PPH麻醉中应用不同剂量地佐辛复合异丙酚的临床效果观察

方法:观察不同剂量地佐辛复合异丙酚在PPH麻醉中的临床效果。目的:资料随机选取行PPH术患者150例,按照随机数字表法分为A、B、C三组,每组各50例,A组予0.1 mg/kg地佐辛复合2 mg/kg异丙酚,B组予0.25 mg/kg地佐辛复合2 mg/kg异丙酚,C组予0.2 mg/kg地佐辛复合2 mg/kg异丙酚,观察三组患者PPH麻醉中用药前后的心率(HR)、平均动脉压(MAP),以及Ramsay镇静评分。结果:PPH麻醉中用药后C组HR、MAP明显优于A、B组,具有统计学意义(P<0.05)。结论:0.2 mg/kg地佐辛复合2 mg/kg异丙酚持续靶控输注应用于PPH麻醉中临床效果最佳。     

不同用药方式用于无痛人流手术麻醉的对比观察

目的:对比研究丙泊酚、丙泊酚复合瑞芬太尼、丙泊酚复合地佐辛3种不同用药方式用于无痛人流手术麻醉的安全性和有效性。方法:120例人工流产手术患者,随机分A(丙泊酚组)、B(丙泊酚复合瑞芬太尼组)、C组(丙泊酚复合地佐辛)3组,A组、B组、C组各4O例。并观察这3组药物麻醉在无痛人流术不同时点对病人MAP、HR、SpO2的影响、术后镇痛效果及不良反应的发生。结果:和A组比较,B、C组患者异丙酚的用量减少,注射痛发生率降低,苏醒时间缩短。与A、B2组比较,C组术中循环平稳,低氧血症发生率低,术后宫缩痛VAS评分较低。结论:地佐辛复合丙泊酚用于无痛人流手术的麻醉镇痛效果好、术中生命体征较平稳、呼吸抑制轻微、术后恢复迅速,且能有效地抑制人工流产术后的子宫收缩痛,可安全、有效应用于无痛人流术。     

丙泊酚复合地佐辛静脉麻醉在人工流产术中的应用

目的:观察人工流产术丙泊酚复合地佐辛静脉麻醉的临床效果。方法:120例自愿要求无痛人工流产术的早期妊娠患者,随机分为两组:芬太尼组(A组),地佐辛组(B组),每组60例,术前分别臀部肌内注射阿托品0.5 mg,两组患者麻醉诱导给予丙泊酚靶控输注,同时,A组缓慢静脉滴注芬太尼0.05~0.1 mg;B组缓慢静脉滴注地佐辛5~10 mg,麻醉起效后开始手术。术中监测患者心电图(ECG)、无创动脉血压(NIBP)、心率(HR)、脉搏血氧饱和度(SpO2);记录患者手术时间、苏醒时间、术中麻醉效果、术后镇痛评分(VAS)、不良反应(恶心、呕吐、呼吸抑制)。结果:和A组患者比较,B组术中麻醉效果欠佳、手术时间延长、术后镇痛评分(VAS)升高,但是苏醒时间缩短、不良反应降低(P<0.05)。结论:丙泊酚复合地佐辛静脉麻醉用于人工流产术苏醒迅速完全、不良反应减少。     

不同剂量地佐辛复合异丙酚在无痛人工流产麻醉中的应用效果比较

目的 观察不同剂量地佐辛复合异丙酚用于无痛人工流产(人流)麻醉中的临床疗效与安全性.方法 选择无痛人流患者60例,随机分为A、B、C三组,分别使用30、60、90μJkg地佐辛复合异丙酚2mg/kg,记录三组血流动力学的变化、麻醉镇痛维持时间、苏醒时间以及术中体动发生率.结果 三组患者麻醉前平均动脉压(MAP)、心率(HR)经比较差异无显著性(P＞0.05).三组患者麻醉后MAP、HR与本组麻醉前相比差异无显著性(P＞0.05).麻醉后,各组MAP、HR组间相比差异无显著性(P＞0.05).C组镇痛维持时间与A、B组相比差异有显著性(P＜0.05).B组镇痛维持时间、体动发生率与A组相比差异有显著性(P＜0.05).C组苏醒时间、体动发生率与A组相比差异有显著性(P＜0.05);与B组相比差异无显著性(P＞0.05).结论 90μg/kg地佐辛复合异丙酚用于无痛人流麻醉中血流动力学平稳,麻醉效果佳,不良反应少,为无痛人流麻醉的较佳剂量.     

地佐辛超前镇痛复合异丙酚用于宫腔镜电切术麻醉效果观察

目的 观察通过静脉预注地佐辛复合异丙酚用于宫腔镜电切术麻醉的临床效果.方法 将80例行宫腔镜电切术患者随机分为两组,每组 40例.即地佐辛复合异丙酚组(A组,n=40),芬太尼复合异丙酚组(B组,n=40).A组在输注异丙酚前10min采用地佐辛0.15mg/kg静脉注射,B组在输注异丙 酚前3min采用芬太尼2ug/kg静脉注射.两组患者均采用1%异丙酚1.5mg/kg诱导,术中持续靶控输注(4mg/kg·h).测定两组麻醉前(T0)、诱导结束时(T1)、扩宫时(T2)、术毕苏醒时(T3)、清醒后5分钟时(T4)的SBp、DBp、HR、RR、SpO2值,并记录手术时间、苏醒时间、异丙酚总量和术中体动、有无呼吸抑制、有无宫 缩痛等情况.结果 两组患者手术时间、苏醒时间、异丙酚总用量及术中体动反应比较无统计学意义(P>0.05);A组呼吸抑制明显低于B组有统计学意 义(P<0.05),术后宫缩痛A组低于B组比较有统计学意义(P<0.05);A组患者T0、T2、T3、T4、SBp、DBp、HR、RR、SpO2值与B组比较均无统计学意义,在T1时间A 组SpO2高于B组(P<0.05).结论 地佐辛超前镇痛复合异丙酚可安全、有效的用于宫腔镜电切术,其镇痛效果好,且呼吸抑制发生率少.     

