辽东楤本化学成分的研究

从辽东楤本(Aralia elata)的根皮中分得8个化合物,利用理化和光谱方法鉴定分别为胡萝卜甙-6’-棕榈酸酯(6’-O-palmitoyl-β-sitosterol-3-O-β-D-glucoside,A_5)、罗盘草甙A(silphioside A,A_9)、楤木皂甙A甲酯(araloside A methyl ester,A_(10))、竹节人参甙I_b(chikusetusaponin I_b,A_(11))、楤木皂甙A(araloside A,A_(12))、楤木皂甙C(araloside C,A_(15)、楤木皂甙G(araloside G,A_(16))、无梗五加甙D(acanthoside D,B_1)。化合物A_5,A_9,A_(11)和B_1为首次从该植物中分得,A_(10)为新天然产物,A_(16)为新化合物命名为楤木皂甙G,归属了化合物A_9,A_(15)的~(13)C-NMR化学位移。     

楤木根皮中皂甙化学成分的研究

楤木根皮中的主要成分是皂甙。将总皂甙以柱层析分离,得到三个化合物(Ⅰ～Ⅲ),经光谱分析和化学方法证明,Ⅰ为楤木皂甙A(araloside A);Ⅱ为银莲花甙(narcissiflorine);Ⅲ是3-O-[β-D-吡喃葡萄糖-(1→2)-β-D-吡喃木糖-(1→)2)-α-L-阿拉伯糖]-齐墩果酸。Ⅲ为一新皂甙,命名为楤木皂甙D(araloside D)。     

楤木根皮中皂甙化学成分的研究

楤木根皮中的主要成分是皂甙。将总皂甙以柱层析分离,得到三个化合物(Ⅰ～Ⅲ),经光谱分析和化学方法证明,Ⅰ为楤木皂甙A(araloside A);Ⅱ为银莲花甙(narcissiflorine);Ⅲ是3-O-[β-D-吡喃葡萄糖-(1→2)-β-D-吡喃木糖-(1→)2)-α-L-阿拉伯糖]-齐墩果酸。Ⅲ为一新皂甙,命名为楤木皂甙D(araloside D)。     

辽东橡木化学成分的研究(Ⅰ)

从辽东楤木根皮中分得22个单体化合物。利用化学和光谱等理化方法首批鉴定了其中6个化合物,分别为β-谷甾醇(β-sitosterol),齐墩果酸(oleanolic acid),胡萝卜甙(daucosterol),齐墩果酸-28-O-β-D-吡喃葡萄糖甙,槐木皂甙A(araloside A)和蔗糖(sucrose)。除齐墩果酸和楤木皂甙A外,其余4个化合物为首次从该植物中分离得到的已知化合物。其余化合物待陆续发表。     

太白楤木根皮的齐墩果酸皂甙

从太白楤木(Aralia taibaiensis Z.Z.Wang et H.C.Zheng)根皮中首次分离到5个齐墩果酸皂甙,根据理化性质和光谱数据,分别鉴定为木皂甙A(1),3-O-[α-L-呋喃阿拉伯糖(1→4)-β-D-吡喃葡萄糖醛酸丁酯]-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(2),3-O-[α-L-呋喃阿拉伯糖(1→4)-β-D-吡喃葡萄糖醛酸乙酯]-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(3),屏边三七甙R₂(4)和3-O-｛β-D-吡喃葡萄糖(1→3)[α-L-呋喃阿拉伯糖(1→4)]-β-D-吡喃葡萄糖醛酸乙酯｝-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(5)。2,3和5为新化合物,分别命名为太白楤木皂甙I(taibaienoside I)、太白楤木皂甙II(taibaienoside II)和太白楤木皂甙III(taibaienoside III)。     

头序楤木叶中三萜化学成分的研究

从头序楤木(Aralia dasyphyla Miq)叶中分离到6个三萜化合物,用化学方法和波谱(UV,IR,MS,¹HNMR,¹³CNMR,¹³CDEPT,HMQC,HMBC)分析,确定其中4种化合物的结构,分别为齐墩果酸(I),16β-羟基-18β-H-齐墩果酸(I),齐墩果酸-28-O-β-D-吡喃葡萄糖甙(II)和16β-羟基-18β-H-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(IV)。用NOESY谱确定化合物I的立体构型。以上4个化合物均为首次从该植物中分离到,化合物IV为新化合物。     

