Coopdech支气管封堵管单肺通气对呼吸道力学及Qs/Qt的影响

目的对比观察应用Coopdech支气管封堵器与双腔气管导管（DLT）两种单肺通气技术对呼吸道力学及肺内分流率Qs/Qt的影响。方法择期肺叶切除手术患者40例,随机分为Ⅰ、Ⅱ两组,分别应用双腔支气管导管和Coopdech支气管封堵管行单肺通气,观察并记录两组患者呼吸力学参数气道峰压平台压、肺动态顺应性、吸气阻力、呼气阻力,并抽取动脉血和中心静脉血监测PaO2,PvO2,计算肺内分流率。结果与TLV时比较,两组OLV时气道峰压、平台压、吸气阻力、呼气阻力均升高,肺动态顺应性降低（P〈0.01）;与Ⅱ组比较,Ⅰ组OLV时气道峰压、气道平台压、吸气阻力、呼气阻力升高（P〈0.05或0.01）,TLV时两组间差异无统计学意义（P〉0.05）,Ⅱ组Qs/Qt在OLV/TLV时均较Ⅰ组降低（P〉0.05）,且在Ⅱ组内TLV时较OLV时降低。结论 Coopdech支气管封堵管单肺通气对呼吸道力学参数的影响较DLT小,而较小的气道阻力有利于非通气侧肺血流向通气肺的再分布,从而有利于减轻单肺通气时的肺内分流。     

Protective Effects of Danlou Tablet (丹蒌片) against Murine Myocardial Ischemia and Reperfusion Injury In Vivo

Objective: To observe the in vivo effect of Danlou Tablet (丹蒌片, DLT) on myocardial ischemia and reperfusion (I/R) injury. Methods: DLT effects were evaluated in mouse heart preparation using 30-min coronary occlusion followed by 24-h reperfusion and compared among sham group (n=6), I/R group (n=8), IPC group (ischemia preconditioning, n=6) and DLT group (I/R with DLT pretreatment for 3 days, 750 mg?kg-1?day-1, n=8). The effects of DLT were characterized in infarction size (IS) compared with risk region (RR) and left ventricle using the Evans blue/triphenyltetrazolium chloride double dye staining method in vivo. Furthermore, the dose-dependent effect of DLT on I/R injury was evaluated by double staining method. Five different concentrations of DLT (0.625, 1.25, 2.5, 5 and 10 g?kg-1?day-1) were chosen in this study, and dose-response curve of DLT was obtained on these data. Results: The ratio of IS to left ventricle was significantly smaller in the DLT and IPC groups than the I/R group (P<0.05 or P<0.01), the ratio of IS to RR was also reduced in the DLT and IPC groups (P<0.01), while there were no differences in RR among the four groups (P>0.05). Experiments showed incidence of arrhythmias was reduced in the DLT group (P<0.01). Furthermore, DLT produced a dose-dependent inhibitory effect with a half maximal inhibitory concentration of 1.225 g?kg-1?day-1. Conclusions: Our research concluded that DLT was effective in reducing I/R injury in mice, and provided experimental supports for the clinical use of DLT.     

Protective Effects of Danlou Tablet (丹蒌片) against Murine Myocardial Ischemia and Reperfusion Injury In Vivo

Objective: To observe the in vivo effect of Danlou Tablet(丹蒌片,DLT) on myocardial ischemia and reperfusion(I/R) injury.Methods: DLT effects were evaluated in mouse heart preparation using 30-min coronary occlusion followed by 24-h reperfusion and compared among sham group(n=6),I/R group(n=8),IPC group(ischemia preconditioning,n=6) and DLT group(I/R with DLT pretreatment for 3 days,750 mg·kg~(-1)·day~(-1),n=8).The effects of DLT were characterized in infarction size(IS) compared with risk region(RR) and left ventricle using the Evans blue/triphenyltetrazolium chloride double dye staining method in vivo.Furthermore,the dose-dependent effect of DLT on I/R injury was evaluated by double staining method.Five different concentrations of DLT(0.625,1.25,2.5,5 and 10 g·kg~(-1)·day~(-1)) were chosen in this study,and dose-response curve of DLT was obtained on these data.Results: The ratio of IS to left ventricle was significantly smaller in the DLT and IPC groups than the I/R group(P0.05 or P0.01),the ratio of IS to RR was also reduced in the DLT and IPC groups(P0.01),while there were no differences in RR among the four groups(P0.05).Experiments showed incidence of arrhythmias was reduced in the DLT group(P0.01).Furthermore,DLT produced a dose-dependent inhibitory effect with a half maximal inhibitory concentration of 1.225 g·kg~(-1)·day~(-1).Conclusions: Our research concluded that DLT was effective in reducing I/R injury in mice,and provided experimental supports for the clinical use of DLT.     

