湖州市居民代谢综合征的患病情况调查

目的调查湖州市代谢综合征(MS)患病情况,为MS的防治工作提供依据。方法采用分层整群抽样方法,进行问卷调查和一般体格检查,同时检测血糖、血脂、脂蛋白等生化指标。结果湖州市居民MS患病率为6.35%,MS各代谢异常组分的患病率分别为,高血压29.98%、糖尿病6.27%、血脂异常29.46%和超重/肥胖(BMI≥25.0kg/m2)15.97%;女性MS患病率随年龄升高呈上升趋势,而男性的MS患病率高峰在30～50岁之间;MS各代谢异常组分的不同组合患病情况存在一定的性别间差异,仅有一种代谢异常组分的患者,女性血脂异常和超重/肥胖患病率高于男性,男性高血压患病率高于女性,而同时具有2种代谢异常组分的情况中,女性患病率高于男性。结论湖州市存在一定程度的MS流行,且至少具有1种MS代谢异常组分的患病比例较高,需要加强对MS的预防控制措施。     

不同性别老年高血压人群代谢综合征患病特点

目的分析不同性别老年高血压人群代谢综合征患病率及特点。方法采用分层整群抽样的方法对辽宁省阜新农村地区年龄≥65岁高血压患者1 637例,按不同年龄、体重指数(BMI)、血脂水平、血糖水平及高血压分级分为不同组分,进行流行病学调查和实验室检查。根据中华医学会糖尿病学分会关于代谢综合征诊断标准,分析不同性别老年人在代谢综合征各组分中患病率及特点。结果 (1)代谢综合征患病率随年龄的增长而降低,女性患病率明显高于男性。(2)代谢综合征患病率随BMl的升高而升高。(3)高TG患病率最高.其次为高LDL-C、低HDL-C和高TC。(4)在高血压各分级中女性患病率均高于男性。(5)代谢综合征患病率随血糖的升高而升高,女性患病率均高于男性。结论 (1)老年代谢综合征患病率随年龄的增长而降低,随BMI及血糖的升高而升高。(2)女性代谢综合征患病率明显高于男性,在高血压及血糖分层中女性患病率均高于男性。     

2030例急性脑梗死患者合并代谢综合征临床特点分析

目的 观察急性脑梗死患者血脂、血压、腰围和空腹血糖水平,并探讨其代谢综合征的临床特点.方法 回顾性分析2030例急性脑梗死患者的血脂、血压(收缩压、舒张压)、腰围和空腹血糖水平.结果 2030例急性脑梗死住院患者的代谢综合征患病率为67.73%,男性为71.80%,显著高于女性的62.00%(P＜0.001).男性患者高血压、腰围异常、血脂异常和窄腹血糖受损比例均显著高于女性(P＜0.005).代谢综合征以及高血压、腰围异常、血脂异常和空腹血糖受损比例随年龄增大而增高(P＜0.05).结论 脑梗死患者的代谢综合征患病率很高.对脑梗死患者进行代谢综合征评价非常重要,控制血脂异常、高血压、高血糖和肥胖在缺血性卒中的一级和二级预防中均不可忽视.     

镇海炼化公司老年人血脂异常横断面调查

目的调查镇海炼化公司老年人血脂异常的现况。方法通过2004年1362位老年人体检化验血脂各组分结果,参照“血脂异常防治建议”判断血脂异常。结果公司老年人的血脂各组分中,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)女性均高于男性(P<0.01)。血脂异常的总患病率为57.78%(男性为52.25%,女性为68.22%,P<0.001);血脂异常中,最常见的是高TC血症为37.52%(男性为34.27%,女性为43.64%,P<0.05);高LDL-C血症的患病率为36.20%(男性为30.22%,女性为47.49%,P<0.01);高TG血症的患病率为20.34%(男性为17.30%,女性为26.06%,P<0.001);低HDL-C血症的患病率为7.49%(男性为8.88%,女性为4.87%,P<0.01)。单种血脂异常率为21%(男性为22.02%,女性为19.07%);合并2种血脂异常率为26.36%(男性为22.58%,女性为33.47%);合并3种血脂异常率为9.69%(男性为7.08%,女性为14.62%);合并4种血脂异常率为0.73%(男性为0.56%,女性为1.06%)。结论公司内老年人无论男性还是女性血脂异常患病率都超过半数,高TC血症最为常见,其次为高LDL-C血症,且以合并2种以上脂质成分异常更为常见。老年女性的血脂异常率明显高于男性。     

