静吸复合全麻与硬膜外阻滞麻醉联合应用于直肠癌根治术的研究

目的：比较静吸复合全麻联合硬膜外阻滞麻醉与单纯静吸复合全麻应用于直肠癌根治术时患者的血流动力学变化、吸入麻醉药用量、麻醉清醒时间和清醒质量的差别。方法：40例直肠癌根治术患者随机分为采用安氟醚为主的静吸复合全麻联合硬膜外阻滞麻醉组（I组）和单纯安氟醚为主的静吸复合全麻组（Ⅱ组），观察不同时相点血压和心率变化，吸入麻醉药用量、麻醉清醒时间和清醒质量。结果：同麻醉前相比，I组患者血压、心率基本平稳，Ⅱ组在不同时相点血压、心率升高幅度显著高于I组；I组安氟醚用量明显少于Ⅱ组（P＜0．01），麻醉清醒时间缩短，清醒质量明显提高（P＜0．01）。结论：静吸复合全麻联合硬膜外阻滞麻醉用于直肠癌根治术是一种更为安全、可控的麻醉方法。     

不同麻醉方法对应激反应的影响

目的：观察全麻复合硬膜外阻滞和全麻两种麻醉时血流动力学，血糖，胰高血糖素，皮质醇的变化。方法；30例择期上腹部手术病人ASA Ⅰ-Ⅱ级，随机分为两组，A组全麻复合硬膜外阻滞，B组单纯全麻，分别于麻醉开始前，气管插管5min后，手术开始1h后，术后24h抽取中心静脉血，用酶法测定血糖，用放免法测定皮质醇，胰高血糖素，结果：术中B组血压，心率均高于A组（P＜0．05），术中A组血糖，皮质醇，胰高血糖素均降低（P＜0．05），而B组明显升高（P＜0．01），且B组血糖，质醇，胰高血糖均明显高于A组（P＜0．01），结论：全麻复合硬膜外阻滞是一种应激反应较轻的麻醉方法。     

全麻复合硬膜外阻滞在十腹部手术中的应用

目的观察全麻复合硬膜外阻滞在上腹部手术中其血流动力学稳定性的探讨。方法选40例择期胃癌根治术或胆道探查术患者,随机分为Ⅰ组（采用硬膜外阻滞复合全麻）和Ⅱ组（采用静吸复合麻醉）,每组20例。两组病人全麻的诱导、维持方法相同,Ⅰ组病人术中间断硬膜外追加利多卡因。观察麻醉、苏醒期间心率、血压的变化和苏醒期苏醒质量及并发症。结果Ⅰ组围麻醉期血流动力学明显较Ⅱ组平稳（P〈0．05）,苏醒及清醒快,且并发症少。结论全麻复合硬膜外麻醉用于上腹部手术其血流动力学稳定性好、并发症少,是一种值得推广的麻醉方法。     

老年食管癌手术不同麻醉方式比较

[目的]观察不同麻醉方式用于老年食管癌患者手术的临床效果.探讨一种较为适合老年食管癌患者手术的麻醉方式.[方法]选择40例老年食管癌手术患者,随机分成两组Ⅰ组为静吸复合全麻,手术过程采用的麻醉方式为吸入异氟醚、静脉持续输注异丙酚、芬太尼及间中追加肌松药仙林;Ⅱ组为硬膜外阻滞复合静吸全麻,手术过程采用的麻醉方式为硬膜外阻滞的基础上吸入异氟醚、静脉持续输注异丙酚、芬太尼及间中追加肌松药仙林.两组病人根据BIS(脑电双频谱指数)调节麻醉深度.诱导前、插管后、术中1 h、拔管后分别抽血检查血糖及皮质醇.[结果]Ⅰ组的全麻用药量大,血压、心率在插管后、切皮、断肋及清醒拔管时明显升高,拔管时患者烦躁的发生率明显增高,血糖和皮质醇在手术后也明显增高.Ⅱ组全麻用药量小,手术过程血压、心率平稳,拔管时患者安静,手术后抽取的皮质醇及血糖升高不明显.[结论]硬膜外阻滞复合全麻在BIS值的指导下,适用于老年食管癌患者手术的麻醉.     

