大株红景天注射液联合依达拉奉治疗急性脑梗死的临床疗效

目的：分析急性脑梗死采取大株红景天注射液联合依达拉奉治疗的临床疗效。方法随机抽取2014年1月—2015年1月期间该院收治的96例急性脑梗死患者作为研究对象,按治疗方法的不同,有48例患者单纯接受依达拉奉治疗（对照组）,有48例患者接受依达拉奉联合大株红景天注射液治疗（观察组）,对两组患者的临床效果、神经功能改善情况及hs-CRP水平进行统计对比。结果观察组治疗后的hs-CRP水平（10.03±1.96）mmol/L,低于对照组（12.76±3.17）mmol/L,组间比较差异有统计学意义（P<0.05）;观察组治疗后的神经功能缺损评分较对照组低,观察组有效率为45例（93.75%）,高于对照组38例（79.17%）,组间比较差异有统计学意义（P<0.05）。结论对急性脑梗死患者的治疗,在依达拉奉治疗基础上联合大株红景天注射液治疗可改善患者的神经功能损伤,降低其病死率,在临床中具有良好的应用价值。     

依达拉奉对急性脑梗死患者血清基质金属蛋白酶9表达的影响

目的探讨依达拉奉治疗急性脑梗死患者的疗效及对血清基质金属蛋白酶9（matrix metalloproteinase-9,MMP-9）蛋白表达的影响。方法选择发病24h内的急性脑梗死患者50例,按照随机数字表法分为对照组和治疗组（各25例）。两组患者视病情轻重及并发症给予对症治疗,其中治疗组联合应用依达拉奉30mg静脉滴注,2次/d,疗程14天。采用Western blot测定两组患者治疗前及治疗后第3天、第7天血清基质金属蛋白酶9蛋白表达,观察两组患者治疗前及治疗后第14天时临床神经功能缺损程度评分。结果治疗组治疗后第3、7天血清MMP-9蛋白表达与对照组比较差异有统计学意义（t3d=10.231,t7d=25.212,P〈0.01）。治疗组患者治疗后14天时神经功能缺损评分明显低于对照组（t=3.077,P〈0.05）。结论依达拉奉改善急性脑梗死患者神经功能的作用,可能与其降低血清中MMP-9蛋白水平有关。     

依达拉奉治疗急性脑梗死的疗效及对自由基含量的影响

目的 探讨依达拉奉治疗急性脑梗死的疗效及其对自由基含量的影响.方法 选取68例急性脑梗死患者作为研究对象,根据治疗方法的不同分为观察组和对照组(n=34),对照组应用丹参酮Ⅱ磺酸钠注射液,观察组应用依达拉奉注射液,比较2组患者的临床疗效及血清SOD(超氧化物歧化酶)、MDA(丙二醛)水平变化.结果 观察组患者治疗后的MDA值为(8.10±1.03)μmol/L,显著低于对照组的(11.54±1.12)μmol/L(P<0.05);观察组治疗后的SOD水平为(97.77±13.56)IU/mL,显著高于对照组的(82.57±12.54)IU/mL(P<0.05);观察组患者的治疗总有效率为88.24%(30/34),显著高于对照组的64.71%(22/34)(P<0.05).结论 对急性脑梗死患者应用依达拉奉注射液,能有效降低自由基含量,改善患者神经功能,临床疗效显著,值得推广应用.     

