Drug compliance influence factors and countermeasure of hypertension patients

INTRODUCTIONThefirstassemblyinternationalconferenceaboutpatient＇sdiscom－pliancesuggestedthatpatientsnotcomplyingwiththerapycouldberegardedasdiscompliance．Patients＇non－complianceisanewtopicofmodernmedicine．Inclinical，HypertensionpatientsalwaystookdecompressiondrugorallyandmaintainsmalldosageafterBPinnormalrange．Doctorswilldeliverdifferenttherapyaccordingtopatients＇differentconditionsandregulatetherapyaccordingtocu－rativeeffectsintimeinordertogainthebesteffects．Patientsshouldcom…     

Postoperative function exercises promoting restoring of knee joint after old fracture of patella

BACKGROUND：Themainaimfortreatmentoffractureofpatellaistorestorecontinuityofkneejointextensionapparatusandanatomicreductionofkneejoint，avoidoccurrenceoftrau－maticarthritis．Problemsintreatmentofoldcomminutedfractureofpatellaarethesamewithfreshfracturethathasbeenagreedoninrecentyears．Exceptseriouscomminutedfractureofpatellacan＇tbereserved，removalofpatellashouldn＇tbeperformedtoothers．OrthopaedicsHospitalofShenyangcitythinksthattheidealmethodisrelaxofkneeextensionapparatus，reductiono…     

Systematic rehabilitation of sympathetic nerve type of cervical spondylopathy and related diseases

INTRODUCTIONTherearemanysymptomsofsympatheticnervetypeofcervicalspondylopathy，mostofwhicharesubjectivesymptomsandoneofthemostcommonsymptomisflustered，chestdistress．Diseaseconditionisoftenprolonged，mainsymptomsofdisturbanceofposteriorthoracicvertebraejointsarebackpainandchestdistress．Diagnosisofbothdiseasesaremainlyaccordingtoclinicalmanifestation，butsomesymptomsaren＇ttypicalandoftenmissedormisdiagnosed．Somepa－tientswithdisturbanceofposteriorthoracicvertebraedon＇tpresentwithobvio…     

The correlation analysis between ambulatory blood pressure monitoring in elderly patients with hypertension and decreasing occurrence of disabled diseases

BACKGROUND：Becauseofrequiringtakingmedicinlong－termly，manypatientswithhypertensioncannotpersevere．Missedtakingandstoppingtakingwithoutauthorizatiowhenbloodpressurearestableornotcontrolledareactivefactointreatmenteffect．Thebloodpressureofsomeoutpatientsarnotcontrolledeffectivelyandbecauseofhavingsubjectivsymptomstheyhasn＇tchangedthekindandquantityomedicine．Thebloodpressureofsomepatientsarenotcontrolleeffectivelyaftertakingonekindofhypotensor，otherwisedoctorhasn＇tadjustedtreatmentre…     

缓解期慢性阻塞性肺疾病32侧的康复指导

BACKGROUND：Chronicobstructivepulmonarydisease（COPD）can＇tbecuredcompletely，soenhancingrehabilitationguideinremissionstageisveryimportanttoamelioratepulmonaryfunction，delayprogressionofCOPDandtoelevatepatients＇livingquality．OBJECTIVE：ToobservetheeffectofrehabilitationguideonCOPDpatientsinremissionstage．UNIT：DepartmentofPediatrics，JiaonanPeople＇sHospitalSUBJECTS：３２COPDcasesthatlivedinourhospitalfromJanuarytoDecember１９９９wereselected，inwhichtherewere２３mal…     

应用抑制性消减杂交技术克隆EB病毒致人B淋巴细胞永生化的差异性表达基因

INTRODUCTIONEpstein－BarrVirus（EBvirus）wasfirstisolatedfromculturedBruitt＇lymphomabyEpstein，BarrandAchongin１９６４．EBvirusbelongstohumanherpesvirus．MostpeopleexperiencedEBvirusinfectionwithoutobvioussymptoms．EBvirusisinvolvedinalotofconditionssuchasinfectiousmononucleosissyndrom（IM），Burkitt＇lymphoma（BL），nasopharyngealcarcinoma（NPC），chronicactiveEBvirusin－fection（CAEBV），Hodgkin＇sdisease（HD），peripheralTcelllym－phoma，gastriccancerandimmunodefficientlym…     