支气管封堵器法选择性肺叶隔离对开胸患者肺内分流及血气的影响

目的 探讨选择性左下肺肺叶隔离对开胸患者肺内分流及血气的影响.方法 选择40例经胸食道下段或贲门手术患者,将其分为A、B两组(n=20),两组患者均采用支气管堵塞法肺隔离单肺通气(OLV).A组:行左肺隔离,术中右肺单肺通气;B组:行左下肺隔离,术中右肺单肺通气+左上肺通气.术中维持呼气末二氧化碳分压(PET CO2)在正常范围,并维持血氧饱和度(SpO2)95％以上,在OLV前(T0)、OLV后20min(T1)、OLV后40 min(T2),OLV后60 min(T3),OLV结束后20min(T4)抽取动脉血行血气分析.观察血气变化和计算术中肺内分流量.结果 与T0和T4时间点比较,两组患者在T1、T2和T3时间点的动脉血氧分压(PaO2)明显下降(P＜0.01);A组下降幅度大于B组,B组T1、T2、T3时间点的PaO2明显高于A组(P＜0.05).与T0和T4时点比较,两组患者在T1、T2和T3时间点的肺内分流率(Qs/Qt)明显增加(P＜0.01);B组T1、T2、T3时间点的Qs/Qt值明显低于A组(P＜0.05).结论 选择性左下肺肺叶隔离可减少开胸患者OLV时肺内分流,并明显提高OLV时氧分压,减少术中低氧血症的发生.     

双腔支气管导管与支气管封堵器进行单肺通气对PetCO2和PaCO2的影响

目的 对比分析双腔支气管导管(DLT)和支气管封堵器(BB)在单肺通气时对呼气末二氧化碳分压(PetCO₂)和动脉血二氧化碳分压(PaCO₂)的影响.方法 30例择期进行胸科手术的患者随机分为DLT组和BB组,每组15例.两组患者在麻醉诱导后进行BB或DLT置入,记录两组进行单肺通气后的PetCO₂和PaCO₂值.结果 进行单肺通气时,DLT组的PetCO₂值高于BB组,PaCO₂值低于BB组, PetCO₂与PaCO₂相关性优于BB组.结论 与使用BB相比,使用DLT进行单肺通气更有利于CO₂的排出.     

支气管封堵器与双腔支气管导管在食管癌根治术中的应用比较

目的 比较支气管封堵器与双腔支气管导管用于食管癌根治术患者单肺通气的效果及安全性.方法 选择2015年12月至2016年12月于该院实施开胸食管癌根治术患者96例,随机均分为两组:双腔支气管导管组(DLT组)麻醉诱导后插入双腔支气管导管,支气管封堵器组(BB组)麻醉诱导后插入气管导管再置入支气管封堵器.比较两组患者插管并发症及苏醒情况.于双肺通气后5min(T1)、单肺通气后30 min(T2)、单肺通气后120 min(T3)、双肺通气后30min(T4)、拔管前(T5)、术后1 d(T6)采集动脉血行血气分析并记录T1～T5时点吸气峰压(Ppeak)、平台压(Pplat)、肺顺应性(Cdyn),以及插管、拔管血流动力学改变.结果 BB组术后声音嘶哑和咽喉疼痛发生率、拔管时间明显低于DLT组(P＜0.05),T2～T5时BB组Pplat、Ppeak均低于DLT组,T2、T3时BB组的Cdyn高于DLT组(P＜0.05);T2～T6时BB组PaO2、PaO2/FiO2均高于DLT组(P＜0.05);BB组插管时SBP、DBP、HR均明显低于DLT组(P＜0.05).结论 支气管封堵器在食管癌根治术麻醉中表现出明显优势,建议首选支气管封堵器.     

