张东岳教授益气活血法治疗气虚血瘀型溃疡性结肠炎60例

目的观察张东岳教授运用益气活血法治疗气虚血瘀型溃疡性结肠炎的临床疗效,从实验室检查、内镜检查及组织学等方面证明其疗效的可靠性,使之成为一个成熟的治疗方案向临床推广。方法将符合诊断的120例气虚血瘀型溃疡性结肠炎患者随机分为治疗组和对照组,其中治疗组（60例）运用益气活血法,给予口服中药汤剂治疗;对照组（60例）给予口服固肠止泻丸,观察两组临床疗效。结果益气活血法治疗气虚血瘀型溃疡性结肠炎的总有效率为95%,对照组的总有效率为81.7%,治疗组在临床综合疗效、临床症状改善以及纤维结肠镜检查方面均明显优于对照组（P〈0.05）。结论益气活血法是治疗气虚血瘀型溃疡性结肠炎的有效方法,且疗效显著。     

通冠胶囊对26例气虚血瘀型急性冠脉综合征患者疗效观察

目的：观察通冠胶囊对气虚血瘀型急性冠脉综合征患者的疗效。方法：临床上气虚血瘀型急性冠脉综合征患者54例,治疗组26例,对照组28例。对照组为常规治疗组,治疗组在对照组常规治疗基础上加用通冠胶囊,治疗后第1天、第7天、1个月,观察临床疗效及中医症候评分。结果：治疗后治疗组多项指标优于对照组,包括胸闷、胸痛等气虚血瘀症状,总有效率为92.31%,而对照组有效率为71.42%,治疗组中医症状量化评分及临床症状总体疗效均优于对照组（P〈0.05）。结论：通冠胶囊应用于气虚血瘀型急性冠脉综合征患者,可明显改善患者气虚血瘀症状。     

益气活血降压汤治疗气虚血瘀型高血压51例

目的:观察益气活血降压汤治疗气虚血瘀型高血压的临床疗效。方法:将102例患者随机分为治疗组和对照组,每组各51例。对照组口服苯磺酸氨氯地平片,治疗组在对照组的基础上联合益气活血降压汤。观察两组患者治疗前后血压、中医血瘀症候积分和血流变学等指标的变化情况。结果:两组患者治疗后血压较治疗前显著下降,且治疗组优于对照组,差异具有统计学意义(P0.05)。两组患者治疗后中医症候积分较治疗前降低,且治疗组低于对照组,差异具有统计学意义(P0.05)。两组患者治疗后血流变学指标均显著低于治疗前,且治疗组优于对照组,差异具有统计学意义(P0.05)。结论:益气活血降压汤治疗气虚血瘀型高血压病,能较好地控制血压水平、改善中医症状、改善血流变学指标。     

益气活血汤治疗气虚血瘀型冠心病慢性心衰临床观察

目的观察自拟益气活血汤治疗气虚血瘀型冠心病慢性心衰的疗效。方法将97例冠心病慢性心衰且中医辨证属气虚血瘀型患者随机分为两组,治疗组51例在常规西药抗心衰治疗的基础上加服中药益气活血汤治疗;对照组46例仅采用常规抗心衰西药治疗。结果治疗组临床疗效总有效率为86.3%,对照组为76.1%;且治疗组在体表心电图疗效、心脏指数、每搏指数、射血分数改善方面均优于对照组(P0.05或P0.01)。结论益气活血汤治疗气虚血瘀型冠心病慢性心衰疗效显著。     

桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗输卵管阻塞性不孕临床观察

目的:观察桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗血瘀型输卵管阻塞性不孕的临床疗效。方法:选取本院收治的78例血瘀型输卵管阻塞性不孕患者为研究对象,按照随机数字表法分为观察组和对照组各39例。对照组采用宫腔镜下输卵管通液术治疗,观察组在对照组治疗基础上口服桂枝茯苓胶囊,服药3个月经周期。观察2组治疗前后中医证候总积分的变化,及治疗后输卵管通畅程度和妊娠情况。结果:治疗后,2组中医证候总积分均较治疗前降低(P0.05),观察组的中医证候总积分较对照组下降更明显(P0.05)。观察组总有效率94.9%,高于对照组的64.1%(P0.01)。观察组输卵管通畅率及输卵管总复通率分别为61.4%和80.7%,对照组输卵管通畅率和输卵管总复通率分别为37.5%和58.9%。2组输卵管通畅率及输卵管总复通率比较,差异均有统计学意义(P0.05)。随访1年,观察组妊娠率为61.5%,高于对照组的35.9%(P0.05)。结论:桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗血瘀型输卵管阻塞性不孕,能有效改善患者的临床症状,提高输卵管复通率和妊娠率。     