三七绒根中皂甙B1及B2的分离和鉴定

从三七Panax notoginseng(Burk.)F.H.Chen绒根中分得二种微量皂甙,三七皂甙B₁和B₂三七皂甙B₁为一种新皂甙,证明其结构为达玛20(22)-烯3β,12β,25三醇6-O-β-D-葡萄吡喃糖甙(Ⅰ),其皂甙元亦为一种新皂甙元,其结构为达玛20(22)-烯-3β,12β,6 C,25四醇。三七皂甙B₂经鉴定为已知皂甙人参皂甙(ginsenoside—Rh₁,Ⅱ)。     

北柴胡中新皂甙的结构鉴定

从北柴胡(Bupleurum chinese DC.)根醇提液的正丁醇部分得到7个化合物,经鉴定分别为柴胡皂甙a(saikosaponina,1),柴胡皂甙d(saikosaponind,2),柴胡皂甙c(saikosaponinc,3),柴胡皂甙f(saikosaponinf,4),柴胡皂甙b₃ (saikosaponin b₃,5),柴胡皂甙b₂(saikosaponin b₂,6)和柴胡皂甙t(saikosaponint,7),化合物7为新化合物,用化学和波谱法确定其结构为3β,16β,28-三羟基-11-α-甲氧基-12-齐墩果烯-3-O-β-D-葡萄糖基-(1→3)-β-D-呋糖甙。化合物1～6均为首次自北柴胡中分离鉴定。     

人参叶微量新成分的研究

从人参(Panax ginseng C.A.Meyer)叶中分离出14种单体化合物。其中4种微量成分用IR、MS、¹HNMR、13CNMR及化学方法等分别鉴定为20(R)-原人参三醇(Ⅰ)、胡萝卜甙(Ⅱ)、3β,12β-二羟基-20(22),24-达玛二烯—3—0—β—D—葡萄吡喃糖甙(Ⅲ)及20(R)-原人参二醇—3—0—β—D—葡萄吡喃糖甙(Ⅳ)。其中Ⅲ及Ⅳ系新化合物,分别命名为人参皂甙-Rh₃(ginsenoside-Rh₃)及20(R)-人参皂甙-Rh₃[20(R)-ginsenoside-Rh₂]。     

肿瘤的化学治疗 ⅩⅩⅢ.若干[双-(β-卤乙基)-氨基]-吲■-2-羧酸及其乙酯的合成

由5(及7)-[双-(β-羥乙基)-氨基]吲(口朶)-2-羧酸乙酯(Ⅶ_a,b)合成了5(及7)-[双-(β-氯乙基)-氨基]吲(口朶)-2-羧酸乙酯(Ⅱ_a和Ⅱ_b)、5(及7)-[双-(β-溴乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅱ_c和Ⅱ_d)以及5(及7)-[双-(β-碘乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅱ_e和Ⅱ_f)。再經水解制得其相应的羧酸(I_a-f)。此外又合成了5(及7)-乙氧羰氨基-吲(口朶)-2-羧酸乙酯(IX_a,b)和5-乙氧基-7-[双-(β-氯乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅶ)。化合物I_a,I_b,I_c,Ⅱ_a,Ⅱ_b,Ⅱ_c,Ⅱ_e和Ⅱ_f对組織培养Hela細胞有明显的抑制作用。化合物Ⅰ_a,Ⅰ_b,Ⅱ_a和Ⅱ_b口服时对小鼠肉瘤180有明显的抑制作用。化合物Ⅰ_e,Ⅰ_f和Ⅻ对肉瘤180具有中度的抑制作用。     

风轮菜中三萜皂甙的研究

从风轮菜[Clinopodium chinense(Benth)O.Kuntze]全草中分离得一个新三萜皂甙,根据化学方法和光谱分析确定其化学结构为3-O-β-D-吡喃葡萄糖(1→6)-[β-D-吡喃葡萄糖(1→4)-β-D-吡喃葡萄糖-11,13(18)-二烯-3β,16β,23,28-四羟基齐墩果烷,命名为风轮菜皂甙A(clinodiside A)。     