依达拉奉对大鼠脑缺血再灌注损伤的保护作用研究

目的：探讨±达拉奉对大鼠脑缺血再灌注损伤的保护作用。方法将36只SD大鼠随机分为假手术组、NS组及±达拉奉组,制备SD脑缺血再灌注模型,±达拉奉组在造模后即刻和12h分别给予±达拉奉腹腔注射,假手术组和NS组分别给予生理盐水腹腔注射,比较3组神经功能缺损评分及SOD、MDA含量。结果与假手术组比较,NS组与±达拉奉组神经功能缺损评分分别为（2.74±0.56）、（1.38±0.22）分均明显升高（P<0.05）,而与NS组比较,±达拉奉组神经功能缺损评分则明显下降（P<0.05）;与假手术组比较,NS组与±达拉奉组SOD活性分别为（113.29±7.61）、（144.93±10.48）U/mL明显下降（P<0.05）,而与NS组相比较,±达拉奉组SOD活性明显增高（P<0.05）;与假手术组比较,NS组与±达拉奉组MDA水平分别为（3.71±1.24）、（2.25±0.98）nmol/mL明显升高（P<0.05）,而与NS组相比较,±达拉奉组MDA水平明显下降。结论±达拉奉对大鼠脑缺血再灌注损伤具有明显的保护作用。     

依达拉奉联合疏血通注射液治疗老年急性脑梗死的临床疗效

目的探讨依达拉奉联合疏血通注射液治疗老年急性脑梗死的临床疗效。方法选取2016年3月至2018年10月唐山市人民医院神经外科收治的91例老年急性脑梗死患者为研究对象,根据治疗方案不同分为两组,对照组(n=45)采用依达拉奉治疗,观察组(n=46)采用依达拉奉联合疏血通注射液治疗,两组给药方式均为每日2次,14 d为1个疗程,连续用药2个疗程。采用美国国立卫生研究院卒中量表(NIHSS)、中国脑卒中临床神经功能缺损程度评分量表(CSS)评价患者神经功能,分析两组患者的临床疗效及治疗前后基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)水平;采用改良Rankin量表评估患者的预后。结果观察组治疗总有效率明显高于对照组[95. 7%(44/46)比77. 8%(35/45)](P <0. 05)。治疗前,两组NIHSS评分、CSS评分和血清MMP-9及VEGF水平比较差异无统计学意义(P> 0. 05);治疗后,观察组NIHSS评分、CSS评分明显低于对照组[(12. 3±1. 9)分比(16. 8±2. 5)分,(13. 1±1. 8)分比(17. 6±2. 2)分](P <0. 05),MMP-9低于对照组[(181. 2±55. 3)μg/L比(215. 5±57. 8)μg/L],VEGF水平高于对照组[(260. 5±52. 6) ng/L比(223. 8±43. 3) ng/L](P <0. 05),两组各指标组间、时点间、组间和时点间交互作用比较差异有统计学意义(P <0. 05)。观察组预后良好率明显高于对照组[91. 3%(42/46)比71. 1%(32/45)](P <0. 05)。结论依达拉奉联合疏血通注射液治疗老年急性脑梗死的临床效果显著,患者预后良好。     

化痰通络汤在脑卒中后认知功能障碍中的应用

目的 探讨化痰通络汤在脑卒中后认知功能障碍中的作用.方法 根据治疗方法将114例脑卒中患者分为对照组和观察组,对照组58例在常规治疗基础上使用依达拉奉治疗,观察组56例在常规治疗基础上使用化痰通络汤治疗.比较两组患者的神经功能缺损评分改变、日常生活能力改变和认知功能损害发生率等情况.结果 治疗后,观察组Hachinski缺血量表评分[（6.5±1.0）分]低于对照组[（6.9士1.0）分],ADL评分[（62.9士16.8）分]高于对照组[（50.0±17.0）分],MMSE评分[（25.7±1.4）分]高于对照组[（24.9±1.1）分],卒中后认知功能障碍发生率[7.1％（4/56）]低于对照组[20.7％（12/58）],差异均有统计学意义（均P＜0.05）.结论 化痰通络汤应用于脑卒中患者有效改善神经功能,降低认知功能障碍发生风险.     

