磷酸肌酸钠对冠心病心绞痛的治疗效果

目的探讨磷酸肌酸钠对冠心病心绞痛的治疗效果。方法选取2018年1—12月新乡市第一人民医院心血管内科和全科医学科收治的68例冠心病心绞痛患者,按随机数表法分为对照组和观察组,每组34例。对照组患者接受阿托伐他汀治疗,观察组患者接受阿托伐他汀联合磷酸肌酸钠治疗。比较两组患者治疗效果和治疗前后血流动力学指标,包括血浆黏度、全血低切黏度、全血高切黏度。结果对照组和观察组患者治疗总有效率分别为67.65%(23/34)、88.24%(30/34)。观察组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血浆黏度、全血低切黏度和全血高切黏度水平均低于治疗前,观察组患者血浆黏度、全血低切黏度和全血高切黏度水平均低于对照组,差异有统计学意义(均P<0.05)。结论磷酸肌酸钠有助于提高冠心病心绞痛的治疗效果,改善血流动力学状态。     

稳心颗粒联合酒石酸美托洛尔治疗冠心病心绞痛的临床效果

目的探讨稳心颗粒联合美托洛尔治疗冠心病心绞痛的临床效果。方法选取2017年1月至2018年1月濮阳市油田总医院收治的110例冠心病心绞痛患者,按照随机数表法分为对照组和观察组,各55例。对照组在常规治疗的基础上口服琥珀酸美托洛尔治疗,观察组在对照组治疗的基础上联合稳心颗粒治疗。记录两组患者治疗前后心绞痛发作频率和持续时间;统计两组患者治疗总有效率;比较两组患者治疗前后血流动力学指标[血浆黏度(PV)、全血高切黏度、全血低切黏度、纤维蛋白原(FIB)]水平;统计两组患者不良反应发生率。结果治疗后,观察组患者心绞痛发作频率和持续时间低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率[92.73%(51/55)]高于对照组[76.36%(42/55)],差异有统计学意义(P<0.05)。治疗后,两组患者PV、全血高切黏度、全血低切黏度与FIB水平低于治疗前,观察组患者PV、全血高切黏度、全血低切黏度与FIB水平低于对照组,差异有统计学意义(P<0.05)。两组患者均未见不良反应发生。结论稳心颗粒联合酒石酸美托洛尔治疗冠心病心绞痛临床效果较好,可有效改善患者血流动力学,具有临床推广价值。     

苯磺酸左旋氨氯地平治疗原发性高血压的临床效果

目的综合分析苯磺酸左旋氨氯地平在原发性高血压患者冶疗中的临床效果及对血流动力学的影响。方法选取于2014年12月~2016年12月在我院收治的156例原发性高血压患者,按照入院顺序随机分为实验组(应用苯磺酸左旋氨氯地平治疗方法,78例)与对照组(应用苯磺酸氨氯地平治疗方法,78例)。采用SPSS20.0统计学软件进行统计学分析两组患者的临床治疗总有效率、治疗前后的舒张压(DBP)、收缩压(SBP)以及血流动力学指标(全血低切还原黏度、红细胞聚集指数以及血浆黏度等)。结果 (1)实验组治疗总有效率为91.03%(71/78),对照组治疗总有效率为89.74%(70/78),两组患者的临床治疗总有效率比较无统计学意义(P0.05);(2)治疗前,两组患者的DBP、SBP水平比较差异无统计学意义(P0.05);治疗后,实验组患者的DBP、SBP水平较显著优于对照组(P0.05);(3)实验组患者全血低切还原黏度、红细胞聚集指数以及血浆黏度水平显著优于对照组(P0.05)。结论苯磺酸左旋氨氯地平在原发性高血压患者中的临床效果显著,有效改善血流动力学指标。     

