中医疾病溯源

通过疾病说文解字、疾病字义引申、疾病实质涵义、疾病本难避免和疾病常也必须5个方面,对疾病作了溯源性的研究,旨在对疾病的诊断与治疗起到提示作用。     

黄煌/大柴胡汤加黄连

最擅长治疗的疾病:消化系统疾病、呼吸系统疾病、循环系统疾病、神经症及相关疾病、口腔黏膜病等,尤其擅长体质的调理。     

麻黄附子细辛汤临床应用新进展

本文综述了近十年以来麻黄附子细辛汤在临床上的应用,从心脏疾病、呼吸系统疾病、血管性疾病、神经系统疾病、泌尿系统疾病、生殖系统疾病、结缔组织疾病、五官科疾病以及其他疾病等诸多方面深入阐明,揭示了张仲景的麻黄附子细辛汤随着现代医学的发展,临床经验的丰富其适应范围不断扩大。从而使这一经典方剂更好的服务于临床。     

推拿手法治疗内科疾病的研究进展

推拿手法治疗内科疾病疗效肯定,在临床中得到广泛开展。本文检索和整理近年来国内利用推拿手法治疗内科疾病的相关文献,分别从临床胃肠道消化类疾病、神经及精神类疾病、血液循环类疾病、内分泌及代谢类疾病、泌尿类疾病、妇科类疾病等以及基础实验研究方面总结了推拿手法治疗内科疾病的临床疗效和作用机制。     

越鞠丸临床应用研究进展述略

从消化系统疾病(食管疾病、消化不良、胃的疾病、肠的疾病、消化性溃疡、肝的疾病、胆的疾病、胰腺疾病)、心血管疾病、呼吸系统疾病等综述越鞠丸的临床研究进展。     

“疾病过程”论

通过对疾病的病因、病机及西医疾病辨识等各个环节进行剖析,认为疾病并非是仅仅局限于器官、组织、分子层面的改变,而是由多种因素引起的机体在功能、结构、精神情志等层面随时间推移而产生变化的动态演变过程。在此过程中,疾病的萌芽、发展、传变及转归各个阶段密切相关。准确把握疾病的演变规律,用"过程论"的观点分析疾病全局,即掌握了疾病的关键环节,有助于实现疾病预防诊治预后一体化。     

疾病是个故事

<正>疾病是个故事,疾病不是一首诗。因此,疾病不适合吟唱,但疾病需要倾诉、讲述。故事有缘起,疾病有始因。疾病发生的时间、地点、环境,至如衣食住行之情状,待人接物     

我院血液透析患者中成药使用情况与需求

目的:探讨医院血液透析患者中成药的使用情况,对其需求进行分析,为促进中成药在血液透析患者中的使用提供科学依据。方法:从医院信息管理系统中导出2016年~2019年在医院进行血液透析的204例患者使用中成药相关信息,通过回访询问患者对中成药的需求进行分析。结果:疾病构成为呼吸系统疾病(22.1%)、循环系统疾病(17.6%)、消化系统疾病(17.2%)、精神神经疾病(14.2%)、皮肤及附属器疾病(11.8%)、泌尿系统疾病(3.9%)、其他疾病(13.2%)等,销售金额前10位中成药为宣肺止咳合剂、疏血通注射液、复方血栓通片、开胃健脾饮、养血安神口服液、消炎止痒霜、健脾渗湿颗粒、红归祛瘀酊、蛇胆川贝液、丹参注射液;各类疾病中成药的使用量为呼吸系统疾病(80.9%)、循环系统疾病(67.6%)、消化系统疾病(81.4%)、精神神经疾病(71.1%)、皮肤及附属器疾病(88.2%)、泌尿系统疾病(46.1%)等(57.8%)。结论:血液透析患者对中成药的使用需求较高,皮肤及附属器疾病、呼吸系统疾病需求量较大。     

“疾病过程”论

通过对疾病的病因、病机及西医疾病辨识等各个环节进行剖析,认为疾病并非是仅仅局限于器官、组织、分子层面的改变,而是由多种因素引起的机体在功能、结构、精神情志等层面随时间推移而产生变化的动态演变过程。在此过程中,疾病的萌芽、发展、传变及转归各个阶段密切相关。准确把握疾病的演变规律,用“过程论”的观点分析疾病全局,即掌握了疾病的关键环节,有助于实现疾病预防诊治预后一体化。     

浅谈文化及信仰对治疗疾病的影响

通过探讨文化、信仰对疾病的影响及信仰疗法和民俗疗法在治疗疾病中的作用分析,认为文化、信仰在某种程度上影响着地方性疾病及某些疑难病的发病与防治,临床中疾病分治,积极主动改变对疾病的单一认识,有助于提高医患治疗疾病和战胜疾病的自信心。     