辽宁省城市人群代谢综合征的流行趋势和危险因素分析

目的:探讨辽宁城市代谢综合征(MS)的流行趋势。方法:选取沈阳市体检人群与社区人群(来自辽宁省各城市)进行分层抽样调查,共调查2000人,其中体检人群1000人,社区人群1000人。根据MS的诊断标准,研究对象被分为超重肥胖组(460人)和正常体重组(1540人),高血糖组(140人)和正常血糖组(1860人),高血压组(399人)和正常血压组(1601人),血脂异常组(486人)和血脂正常组(1514人),比较各分组间MS患病率。结果:符合代谢综合征诊断标准的有441例,即人群患病率为22.05%,男性代谢综合征的有263人,患病率为24.15%,女性为178例,患病率为19.53%,男性的显著多于女性(P0.01)。MS患病率随年龄增长而增加(P0.05)。超重肥胖组和正常体重组MS的患病率分别为42.12%和4.13%;高血糖组和正常血糖组MS患病率分别为49.47%和5.49%;血脂异常组和血脂正常组MS的患病率分别为38.35%和4.41%,高血压组和血压正常组的MS患病率分别为43.42%,3.56%。以上两组间比较差异均有显著性(P0.01)。结论:辽宁城市代谢综合征的患病率随年龄的增加而增长,男性高于女性;代谢综合征各分组的较对照组显著增加,以超重肥胖人群和高血压人群更甚。     

糖尿病血脂异常的非药物调治及其现代认识

2型糖尿病的胰岛素抵抗(IR)及以高甘油三脂血症为主的脂质三联征,作为一种新的代谢综合征己被越来越多的临床医师们所重视.贾伟平等报告上海40～49岁人群随机抽样的771例男性和1189例女性IR流行情况.以高血糖、高血压及血脂异常兼具者为全代谢综合征.调查结果标化后的患病率中血脂异常为67.5%[1].血脂紊乱对动脉的影响,已被众多的研究结果所证实.2型糖尿病的高胰岛素血症与高血脂又相辅组成的加重血管病变,其合并冠心病,发生心力衰竭以及死亡的机率,都显著高于单纯冠心病患者.开展胰岛素抵抗与动脉粥样硬化研究是当今的热点.对2型糖尿病患者而言,调整血脂紊乱、控制血糖,已成为降低心血管并发症,减少死亡率的重要手段.     

辽宁省城市体检人群代谢综合征肾脏损害调查研究

目的:探讨沈阳市代谢综合征(MS)人群肾脏损害情况。方法:选取辽宁省城市体检人群与社区人群进行分层抽样调查,共调查2000人,其中体检人群1000人,社区人群1000人(来自辽宁省各城市)。根据MS的诊断标准,研究对象被分为超重肥胖组(460人)和正常体重组(1540人),高血糖组(140人)和正常血糖组(1860人),高血压组(399人)和正常血压组(1601人),血脂异常组(486人)和血脂正常组(1514人),比较各分组间肾脏损害的患病率。结果:调查人群中肾脏损害患病率为15%,男性与女性之比为1:1。超重肥胖组和非超重肥胖组肾脏损害患病率分别为10%和1%;高血糖组和正常血糖组肾脏损害患病率分别为10%和1%;高血压组和正常血压组肾脏损害患病率分别为10%和2%;血脂异常组和血脂正常组肾脏损害患病率分别为10%和1%,以上两组间比较差异均有显著性(P0.01)。结论:辽宁省城市代谢综合征患者的肾脏损害患病率较正常人群显著升高。     

武汉市离退休老年人非酒精性脂肪肝及代谢综合征的相关性研究

目的 了解武汉市离退休老年人群非酒精性脂肪肝和代谢综合征的现况特点及2种疾病的相关性. 方法 抽样调查60岁及以上离退休老年人共718例,检测身高、体质量、腰围、血压、血糖、血脂、肝脏B超. 结果 所调查人群代谢综合征及非酒精性脂肪肝的患病率分别为25.2%及25.9%,而高血压、高血糖、高三酰甘油、低高密度脂蛋白胆固醇及腹型肥胖的患病率分别为89.2%,29.6%,40.3%,10.3%及38.6%;女性代谢综合征患病率高于男性(χ2=21.0,P<0.05);随着代谢综合征中异常组分的数目增多,非酒精性脂肪肝的患病率亦增加(男性χ2=82.9,女性χ2=23.7,均为P<0.01);老年人非酒精性脂肪肝患病率与代谢综合征呈显著正相关(男性OR=2.216,女性OR=4.848,均为P<0.01). 结论 离退休老年人群非酒精性脂肪肝及代谢综合征患病率较高,并且两者显著相关,应积极防治心血管疾病高危因子.     

