电针治疗癫痫伴发抑郁症的疗效观察

目的:观察电针治疗癫痫伴发抑郁症的疗效。方法:将2008年1月～2011年12月我院收治的85例癫痫伴发抑郁症患者按照随机数字表法随机分为观察组43例和对照组42例,观察组给予患者电针治疗,对照组给予患者拉莫三嗪治疗,观察两组患者的疗效、HAMD量表积分、不良反应情况、月平均发作次数。结果:观察组总有效率(88.37%)显著高于对照组总有效率(69.09%),P<0.05;两组治疗后较治疗前HAMD抑郁量表积分均显著降低(P<0.05),治疗后观察组HAMD抑郁量表积分显著低于对照组,两组具有显著性差异(P<0.05);观察组不良反应发生率显著低于对照组,P<0.05,存在显著性差异。结论:电针治疗癫痫伴发抑郁症的疗效较好,安全、可行,值得临床推广。     

电针治疗围绝经期抑郁症临床观察

目的：观察电针治疗围绝经期抑郁症的临床疗效。方法：将60例围绝经期抑郁症患者随机分为治疗组和对照组,各30例;治疗组采用电针治疗,对照组给予坤泰胶囊口服。治疗1个月后观察两组改良Kupperman评分及Hamilton抑郁量表评分变化。结果：治疗后两组改良Kupperman评分和Hamilton抑郁量表评分均显著降低（P〈0．01）,且治疗组的降低较对照组显著（P〈0．05）。结论：电针治疗围绝经期抑郁症疗效确切。     

老年慢性酒精中毒与抑郁症的抑郁症状比较

目的 :探讨老年慢性酒精中毒性精神障碍与老年抑郁症之间抑郁症状有何差异。方法 :应用老年抑郁量表 (GDS)、汉密尔顿抑郁量表 (HAMD)、症状自评量表 (SCL 90 )及简易智能状态检查表 (MMSE)测定 4 8例伴有抑郁症状的老年慢性酒精中毒病人与 36例老年抑郁症病人。结果 :酒精中毒组的躯体症状、精神运动性抑制及自杀行为的发生率较抑郁症组低 ,其差异有显著性 (P <0 0 1) ,而焦虑与激越较抑郁症组高 ,其差异有显著性 (P <0 . 0 1)。酒精中毒组的HAMD总分明显低于抑郁症组 (P <0 . 0 1)。SCL 90中的躯体化、人际关系敏感、敌对及精神病性因子方面 ,二者之间有显著性差异 (P <0 . 0 1)。酒精中毒组MMSE总分较抑郁症组高(P <0 . 0 1)。结论 :老年慢性酒精中毒的抑郁症状程度较抑郁症轻 ,某些抑郁症状表现与抑郁症不同 ,其认知功能缺损较抑郁症为重     

焦虑和抑郁障碍共病患者功能失调性认知的对照研究

目的　从认知心理学角度来探讨焦虑症、抑郁症和焦虑抑郁障碍共病有无差异。方法　使用功能失调性状况评定量表(DAS)、汉密顿抑郁量表 (HAMD)及汉密顿焦虑量表 (HAMA)对 3 5例抑郁症、3 0例焦虑症及 3 0例焦虑抑郁障碍共病患者于治疗前后 ( 6～ 8周 )进行评定 ,并与 3 0名正常人进行对照。结果　 ( 1)治疗前后患者组DAS总分及各因子分均高于对照组 ;( 2 )焦虑抑郁障碍共病组治疗前后的DAS总分值及大多数因子分明显高于焦虑症组及抑郁症组 (P <0 .0 5 ) ,而后两组间差异无显著性 (P >0 .0 5 ) ;( 3 )患者组治疗前后的DAS减分值与各自相应的HAMD和 /或HAMA减分值均无相关性。结论　焦虑症、抑郁症及焦虑抑郁共病患者均存在明显的功能失调性认知 ,后者较前两者严重 (P <0 .0 5 )。     