The Effects of Galangin on a Mouse Model of Vitiligo Induced by Hydroquinone

Galangin, the main active component of Alpinia officinarum Hance, was tested in a mouse model of vitiligo induced in C57BL/6 mice by the topical application of 2 mL of 2.5% hydroquinone daily to shaved areas (2 × 2 cm) of dorsal skin for 60 days. Thirty days after the final application of hydroquinone, galangin (0.425, and 4.25 mg/kg) was administered orally for 30 days. The hair colour darkened when it grew back after treatment, and histological analysis showed that the number of melanin‐containing hair follicles had increased after treatment with all doses of galangin groups and 8‐methoxypsoralen (8‐MOP, the positive control) compared with the untreated vitiligo group (p < 0.05). The number of skin basal layer melanocytes and melanin‐containing epidermal cells had also increased significantly with the application of 4.25 mg/kg of galangin. The concentration of tyrosinase (TYR) in serum was found to have increased, whereas the content of malondialdehyde and the activity of cholinesterase had decreased after treatment with all doses of galangin and 8‐MOP, compared with control (p < 0.05). The expression of TYR protein in treated areas of skin also increased with the application of 4.25 mg/kg galangin and 8‐MOP. In conclusion, the results showed that galangin was able to improve vitiligo induced by hydroquinone in mice, with the activity related to concentrations of TYR, expression of TYR protein, activity of malondialdehyde and content of cholinesterase. Galangin may therefore be a potential candidate for the treatment of vitiligo, subject to further investigation. Copyright © 2014 John Wiley & Sons, Ltd.     

针刺丰隆、曲池及三阴交对高脂血症小鼠血脂的影响

目的观察针刺丰隆、曲池及三阴交对高脂血症小鼠血脂的影响。方法将120只雄性小鼠随机分为正常组40只、模型组40只、针刺组20只及药物组20只。正常组予普通平价饲料喂养,其余3组采用高脂饮食诱导法制备高脂血症小鼠模型,连续10 d。造模成功后,针刺组予针刺双侧丰隆、曲池及三阴交,并接通韩氏电针仪,同时予2 mL/（g.d）蒸馏水灌胃;药物组将辛伐他丁胶囊6.6 mg/（g.d）予蒸馏水2mL稀释灌胃;正常组及模型组予等容积蒸馏水灌胃,连续10 d。分别于造模后第15 d取正常组、模型组小鼠各20只及治疗后取各组剩余小鼠,检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）含量。结果造模后第15 d模型组TC、TG和LDL-C含量均高于正常组（P〈0.05）,HDL-C含量低于正常组（P〈0.01）,提示高脂血症小鼠模型造模成功。治疗后模型组TC、TG、LDL-C含量均高于正常组（P〈0.01）,HDL-C含量低于正常组（P〈0.01）。针刺组、药物组TC、TG及LDL-C含量均低于模型组,HDL-C含量高于模型组（P〈0.05或P〈0.01）。针刺组TC、LDL-C含量均低于药物组（P〈0.05,P〈0.01）。结论针刺丰隆、三阴交、曲池穴可降低高脂血症模型小鼠血清中的TC、TG、LDL-C,升高HDL-C,具有良好的调节脂质代谢作用。     

从宇宙的向心力和离心力探生命个体动力学说

向心力和离心力是形成生命运动的动力,生命现象是能量在特定大小时的一种物质空间变化方式。人类对宇宙和生命的认识,在早期是从阴阳开始,并形成了一套完整的阴阳理论,中医是基于阴阳学说上的古代人体科学,有天地人合一,人与自然宇宙一体的认识,是一种描述在人体中,物质,空间,能量在向心力和离心力作用下,三种状态转化的理论。     

证候与基因组学、蛋白质组学相关研究及其思考

证候是中医独有的概念,证候实质的研究,就是用现代科学理论揭示中医证候理论中蕴藏的科学内涵,阐明证候及其相关疾病的微观机制。基因组学与蛋白质组学的引入有望给证候学研究带来契机。从证候实质研究现状、证候与基因组学、蛋白质组学相关研究和复杂系统研究的方法论问题等方面,探讨了从基因组学和蛋白质组学研究中医证候实质可能的思路与方法。     

肾虚,脾虚造型动物免疫超微结构的比较研究

本文采用对比研究的方法,在相同实验条件下,观察和比较了肾阳虚证、脾虚证实验动物的免疫器官脾、胸腺的超微结构改变及补肾方药肾气汤,补脾方药四君子汤对他们的影响。结果显示：脾虚、肾阳虚证动物的脾脏、胸腺超微结构均有明显的破坏现象,肾阳虚证尤甚。提示免疫器官超微结构的这一改变可作为脾虚、肾阳虚证的病理学证据之一。补脾和补肾方药治疗可分别改善脾虚证、肾阳虚证动物已受破坏的组织结构实验结果,也佐证上述的观点。     