甲状腺结节与代谢综合征及其组分的相关性分析

目的 了解大连地区体检人群甲状腺结节、代谢综合征的患病率并探讨甲状腺结节与代谢综合征及其组分的相关性.方法 收集体检中心8 217例体检人群临床资料,包括病史、身高、体重、血压、血糖、血脂、肝功能、肾功能、甲状腺超声.代谢综合征诊断根据中华医学会糖尿病学分会关于代谢综合征的诊断标准诊断,针对上述临床资料进行统计学分析.结果 (1)体检人群甲状腺结节患病率为42.1％,其中男性38.4％,女性49.6％,女性明显高于男性(P＜0.01),男、女患病率均随年龄增长而升高.(2)体检人群代谢综合征患病率为21.7％,其中男性28.5％,女性12.8％,男性高于女性(P＜0.01),除男性大于70岁组外,男、女代谢综合征患病率均随年龄增长而升高.(3)按照有无甲状腺结节分为甲状腺结节组和非甲状腺结节组,甲状腺结节组体重指数、收缩压、舒张压、血糖、甘油三酯水平明显高于非甲状腺结节组(P＜0.05);两组高密度脂蛋白胆固醇水平没有差异(P＞0.05).(4)对甲状腺结节进行logistic回归分析,经年龄及性别校正,结果显示超重/肥胖是甲状腺结节的危险因素(OR=1.263,95％可信区间为1.134 ～1.407).结论 (1)大连地区体检人群中甲状腺结节、代谢综合征患病率均较高,且两者患病率均随年龄增长而升高;(2)甲状腺结节与代谢综合征及其组分具有一定相关性,超重/肥胖是甲状腺结节的危险因素之一.     

贵州省18岁以上成人2型糖尿病和血脂异常的关系分析

目的 调查2011年贵州省18岁以上居民糖尿病和血脂异常的状况及关系. 方法 采用多阶段分层整群随机抽样方法选取9280名居民进行问卷调查,检测血糖、血脂,比较不同性别、年龄、城乡人群糖尿病和血脂异常的状况及关系. 结果 贵州省糖尿病患病率7.60％,标化后7.89％,其中,男性患病率高于女性(8.80％ vs 6.50％,P=0.000),糖尿病患病率随年龄增长逐渐增高(6.80％vs7.50％ vs8.90％,P=0.038),糖尿病患者血脂异常患病率高于非糖尿病患者(72.0％ vs 56.7％,P=0.000),血脂异常患者糖尿病患病率高于血脂正常患者(9.5％ vs 5.0％,P=0.000).糖尿病患者中,高LDL-C血症患病率最高,其次是高TC血症. 结论 贵州省糖尿病和血脂异常患病率较高.性别、年龄、城乡比较,糖尿病患者血脂异常患病率均高于非糖尿病患者,血脂异常患者糖尿病患病率均高于血脂正常患者.     

Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes

We studied the association of obesity with lipid and lipoprotein concentrations in 92 patients (49 men, 43 women) with insulin-dependent diabetes (IDDM), in 305 patients (152 men, 153 women) with non-insulin-dependent diabetes (NIDDM), and in 122 nondiabetic control subjects (65 men, 57 women). Obesity (body mass index, BMI) was associated with abnormal lipid and lipoprotein levels only in the presence of diabetes, and lipid and lipoprotein changes were substantially more abnormal in patients with NIDDM than in patients with IDDM. In men and women with NIDDM, obesity was associated with low high-density lipoprotein (HDL) and HDL2 cholesterol and high total, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) triglyceride concentrations. In men with IDDM, obesity was related only to low HDL and HDL2 cholesterol and in women with IDDM to low HDL3 cholesterol. BMI and diabetes status had a statistically significant interaction (analysis of variance) with respect to HDL and HDL2 cholesterol and total and VLDL triglycerides, indicating that the effects of obesity on lipids and lipoproteins were more severe in patients with diabetes than in nondiabetic subjects. In conclusion, obesity and diabetes status have an unfavorable interaction that results in multiple pathologic lipid and lipoprotein changes, particularly in NIDDM.     