Non-taxane compounds from the bark of Taxus yunnanensis

From the bark of Taxus yunnanensis, 15 non-taxane compounds were isolated. Through spectroscopic methods such as ID and 2D NMR and MS experiments, one of them was determined as a new abietane-type diterpenoid named taxayunnin (1). The other 14 known compounds were identified as taxamairin C (2), taxamairin A (3), 3beta-hydroxy-sandaracopimaric acid (4), (+)-3-hydroxy-isodrimenin (5), rubrosterone (6), ponasterone A (7), ecdysterone (8), 20-hydroxy-echysone-20,22-monoacetonide (9), 7-oxositosterol (10), stigmast-4-en-6beta-ol-3-one (11), 5alpha,6beta-dihydroxy-daucosterol (12), beta-sitosterol (13), daucosterol (14), 1-O-beta-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-N-(2'-hydroxypalmitoy])-octadeca-sphinga-4,8-dienine (15), respectively. Compounds 4-6, 9-12 and 15 were isolated from Taxus plants for the first time.     

黄丝郁金中的生物碱和倍半萜类成分

姜科植物姜黄(Curcuma longa)的块根称为黄丝郁金，是常用中药郁金的来源之一。为了研究黄丝郁金的利胆活性成分，采用柱色谱法对姜黄干燥块根的化学成分进行了研究。本文主要报道从中分离得到的1个喹啉类生物碱2-(2′-methyl-1′-propenyl)-4,6-dimethyl-7-hydroxyquinoline (1)，7个没药烷型倍半萜2,5-dihydroxybisabola-3,10-diene (2), 4,5-dihydroxybisabola-2,10-diene (3), turmeronol A (4), bisacurone (5), bisacurone A (6), bisacurone B (7)和bisacurone C (8)，以及dehydrozingerone (9)和zingerone (10)的分离和鉴定。化合物1为一个新的生物碱类化合物，化合物6～8为首次从姜黄中分得，化合物9～10为首次从姜黄属植物中分离得到。     

川藏香茶菜丁素和己素的结构确定

从川藏香茶菜中分离得到2个新化合物,经光谱解析和化学转换反应,确定川藏香茶菜丁素为3α,11β,13α-trihydroxy-entkaur-16-en-15-one(1),川藏香茶菜己素为11β,13α,15α-trihydroxy-entkaur-16-en-3α-β-D-glucoside(2)。     

Two novel bibenzyls from Dendrobium trigonopus

Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 x 10(- 3) M.     

Two novel bibenzyls from Dendrobium trigonopus

Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 x 10(- 3) M.     

Chemical Study of Alkaloids from Corydalis bungeana

From the herbs of CORYDALIS BUNGEANA, 16 alkaloids were isolated; 3 of them were identical with acetylcorynoline ( 2), corynoline ( 5), protopine ( 9), which had been obtained before from this plant. A further 11 known alkaloids: dihydrosanguinarine ( 1), acetylisocorynoline ( 3), 11-epicorynoline ( 4), corycavine ( 6), bicuculine ( 7), 12-hydroxycorynoline ( 8), scoulerine ( 12), cheilanthifoline ( 13), yuziphine ( 14), isoboldine ( 15), noryuziphine ( 16) were isolated for the first time from this plant. The tenth, named (+)-bungeanine, is a new alkaloid. Its structure has been established to be N-nor-5,14-dehydroacetylcorynoline. The conformation of (+)-bungeanine in solution is also discussed.     

中药云前胡的化学成分研究

从云前胡(Peucedanum rubricaule Shan et Shch)的乙醇提取物中分离鉴定了二十个成分,有十三个是香豆素化合物,其中化合物ⅩⅤ是一个新的香豆素配糖体,命名为云前胡甙(rubr icauloside),经光谱测定及化学降解确定其结构为:5,7-二甲氧基-8-[2′-羟基-3′-甲基,3′-O-β-D-呋喃芹糖基(1→6)-β-D-吡喃葡萄糖基-丁基]-香豆素。