the level and cause of obstruction and should be the technique of choice when clinical or plain radiographic findings are equivocal.     

Staging of hilar cholangiocarcinoma by ultrasound and duplex sonography: a comparison with angiography and operative findings.

The pre-operative radiological assessment of proximal bile duct tumours is clinically important as resection may be limited by tumour extension along the bile ducts, into hepatic parenchyma or the adjacent vascular structures. Demonstration of the extent of biliary and vascular involvement can direct additional investigations and definitive treatment. 22 patients with hilar cholangiocarcinoma were studied pre-operatively by conventional ultrasound (US) and duplex sonography (DS). The extent of tumour infiltration and vascular involvement was compared with arteriography and operative findings. Bile duct dilatation and the level of obstruction was documented by US in 22 (100%), and the tumour was shown by US in 19 (86%). In these 19 patients, the extent of extraductal extension compared with operative findings was correct in 13, underestimated in two, and in four infiltration was massed. Vascular patency or involvement was correctly determined by DS in 19 (86%), and by arteriography in 18 (82%). In two of the three incorrect DS interpretations, lobar atrophy and contralateral hypertrophy distorted the hilar anatomy. US with DS is valuable in the pre-operative staging of proximal bile duct tumours in predicting ductal and vascular involvement.     

肝细胞癌合并胆管癌栓的影像表现

目的 探讨胆管癌栓的影像表现,以提高影像诊断水平.方法 回顾性分析经手术病理证实的肝细胞癌(HCC)胆管癌栓13例患者资料,其中3例进行了CT和MR检查,2例仅行CT检查,8例仅行MR检查,7例进行了MR胰胆管成像检查,13例均进行了超声检查.采用四格表Fisher 确切概率检验方法比较超声与CT、MR诊断HCC胆管癌栓的准确性.结果 13例HCC肿瘤及胆管癌栓均在CT或MRI上显示.4例胆管癌栓在CT上表现为胆管内软组织块影,动脉期可见癌栓轻度增强,癌栓远端胆管扩张.11例胆管癌栓在T1 WI上均呈稍低信号,T2 WI为稍高信号,增强后可见轻、中度强化.MR胰胆管成像上胆管癌栓表现为:胆管阻塞中断、狭窄或不规则充盈缺损伴有梗阻上方胆管扩张,胆管突然截断或呈"鼠尾"状(5例);肝内胆管扩张,癌栓充满整个胆总管.胆总管不显示(2例).超声检查准确诊断胆管癌栓7例,误、漏诊6例.CT、MRI准确诊断12例,误诊4例,超声与CT、MRI诊断胆管癌栓差异无统计学意义(P=0.270).结论 CT或MRI对诊断HCC合并胆管癌栓及明确癌栓范围有价值.     

胰腺癌的可切除性评价(经动脉双期螺旋CT与血管造影的对比分析)

分别采用经动脉双期螺旋ＣＴ扫描和选择性血管造影,对胰腺癌的可切除性进行术前前瞻性评价,以确定各自的临床应用价值。方法对１５例胰腺癌术前均行选择性造影及经动脉增强双期螺旋ＣＴ扫描,对胰腺癌的临床应用价值。结论经动脉双期螺旋ＣＴ扫描弥补了血管造影的不足,能够更为准确,全面地评价胰腺癌的可切除术,具有较高的临床应用价值。     

Site and number of liver tumors recorded at angiography and computed tomography compared with the findings at laparotomy and of resected liver specimens

Angiography and computed tomography (CT) were performed in 96 patients before laparotomy for an intended liver resection. Of these, 73 patients underwent liver resection, from a local excision to a trisegmentectomy. The accuracy of angiography in tumor localization was 77 per cent when the results were compared with the findings at laparotomy and from resected specimens. With CT the accuracy was 85 per cent. In 47 patients an analysis of the number of tumor nodules was possible. There were 76 nodules, and 42 (55%) were correctly identified by angiography and 58% (76%) by CT. Thirty-four tumor nodules were not seen at angiography, with the majority of these situated in the left liver lobe. At CT, 18 nodules were not observed, about equal numbers in right and left lobes. Five lesions thought to be present at angiography (9 at CT), could not be verified upon inspecting the resected specimens. Neither angiography nor CT seems to be reliable enough for an accurate prediction of resectability of liver tumors prior to laparotomy.     