Effect of volume replacement with hydroxyethyl starch solution on splanchnic oxygenation in patients undergoing cytoreductive surgery for ovarian cancer

Objective To investigate the effectiveness of using a medium molecular weight hydroxyethyl starch solution (HES) administered as a replacement for estimated blood loss (EBL) during cytoreductive surgery for ovarian cancer on splanchnic oxygenation. Methods Forty-two patients undergoing cytoreductive surgery for ovarian cancer were enrolled in this prospective randomized study. As soon as the EBL exceeded 10% but was less than 20% of the estimated blood volume, the patients were randomly assigned to receive either a volume of lactated Ringer’s solution (LRS) equal to three times the EBL (LRS group, n=22) or a volume of 6% HES equal to the EBL (HES group, n=20). Tissue oxygenation was assessed indirectly by measuring tonometric parameters, including the difference between gastric intramucosal PsCO2 and arterial PaCO2 （Ps-a CO2 gap）, gastric intramucosal pH (pHi) and arterial lactate acid concentration at 30 min after induction of anesthesia (baseline value), 1 hour and 2 hours after skin incision, and at the end of surgery. Results At the end of surgery,the Ps-a CO2 gap in the HES group (8.7±1.6 mmHg) was significantly lower than that of the LRS group (18.74±4.4 mmHg, P&lt;0.01), while the pHi (7.30±0.05 mmHg) in the HES group was significantly higher than that of the LRS group (7.21±0.07 mmHg, P&lt;0.01). There was no significant difference between the two groups in terms of arterial lactate acid concentration. Conclusion In patients undergoing major surgery with relatively large blood losses, volume resuscitation with medium molecular weight hydroxyethyl starch solution may improve splanchnic blood flow and tissue oxygenation.     

Bridging bronchus complicated with a left pulmonary artery sling a rare entity

To the editor： The bridging bronchus （BB） is a rarely reported congenital anomaly in which right middle and lower lobes are supplied by an accessory bronchus arising from the left main bronchus,1 A sling left pulmonary artery （SLPA） is also a rare congenital cardiac malformation, in which the left pulmonary artery arises from the right pulmonary artery and passes between the trachea and esophagus, causing tracheal stenosis by the pulsating pulmonary artery.： Here we present a rare pediatric case of BB complicated with a SLPA.     

肺磨玻璃结节患者行胸腔镜局限性肺切除术中支气管封堵器肺隔离的可行性和安全性研究

目的 评价肺磨玻璃结节患者行胸腔镜局限性肺切除术中支气管封堵器(bronchial blocker,BB)肺隔离的可行性和安全陛.方法 选取2018年1月至2019年12月首都医科大学附属北京友谊医院平谷医院拟行胸腔镜下肺磨玻璃结节局限性肺切除术患者122例,采用随机数字表法分为双腔支气管导管(double lumen tube,DLT)组和BB组,每组61例.DLT组采用DLT辅助单肺通气,BB组采用BB辅助单肺通气,比较两组支气管镜定位时间、一次性插管成功率、肺萎缩质量、单肺通气前后血气指标及术后咽痛发生率.结果 BB组支气管镜定位及插管时间长于DLT组[(158.5±13.2)s比(129.7±22.8)s],差异有统计学意义(P＜0.05).两组手术时间比较,差异无统计学意义(P＞0.05).BB组一次性插管成功率明显高于DLT组(83.6％比55.7％),术后咽痛发生率明显低于DLT组(14.8％比45.9％),差异均有统计学意义(P＜ 0.05).两组肺萎缩质量比较,差异无统计学意义(P＞0.05).DLT组和BB组单肺通气10 min、30 min的PaO2[(177.9±13.6) mmHg和(161.8±12.6) mmHg、(218.6±16.0)mmHg和(231.5±18.9) mmHg,lmmHg=0.133 kPa]低于单肺通气前[(242.5±17.3) mmHg和(237.0±20.3) mmHg],两组气道峰压[(25.2±2.7) mmHg和(25.7±2.5) mmHg、 (21.5±2.5) mmHg和(21.1±2.2) mmHg]明显高于单肺通气前[(13.9±1.8) mmHg和(14.0±2.1) mmHg],差异有统计学意义(P＜0.05).两组单肺通气10 min、30 min的PaCO2和MAP与单肺通气前比较,差异无统计学意义(P＞0.05);且两组间同时点比较,差异无统计学意义(P＞0.05).BB组单肺通气10 min、30 min的PaO2高于DLT组[(218.6±16.0) mmHg比(177.9±13.6) mmHg、(231.5±18.9) mmHg比(161.8±12.6) mmHg],气道峰压低于DLT组[(21.5±2.5) mmHg比(25.2±2.7) mmHg、 (21.1±2.2) mmHg比(25.7±2.5) mmHg],差异有统计学意义(P＜0.05).结论 胸腔镜下肺磨玻璃结节局限性肺切除术中应用BB操作简单,插管成功率高,是安全可行的肺隔离、单肺通气方法,建议推广应用.     