Effect of hormone replacement therapy on blood serum lipids in postmenopausal women with type 2 diabetes

There are limited data concerning influence of hormone replacement therapy (HRT) on lipid profile in women with type 2 diabetes. Aim of the study was to compare changes of blood lipids during HRT in postmenopausal women with and without type 2 diabetes. Seventy seven women included in the study were assigned to 1 of 4 groups, basing on being diabetic or nondiabetic, and further subdivided into users of estrogen alone (ERT), and of estrogen plus progestin (EPRT). Effect of 6-month ERT (oral estradiol valerate 2 mg/day) and EPRT (oral estradiol valerate 2 mg/day sequentially combined with cyproterone acetate 1 mg/day) on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and lipoprotein (a) [Lp(a)] was separately assessed. EPRT and ERT caused decrease in LDL-C by 15% and 12%, and increase in HDL-C by 12% and 13%, respectively, in patients with diabetes (p<0.05 in all cases). LDL-C decreased by 11% and 15%, respectively, in women without diabetes (p<0.05 in all cases). Lp(a) was also reduced 25% with EPRT (p<0.01) and ERT (p<0.05). HDL-C increased 10% (p<0.05) with ERT but remained unchanged with EPRT. In conclusion, changes in all lipid parameters except Lp(a) caused by ERT and EPRT were comparable in postmenopausal women with and without type 2 diabetes.     

2型糖尿病合并冠心病患者心血管危险因素控制现状的调查

目的:根据指南要求,调查2型糖尿病合并冠心病患者主要心血管危险因素的控制情况,分析影响血糖的相关因素。方法:采用横断面调查方法,对收集的2型糖尿病合并冠心病者421例进行问卷调查、体格检查及血液检查,以获取一般资料、血糖、血压、血脂及体质量等。按指南标准计算各指标达标率。结果:HbA1c、收缩压、舒张压、HDL-C、TG、LDL-C和BMI的达标率,分别是61.9%、43.2%、69.3%、62.4%(男性)/50.1%(女性)、43.3%、63.1%和29.1%(男性)/32.9%(女性)。影响血糖的因素有饮食运动控制、规律用药和知晓血糖控制目标。结论:2型糖尿病合并冠心病患者控制现状与指南要求仍有差距,可通过加强患者的自我管理和糖尿病知识的认知,提高治疗质量。     

Hypertension in the metabolic syndrome among Caribbean non diabetic subjects

OBJECTIVE: To study the metabolic syndrome (MS) components in Caribbean non diabetic individuals and to determine the magnitude of hypertension (HT) in those with and without MS. RESEARCH METHODS: We conducted a cross-sectional study, of 966 consecutive subjects aged 18-74 years. The MS was identified according to the NCEP/ATpiiI definition. Age, gender, body mass index and the MS components (blood pressure, waist circumference, fasting blood glucose, triglycerides, HDL cholesterol) were taken into account. The Principal component analysis (PCA) was used to understand correlations between these continuous variables within the data base, and to identify principal factors (combinations of variables) and the magnitude of HT in these combinations. RESULTS: In the overall study population, mean age was 38 years and there were 60.1% of women. HT was more frequently found in men than in women (52.2% vs. 41.3%; p=0.001). Prevalence of MS was 11.3%. With PCA, in the complete sample of men, the first factor, explained 31.5% of the total variance in the original variables and was dominated by blood pressure, clustered with age and fasting blood glucose (FBG). In the women's sample, the first factor (31.1% of the variance) was dominated by obesity combined with FBG and lipids. In subjects with the metabolic syndrome the principal factors were dominated by blood pressure in both genders with higher loadings in men than in women. CONCLUSION: In this non diabetic population study the prevailing obese women profile clustering with fasting glucose and lipid disturbances might explain the higher prevalence of type 2 diabetes among women, observed in this Caribbean region.     