无痛人工流产术静脉复合麻醉临床用药效果观察

目的:探讨无痛人工流产术静脉复合麻醉的临床用药效果。方法:本次入选为我院2014年7月至2015年8月期间收治的无痛人工流产手术患者90例,患者在入组前均签署知情同意书,根据随机数学法将患者随机分为三组,每组30人,组别用A、B、C表示,根据患者的自身身体情况决定使用麻醉的剂量,三组患者具体麻醉方法如下:A组患者采用异丙酚+地佐辛;B组患者采用异丙酚加芬太尼;C组患者采用异丙酚。结果:三组患者在麻醉药品使用效果上具有差异性(P0.05),B组的氧气分压较低,A组和C组的属于正常。A组的麻醉诱导时间、清醒时间、出血时间均优于B组和C组两组患者,且P0.05统计学差异显著;A组无麻醉并发症发生,优于B组B组和C组两组患者,且P0.05统计学差异显著。结论:采用异丙酚复合新型镇痛药地佐辛进行麻醉,患者可在全麻状态下进行人工流产手术,并且手术顺利进行、呼吸抑制等并发症少,患者麻醉时间短、氧气分压值正常,值得在临床中应用。     

地佐辛复合丙泊酚用于无痛人流术的临床观察

目的:观察地佐辛复合丙泊酚用于无痛人流术的麻醉效果及安全性。方法:选择妊娠7~10周自愿要求行无痛人工流产手术患者60例,ASAⅠ~Ⅱ级,随机分为两组,即地佐辛复合丙泊酚组(D组,n=30)、单纯丙泊酚组(B组,n=30),行静脉全麻,必要时追加丙泊酚。记录两组生命体征变化、不良反应、麻醉诱导时间、苏醒时间、定向力恢复时间、离院时间、丙泊酚总用量、术后宫缩痛发生状况。结果:D组丙泊酚用药量较B组明显减少(P<0.05),唤醒时间及定向力恢复时间均较B组明显缩短(P<0.05),而术后宫缩痛明显少于B组(P<0.05),两组患者诱导时间、手术时间、离院时间和麻醉不良反应组间差异均无统计学意义(P>0.05)。结论:地佐辛复合丙泊酚用于无痛人流术的麻醉效果优于单纯应用丙泊酚,且安全性好。     

地佐辛复合左布比卡因在臂丛神经阻滞中的应用

目的观察地佐辛复合左布比卡因用于臂丛神经阻滞麻醉的效果。方法选择上肢手术患者70例,随机分为两组,A组患者采用地佐辛10mg＋0．25％左布比卡因25mL肌间沟注射行臂丛神经阻滞,B组患者采用0．25％左布比卡因25mL肌间沟注射行臂丛神经阻滞,分别记录两组麻醉起效时间,持续时间及不良反应,同时记录麻醉后4、6、8h静息VAS评分,采用VAS评分评价镇痛效果。结果A组麻醉起效时间明显快于B组,镇痛持续时间长于B组,两组比较差异有统计学意义（P〈0．05）。结论地佐辛复合左布比卡因在臂丛神经阻滞中能缩短麻醉起效时间,延长镇痛持续时间,无明显不良反应。     

地佐辛复合丙泊酚用于宫腔镜电切术的麻醉效果分析

目的:分析地佐辛复合丙泊酚用于宫腔镜电切术的麻痹效果.方法:对180例进行宫腔镜电切术的患者随机分为三组各60例,A组患者应用地佐辛复合丙泊酚进行麻醉治疗,B组患者应用芬太尼复合丙泊酚进行麻醉治疗,C组患者应用单一的丙泊酚进行麻醉治疗.对麻醉治疗后的丙泊酚用量、麻醉起效时间和意识恢复时间进行记录,对术中和术后不良反应进行观察,对患者清醒后的视觉进行模拟评分.结果:丙泊酚的总用量C组明显比A组和B组多(P＜0.05)；麻醉起效时间和意识恢复时间没有明显的差异(P＞0.05)；术中和术后患者的不良反应率A组明显比B组和C组少(P＜0.05)；术后患者的视觉模拟评分中A组低于B组和C组(P＜0.05).结论:使用地佐辛复合丙泊酚用于宫腔镜电切术的麻醉效果显著,且明显减少了丙泊酚的使用量,无不良反应,患者术后恢复治疗好.     

地佐辛罗哌卡因混合液颈丛麻醉用于甲状腺手术的临床研究

目的研究地佐辛罗哌卡因混合液颈丛麻醉用于甲状腺手术的镇痛效果.方法选择择期甲状腺肿瘤切除术患者60例,A S AⅠ-Ⅱ级,均采用颈丛麻醉.随机分为地佐辛复合罗哌卡因组(A组)和单纯应用罗哌卡因组(B组).注药后观察两组患者的麻醉起效时间.镇痛持续时间.对心血管系统的影响及辅助用药情况.结果 A组麻醉起效时间明显快于B组,镇痛持续时间明显长于B组,两组比较差异有统计学意义(P<0.05).两组麻醉效果满意度差异有统计学意义(P<0.05).两组SPO2及RR无差异无统计学意义(P>0.05),MAP.HR差异有统计学意义(P<0.05).结论地佐辛复合罗哌卡因颈丛神经阻滞在甲状腺手术中阻滞起效快.持续时间长.镇痛效果好.对甲状腺手术的心血管反应有显著的抑制作用.不良反应少.安全性好.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.