医用臭氧疼痛触发点注射治疗腰部肌筋膜疼痛综合征的效果与安全性

目的：：探索医用臭氧疼痛触发点注射治疗腰部肌筋膜疼痛综合征( MPS)的临床疗效及安全性。方法：将118例入选临床研究的 MPS 患者采用随机、单盲法分作两组,其中对照组59例使用消炎镇痛液注射治疗而研究组59例应用低浓度医用臭氧注射治疗,评价两组临床疗效及安全性。结果：两组治疗前 VAS 评分及腰背功能活动评分比较差异均无统计学意义( P >0.05)。两组治疗后 VAS评分及腰背功能活动评分均较治疗前明显减少,差异有统计学意义( P <0.05);且观察组与对照组比较明显减少,差异有统计学意义(P<0.05)。观察组治疗有效率(89.83％)高于对照组(71.19％),差异具有统计学意义(P<0.05)。观察组不良反应发生率(1.69％)较对照组降低(23.73％),安全性更好,差异具有统计学意义(P<0.05)。结论：医用臭氧疼痛触发点注射治疗腰部 MPS 疗效更好,安全性更高,适合临床进行广泛推广和应用。     

微创清除术治疗高血压脑出血的临床研究

目的 观察应用微创清除术救治高血压脑出血的临床疗效.方法 对68例高血压脑出血患者随机分成内科组33例,采用控制血压治疗脑水肿等方法;微创组35例,采用微创清除术治疗.采用格拉斯神经功能缺损评分量表及日常生活能力量表评分比较两组的近期(1个月)和远期(6个月)疗效.结果 微创组近期优良率(60％)和远期良好以上率(70.3％)高于内科组(30.3％、46.2％),差异有显著性(P<0.05,P相似文献   

急性脑梗死早期应用巴曲酶治疗的临床对照观察

目的:探讨巴曲酶(东菱迪芙)在急性脑梗死早期治疗的临床价值。方法:对巴曲酶治疗组56例及常规治疗组51例两组的疗效进行比较。结果:巴曲酶治疗组治愈23例(41.1％),显效15例(26.8％),有效11例(19.6％),总有效率为87.5％。常规治疗组治愈7例(13.7％),显效11例(21.6％),有效16例(31.4％),总有效率为66.7％。两组疗效差异显著(P<0.01)。结论:巴曲酶是急性脑梗死治疗的有效措施,治疗开始的时间越早越好,最好在脑梗塞发生12小时以内实施。     

中药封包联合手法治疗对半月板损伤的疗效观察

目的 探讨中药封包联合手法治疗对半月板损伤患者的临床疗效及对膝关节功能的影响.方法 选取2019年1月至2020年12月在四川省骨科医院治疗的102例半月板损伤患者为研究对象,按照随机数字表法分为试验组和对照组,每组51例.对照组给予手法治疗,试验组在对照组治疗基础上采取中药封包治疗,两组疗程均为2周.观察比较两组患者临床治疗效果、半月板脱落情况及不良反应发生情况;治疗前后视觉模拟评分(VAS)、Lysholm膝关节功能评分表(LKSS)、Barthel指数(BI)评分、关节活动度(ROM)变化情况.结果 102例膝关节的204个内外半月板中,Ⅰ级损伤45个(22.06％),Ⅱ级损伤159个(77.94％);内侧半月板120个(58.82％),外侧半月板84个(41.18％).治疗后,试验组总有效率94.12％,高于对照组80.39％(P<0.05);两组VAS评分均下降(P<0.05),且试验组低于对照组(P<0.05);两组BI评分均升高(P<0.05),且试验组高于对照组(P<0.05);两组患者LKSS均升高(P<0.05),且试验组高于对照组(P<0.05);两组ROM变化情况和不良反应发生情况比较,差异无统计学意义(P>0.05).结论 中药封包联合手法治疗半月板损伤,可改善患者关节疼痛、肿胀等症状,减轻患者膝关节活动障碍,改善患者日常生活.     

微型加压骨外固定器治疗手指骨折的临床效果

目的 探究应用微型加压骨外固定器治疗手指骨折患者的效果.方法 选取本院2017年1月至2019年12月收治的80例手指骨折患者,按照信封法分为对照组与观察组,各40例.对照组接受单纯内固定方式治疗,观察组在对照组基础上接受微型加压骨外固定器治疗,比较两组治疗效果.结果 观察组骨折愈合时间短于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率(97.50％)高于对照组(85.00％),差异有统计学意义(P<0.05);观察组手指总主动活动度优良率(90.00％)高于对照组(72.50％),差异有统计学意义(P<0.05);观察组并发症发生率(5.00％)低于对照组(27.50％),差异有统计学意义(P<0.05).结论 手指骨折患者应用微型加压骨外固定器治疗效果显著,值得临床推广运用.     