Role of Nuclear Transcription Factor-κB in Endotoxin-induced Shock in Rats

To investigate the role of NF-κB in endotoxic shock in rats. the model of endotoxinshock rats was induced by intravenous infusion of lipopolysaccharidc (LPS). 1 h. 2 h. 4 h and 6 h after LPS injection, the activation of NF-κB in blood mononuclear cells and the content of TNF-α and IL-6 in plasma was detected by enzyme-linked immunoadsordent assay (ELISA). The level of mean arterial pressure (MAP) and the histopathological changes of lung and liver were also observed. The activation of NF-κB in mononuclear cells increased 1 h after LPS injection and reached its peak 2 h after the injection, and its level was higher than that of normal group. The level of TNF-α was increased 1 h after the infusion and peaked 2 h after the injection, and its level was higher than that of normal group after LPS infusion. The content of IL-6 increased gradually with time. the IL-6 level was higher than that of normal group after LPS injection. MAP was decreased gradually with time and its level was lower than that of normal group after LPS injection. Pathological examination showed that endotoxic shock could cause pulmonary alveolar hemorrhage, edema and infiltration of inflammatory cell in lung tissue and congestion, edema, capillary dilation and inflammatory cell infiltration in liver tissue. It is concluded that NF-κB can up-regulate the expression of TNF-α and IL-6 in plasma and play an important role in endotoxin induced shock in rats.     

两侧肺分别通气应用于开胸手术麻醉的临床观察

21例侧卧开胸手术患者,静吸复合全麻,经双腔支气管插管,术中施行双肺、单肺和左右肺分别通气各20分钟,以自身对照比较通气效果。动脉血气分析结果:单肺间歇正压通气(IPPV)较双肺IPPV,PaO_2明显下降,而A~-DO_2和Qs/Qt则明显升高。术侧肺相继加用高频喷射通气和持续气流通气,肺换气功能各主要指标均明显改善。我们认为单肺通气时应进行血气监测,对心肺功能不良及贫血患者选用双腔支气管插管应慎重,必须使用时应采取左右肺分别通气等有效改善措施,既保持单肺通气的主要优点又可减少分流改善氧合。本文介绍了自制的持续吹氧装置,通气效果和高频呼吸机一致,但更简便适用。     

开胸手术单肺通气时行PEEP和CPAP对氧合作用的影响及麻醉管理

目的:评价开胸单肺通气麻醉时行呼气未正压通气(PEEP)和连续气道正压通气(CPAP)对患者血氧合作用的影响。方法:选择40例开胸行肺叶切除的单纯肺癌患者,随机分为A、B两组。A组于手术开始后15min(A1),单肺通气后15min(A2),患侧肺0cmH2OPEEP健侧肺5cmH2OPEEP后15min(A3)、患侧肺5cmH2OCPAP健侧肺0cmH2OPEEP后15min(A4)、患侧肺5cmH2OCPAP健侧肺5cmH2OPEEP后15min(A5)。分别监测平均动脉压(MAP)、心率(HR)、动脉血氧分压(PaO2、混合静脉血氧分压(PvO2)、动脉血氧饱和度(SaO2)、混和静脉血氧饱和度(SvO2),计算分流值(Qs/Qt)。B组用10cmH2OPEEP和10cmH2OCPAP重复上述过程。结果:与A2相比,A3、A4和A5PaO2显著增加,Qs/Qt值显著降低(P<0.05),但A3、A4、A5间相比较差异则无显著性(P>0.05)。B组各时点的各项指标变化与A组类同。结论:在开胸行单肺通气麻醉时,健肺使用PEEP、患肺使用CPAP或联合使用PEEP和CPAP,能提高患者手术中的氧合作用,降低Qs/Qt值,与5cmH2OPEEP和CAMP比较,10cmH2OPEEP和CPAP不能进一步改善PaO2和Qs/Qt。麻醉管理应采取措施,预防低氧血症。     