全麻复合硬膜外阻滞对老年上腹部手术患者应激和循环的影响

目的观察全麻复合硬膜外阻滞对老年上腹部手术患者血流动力学、血糖、皮质醇和IL-6的影响。方法30例老年上腹部手术患者ASAⅠ-Ⅱ级，随机分为A、B两组，A组全麻复合硬膜外阻滞，B组单纯全麻，分别于麻醉开始前、气管插管5rain后、手术开始1h后、术后24h抽取中心静脉血，测定血糖（Glu）、皮质醇（Cor）和IL-6，同时记录BP、HR。结果术中B组血压、心率均高于A组（P〈0．05），术中A组血糖、皮质醇、IL-6无明显变化，而B组升高（P〈0．05），且B组血糖、皮质醇、IL-6均高于A组（P〈0．05）。结论全麻复合硬膜外阻滞可明显抑制应激反应，更适用于老年上腹部手术。     

硬膜外阻滞复合异丙酚全麻在老年消化系统肿瘤手术中的应用

目的：研究硬膜外阻滞复合异丙酚全麻在老年消化系统肿瘤手术中的应用。方法：ASAⅡ～Ⅲ级、40例老年上腹部手术病人，年龄65～82岁．随机分为2组，Ⅰ组采用硬膜外阻滞复合异丙酚全麻；Ⅱ组采用静吸复合麻醉．观察麻醉、苏醒期间心率、血压、脉搏、血氧饱和度的变化和苏醒期苏醒质量及相关时间。结果：Ⅰ组围麻醉期血流动力学明显较Ⅱ组平稳，苏醒及清醒快，术后并发症少。结论：硬膜外阻滞复合异丙酚全麻可安全有效地用于老年上腹部手术的麻醉。     

静吸复合全麻联合硬膜外阻滞在妇科高血压患者腹腔镜手术的应用

目的:探讨静吸复合全麻联合硬膜外阻滞在妇科高血压患者腹腔镜手术的应用效果。方法:选择ASAI~II级高血压患者50例,随机分为静吸复合全麻联合连续硬膜外阻滞麻醉(I组)和单纯静吸复合全麻(II组)。结果:2组的血压、心率的比较:I组插管即刻心率、收缩压、舒张压同诱导前无显著性差异切皮后1分钟、气腹后5分钟、术毕拔管时心率、收缩压、舒张压均低于诱导前,II插管即刻、切皮后1分钟、气腹后5分钟、术毕拔管时的心率、收缩压、舒张压均高于诱导前,2组结果有显著性差异P0.05。结论:静吸复合全麻联合连续硬膜外阻滞麻醉用于妇科高血压患者腹腔镜手术比单纯静吸复合全麻可提供更稳定的血流动力学,降低高血压患者妇科腹腔镜手术时心脑血管疾病的发生率。静吸复合全麻联合连续硬膜外阻滞麻醉是妇科高血压患者腹腔镜手术较为理想的麻醉方法。     

不同麻醉方法下行子宫切除时机体应激反应的比较

目的比较不同麻醉方法下行子宫切除时机体的应激反应，寻找较适度的一种麻醉方法。方法将60例30—60岁拟施子宫全切（次全切）、ASAI-Ⅱ级的患者，随机区组设计分配到四个组：A组选硬膜外阻滞，B组选腰硬联合阻滞，C组选异丙酚靶控输注插管全麻，D组选全麻复合硬膜外阻滞。各组在麻醉前、麻醉后5min、切开腹膜时、切除子宫时、术毕五个时间点测肾素、血管紧张素Ⅱ、醛固酮、皮质醇、胰岛素、血糖、生长素，同时监测患者的血流动力学指标。结果A、B、D三组的肾素活性于麻醉后各时点下降，与麻醉前相比差异有统计学意义。C组肾素活性、血糖于切开腹膜后各时点较麻醉前升高（P〈0．05），胰岛素于切开腹膜后各时点较麻醉前降低（P〈0．05），皮质醇、生长素切除子宫时增高（P〈0．05）。A、B、D三组的血压、心率于麻醉后各时点显著降低，而C组的血压、心率基本维持在麻醉前水平。结论四种麻醉方法均能抑制子宫切除引起的应激反应，尤以腰硬联合阻滞、全麻复合硬膜外阻滞为著，异丙酚靶控输注插管全麻虽能抑制气管内插管引起的应激反应，但不能完全抑制手术导致的。肾素活性、皮质醇、血糖升高和胰岛素降低。     

硬膜外阻滞麻醉复合全麻在胆管手术中对老年患者心血管功能的影响

目的 比较观察老年胆管手术病手术时采用全麻复合硬膜外能否减轻在围插管期及拔管期心血管反应的影响。方法40例老年胆管手术患者，每组20例，Ⅰ组为全麻复合硬膜外阻滞，Ⅱ组为全麻组，两组患者入室后，测心率（HR）和平均动脉压（MAP），Ⅰ组患者全麻前行T8-9硬膜外麻醉起效后，开始诱导插管，Ⅱ组患者直接行静吸复合全麻。结果Ⅰ组患者插管后1-5min及拔管时HR、MAP较麻醉前低p〈0．05，II组患者比麻醉前高p〈0．05，两组患者插管后1-5min及拔管时HR、HAP相比有显著性差异（p〈0．05和〈0．01）。结论全麻复合硬膜外阻滞麻醉能减轻老年患者存胆管手术中的心血管反应。     