不同抗结核治疗方案对慢性乙肝合并肺结核的疗效及肝损伤作用对比

目的:比较在慢性乙肝合并肺结核患者治疗中应用两种不同抗结核治疗方案的效果及肝损伤情况。方法:选取医院收治的慢性乙肝合并肺结核患者90例,以随机数字表将患者分为A组(45例)和B组(45例),分别予以2HRZE/4HR方案和3HELLfx/3HELfx方案治疗,同时予以保肝和抗乙肝病毒治疗。对比治疗前后两组的肝功能指标变化,并对比两组的治疗效果。结果:治疗后两组的天门冬氨酸转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)均升高(P<0.05),B组低于A组(P<0.05),两组治疗后的白蛋白(ALB)均下降(P<0.05),B组高于A组(P<0.05);B组的治疗有效率高于A组(P<0.05)。结论:在慢性乙肝合并肺结核患者中应用3HELLfx/3HELfx抗结核方案对肝功能的损伤小于2HRZE/4HR方案,并可获得更好的治疗效果。     

评估川芎嗪治疗单纯型糖尿病视网膜病变的疗效及安全性

目的:评估川芎嗪在单纯型糖尿病视网膜病变中的应用效果及安全性。方法:选取收治的120例单纯型糖尿病视网膜病变患者进行研究,分为两组。对照组应用葛根素注射液治疗,观察组加用川芎嗪治疗,比较两组患者治疗前后视力变化情况、并发症发生率及治疗总有效率。结果:两组治疗前的视力比较,差异无统计学意义(P>0.05),经治疗后,两组与治疗前比较,差异有统计学意义(P<0.05),同时观察组治疗后的视力高于对照组,差异有统计学意义(P<0.05),提示视力改善幅度更大。观察组共31例为显效,26例为有效,治疗有效率为90.5%(57/63),对照组为73.7%(42/57),观察组显著高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为6.3%(4/63),对照组为5.3%(3/57),两组比较,差异无统计学意义(P>0.05)。结论:应用川芎嗪治疗单纯型糖尿病视网膜病变可显著强化治疗效果,且安全性高,具有较大临床价值。     

双侧平衡去骨瓣减压术治疗重型闭合性颅脑损伤的应用意义

目的:对重型闭合性颅脑损伤的患者使用双侧平衡去骨瓣减压术治疗的应用价值进行分析。方法:选择重型闭合性颅脑损伤患者60例,按照手术方式不同,分为应用2次去骨瓣减压术治疗组(常规组)和1次双侧平衡去骨瓣减压术治疗组(观察组),每组30例。对比两组治疗的疗效及术后并发症。结果:两组治疗效果比较,观察组在疗效良好方面明显优于常规组(P<0.05),同时在疗效差方面明显少于常规组(P<0.05),但是在疗效一般方面,两组差异无统计学意义(P>0.05)。在术后并发症方面,两组比较,观察组明显少于常规组(P<0.05)。结论:双侧平衡去骨瓣减压术治疗重型闭合性颅脑损伤疗效显著,值得应用。     

隔姜灸与悬起灸治疗不寐的临床随机对照效应对比

目的 探究隔姜灸、悬起灸治疗不寐的临床疗效.方法 选取2017年7月至2019年12月于本院失眠科就诊的40例不寐患者作为研究对象,随机分为隔姜灸组(隔姜灸治疗)和悬起灸组(悬起灸治疗),每组20例.比较两组临床疗效、睡眠质量、满意度及不良反应发生率.结果 隔姜灸组治疗总有效率为90.00％,明显高于悬起灸组的55.00％(P<0.05).治疗前,两组PSQI积分比较差异无统计学意义;隔姜灸组治疗前后PSQI各项目积分及PSQI总分比较差异有统计学意义(P<0.05),悬起灸组催眠药物、日间功能紊乱治疗前后比较差异无统计学意义.治疗后,隔姜灸组PSQI各项目积分及PSQI总分均低于悬起灸组,两组睡眠时间、睡眠效率、催眠药物、日渐功能紊乱积分及PQSI总分比较差异有统计学意义(P<0.05),两组睡眠质量、入睡时间、睡眠障碍积分比较差异无统计学意义.隔姜灸组不良反应发生率为5.00％,低于悬起灸组的15.00％,但差异无统计学意义.隔姜灸组满意度为95.00％,明显高于悬起灸组的65.00％(P<0.05).结论 隔姜灸治疗不寐效果显著,可明显改善睡眠状况,降低不良反应发生率,提高患者满意度,值得临床推广应用.     

奥美拉唑联合阿托品治疗急性胃炎的疗效分析

目的:分析在急性胃炎患者中应用奥美拉唑联合阿托品的效果。方法:以完全随机化法将88例急性胃炎患者分为两组,参照组(44例)应用奥美拉唑治疗,试验组(44例)在参照组基础上应用阿托品治疗。对比两组治疗前后的血清炎性因子水平,比较两组的症状消失时间及治疗效果。结果:治疗后两组的血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均下降,差异有统计学意义(P<0.05),两组间比较试验组更低,差异有统计学意义(P<0.05);试验组的恶心、呕吐、腹痛、腹泻消失时间均短于参照组,差异有统计学意义(P<0.05),试验组的治疗有效率高于参照组,差异有统计学意义(P<0.05)。结论:在急性胃炎患者中应用奥美拉唑联合阿托品治疗,更利于减轻炎性反应,促进症状的好转,提高治疗效果。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.