中医药配合氦氖激光对黄褐斑患者血液流变学的影响

目的观察中药、川芎嗪配合氦氖激光对黄褐斑患者血液流变学的影响。方法90例黄褐斑患者随机分为两组:治疗组54例,采用自拟补肾疏肝化瘀方、川芎嗪配合氦氖激光治疗。治疗组治疗前有53例检测血液流变学低切、高切、血浆黏度,并与30例健康人对照;治疗组有34人治疗后检测血液流变学低切、高切、血浆黏度,并进行治疗前后对比。对照组36例,采用口服维生素E、维生素C,20%壬二酸霜外涂治疗。结果治疗组54例,基本治愈17例,显效26例,总有效率79.6%,明显优于对照组(P<0.05)。黄褐斑患者全血黏度低切、高切和血浆黏度检测均明显高于健康对照组(P<0.01)。经中药、川芎嗪配合氦氖激光治疗后,患者全血黏度低切、高切和血浆黏度均明显降低(P均<0.01)。结论黄褐斑患者存在血液流变学异常;自拟补肾疏肝化瘀方、川芎嗪配合氦氖激光治疗黄褐斑,具有降低全血黏度、血浆黏度等作用,临床疗效较好。     

前列地尔联合鼓室注射地塞米松对突发性耳聋患者听力恢复程度及血液流变学的影响

目的 探讨静脉注射前列地尔联合鼓室注射地塞米松对突发性耳聋患者听力恢复程度及血液流变学的影响,为临床治疗提供理论依据.方法 整群收集2013年7月—2015年7月该院符合标准的突发性耳聋患者63例,按随机数字表法分为观察组32例和对照组31例,两组患者均给予常规治疗.结果 治疗前,两组患者全血高切黏度、全血低切黏度、血浆黏度及空气传导听阈值比较,差异无统计学意义(P>0.05).观察组患者耳鸣恢复率92.86%、眩晕恢复率84.00%,对照组耳鸣恢复率77.78%、眩晕恢复率73.91%,差异有统计学意义(P<0.05).结论 在常规治疗的基础上,加用静脉注射前列地尔联合鼓室注射地塞米松治疗发性耳聋能,可明显改善患者血液流变,促进听力恢复,提高治愈率和总有效率.     

氯吡格雷辅助阿替普酶静脉溶栓对急性脑梗死的疗效

目的分析氯吡格雷辅助阿替普酶静脉溶栓对急性脑梗死(ACI)的疗效。方法选取通许县人民医院2018年3月至2019年10月收治的104例ACI患者,依据治疗方案分为对照组(52例)和辅助治疗组(52例)。对照组接受阿替普酶静脉溶栓治疗,辅助治疗组接受氯吡格雷辅助阿替普酶静脉溶栓治疗。观察对比两组临床疗效、治疗前后美国国立卫生院卒中量表(NIHSS)评分及血液流变学指标[血浆黏度、全血还原黏度、全血低切黏度、全血高切黏度、血小板聚集指数]水平。结果辅助治疗组有效率[94.23%(49/52)]较对照组[75.00%(39/52)]高(P<0.05)。治疗后,对照组和辅助治疗组NIHSS评分较治疗前降低,辅助治疗组NIHSS评分低于对照组(P<0.05)。治疗后,对照组和辅助治疗组血浆黏度、全血还原黏度、全血高切黏度、全血低切黏度及血小板聚集指数较治疗前降低,且辅助治疗组血浆黏度、全血还原黏度、全血高切黏度、全血低切黏度以及血小板聚集指数较对照组低(P<0.05)。结论氯吡格雷辅助阿替普酶静脉溶栓治疗ACI效果明显,可提高患者神经功能,改善血液流变学。     

乌司他丁联合奥曲肽治疗老年急性重症胰腺炎的效果

目的分析乌司他丁联合奥曲肽治疗老年急性重症胰腺炎的效果。方法选取2017年5月至2018年5月平舆县人民医院收治的108例老年急性重症胰腺炎患者,采用随机数表法将其分为对照组和观察组,每组54例。给予对照组奥曲肽治疗,观察组在对照组治疗基础上联合乌司他丁治疗。观察两组治疗效果及血液流变学。结果观察组治疗总有效率为92.59%(50/54),高于对照组的77.78%(42/54),差异有统计学意义(P<0.05);治疗后,两组全血低切黏度、全血高切黏度、血浆黏度均较治疗前降低,且观察组全血低切黏度、全血高切黏度、血浆黏度均低于对照组,差异有统计学意义(均P<0.05)。结论采用乌司他丁联合奥曲肽治疗老年急性重症胰腺炎,可有效改善患者血液流变学,治疗效果较佳。     