不同麻醉方法在高血压患者腹腔镜胆囊切除术中的应用

目的观察2种麻醉方法对高血压患者行腹腔镜胆囊切除术时应激反应的影响。方法择期行腹腔镜胆囊切除术的高血压患者40例，随机分成2组，每组20例。Ⅰ组（GE组）采用连续硬膜外阻滞加静吸复合麻醉，Ⅱ组（G组）采用静吸复合麻醉。2组分别于麻醉前（T0）、气管插管时（T1）、气腹后5min（T2）、气腹后20min（T3）及拔管时（T4），观察心率（HR）、收缩压（SBP）及舒张压（DBP），同时抽取静脉血测各时点血糖（GLU）、皮质醇（COR）和醛固酮（ALD）。结果与T0时比较，Ⅰ组各时点COR、GLU、ALD及HR、SBP、DBP差异无统计学意义；Ⅱ组T2、T3、T4时，HR、SBP、DBP及COR、GLU、ALD显著高于T0（P〈0．05）。组间比较，Ⅱ组B、T3、T4时，COR、GLU、ALD及HR、SBP、DBP显著高于Ⅰ组同时点（P〈0．05）。结论全麻-硬膜外联合麻醉能有效抑制高血压患者手术麻醉期间应激反应，为高血压患者腹腔镜胆囊切除术较为安全的麻醉方法。     

探讨腰麻-硬膜外联合阻滞麻醉与单纯硬膜外麻醉的临床麻醉效果

目的 评价腰麻-硬膜外联合阻滞麻醉与单纯硬膜外麻醉的临床麻醉效果.方法 方便选取2016年1月—2017年2月,重庆市武警重庆市消防总队医院普外科、骨外科等科室收治的下肢手术患者90例,黑箱摸球分组,42例纳入硬膜外组,48例纳入腰硬组.对比血压变化差值、术后腰痛VAS水平、不良事件发生情况.结果 腰硬组手术期间HR、SBP、DBP峰值与谷值差值分别为(7.54±1.65)次/min、(17.43±5.58)mmHg、(13.65±5.16)mmHg低于硬膜外组(11.47±5.51)次/min、(23.52±6.33)mmHg、(18.26±5.46)mmHg,腰硬组术后腰痛VAS评分(1.3±0.5)分、术中呼吸循环紊乱发生率22.92%低于硬膜外组(2.5±1.0)分、57.14%,差异有统计学意义(P<0.05).结论 下肢手术更适合腰麻-硬膜外联合阻滞麻醉.     

Anesthesia

Effects of DO2-directed hemodynamic management on pulmonary function in to course of anaesthesia of liver transplantation; Rectal midazolam, atropine and ketamine as premedication for infants and young children; Supraclavicular subclavian venous catheterization through the insertion point medial to the middle of clavicle in infants; Effect of acute normovolemic hemodilution on context-sensitive half-time for propofol given by target controlled infusion during hip joint replacement; Effect of acute hypervolemic hemodilution on pharmacokinetics of propofol in patients undergoing total hip replacement; Influence of leukocyte filtration on systemic inflammatory response to cardiopulmonary bypass in dogs;Effect of urapidil on L-type calcium current in rat ventricular myocytes; Changes in systemic and pulmonary hemodynamics in patients with liver cirrhosis and portopulmonary hypertension during liver transplantation;……     

Anesthesia

Effect of propofol on the release of glutamate γ-amino-butyric acid in hippocampus in rats during recovery from paradoxical steep deprivation;The effect-site concentration of midazolam achninistered by TCI and BIS values for conscious sedation in patients of differmt ages;Effects of ephedrine pretreatment and rocuronium priming on the rocuronium-induced neuromuscular blockade;Effects of different doses of propofol on cerebral venous blood S-100 protein and neuron-specific eno- lase in patients undergoing open heart surgery under CPB at mild hypothermia;Effect of different doses of ambroxol in car- diopulmonary bypass induced lung injury in children     