Assessment of hilar and extrahepatic bile duct cancer using multidetector CT: value of adding multiplanar reformations to standard axial images

To retrospectively assess the value of multiplanar reformations (MPRs) compared with standard axial images in the assessment of hilar and extrahepatic bile duct cancer. Forty-eight patients with confirmed bile duct cancer were included as preoperative work-ups; all of these patients underwent contrast-enhanced multidetector CT consisting of axial and MPR images. Two radiologists independently assessed the axial images alone and the combined axial and MPR images in the coronal and sagittal planes for the presence of tumor, its extent, vascular involvement, and resectability. The results were compared with surgical and pathologic findings. For tumor presence and conspicuity, combined axial and MPR images had higher values than the axial only images. For evaluation of tumoral extent, there was no difference between the two image sets for either reader. The accuracy for tumor extent was lower in hilar cancer than in extrahepatic bile duct cancer. For evaluation of vascular involvement and resectability, the area under the receiver operating characteristic curve of axial images was not significantly different from that of the reformatted images.The addition of MPR images to the standard axial images did not significantly improve the diagnostic performance of MDCT in the evaluation of the bile duct cancer.     

Radiologic diagnosis of liver metastases in colo-rectal carcinoma. Prospective evaluation of the accuracy of angiography, ultrasonography, computed tomography and computed tomographic angiography

To evaluate the accuracy of radiologic methods in liver metastases from colo-rectal carcinoma, a prospective investigation of 71 patients was performed. These patients were examined by angiography, ultrasound (US), computed tomography (CT) and computed tomographic angiography (CTA). The primary aim of the investigation was to determine the accuracy of CTA. The results of these examinations were then compared with the results from inspection and palpation of the liver at laparotomy. An analysis of liver tumor distribution, as well as a lesion-by-lesion analysis, was performed. In 20 patients, tumor growth was found in the liver in 36 lobes/segments at laparotomy. Three patients called false positives (angiography 2, US, CT and CTA 3 patients) turned out to be true positives since the lesions were overlooked at operation. The changes in sensitivity obtained when these patients are considered are given in parentheses. Of the lobes/segments affected by tumor growth at surgery, angiography revealed 47 (48) per cent, US 69 (71) per cent, CT 80 (82) per cent and CTA 83 (84) per cent. At a lesion-by-lesion analysis, angiography showed 33 per cent, US 69 per cent, CT 61 per cent and CTA 76 per cent of the lesions. Because of a larger number of false positives recorded with CTA compared with CT the former examination is not suitable as a single method for evaluating resectability of liver metastases.     

Malignant biliary obstruction: efficacy of thin-section dynamic CT in determining resectability.

OBJECTIVE. Several authorities advocate the use of preoperative angiography to determine the resectability of pancreatic and periampullary tumors, claiming that CT alone is not sufficiently accurate for this purpose. Our objective was to assess the value of CT in predicting surgical resectability in patients with malignant biliary obstruction. MATERIALS AND METHODS. We performed a retrospective analysis of 380 consecutive cases of malignant biliary obstruction spanning a 4-year period. Most patients (230) were treated nonoperatively. Sixty-seven patients had surgery, pathologic confirmation of malignancy, and preoperative CT scans available for review. The CT scans were assessed for surgical resectability of tumor by an interpreter who did not know the patient's history. RESULTS. Forty-two patients had pancreatic adenocarcinoma, six had ampullary carcinoma, seven had cholangiocarcinoma, and 12 had other malignant neoplasms. Of 47 patients with tumors thought to be unresectable on the basis of CT findings, 42 had tumors that were found to be unresectable at surgery (positive predictive value, 89%). Of 20 patients with tumors thought to be resectable, 16 had tumors that were surgically resectable (positive predictive value, 80%). CT did not show metastases to duodenal lymph nodes (n = 2), portal vein infiltration (n = 1), and small hepatic metastases (n = 1). Visualization of most of these at angiography would not be expected. The CT finding of infiltration of the periarterial fat around the celiac or superior mesenteric arteries was reliable for predicting surgical unresectability. Lymphadenopathy and infiltration of nonperivascular fat planes were less reliable predictors of unresectability. CONCLUSION. Although some findings on CT that suggest unresectability are less reliable than others, the accuracy of CT compares favorably with reports on the accuracy of angiography for assessing tumor resectability in cases of malignant biliary obstruction. The addition of angiography to the examination of patients with potentially resectable lesions is not justified when high-quality, thin-section dynamic CT has been performed.     