2型糖尿病患者颈围与血脂关系及其对血脂异常的预测作用——北京社区糖尿病研究（BCDS-10）

目的了解2型糖尿病患者颈围与血脂谱问的关系。方法选择2008年8月至2009年7月北京三甲医院与15个城区社区联合开展糖尿病纵向管理项目基线数据库中2410例2型糖尿病患者。全体参与医师经过专门培训,按统一要求调查并填写调查表,同时对患者进行体格检查及相关的实验室检查,血脂异常的诊断根据2007年中国成人血脂异常防治指南。结果（1）2410例中男986例,女1424例。平均颈围为（36±4）cm。总胆固醇为（5．2±1．1）mmol／L;甘油三酯为（1．8±1．2）mmol／L;高密度脂蛋白胆固醇（HDL-C）为（1．3±0．4）mmol／L;低密度脂蛋白胆固醇（LDL-C）为（3．0±0．9）mmol／L;（2）男性、女性的颈围均与甘油三酯呈正相关（男性r=0．093,女性r=0．077,均P〈0．01）,与HDL-C呈负相关（男性r=一0．144,女性r=一0．062,均P〈0．05）;（3）预测高甘油三酯血症最佳的颈围切点：男性为37em,女性为35em;预测HDL-C降低的颈围切点男性为40em,女性为35em;（4）预测高胆固醇血症受试者操作特征（ROC）曲线下面积男性组为0．511,女性组为0．480（P〉0．05）;预测LDL-C升高ROC曲线下面积男性为0．527;女性为0．519（P〉0．05）。结论2型糖尿病患者的颈围与血脂密切相关,尤其是甘油三酯和HDL-C;颈围可能做为筛查／评价2型糖尿病患者血脂异常的指标之一。     

CHD: a major burden in type 2 diabetes

Patients with type 2 diabetes have a two- to four-fold greater risk of cardiovascular mortality than non-diabetic individuals. In order to prevent coronary events in the diabetic population, it is important to treat modifiable cardiovascular risk factors. Data from the Multiple Risk Factor Intervention Trial (MRFIT) show that serum cholesterol level, systolic blood pressure level and cigarette smoking were significant predictors of cardiovascular disease mortality in men with and without diabetes. At every risk factor level, the absolute risk of age-adjusted coronary death rate was three times greater for diabetic men than non-diabetic men (p<0.0001). Patients with diabetes have an abnormal (dyslipidaemic) lipoprotein profile with high levels of very low density lipoprotein cholesterol and triglycerides, and a low level of high density lipoprotein cholesterol. Although levels of total cholesterol or low density lipoprotein (LDL) cholesterol do not differ significantly between patients with and without diabetes, those with diabetes have higher levels of atherogenic small dense LDL particles. MRFIT data show that at any serum cholesterol level, diabetes confers two-three times the risk for a coronary event. These findings constitute the rationale for considering hypolipaemic therapy, e.g. with HMG-CoA reductase inhibitors (statins), in diabetic patients with dyslipidaemia, particularly in those with evidence of coronary heart disease. Evidence shows that statins significantly lower cholesterol, exhibit beneficial effects on many components of atherosclerosis, and can significantly reduce the incidence of stroke.     

Glycaemic control and obesity are the major determinants of diabetic dyslipidaemia in Hong Kong Chinese

OBJECTIVES: Dyslipidaemia plays a major role in the increased mortality in diabetes. Our aim was to address the quantitative abnormalities and determinants for lipid abnormalities in Chinese Type 2 diabetic patients. MATERIAL AND METHODS: In this study, we examined 1 279 Chinese type 2 diabetic patients and compared them with 959 non-diabetic control subjects. RESULTS: Of the 1 279 Type 2 diabetic patients, 588 (46.0%) were men and 691 (54.0%) were women. The mean age was 40.4 +/- 8.1 years (median: 41.0 years, range: 16-72 years). Compared to the 959 age- and sex-matched non-diabetic controls, diabetic patients were more obese, had higher blood pressure and adverse lipid profile characterized by high triglycerides and low high-density lipoprotein cholesterol. After adjusting for age, sex, smoking, obesity, use of lipid-lowering drugs and anti-diabetic agents, diabetic patients had higher risk of having hypertriglyceridaemia (>=2.3 mmol/L) and low high-density lipoprotein cholesterol (<0.9 mmol/L) than non-diabetic subjects. The corresponding odds ratios were 2.9 and 1.5, respectively. With multiple regression analysis (stepwise), dyslipidaemia was mainly associated with glycaemia, obesity and age in diabetic patients, and obesity, male gender and age in non-diabetic subjects. CONCLUSION: We have confirmed the high prevalence and increased risk of dyslipidaemia in Chinese type 2 diabetic patients. The long-term significance of these lipid abnormalities and their synergism on clinical outcomes requires further evaluation.     