Anesthesia

Protective effects of colquhounia root tablet against oleic acid induced acute lung injury in rats , Effect of ketamine on iNOS mRNA expression in spinal cord of mice in the development of morphine tolerance, Analgesic effect of intrathecal SB203580 in a rat model of neuropathic pain , Interleukin.lO gene therapy for neuropathic pain in a rat model of chronic constriction injury , Effects of epidural capsaicin on pain thresh. old, neurological function and spinal neurons in rabbits, Effects of different concentrations of heparin in the preservation solution on blood coagulation after reperfusion in patients undergoing orthotopie liver transplantation, Influence of lidocaine on systemic inflammatory response to cardiopulmonary bypass in patients undergoing coronary artery bypass grafting , Effect of midazolam pretreatment on neurotoxicity of ropivacaine in rats , Anesthetic efficacy of epidural ropivaeaine mixed with different doses of sufentanil for hysterectomy     

Anesthesia

<正>209016 Effects of flurbiprofen on cellular immune function during patient-controlled intravenous analgesia with fentanyl in patients after esophagectomy/Feng Yanping(冯艳平,Dept Anesthesiol,Cancer Hosp He’nan Province,Zhengzhou 450003)…∥Chin J Anesthesiol. -2009,29(9). -773～774 Objective To investigate the effects of flurbiprofen on cellular immune function during patient-controlled in- travenous analgesia(PCIA) with fentanyl in the patients after esophagectomy.     

Anesthesia

<正>209163 Changes in plasma colloid osmotic pressure during off-pump orthotopic liver transplantation/Zhang Xiaomei(Dept Anesthesiol,Tianjin 1st Centre Hosp,Tianjian 300192)…∥Chin J Anesthesiol.-2009,29(2).-151~153Objective To investigate the changes in plasma colloid osmotic pressure(COP)in patients undergoing off-pump orthotopic liver transplantation(OLT).Methods Thirty ASA Ⅱ-Ⅳ patients(liver function Child-Pugh grade B or C)aged 35-60 yr undergoing off-pump OLT were studied.Anesthesia was induced with midazolam,sufentanil,propofol and vecuronium and maintained with propofol infusion,isoflurane inhalation and intermittent iv boluses of sufentanil and vecuronium.Human albumin and fresh frozen plasma were infused during operation.Hemoglobin was maintained at 70-80 and 80-100 g/L during preanhepatic and anhepatic phase respectively.Urine output was maintained at 1,0.5 and 1-2 ml·kg-1·min-1 while CVP at 4-7,0-3 and 4-10 mm Hg respectively during preanhepatic,anhepatic and neo-hepatic phase.Blood samples were taken immediately before intravenous line was established (T0,baseline),at skin incision(T1),60 min of preanhepatic phase(T2)beginning of anhepatic phase(T3),30 min of anhepatic phase (T4),beginning of neohepatic phase(T5),30 min of neohepatic phase(T6) and the end of operation(T7)from internal jugular vein for determination of plasma COP,crystalloid osmotic pressure and serum albumin concentration.     

Anesthesia

Preventive effects of remifentanil on sympathetic activation induced by desflurane,Effects of different doses of ketamine on cognitive function in aged rats,Efficacy of sufentanil combined with propofol for video-assisted endoscopic transthoracic sympathectomy,Accuracy of target-controlled infusion of sufentanil in clinical anesthesia.     

Anesthesia

Anesthetic choice for patients undergoing simuitaneous pancreas-kidney transplantation,Effect of morphine pretrealment on expression of substance P and calcitonin gene related peptide in myocardium following acute myocardial ischemia in rats,Effects of lidocaine and ropivacaine on con- tractility of isolated pregnarlt rat myometrium,Effect of acute hypervolemic hemodilution with different colloids on GP Ⅱ b/Ⅲ a and P-selectin expression in patients with colon cancer during perioperative period,Effects of propofol on extracellular signal-regulated kinase 1/2 phosphorylation in mouse hippocampal slices[第一段]     

Anesthesia

Cerebral protective effect of nicorandil premedication in patients undergoing coronary artery bypass grafting with cardiopuimonary bypass;Protective effects of remifentanil preconditioning on myocardium against ischemia-reperfusion injury in rats; Effects of ultrarapid opiate detoxification during general anesthesia on plasma morphine concentration and brain β-endorphin content in rats addicted to morphine;The effect of propofol on platelet aggregation and blood coagulation in patients undergoing upper ab- dominal surgery/Tao Guocai ; Protective effects of pretreatment with rosigli tazone on the lungs against endotoxin-induced acute injm＇y in rats; ……     

Anesthesia

<正>209480 Effect of high thoracic epidural block on expression of β1-ARK mRNA in lymphocytes in elderly patients with essential hypertension complicated with