Manual treating of 2cases with cer-vicogenous arrhythmia

MATERIALSANDMETHODSMaterials２caseswerediagnosedasarrhythmiawithoutclearreasonsbyECGandwereconfirmedthattheydidn＇tsufferedorganicdiseases．Allthecasesreceivedanti－arrhythmiaandheartmusclenutritiondrugsanddidn＇tgaingoodeffects．Methodspatientwasinsittingposition．Doctorstoodback，relaxcervical，shoulderandbackmusclesinorderwithpinch，grasp，massageandrollingmaneuver．Plug，extension，rotationshakingheadmethod．Doctorstoodonlateralposteriorside，onehandsupportedupperpartofhead，theo…     

Advance in senile disease prevention and treatment in China during “Nine Five” phase

Forthefirsttime，preventionandtreatmentofsenilediseasewaslistedinNationalKeyProjectsafterrepeatedprovementamongspecialistsduring“NineFive”phase，whichpromotesdevelopmentofsenilehealthwork．Diabetes，osteoporosis，Parkinson＇sdiseaseandseniledementiaarefrequentlyencountereddiseasesamongel－ders．Thereconditionsarenotleadingcausesofdeath，buttheyconsumedalotofmedicalresource．Complicationsandhigherdis－bilityrateseriouslyendangerelders＇qualityoflifeandincreasefamilyandsocialload．Thereseni…     

Effect of music therapy and behavioral therapy on schizophrenia patients

BACKGROUND：Musicplaysstronginfluenceonhumanpsycheandphysiology．Itcanamelioratepeople＇semotionandcog－nitionlevelandchangepeople＇svolitionalbehavior．Behavioralcorrectionchangescognitiveprocessandideasandcorrectsbadmotionandbehaviorthroughpositivereinforcement，negativerein－forcement，positivepunishmentandnegativepunishment．OBJECTIVE：Toinvestigatetheeffectofmusictherapyandbehavioraltherapyonschizophreniapatients．UNIT：SchizophreniaPreventionandTreatmentHospitalofJiningCitySU…     

异体脱钙骨基质骨粒复合骨水泥骨缺损修复材料结构特征及生物力学性能

INTRODUCTIONAsthematerialstorepairthebonedefect，bonecementandde－calcifiedbonematrixareusuallyusedinclinic．Forresearchingthematerialwhichhasthecapabilityofboneinductionandbiome－chanicalstrength，wedesignedthecompoundbiomedicalmaterialimpregnatedthedecalcifiedbonematrixwithbonecementandanalyzedit＇sconstructiveandbiomechanicalproperties．MATERIALSANDMETHODSPreparationofDBMparticlesAccordingtotheUrist＇smethods[１]，thecortexboneseliminatedthesofttissueandmarrowwerebrokenintopie…     

中晚期胆囊癌放疗疗效及预后影响因素分析

[目的]回顾性分析中晚期胆囊癌放疗疗效及评价其安全性,以期改善其预后.[方法]87例胆囊癌患者行三维适形放射治疗,可评价疗效81例,Nevin分期Ⅳ期23例、Ⅴ期58例.其中男性35例,女性46例.单次照射剂量1.8～2.2 Gy,每日1次,每周5次,总剂量38～65 Gy.[结果]Cox回归分析提示:CA199值、近期疗效与预后有关.81例中晚期胆囊癌患者,完全缓解率12.3％(10例),部分缓解率42.0％(34例),有效率54.3％.3个月生存期为95.1％(77例),6个月生存期为69.1％(56例),1、2、3年生存率分别为24.7％、3.7％、1.2％,中位生存期为8.5个月.毒副作用主要表现为近期胃肠道反应,经对症处理恢复正常.消化道反应Ⅰ级31例,Ⅱ级10例,发生率为50.6％;血液学毒性白细胞下降Ⅰ度15例,Ⅱ度5例,发生率为24.7％,血小板下降Ⅰ度8例,Ⅱ度3例,发生率为35.5％.无一例因严重放疗反应而终止治疗.[结论]三维适形放疗可延长中晚期胆囊癌患者生存期,减轻患者症状;且副作用大部分患者能耐受.     