双腔支气管导管管端位置对肺隔离和通气效果的影响

目的 观测胸科麻醉用双腔支气管导管（DLT）行肺隔离时变动体位和手术操作引起DLT管端错位而影响肺隔离和通气效果的发生率和影响程度，并探讨有效处理措施。方法 选择成年胸科麻醉手术患者688例，静脉诱导后插入Mallinckrodt DLT。平卧位用纤维支气管镜（FOB）检查导管管端正确到位，并确认单肺通气获得完善的肺隔离和通气效果。侧卧位后行非术侧单侧肺通气15min时．以及术中发生肺隔离效果不佳或脉搏血氧饱和度〈90％时用FOB检查DLT管端位置并予以必要的调整。结果 侧卧位后112例患者发生管端错位（16.3％），其中12．8％患者发生低氧血症。3．3％患者出现隔离漏气现象。侧卧位后左DLT管端错位发生率（19．7％）比右DLT（12．2％）高（P〈0．01）。侧卧位时曾发生过管端错位的112例中，术中有16例（14．3％）再次发生管端错位，比侧卧位时未发生管端错位而术中出现管端错位的发生率（1．2％）明显高（P〈0．01）。结论 胸科麻醉用Mallinckrodt DLT行肺隔离时，侧卧位过程可以引起16.3％已正确到位的DLT管端发生错位；在FOB直视下调整管端位置后，术中仍有14．3％的几率再次发生管端错位。     

维迪欧视频喉镜和GlideScope视频喉镜在双腔支气管插管中的应用比较

目的 评估维迪欧视频喉镜在择期肺叶切除术患者行全身麻醉诱导双腔支气管插管中的实用性和安全性。方法 择期拟行经口左双腔支气管插管全身麻醉手术患者400例,美国麻醉医师协会（ASA）分级Ⅰ～Ⅲ级,年龄18～70岁。采用随机数表法将患者纳入A、B两组,A组代表GlideScope视频喉镜组,B组代表维迪欧视频喉镜组。记录两组插管时间、一次插管成功率、插管前后血流动力学波动、术后咽喉疼痛及声嘶等情况。结果 A,B两组的插管时间差异无统计学意义,第1次插管成功率差异也无统计学意义;插管前后A,B两组的平均动脉压及心率的波动差异无统计学意义;拔管后1h及拔管后1d,A,B两组的术后声嘶的差异无统计学意义（均P≥0.05）。但A组在拔管1d后轻度咽喉疼痛的发病率显著高于B组（14% vs 7.5%,P＜0.05）。结论 从插管时间、成功率,插管所导致的心血管反应,术后咽喉疼痛及声嘶等方面的结果来看,维迪欧视频喉镜可以安全应用于辅助DLT插管。     

双腔支气管导管型号与左主支气管内径相关性分析

目的 探讨左侧双腔支气管导管(DLT)型号与左主支气管内径的相关性。方法 随机抽取胸外科手术需行左侧DLT插管的成年病人100例,所有病人术前均行胸部螺旋CT扫描,利用三维图像重建技术测定病人隆突水平与左主支气管纵轴垂直平面的左主支气管内径值,根据左主支气管内径值插入左DLT,以纤维支气管镜定位或引导插管、采用“气泡溢出法”和“主支气管套囊压力测定法”判断DLT型号的合适性和插管的准确性。结果 合适的左DLT型号与左主支气管内径有相关性,相关系数为0.7346。结论 临床上,可根据左主支气管内径测量值指导选择左DLT。     

