慢性前列腺炎380例诊治分析

慢性前列腺炎(clironic prostatitis,CP)是国际前列腺协作网络会议分类方法中的Ⅱ型慢性细菌性前列腺炎(CBP)和Ⅲ型慢性非细菌性前列腺炎/慢性盆腔疼痛综合征(CAP/CPPS),其中Ⅲ型前列腺炎又分为炎症性(ⅢA)和非炎症性(ⅢB).     

慢性非细菌性前列腺炎/慢性骨盆疼痛综合征患者外周血CD4+CD25+T调节细胞功能检测及意义

目的 探讨慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(chronic abacterial prostatitis/chronic pelvic pain syndrome,CAP/CPPS)患者外周血CD4+CD25+调节性T细胞数量和功能的变化及其临床意义.方法 对45例CAP/CPPS患者和18名正常人采用流式细胞术检测外周血CD4+CD25+,CD4+CD25highT淋巴细胞占CD4+T淋巴细胞的百分率,RT-PCR检测Foxp3mRNA表达,ELISA法检测TGF-β1水平.结果 CAP/CPPS患者外周血CD4+CD25+T细胞、CD4+CD25highT细胞占CD4+T淋巴细胞的百分率与正常对照组比较差异无统计学意义(P>0.05);CAP/CPPSⅢA、ⅢB组患者外周血单个核细胞(PBMC)中Foxp3mRNA表达水平[(0.69±0.23)、(0.44±0.18)]较对照组(1.37±0.19)明显降低(P=0.035,P=0.014);CAP/CPPSⅢA、ⅢB组患者血清中TGF-β1水平[(18.09±10.45)pg/ml、(14.06±6.22)pg/ml]较对照组[(27.01±13.29)pg/ml]降低(P=0.041,P=0.024).结论 外周血CD44CD25+调节性T细胞数量与CAP/CPPS的发病无明显关联,CD4+CD25+调节性T细胞功能障碍可能参与CAP/CPPS发病机制;Foxp3基因与TGF-β1在CAP/CPPS的发病过程中起重要作用.     

千雪清精方治疗湿热下注型慢性前列腺炎的临床观察

慢性前列腺炎是中青年男性的常见病、多发病，近年来该病的发病率有增高的趋势。，根据美闰国立卫生研究院（NIH）的前列腺炎分类方法．将前列腺炎分为Ⅰ、Ⅱ、Ⅲ、Ⅳ型。其中Ⅱ型为慢性细菌性前列腺炎（CBP），Ⅲ型为慢性非细菌性前列’腺炎／慢性骨盆疼痛综合征,（CAP／CPPS）。本病中医学辨证分型最常见的有湿热、瘀血、阴虚、阳虚或虚实夹杂型等。     

慢性前列腺炎患者EPS中IL-1βIL-2IL-10测定的意义

目的探讨前列腺液(EPS)中白细胞介素-1β(IL-1β)、白细胞介素-2(IL-2)、白细胞介素-10(IL-10)水平与不同类型慢性前列腺炎患者之间的关系。方法86例慢性前列腺炎患者按美国国立卫生研究院(NIH)分类法分为慢性细菌性前列腺炎(CBP)组,慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CPPSⅢA)组和慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CPPSⅢB)组3组。应用放射免疫分析(RIA)法分别对患者EPS中IL-1βI、L-2I、L-10含量进行了检测。结果慢性前列腺炎组IL-1βI、L-2浓度均明显高于对照组(P均<0.05或0.01),IL-10浓度明显低于对照组(P<0.01)。按CBP组、CPPSⅢA组、CPPSⅢB组的顺序,EPS中的IL-1β、IL-2浓度呈现明显的下降趋势,IL-10浓度呈现明显的升高趋势。其中IL-1βI、L-10在CBP组和CPPSⅢA组分别与CPPSⅢB组结果之间存在显著性差异(P均<0.05或0.01);CBP组与CPPSⅢA组IL-1β、IL-10结果之间差异无显著性(P>0.05)。IL-2在CBP组、CPPSⅢA组、CPPSⅢB组三组结果之间差异无显著性(P>0.05)。结论EPS中IL-1βI、L-2I、L-10在慢性前列腺炎的发病过程中起重要作用,检测EPS中的IL-1βI、L-2I、L-10水平是诊断慢性前列腺炎有价值的指标,EPS中的IL-1β、IL-10水平对于CPPSⅢ的诊断与分型亦具有重要价值。     