2168例电视腹腔镜胆囊切除术的临床观察

目的：探讨腹腔镜胆囊切除术的适应症及适用人群。方法：回顾分析我院1998-2007年2168例腹腔镜胆囊切除术的疾病种类及年龄、性别分布。结果：胆结石伴慢性胆囊炎1994例占91.97%,胆囊息肉106例,占4.89%,急性胆囊炎伴胆囊结石68例,占3.14%;男性575例,占26.52%,女性1693例,占73.48%;年龄〈20岁21例,占0.97%,21-55岁1570例,占72.70%,56-65岁363例,占16.74%,年龄〉66岁208例,占9.59%,最小年龄15岁,最大年龄84岁。手术中转59例,占2.72%。结论：慢性胆囊炎、胆囊结石、胆囊良性隆起样病变是腹腔镜胆囊切除术的主要适应症;腹腔镜胆囊切除术适用于各年龄段的患者。     

儿童肺炎支原体抗体检测分析

目的了解不同时间、不同年龄儿童肺炎支原体（Mycoylasma pneumonsia，Mp）的感染情况。方法采用明腕疑集法，于2003年1月～2005年12月间共检测儿科门诊患儿3086例。结果儿科门诊患儿抗-Mp—IgM阳性率为39．6％，女患儿阳性率显著高于男患儿。冬春季节（11月～次年4月）发病率较高。随年龄增长，抗Mp—IgM阳性率逐渐增加。结论肺炎支原体感染在儿童呼吸道感染中占有较高比例，阳性率与季节、年龄有关。     

The development of children's concepts of death

This study had three purposes. The first was to construct a reliable test to assess children's concepts of death. Such a test was devised and was found to be reliable. The second purpose was to assess the development of children's understandings of subconcepts of the concept of death (cessation, necessity, irreversibility, causality, and university) for different content (humans and animals). The findings were: More younger than older children correctly judges tasks measuring these subconcepts, some of the subconcepts were more difficult than others, and there were no differences between children's understanding of these subconcepts for humans and animals. The third purpose was to find two kinds of developmental sequences. The first was development between the subconcepts. Two sequences were predicted based on an analysis of prerequisite relations: One of these was found in part, and the other was within a subconcept. It was found that children believe that in death there is cessation of external events (moving, speaking) before internal events (thinking, dreaming).     

血清总蛋白参考方法建立及不确定度评估

目的 建立血清总蛋白(TP)参考方法,评价其性能,并评估其测量结果不确定度.方法 根据国际医学检验溯源联合委员会(JCTLM)相关文件要求建立血清TP参考方法,对仪器、试剂、加样、温度等主要试验条件进行确认和优化,对方法灵敏度、精密度、线性、准确度进行评价,测量结果不确定度根据ISO不确定度评估指南进行评估.结果 参考方法使用的仪器设备及试剂性能满足方法要求;反应条件为37 ℃孵育10 min;方法灵敏度为0.005 82,室内测量不精密度小于0.7%,0～120 g/L线性范围良好;室间比对结果无统计学差异(P>0.05);参加TP国际参考实验室质量比对计划,样本测定结果在等效范围内,相对标准不确定度1.8%.结论 成功建立血清TP参考方法,性能指标满足要求,初步评估了测量结果不确定度,可用于TP测定的量值溯源和标准化.     

HBOV病毒VP1蛋白的重组表达及在感染检测中的应用

[目的]建立检测HBOV感染的免疫学检测方法和进行儿童人群中感染调查。[方法]采用PCR扩增克隆HBOV病毒VP1核衣壳蛋白部分基因，将其基因克隆至PET32a，构建原核表达重组质粒，在大肠杆菌中以包涵体形式获得表达。诱导表达后采用凝胶电泳切胶纯化目的蛋白。用重组蛋白作包被抗原建立了间接酶联免疫检测方法。[结果]病人血清及献血员血清均以1：50稀释。经检测北京和深圳的85份标本，阳性6人，阳性率7．06％，而正常献血员150人均为阴性，人群中感染率较低。[结论]成功重组表达了VP1蛋白，建立了检测抗体的ELISA方法。国内存在该病毒感染，被调查的人群中HBOV感染率较低。     