依达拉奉联合高压氧治疗进展型脑梗死的临床疗效观察

目的探究依达拉奉联合高压氧治疗进展型脑梗死的临床疗效。方法选取2014年11月至2015年10月昆山市第一人民医院收治的进展型脑梗死患者90例,依据抽签法随机分为观察组和对照组,各45例。所有患者均予抗血小板、营养神经、降压、控制血糖、维持水电解质平衡、脱水等常规治疗,对照组在常规治疗的基础上应用高压氧(每次30 min,每日2次)治疗;观察组在常规治疗的基础上加用依达拉奉(30 mg,每日2次,静脉滴注)联合高压氧治疗(同对照组)。两组患者均治疗14 d,比较两组患者的临床疗效,比较治疗前后美国国立卫生院卒中评分(NIHSS)、日常生活能力评估指标[Barthel指数(BI)]和血流动力学变化,以及不良反应发生情况。结果治疗后,观察组总有效率显著高于对照组[95.6%(43/45)比80.0%(36/45),P<0.05]。治疗后30 d,观察组NIHSS评分显著低于对照组[(7.4±0.8)分比(10.5±1.0)分],BI评分显著高于对照组[(75.3±5.8)分比(64.5±4.2)分],差异有统计学意义(P<0.01)。观察组纤维蛋白原、D-二聚体显著低于对照组[(2.30±0.50)g/L比(3.03±0.62)g/L,(1.26±0.25)mg/L比(1.88±0.32)mg/L],差异有统计学意义(P<0.01)。两组治疗期间均未出现明显不良反应。结论依达拉奉联合高压氧治疗进展型脑梗死临床疗效确切,可促进神经功能恢复,有效改善患者血流动力学,无明显不良反应,值得临床推广。     

依达拉奉治疗急性缺血性脑卒中的临床疗效观察

目的：探讨依达拉奉治疗急性缺血性脑卒中的临床疗效。方法选择96例急性缺血性脑卒中患者,随机分为常规治疗组（对照组）和依达拉奉加常规治疗组（治疗组）,每组各48例,2周后,观察患者神经功能缺损改善及临床疗效,并记录不良反应。结果治疗后,治疗组和对照组总有效率分别为93.7％和87.5％,治疗组显著高于对照组（P〈0.05）;治疗组和对照组神经功能缺损评分分别为（6.19±4.32）分和（12.21±5.39）分,治疗组较对照组改善更明显（P〈0.05）。结论依达拉奉能明显改善患者的神经功能缺损程度,提高其生活自理能力,值得在临床治疗中推广使用。     

依达拉奉治疗急性脑梗塞的临床研究

目的 观察依达拉奉治疗急性脑梗塞的临床疗效及其安全性.方法 纳入急性脑梗塞患者48例,随机分为治疗组和对照组,各24例.治疗组予依达拉奉联合低分子肝素钙治疗,对照组予银杏达莫联合低分子肝素钙治疗.疗程为14 d,观察患者神经功能缺损改善及临床疗效,并记录不良反应.结果 治疗后,治疗组和对照组总有效率分别为95.8%和83.3%.治疗组明显高于对照组(P<0.05);治疗组和对照组神经功能缺损评分分别为6.17±4.35和12.09±5.44,治疗组较对照组改善更明显(P<0.05);治疗组血清SOD含量明显高于对照组(P<0.05),治疗组血清MDA含量明显低于对照组(P<0.05).结论 依达拉奉联合低分子肝素钙治疗急性脑梗塞能有效改善神经功能缺损,临床应用安全有效.     

依达拉奉对急性脑梗死患者血清基质金属蛋白酶9表达的影响

目的观察分析依达拉奉治疗急性脑梗死的疗效以及对急性脑梗死患者血清基质金属蛋白酶9（MMP-9）表达的影响。方法100例急性脑梗死患者根据人院先后顺序随机分为治疗组（常规治疗＋依达拉奉）和对照组（常规治疗）各50例,比较两组的疗效及MMP-9的变化情况。结果治疗组的总有效率高于对照组,两组神经功能缺损评分均降低,治疗组神经功能缺损评分降低明显,两组MMP-9的含量均明显降低,治疗组的MMP-9明显低于对照组（P〈0．05）。结论依达拉奉治疗急性脑梗死疗效明显,可以降低MMP-9的水平,值得临床予以重视。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.