ERCP、CT、B超对胰胆管下段疾病的诊断准确性

目的 比较ERCP、CT、B超对胰胆管下段疾病的诊断准确性。方法 100例临床表现为梗阻性黄疸，反复上腹痛、恶心呕吐的患均经ERCP、CT及B超检查本组患经手术病理或活检证实为良性病变(胆总管结石)57例，恶性肿瘤31例，其中胆总管癌11例，胰头癌13例，以及壶腹癌8例。上述3种方法术前的定性诊断准确率均与手术病理结果对照。结果 对胆总管结石的定性诊断准确率：ERCP为98％(n=56)，CT为72％(n=41)，B超为61％(n=35)；对恶性肿瘤的定性诊断准确率：ERCP为97％(n=31)，CT为78％(n=25)，B超为63％(n=20）。结论 ERCP对胰胆管下段良恶性病变的定性诊断准确率明显高于CT和B超，但因CT与B超均属无创性操作且对某些恶性肿瘤也有较高的定性诊断准确率，因此在影像诊断中应考虑3项技术优势互补。     

胆管癌的CT表现及诊断价值

目的：提高胆管癌ＣＴ诊断的正确率，探讨ＣＴ及超声对胆管癌的诊断价值。材料和方法：回顾经手术病理证实的６４例胆管癌资料，包括ＣＴ６４例、Ｂ超４９例。分析病变的ＣＴ表现，评价ＣＴ和超声对胆管癌的诊断准确率。结果：按胆管癌的发生部位将其分为三类：（１）肝内胆管癌；（２）肝门区胆管癌；（３）胆总管癌。三种类型各有其ＣＴ特征。ＣＴ确诊率为８４％，超声确诊率为８６％，ＣＴ和超声作为互补的检查方法，其确诊率可达９６％。结论：ＣＴ和超声互补，可作为胆管癌尤其是肝门区胆管癌和胆总管癌术前可靠的诊断方法。     

Percutaneous transhepatic intraductal biliary sonography for lymph node staging at 12.5 MHz in malignant bile duct obstruction: Work in progress

Purpose To assess the value of intraductal ultrasound (US) for lymph node staging in malignant biliary obstruction. Methods Eighteen patients with malignant extrahepatic obstruction were imaged during percutaneous bile duct drainage with a mechanically rotating US transducer at 12.5 MHz. Detectable lymph nodes were classified as malignant when two of three criteria (hypoechoic, rounded, conspicuous margins) were fulfilled. The results were compared with histopathological data in 8 patients and follow-up CT findings in 10 patients. Results In 15 of 18 patients (83%) malignant lymph node involvement was suspected at intraductal US and in 5 of 18 patients (28%) during CT. Histopathological investigation after operation (n=8) and follow-up CT studies (n=10) revealed the presence of malignant nodal involvement in 13 of 18 (72%) patients. The sensitivity, specificity, and accuracy of transhepatic intraductal biliary US in determining merely the presence or absence of malignant lymph nodes without specific topographic assignment were 92%, 40%, and 78%, respectively. Conclusion These preliminary results suggest that intraductal US may develop into a promising adjunctive modality during percutaneous bile duct drainage in patients with suspected malignant regional lymph node involvement.     

Papillary neoplasms of the bile duct that mimic biliary stone disease.

Papillary tumors of the bile duct are intraductal tumors with innumerable minute, frondlike papillary projections. These tumors may be either fixed to or detached from the bile duct wall. However, because the papillary projections on the surface of papillary tumors are long and slender, the tumors are friable and slough easily. The sloughed tumor fragments may float within the bile ducts, resulting in intermittent partial biliary obstruction and mimicking bile duct stones at clinical examination and at ultrasonography (US), computed tomography (CT), and cholangiography. A tumor manifests radiologically as thickening and irregularity of the bile duct wall or as a fixed or sloughed intraductal mass. A nonshadowing intraductal echogenic cast seen at US, an intraductal noncalcified soft-tissue mass with asymmetric wall thickening seen at CT, and an intraductal mass with a papillary surface and a serrated bile duct margin seen at cholangiography are all appearances that suggest a papillary tumor and may be helpful in differentiating a tumor from a bile duct stone.     