依达拉奉联合尤瑞克林治疗ACI疗效及对血液流变学和外周血神经因子水平的影响

目的:观察依达拉奉联合尤瑞克林治疗急性脑梗死(ACI)疗效及对血液流变学和外周血神经因子水平的影响。方法:按照入院顺序将我院收治的100例ACI患者分为实验组(依达拉奉联合尤瑞克林组)和对照组(依达拉奉组),各50例。比较两组患者治疗总有效率,记录治疗前、治疗14d后血液流变学状态(血浆黏度、全血高切还原黏度、全血低切还原黏度、血细胞比容、纤维蛋白原)变化以及外周血神经因子[神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)、神经营养因子(NTF)]水平变化。结果:治疗14d后,实验组患者治疗总有效率明显高于对照组(P<0.05);两组患者血浆黏度、全血高切还原黏度、全血低切还原黏度、血细胞比容、纤维蛋白原指标水平均低于术前(P均<0.05),且实验组患者降幅更大(P均<0.05);两组患者外周血NSE水平较治疗前明显下降,NGF、NTF水平较治疗前明显升高(P均<0.05),且实验组以上指标变化幅度更大(P均<0.05)。结论:对ACI患者采取依达拉奉联合尤瑞克林用药方案可提高临床疗效,改善患者血液流变学状态与神经功能。     

身痛逐瘀汤联合艾瑞昔布片治疗骨质疏松性椎体压缩性骨折患者术后残余痛的效果

目的:探讨身痛逐瘀汤联合艾瑞昔布片治疗骨质疏松性椎体压缩性骨折(OVCF)患者经皮穿刺椎体成形术(PVP)后残余痛的效果。方法:选取2019年10月至2022年1月于该院行PVP的88例OVCF患者进行前瞻性研究,采用随机数字表法将患者分为对照组和观察组各44例。两组均行PVP治疗,对照组术后口服艾瑞昔布片治疗,观察组在对照组基础上加用身痛逐瘀汤治疗。比较两组临床疗效、治疗前后中医证候积分(包括刺痛、肢体麻木、肌肤甲错、皮下瘀斑)、疼痛程度[视觉模拟评分法(VAS)]评分、腰椎功能[Oswestry功能障碍指数(ODI)]、血液流变学指标(全血高切黏度、全血低切黏度和血浆黏度)水平,以及不良反应发生率。结果:观察组治疗总有效率为95.45%(42/44),高于对照组的81.82%(36/44),差异有统计学意义(P<0.05);治疗后,观察组中医证候积分、VAS评分、ODI评分、全血高切黏度、全血低切黏度及血浆黏度均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:身痛逐瘀汤联合艾瑞昔布片治疗OVCF患者PVP术后残余痛可提高治疗总有效率,加快症状缓解,减轻疼痛程度,改善腰椎功能及血液流变学指标水平,效果优于单用艾瑞昔布片。     

灯盏花素注射液联合单硝酸异山醇酯片治疗不稳定型心绞痛的效果

目的研究灯盏花素注射液联合单硝酸异山醇酯片治疗不稳定型心绞痛(UAP)的效果。方法选取2016年4月至2018年5月濮阳县人民医院收治的96例UAP患者,按照随机数表法分为对照组和观察组,各48例。对照组接受单硝酸异山醇酯片治疗,观察组接受灯盏花素注射液联合单硝酸异山醇酯片治疗。对比两组心电图疗效、治疗前后血流动力学(全血高切黏度、全血低切黏度、血浆黏度、红细胞压积)以及纤维蛋白原水平。结果观察组心电图治疗总有效率[91.67%(44/48)]高于对照组[72.92%(35/48)],差异有统计学意义(P<0.05)。治疗后,两组全血高切黏度、全血低切黏度、血浆黏度、红细胞压积、纤维蛋白原水平均较治疗前降低,且观察组全血高切黏度、全血低切黏度、血浆黏度、红细胞压积、纤维蛋白原水平均低于对照组,差异有统计学意义(均P<0.05)。结论采用灯盏花素注射液联合单硝酸异山醇酯片治疗UAP,可改善患者血流动力学和纤维蛋白原水平,提高疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.