中文版波士顿腕管量表的信效度研究

目的分析中文版波士顿腕管量表(Boston carpal tunnel questionnaire,BCTQ)的信效度。方法将英文版BCTQ经过翻译、回译和文化调适后,对195例腕管综合征患者进行问卷调查,评定该工具的信效度。结果中文版BCTQ共19个条目2个维度,量表的Cronbachα系数为0.90~0.947。各条目的内容效度(content validity index,CVI)为0.9~1.0,全部条目的平均CVI为0.95。因子分析按2个维度分别进行,第1个维度提取2个公因子解释总变异的66.7%,第2个维度提取1个公因子解释总变异的73.25%。结论中文版BCTQ是一份具有较好信度和效度的评定工具,可用于我国腕管综合征患者的病情评估。     

熄风通络汤治疗脑卒中后眩晕的效果及对血液流变学指标水平的影响分析

目的分析脑卒中后眩晕患者应用熄风通络汤治疗后的效果.方法将某院91例脑卒中后眩晕患者采用随机数表法分组,对照组45例应用地芬尼多治疗,观察组46例联合熄风通络汤煎服,对比两组患者治疗后运动功能、平衡能力、眩晕障碍程度、血液流变学及临床疗效.结果治疗后,对照组的总有效率为80.00%(36/45),观察组总有效率为95.65%(44/46),两者比较差异有统计学意义(P<0.05).对照组Berg平衡量表评分(BBS)为(52.26±4.63)分,观察组BBS为(59.69±4.91)分,两者比较差异有统计学意义(P<0.05).对照组WOLF运动功能测试量表评分(WMFT)为(49.36±5.02)分,观察组WMFT为(67.88±6.35)分,两者比较差异有统计学意义(P<0.05).观察组眩晕障碍程度量表评分(DHI)为(28.16±2.19)分,对照组DHI为(41.39±4.1)分,两者比较差异有统计学意义(P<0.05).对照组低切全血黏度为(49.99±4.96)mpa·s,观察组低切全血黏度为(45.06±4.71)mpa·s,两者比较差异有统计学意义(P<0.05).对照组红细胞聚集指数为(4.50±0.40),观察组红细胞聚集指数为(4.06±0.38),两者比较差异有统计学意义(P<0.05).对照组高切全血黏度为(5.88±0.50)mpa·s,观察组高切全血黏度为(5.39±0.45)mpa·s,两者比较差异有统计学意义(P<0.05).对照组血液黏度为(1.52±0.11)mpa·s,观察组血液黏度为(1.29±0.09)mpa·s,两者比较差异有统计学意义(P<0.05).结论熄风通络汤能够有效调节脑卒中后眩晕患者血液流变学水平,改善患者运动功能及平衡能力,提升治疗效果.     

Evaluation of management of Graves' disease in District General Hospital: achievement of consensus guidelines

The management of Graves' disease in a District General Hospital was audited. A local care pathway was designed, which was inclusive of diagnosis, treatment and follow-up. This was then compared with consensus guidelines proposed by the Royal College of Physicians. Forty-six patients with Graves' disease attended the endocrine clinic. The diagnosis was based on clinical and biochemical features of autoimmune thyrotoxicosis, a raised thyroid-stimulating hormone receptor antibody (TRAB) and a diffusely increased uptake in thyroid technetium scan. They were treated for 18 months with antithyroid medications, which was subsequently discontinued provided satisfactory euthyroid state was achieved. Patients were followed up to assess remission and relapse status. The audit suggested that care pathway was in keeping with the guidelines. A few excess TRAB tests were requested. The relapse rate was 42% in our series and one-third of them (33%) chose to continue medical therapy.     

SSA抗原真核表达载体的构建

目的：通过基因克隆构建表达人干燥综合征抗原A（SSA）的巴斯德毕赤酵母分泌型表达载体。方法：从人白血病淋巴细胞HL60株中提取RNA，反转录出cDNA，然后以cDNA为模板，通过PCR法扩增目的基因SSA，经纯化、双酶切、DNA浓缩回收，插入到酵母分泌型表达载体pPIC9k，用热冲击法转化感受态细胞DH5a，筛选阳性克隆提取质粒，双酶切鉴定并测序。结果：PCR产物大小符合要求，重组质粒pPIC9k-SSA双酶切鉴定与预期一致，测序结果正确。结论：成功构建SSA毕赤酵母分泌型表达载体，为今后获取高纯度、高产量的SSA抗原，研制新型抗SSA诊断试剂盒作前期准备。