Multislice CT cholangiography without biliary contrast agent: technique and initial clinical results in the assessment of patients with biliary obstruction

Our objective was to describe our technique for multislice CT cholangiography without cholangiographic contrast agent, and to present our preliminary clinical results. Thirty-seven patients with suspected biliary obstruction were studied. A multislice CT unit was used with the following technical parameters: 2.5-mm collimation; 7.5-mm/s table speed; pitch 6; 0.8-s rotation time; 300 mA; 120 kVp; 18- to 24-s scan time; scan volume ranging from the hepatic dome to below the pancreatic head; 70-s delay after injection of 150 ml of iodinated contrast agent at 4 ml/s. No biliary contrast material was given; oral iodinated contrast agent was administered to opacify bowel loops. Axial, multiplanar reformatted, and minimum intensity projection images were evaluated. The CT findings were compared with the gold standard techniques: endoscopic retrograde cholangiography (ERCP) in 30 patients, percutaneous transhepatic cholangiography in 5, and intraoperative cholangiography in 2. In 5 patients with ampullary lesions biopsy was made during ERCP, 9 underwent surgery, and 11 US-guided fine-needle aspiration. Bile ducts appeared hypodense within the surrounding enhanced structures. Regarding the site of obstruction, agreement between multislice CT and conventional cholangiography was observed in all cases. One patient presented negative findings on both CT and ERCP. In 31 of 36 (86%) patients, multislice CT cholangiography without cholangiographic contrast agent correctly assessed the cause of bile duct obstruction. Multislice CT cholangiography without cholangiographic contrast agent seems to be a promising diagnostic tool in the assessment of patients with bile duct obstruction. Electronic Publication     

64层螺旋CT曲面重组技术对胆管梗阻的诊断价值

目的：研究胆管梗阻64层螺旋CT曲面重组（CPR）技术的操作方法、临床应用价值及其局限性。方法：搜集本院2008年7月～2009年3月阻塞性黄疸患者资料47例,全部采用GE公司Light Speed64层螺旋CT行上腹部平扫及四期增强扫描,后将其0.625mm薄层扫描轴位源像（ASI）传到工作站进行后处理,行扩张胆管曲面重建成像,作任意曲面以清晰显示梗阻部位及梗阻上段胆管的扩张情况,对胆管梗阻原因进行定位和定性诊断,并与手术所见及术后病理结果进行对比。结果：10例肝外胆管结石患者,术前64层螺旋CT曲面重组（CPR）技术定位、定性诊断准确率达到94%及87%。37例胆管、胰头肿瘤或先天性疾病患者（25例为肝门部、肝外胆管癌或胆管炎症,3例为壶腹部癌,胰头癌8例,先天性胆总管囊肿1例）中,36例准确定位,32例得到正确诊断,术前64层螺旋CTCPR定位、定性诊断准确率分别达到97%及86%。结论：64层螺旋CT曲面重建技术（CPR）能直观显示胆管病变,对诊断胆管梗阻具有重要价值。     

CT of intrahepatic lithiasis

Twenty out of 65 patients, submitted to percutaneous treatment for intrahepatic stones at our department since 1983, had ultrasound (US) and computed tomography (CT) performed before any treatment. CT visualised stones in 65% of patients while distribution of stones was assessed correctly in 40%. In 5 patients CT provided information useful for treatment: in one case extremely dilated bile ducts hindered cholangiographic evaluation of lithiasis while in the other four cases CT examinations showed stones in dilated bile ducts unrecognised on percutaneous or endoscopic retrograde cholangiography. It is concluded that CT is a useful tool in the diagnosis of bile duct lithiasis. It aids in treatment selection and, when the percutaneous approach is chosen, allows the interventional radiologist to select the ducts to be catheterised. Correspondence to: D. ReggePresented at the ECR 91