全麻单肺通气过程中硬膜外阻滞对肺内分流和氧合的影响

目的通过观察在全麻开胸单肺通气(OLV)2小时后,给予胸段硬膜外0.5%罗哌卡因阻滞时肺内分流率、动脉氧合及血流动力学的变化,了解硬膜外麻醉对单肺通气过程中肺内分流和氧合的影响.方法 20例ASAI～II择期需单肺通气开胸行食管癌根治手术的病人,均以静脉异丙酚维持麻醉,单肺通气120分钟后随机分为:静脉丙泊酚(异丙酚)组和静脉异丙酚加硬膜外组.连续监测平均动脉压、平均肺动脉压、中心静脉压、心输出量、心电图、脉搏氧饱和度等.调整异丙酚输注速度使脑电双频指数维持在44～55.两组分别于清醒状态(Base)、OLV60、120分钟,OLV135、150、180分钟(即硬膜外给药后15、30、60分钟)及恢复双肺通气30分钟(Da30分钟)时测定动脉及混合静脉血血气,计算肺内分流率(Qs/Qt).结果 GPE组硬膜外给药后与给药前相比肺内分流率差异无显著性(P＞0.05).GPE组动脉氧分压(PaO2)在硬膜外给药后30分钟(239±60mmHg)及60分钟(275±45mmHg)高于给药前OLV120分钟(170±75mmHg)(P＜0.05).两组间各时间点分流率、PaO2及循环指标差异无显著性(P＞0.05).结论单肺通气过程中给予硬膜外阻滞不会增加肺内分流率和降低PaO2.     

比较三种支气管封堵器在胸腔镜下肺大泡切除术中的应用效果

目的：比较Coopdech、Univent、Arndt三种支气管封堵器在胸腔镜下肺大泡切除术中的应用效果。方法：选择112例行胸腔镜下肺大疱切除术患者,按照单肺通气方式和封堵器种类分为Coopdech组、Univent组、Arndt组和双腔管组,各28例。观察各组的手术相关指标、血流定力学变化情况、通气指标和拔管后不良反应的发生情况。结果：单肺通气时,三个封堵器组的平均气道压均小于双腔管组;改变手术体位过程中,Univent组发生导管移位的次数大于其它三个组;三个封堵器组拔管后呛咳和咽喉疼痛的发生例数均少于双腔管组;各组一般情况、其它术中相关指标、全程血流动力学改变、PaO2和PaCO2变化情况和拔管后恶心呕吐发生情况组间差异无统计学意义。结论：三种支气管封堵器与双腔支气管导管均能够安全有效地应用在胸腔镜肺大泡切除手术中,使用三种支气管封堵器都可降低单肺通气时的平均气道压和拔管后呛咳和咽喉痛的发生率。     

不同吸入氧浓度对肺癌根治术患者单肺通气后氧合及氧化应激的影响

目的  探讨不同吸入氧浓度对肺癌根治术患者单肺通气（OLV）后氧合和氧化应激的影响。方法  选择60例开胸单叶肺切除术的肺癌患者,随机分为A、B两组（每组30例）,OLV后吸入氧浓度（FiO2）A组为100%,B组为50%。分别于侧卧位单肺通气前（T0）、OLV 30 min（T1）、OLV结束前（T2）、关胸后（T3）及术后2 h（T4）抽取桡动脉血和右心房血行血气分析,计算氧合指数（PaO2/FiO2）、呼吸指数（RI）和肺内分流率（Qs/Qt）。同时抽桡动脉血测定氧化应激指标超氧化物歧化酶（SOD）和丙二醛（MDA）。结果  两组各时间PaO2/FiO2比较,差异无统计学意义（P >0.05）。T1~T4时B组RI低于A组（P <0.05）,Qs/Qt也低于A组（P <0.05）。T4时B组MDA值低于A组（P <0.05）,SOD值高于A组（P <0.05）。结论  OLV后50%吸入氧浓度可降低Qs/Qt和氧化应激反应,改善氧合。

     

右美托咪定对单肺通气时缺氧性肺血管收缩及氧合的影响

目的 探讨右美托咪定对单肺通气时缺氧性肺血管收缩及氧合的影响.方法 将40例择期行单肺通气下肺叶切除术的肺癌患者分为对照组和治疗组,各20例,记录患者一般临床资料,并分别于麻醉诱导前（T0）、侧卧位双肺通气（TLV）后10 min（T1）、单肺通气（OLV）后10 min （T2）、OLV后60min（T3）及侧卧位恢复TLV后10min（T4）行血气分析计算肺内分流率（Qs/Qt）及氧合指数.结果 两组患者手术时间及OLV时间差异均无统计学意义（均P＞0.05）;治疗组异丙酚的用量显著少于对照组,差异有统计学意义（P＜0.05）;治疗组在T2、T3时肺内分流率少于对照组,氧和指数明显增加,差异均有统计学意义（均P＜ 0.05）.结论 右美托咪定可以缓解OLV时肺内分流、提高氧合,在一定程度上预防OLV时低氧血症的发生.