慢性非细菌性前列腺炎/慢性骨盆疼痛综合征患者外周血Th_1/Th_2淋巴细胞比值的免疫学研究

目的:探讨慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CAP/CPPS)患者外周血Th1/Th2细胞分布的变化情况,了解其在CAP/CPPS发病过程中的意义。方法:采用流式细胞学检测40例CAP/CPPS患者和20例健康体检者外周血CD3+CD8-T细胞内细胞因子干扰素γ(IFN-γ)和白细胞介素(IL-4)的表达。结果:与正常对照相比,Ⅲa型、Ⅲb型CAP/CPPS患者的Th1细胞数均升高,Th1/Th2比值升高,差异有显著性(P<0.05),Th2细胞数差异无显著性(P>0.05)。结论:CAP/CPPS患者Th1/Th2平衡失调,Th1型免疫反应模式占优势状态,提示Th1细胞在CAP/CPPS的疾病发生中可能起重要作用。     

性传播疾病治疗后病人前列腺炎病原体的检测

①目的 了解性传播疾病治疗后病人慢性前列腺炎病原体感染的情况。②方法 随机抽取205例性传播疾病治疗后病人的前列腺液，进行病原体检测。③结果 205例慢性前列腺炎病人中非炎症性前列腺炎115例，占56．10％。90例检出病原体，检出率为43．90％；其中细菌性前列腺炎57例(27．80％)，非细菌性前列腺炎33例(16．0g％)。④结论 性传播疾病治疗后病人前列腺炎大部分为非炎症性的，性传播性疾病的病原体不是导致前列腺炎的主要病原体。     

男性尿道炎后综合征

目的探讨男性尿道炎后综合征(MPUS)的有效诊治方法.方法对1998年5月～2003年6月门诊治疗的120例患者进行尿液和前列腺按摩液(EPS)常规分析和病原体检测.结果全部患者获得3个月～2年随访.临床治愈36例,治愈率30%,总有效率85%.结论男性尿道炎后综合征是泌尿科常见疾病,其主要病因为慢性无菌性前列腺炎/慢性盆腔疼痛综合征(CAP/CPPS)及性病神经症(VN).治疗以采用综合疗法为宜.     

124例前列腺炎综合征患者前列腺液细菌培养及PCR结果分析

对１２４例前列腺炎综合征患者的前列腺液（ＥＰＳ）进行细菌培养和聚合酶链反应（ＰＣＲ）检查：慢性细菌性前列腺炎占５３．２３％（６６／１２４），以表皮葡萄球菌为主６９．６９％（４６／６６）；非细菌性前列腺炎占３５．４８％（４４／１２４），以沙眼衣原体、解脲支原体为主７９．５５％（３５／４４）；前列腺痛占１１．２９％（１４／１２４）。认为表皮葡萄球菌是慢性前列腺炎的主要致病菌，而性传播性病原体沙眼衣原体，解脲支原体的感染成为非细菌性前列腺炎的主要致病因素。     

慢性前列腺炎的病因与治疗进展

慢性前列腺炎(chronic prostatitis,CP)多发生于青壮年,是泌尿外科常见疾病,发病率为4%～25%。目前对其发病机制仍未完全明了,治疗也不尽如人意。1995年,美国国立卫生研究院(nationalinstitute of health,NI H)对前列腺炎进行了重新分类,即NI H分类法。Ⅰ型:急性细菌性前列腺炎(a-cute bacterial prostatitis,ABP);Ⅱ型:慢性细菌性前列腺炎(chronic bacterial prostatitis,CBP);Ⅲ型:ⅢA,慢性非细菌性前列腺炎(chronic non-bacteri-al prostatitis,CNP)和ⅢB,慢性骨盆疼痛综合征(chronic pelvic pain syndrome,CPPS);Ⅳ型:无症状…     

细胞因子与慢性非细菌性前列腺炎

慢性非细菌性前列腺炎(chronic abacterial prostatitis, CAP)是最常见的一种前列腺疾病, 约占临床前列腺炎病例的90 %～95 %,本病又称慢性骨盆疼痛综合征(chronic pelvic pain syndrome,CPPS),易反复发作﹑缠绵难愈,给患者带来很大的生理痛苦及精神负担.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.