益气活血通络法治疗缺血性中风恢复期的临床观察

目的:观察益气活血通络法治疗气虚血瘀型中风恢复期患者的临床疗效。方法:将95例患者随机分为两组,对照组予以常规西药治疗,包括降脂、调控血压、调血糖、抗血小板聚集等。治疗组除上述常规治疗外,又予以益气活血通络之中药汤剂口服,两组疗程均为14天。结果:治疗组总有效率为87.76%,对照组总有效率为67.39%。治疗组优于对照组。两组患者治疗后,治疗组的MSSS评分与B I指数评分优于治疗前,与对照组分数比较优于对照组,P<0.05,具有统计学意义。结论:对于气虚血瘀型恢复期中风患者,加服益气活血通络之中药汤剂可提高临床疗效。     

中西医结合治疗难治性输卵管不通型不孕58例

目的 :观察中西医结合治疗输卵管不通型不孕的临床疗效。方法 :将 10 8例患者随机分为两组 ,中西医结合组 (治疗组 ) ,用益气活血通络结合常规输卵管通液术治疗 ,西药组 (对照组 ) ,单用输卵管通液术治疗。结果 :治疗组总有效率 96 6 %;对照组总有效率 78 0 %。两组总有效率比较 ,差异有显著意义 (P <0 0 5 )。结论 :中西医结合治疗输卵管不通型不孕能提高临床疗效     

益气活血汤治疗环形混合痔术后便秘80例临床观察

目的 观察益气活血汤治疗环痔术后便秘的临床疗效,探讨益气活血法治疗环痔术后便秘的机制.方法 临床选择符合诊断标准的环痔术后便秘患者80例,随机分为2组,每组各40例.治疗组给予益气活血汤水煎剂,对照组给予麻仁软胶囊口服,观察2组的临床疗效.结果 临床研究显示,治疗组总有效率92.5%,对照组总有效率70.0%,治疗组有效率明显优于对照组(P<0.05).结论 益气活血汤针对环痔术后便秘气虚、气滞、血瘀的病因病机标本兼治,疗效确切.     

中医药配合输卵管通液术治疗肾虚血瘀型输卵管炎性阻塞性不孕临床观察

目的 观察内服疏通汤、康妇消炎栓纳肛与输卵管通液术联合治疗肾虚血瘀型输卵管炎性阻塞性不孕症的临床疗效.方法 采用信封法将符合诊断的100例患者以2:1:1的比例随机分为中药组(疏通汤口服+康妇消炎栓纳肛)25例,对照组(输卵管通液术)25例,治疗组(疏通汤口服+康妇消炎栓纳肛+输卵管通液术)50例.1个月为l疗程,治疗6个疗程.观察治疗前后各组患者的主要临床症状改善情况及临床疗效.结果 3组患者治疗后少腹双侧坠胀或一侧痛、腰骶痛等症状均较治疗前改善,中药组优于对照组,治疗组与对照组比较差异有统计学意义(P<0.05).治疗组、中药组与对照组的临床有效率分别为88.1%、68.17%、60%,治疗组较对照组差异有统计学意义(P<0.05).结论 内服疏通汤、康妇消炎栓纳肛与输卵管通液术联合治疗肾虚血瘀型输卵管炎性阻塞性不孕症的临床疗效优于单纯输卵管通液术及中药治疗,且能明显改善临床症状.     

益气活血汤治疗环形混合痔术后便秘80例临床观察

目的观察益气活血汤治疗环痔术后便秘的临床疗效,探讨益气活血法治疗环痔术后便秘的机制。方法临床选择符合诊断标准的环痔术后便秘患者80例,随机分为2组,每组各40例。治疗组给予益气活血汤水煎剂,对照组给予麻仁软胶囊口服,观察2组的临床疗效。结果临床研究显示,治疗组总有效率92.5%,对照组总有效率70.0%,治疗组有效率明显优于对照组（P〈0.05）。结论益气活血汤针对环痔术后便秘气虚、气滞、血瘀的病因病机标本兼治,疗效确切。     

阳微阴弦-气虚血瘀-益气活血与冠状动脉粥样硬化性心脏病

冠状动脉粥样硬化性心脏病属"胸痹""心痛"范畴,"阳微阴弦"是对胸痹病因病机的高度概括,"阳微,寸口脉微也,(关前为阳)阳得阴脉,为阳不及,上焦阳虚也;阴弦,尺中脉弦也,(关后为阴)阴得阴脉,为阴太过,下焦阴实也。凡阴实之邪,皆得以上乘阳虚之胸,所以病胸痹心痛"。气虚是发生发展基础,气虚血瘀是病机关键。宜辨证与辨病结合,灵活运用益气活血法,临床疗效显著。未来应开展大样本多中心随机实验,运用循证医学手段,系统深入研究,为中医药治疗冠状动脉粥样硬化性心脏病提供理论依据。     