针药结合治疗抑郁症的临床研究

目的　观察电针结合SSRI类药物对抑郁症的疗效。方法　随机分为 2组 ,治疗组 36例 ,采用电针结合SSRI ;对照组 30例 ,单纯给予SSRI,分别观察 2组HAMD量表的变化及治疗 6周后的临床疗效。结果　 2组显效率无明显差异 (P>0 .0 5 ) ,HAMD量表总分及部分因子分有显著性差异 (P <0 .0 5 )。结论　针药组见效快 ,对焦虑 /躯体化及失眠症状的改善优于单纯药物组     

中西医结合治疗抑郁症临床研究

目的:探讨中西医结合治疗抑郁症的临床疗效。方法:将80例抑郁症患者按随机数字表法分为对照组和试验组,对照组给予米氮平治疗;试验组在对照组基础上加服自拟逍遥汤治疗。结果:两组治疗6周后汉密尔顿抑郁量表(HAMD)评分均有显著降低(P<0.05),其中试验组HAMD总分降低更为明显(P<0.05)。试验组治疗有效率为90.0%,明显高于对照组72.5%(χ2=4.02,P<0.05)。结论:中西医结合治疗抑郁症疗效显著,治疗期间必须加强对抑郁症患者的护理,尤其要高度重视对抑郁症患者的心理护理与健康教育。     

电针及电针合并麦普替林治疗抑郁症临床疗效观察

目的评价电针及电针合并麦普替林对抑郁症的疗效.方法采用随机分组方法,将抑郁症患者分为电针加麦普替林组(简称合并组)和电针组,治疗6周.以汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评定疗效.结果第2周后两组HAMD、SDS、SAS评分降低均显著大于治疗前,合并组HAMD降分率显著大于电针组,但第4、第6周降分率无明显差异.用传统疗效评定标准,两组显效率分别为77.3%和75.0%,合并组的副反应多于电针组.     

老年期抑郁症的临床分析

目的了解老年抑郁症的临床特征。方法对60岁以上的老年期抑郁症患者30例对照组中青年抑郁症患者30例分别以Hamilton抑郁量表(HAMD)在抗抑郁治疗前进行测查。结果HAMD量表总分两组大致相同，但从各因子分计分结果、各单项两组相比，绝大多数均值，老年组较对照组为重。结论老年组在躯体焦虑、疑病、有罪感、激越、睡眠不深及自杀行为均较对照为重，但晨重暮轻的日夜变化及阻滞反比对照组为轻。     

改良性电抽搐与抗抑郁剂治疗抑郁症的对照研究

目的分析比较改良性电抽搐治疗(modified electroconvulsive therapy,MECT)和抗抑郁药物治疗抑郁症的临床疗效及安全性。方法将80例抑郁症患者随机分成两组,MECT组40例,使用MECT治疗,隔天1次,连续3周,后改为每周1次,共治疗8周;对照组40例,使用抗抑郁剂帕罗西汀(赛乐特),口服,20mg/d,总疗程8周。所有入组患者使用汉密尔顿抑郁量表(hamilton depression scale,HAMD)、副反应量表(treatment emergentsymptom scale,TESS)评定。结果治疗第1周末MECT组HAMD总分明显下降,对照组在第2周开始起效。8周末两组HAMD总分均明显下降,两组总分无显著差异。两组出现副作用均少,MECT组5例出现头痛,4例记忆轻度减退。两组TESS分值无显著差异。结论MECT治疗抑郁症安全有效,起效较快,对记忆功能早期有一定影响,一般2~3 d可以恢复。     

万拉法新治疗抑郁症33例临床分析

目的　评价万拉法新治疗抑郁症的疗效和副作用。方法　对 66例抑郁症患者随机分别予万拉法新 (治疗组 )、阿米替林 (对照组 )治疗 ,用汉密尔顿抑郁量表 (HAMD)、汉密尔顿焦虑量表 (HAMA)、不良反应症状量表 (TESS)评定疗效和副作用。结果　治疗组总有效率为 10 0 % (3 3 /3 3 ) ,对照组为 75 .76% (2 5 /3 3 ) ,两组比较差异有高度显著性 (P <0 .0 1) ;治疗组治疗 4周后HAMD、HAMA评分低于对照组 (P <0 .0 1或 0 .0 5 ) ,且副作用小 (P均 <0 .0 1)。结论　万拉法新是一种安全、有效的新一代抗抑郁新药     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.