血脂研究与中医整体观关系初探

整体观念是中医理论的基本特征之一。中医脾与血脂代谢的关系密切。笔者在血脂研究中重视血脂状态的整体特征,应用双梯度聚丙烯酰胺凝胶电泳（ＤＧＰＡＧＥ）技术检测血清脂蛋白谱（ＳＬＰＧ）,可以整体评价血清脂蛋白动态平衡关系,亦为中医“内脾虚”证的诊断提供新的实验室指标,探索中医和西医有机结合,共同发展。     

An Acute,Double‐Blind,Placebo‐Controlled Crossover Study of 320 mg and 640 mg Doses of a Special Extract of Bacopa monnieri (CDRI 08) on Sustained Cognitive Performance

Standardized extracts of the traditional Ayurvedic medicine Bacopa monnieri (BM) (Brahmi) have been recently shown to have cognitive enhancing effects in chronic administration studies. Pre‐clinical work has also identified a number of acute anxiolytic, nootropic, and cardiovascular effects of BM. There has, however, been little research on the acute effects of BM on cognitive function. The current study aimed to assess the acute effects of a specific extract of BM (KeenMind® ‐ CDRI 08) in a double‐blind, placebo‐controlled study in normal healthy participants who completed a cognitively demanding series of tests. Twenty‐four healthy volunteers completed six repetitions of the Cognitive Demand Battery (CDB) after consuming a placebo, 320 mg BM or 640 mg of BM in a cross‐over design and provided cardiovascular and mood assessments before and after treatment. Change from baseline scores indicated that the 320 mg dose of BM improved performance at the first, second, and fourth repetition post‐dosing on the CDB, and the treatments had no effect upon cardiovascular activity or in attenuating task‐induced ratings of stress and fatigue. It was concluded that assessment of an earlier pharmacological window and use of less memory‐specific cognitive tests together with more temporally sensitive measures of brain activity may improve our understanding of the acute neurocognitive properties of BM. Copyright © 2012 John Wiley & Sons, Ltd.     

补骨脂药材UPLC指纹图谱建立及12种主要成分含量测定

目的建立补骨脂Psoralea corylifolia药材的UPLC指纹图谱,同时对其中12种成分进行含量测定,为其质量控制提供参考。方法采用Shim-pack GIST-HP色谱柱(100 mm×2.1 mm,1.9μm);以水和乙腈为流动相,梯度洗脱,建立10个产地29个批次的补骨脂药材的UPLC指纹图谱,并采用中药色谱指纹图谱相似度评价软件(2012年版)进行相似度评价。同时测定了补骨脂药材中12种成分的含量。结果建立了补骨脂药材的UPLC指纹图谱,29批药材的相似度在0.827~0.989,共标定出21个共有峰,并指认出其中12个色谱峰。定量分析条件方法学考察结果良好,29批药材中补骨脂素、异补骨脂素、异补骨脂二氢黄酮、新补骨脂异黄酮、补骨脂甲素、欧前胡素、补骨脂宁、补骨脂定、4,5-去氢异补骨脂定、补骨脂乙素、异补骨脂色烯查耳酮、补骨脂酚的质量分数依次为1.08~6.95、0.76~5.01、0~0.62、0.40~2.54、0.32~1.75、0~0.25,0.06~0.73、0.23~1.83、0~0.27、0.86~6.86、0.08~1.59、4.20~20.76 mg/g。结论UPLC指纹图谱结合多成分同时测定的方法,操作简便,结果准确、稳定,可为补骨脂药材的质量评价提供参考。     

Meditationsforschung: neuroanatomische Befunde

Meditation practices can be conceived as forms of mental training for enhancing the ability to regulate autonomic arousal, attention, and emotions. Recent research has utilized neuroimaging methods (anatomical magnetic resonance imaging) to identify brain regions that show morphological changes following the practice of meditation. In this article we summarize the findings of published studies comparing experienced meditators and non-meditators. Furthermore, we'll briefly review results of the first longitudinal studies that investigated participants of 8-week meditation courses and compared images taken before and after the training. Brain regions that were identified in these studies are involved in the regulation of autonomic functions, attention, and emotion. Morphological changes in these regions might support the beneficial effects of meditation reported by practitioners. Detailed knowledge of the neurobiological mechanisms underlying the benefits of meditation training is indispensible for the targeted application of such techniques in the treatment of patient populations.