试论肝生血气与肝藏血

结合传统中医理论和现代医学理论,进一步阐明肝为血气化生之所的实质及其与肝藏血的关系,为正确认识诸多肝病的病理特点和进行临床治疗提供理论依据,     

高血压急症从气血论治

探讨高血压急症病因病机与证候的关系，为中医药救治高血压急症提供新的思路与方法。肝之疏泄失常，肝不藏血，内生风火热毒，气血逆乱乃高血压急症的主要病机。清除“内毒”，调和气血是救治高血压急症的关键。     

胃癌从气血论治

从胃癌的病因病机与气血的关系及胃癌的治疗方法方面阐述了胃癌应以气血理论为纲,以气血同治为大法,立疏肝调气,理气化痰,活血化瘀,健脾益气四项主要治则进行辨治。     

Study on the Biological Basis of Qi,Blood, and Vessel in Immune Thrombocytopenia Patients With Syndrome of Qi Failing to Govern Blood Based on the Theory of Qi and Blood

Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total of 52 ITP patients with SQFCB were enrolled and divided into bleeding group(38 cases) and non-bleeding group(14 cases).Bleeding group was further divided into mild qi deficiency group(25 cases) and moderate/severe qi deficiency group(13 cases) based on Chinese Medicine syndrome score.20 healthy volunteer were recruited as control group.The count of platelet(PLT) was taken as the blood related indicator.The expressions of cytokines including IL-1β, IL-17 A, TNF-α, CD40 L, and TGF-β, detected by Aim Plex Multiple Immunoassays for Flow, were taken as the qi related indicators.The expressions of VEGF-A, detected by Aim Plex Multiple Immunoassays for Flow and NO, NOS, and ET-1 detected by ELISA, were taken as the vessel related indicators.Results: As compared to the control group, the count of PLT, taken as the blood related indicator, was significantly lower in ITP group patients with SQFCB(P<0.05).The expression levels of IL-17 A and TNF-α, taken as the qi related indicators, were significantly higher, while those of CD40 L, IL-1β, and TGF-β, also taken as the qi related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The expression levels of NO and ET-1, taken as the vessel related indicators, were significantly higher, while the expression levels of NOS and VEGF-A also taken as the vessel related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The count of PLT, taken as the blood related indicator, was significantly lower in moderate/severe group than those in mild group(P<0.05).The expression levels of CD40 L and TGF-β, taken as the qi related indicators, were also significantly lower in moderate/severe group than those in mild group, respectively(P<0.05).Conclusion: The count of PLT might be the biological basis of blood.The expressions of NO, NOS, ET-1 and VEGF-A might be the biological basis of vessel.The expressions of IL-1β, IL-17 A, TNF-α, TGF-β, and CD40 L may be the biological basis of qi.The expressions of CD40 L and TGF-β could reflect the degree of qi deficiency in ITP patients based on the theory of qi and blood.     

益气活血法治疗气虚血瘀型糖尿病肾病35例

目的:观察益气活血法治疗气虚血瘀型糖尿病肾病的临床疗效及对血脂水平的影响.方法:选取气虚血瘀型糖尿病肾病患者70例,按照随机数字表法分为观察组和对照组,每组35例.两组患者均给予低盐、低脂饮食,控制血压、血糖等对症支持治疗,观察组另加用当归补血汤治疗.结果:观察组有效率为85.7％,对照组有效率为74.3％,观察组优于对照组(P＜0.05);观察组在降低血脂、24 h尿蛋白、改善肾功能和血脂水平等方面明显优于对照组(P均＜0.05).结论:益气活血法可有效改善糖尿病肾病患者蛋白尿及临床症状,改善患者血脂水平,发挥肾功能保护作用.     

浅谈从气血论治缺血性脑卒中

气血失调是疾病产生的根本原因,也是中风病的基本病机,祖国医学在诊治中风病上积累了丰富的经验,尤其是从气血论治方面,文章将从气血辨证关系、理论基础和方药研究三个方面进行论述。     

Special Issue on Qi Deficiency and Blood Stasis

正Qi deficiency and blood stasis is a common feature in coronary heart disease,cardiac hypertrophy,myocardial ischemia-reperfusion injury and heart failure,for which there is a lack of effective prevention and treatment methods in modern medicine.Some traditional Chinese medicine (TCM) has shown beneficial effect on heart diseases in clinic,and increasing clinical and basic studies have been carried out devoting to the mechanism behand these medicines,particularly focusing on their potential of tonifying Qi and promoting blood circulation,as well as the scientific essence of the Qi deficiency and Blood Stasis.In order to exchange the latest research results in this field,we have organized special issues of Qi deficiency and blood stasis,tonifying Qi and promoting blood circulation.Experts from this field are welcome to contribute original research articles or reviews.     

从气血辨治子宫肌瘤

目的:探讨从气血辨治子宫肌瘤。方法:通过对子宫肌瘤的诊治,结合相关文献资料以气血相关立论辨治子宫肌瘤。结论:子宫肌瘤的辨证,重在辨气血,辨虚实,在后期往往虚实夹杂,易成痼疾,所以审证求因,治法也应随气血而"变",调气行血为其根本,以衡为期。