代谢综合征及其组分与不同性别脑梗死患者的关系探讨

目的使用修订后的中国人代谢综合征(MS)诊断标准,对MS及其组分与不同性别脑梗死患者的关系进行探讨。方法选择脑梗死患者892例(脑梗死组),其中动脉粥样硬化性血栓性脑梗死(ATCI)男、女性亚组分别为308例和200例;腔隙性脑梗死(LACI)男、女性亚组分别为232例和152例。健康体检者233例(对照组),男、女性亚组分别为102例和131例。观察MS及其组分在脑梗死组各亚组和对照组各亚组的患病率、MS各组分水平以及MS对脑梗死组各亚组的危险度。结果脑梗死组各亚组MS的患病率(38.4%～46.0%)与同性别对照组比较,差异有统计学意义(P<0.01)。多因素logistic回归分析显示,MS是男、女性ATCI和LACI发病的危险因素(OR=5.604,OR=2.751;OR=6.224,OR=3.387,P<0.01)。MS各组分中高血压和低HDL-C对男、女性ATCI的发病起重要作用;高血压和高空腹血清葡萄糖对男、女性LACI的发病起重要作用。结论 MS是男、女性脑梗死各亚型的重要危险因素;MS各组分致不同亚型脑梗死的重要性有所不同。     

Lipid peroxidation,antioxidants, lipid profile,and HbA1c in diabetic patients

Diabetes mellitus is characterized by hyperglycemia together with biochemical changes in glucose, lipid profile, lipid peroxidation, and antioxidants status. This study aims to assess lipid profile, lipid peroxidation, antioxidants, and glycated hemoglobin (HbA1c) in type 1 and type 2 diabetic subjects. Type 1 and type 2 diabetic patients were selected from the subjects attending OPD in Nepalgunj Medical College, Nepal, for medical checkup. Fasting blood sugar (FBS), lipid profile, lipid peroxidation (malondialdehyde), and antioxidants status (reduced glutathione and vitamin E) were estimated in both groups and were compared with healthy controls. Low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio was calculated to assess the cardiovascular risk factors. When type 1 diabetic patients were compared with type 2 diabetic patients, it showed statistically significant increase in the levels of HbA1c, triglycerides (TGs), and high-density lipoprotein cholesterol (HDL-C), whereas statistically significant decreased level was found in malondialdehyde (MDA). FBS, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), vitamin E, and HDL/LDL ratio were not significant. Early diagnosis of dyslipidemia and oxidative stress can be used as a preventive measure for the development of microvascular and macrovascular complications in type 1 and type 2 diabetes mellitus.     

不同性别2型糖尿病患者血清γ-谷氨酰转肽酶水平与代谢综合征的相关性研究

目的探讨江苏省成人2型糖尿病（T2DM）患者血清γ-谷氨酰转肽酶（GGT）与代谢综合征（MS）组分的相关性。方法测定T2DM患者（男438例,女300例）的GGT、血脂、空腹血糖（FBG）、空腹胰岛素（FINS）、血压、腰围等。结果①随着GGT四分位数的升高,男、女2组的体质量指数（BMI）、三酰甘油（TG）、FINS及稳态胰岛素评估模型胰岛素抵抗（HOMA—IR）指数升高;②男性组的GGT与腰围、BMI、舒张压（DBP）、TG、总胆固醇（TC）、FINS及MS组分数呈正相关,女性组的GGT与TG呈正相关（P均〈0．01）;③男、女性组GGT与HOMA—IR呈正相关（P均〈0．05）;④线性回归模型的结果显示,男性组中GGT水平主要受腰围及TG水平的影响,女性组中GGT水平主要受TG水平的影响。结论T2DM患者血清GGT与胰岛素抵抗及MS组分相关,同时在MS各组分中,GGT与TG水平最具相关性,提示GGT可能与肝脏胰岛素抵抗密切相关。